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The Role of Pyridoxine in the Prevention and Treatment of Neuropathy and Neurotoxicity Associated with Rifampicin-Resistant Tuberculosis Treatment Regimens: A Topic Review

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Journal of Tuberculosis Research 2023年第2期11卷 33-48页

作者： joseph G. Kariuki Symon m. Kariuki Phuti Angel Department of International Health Charité-Universit&#228tsmedizin Berlin Berlin Germany Department of Tropical Neurosciences KEMRI-Wellcome Trust Research Programme Kilifi Kenya

Rifampicin-resistant tuberculosis (RR-TB) is a global public health problem caused by mycobacterium tuberculosis resistant to Rifampicin. Drug-induced peripheral neuropathy and neurotoxicity are well-known adverse effects of treatment regimens that cause significant morbidity. Pyridoxine is often added to treatment regimens for the prevention and/or treatment of these side effects. The basis and effectiveness of this practice are unclear. We conducted a systematic review to evaluate the effectiveness of pyridoxine in preventing and/or treating neuropathy and neurotoxicity associated with RR-TB treatment. We included studies with patients with RR-TB who experienced neuropathy or neurotoxicity attributed to RR-TB regimens and were given pyridoxine. Our findings showed contradicting evidence on the use of pyridoxine for preventing or treating neurotoxicity due to cycloserine in the treatment of RR-TB. moreover, pyridoxine did not have a protective effect against neuropathy and/or neurotoxicity caused by other RR-TB regimens that do not contain isoniazid. In conclusion, we found that withdrawing or withholding medications such as linezolid, cycloserine, thioamides, fluoroquinolones, and ethambutol, implicated in causing neuropathy or neurotoxicity was more effective than using pyridoxine to stop the progression of symptoms, and in some instances, led to their reversal over time.

关键词： Rifampicin-Resistant Tuberculosis Pyridoxine Vitamin B6 Neuropathy Neurotoxicity multidrug-Resistant Tuberculosis Extensively Drug-Resistant Tuberculosis

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microstructure and battery performance of mg-Zn-Sn alloys as anodes for magnesium-air battery

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Journal of magnesium and Alloys 2021年第6期9卷 1967-1976页

作者： Fanglei Tong Xize Chen Shanghai Wei Jenny malmstr^m joseph Vella Wei Gao Department of Chemical&materials Engineering Faculty of EngineeringThe University of AucklandNew Zealand macDiarmid Institute for Advanced materials and Nanotechnology WellingtonNew Zealand School of Chemical Science Faculty of ScienceThe University of AucklandNew Zealand

Four mg-x Zn-y Sn(x=2,4 and y=1,3 wt.%)alloys are investigated as anode materials for magnesium-air(mg-air)*** self-corrosion and battery discharge behavior of these four mg-Zn-Sn alloys are analyzed by electrochemical measurements and mg-air battery *** results show that addition of Sn stimulates the electrochemical activity and significantly improves the anodic efficiency and specific capacity of mg-Zn alloy *** the four alloy anodes,mg-2Zn-3Sn(ZT23)shows the best battery discharge performance at low current densities(≤5 m A cm^(-2)),achieving high energy density of 1367 m Wh g^(-1)at 2 mA cm^(-2).After battery discharging,the surface morphology and electrochemical measurement results illustrate that a ZnO and SnO/SnO_(2)mixed film on alloy anode surface decreases self-corrosion and improves anodic efficiency during *** excessive intermetallic phases lead to the failure of passivation films,acting as micro-cathodes to accelerate self-corrosion.

关键词： magnesium alloys Alloy anode Self-corrosion magnesium-air battery Discharge performance

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糖尿病相关的足病的定义和标准(2023年更新版)

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感染、炎症、修复 2024年第1期25卷 80-85页

作者： Jaap J.van Netten Sicco A.Bus Jan Apelqvist Pam Chen Vivienne Chuter Robert Fitridge Frances Game Robert J.Hinchliffe Peter A.Lazzarini joseph mills matilde monteiro-Soares Edgar J.G.Peters Katherine m.Raspovic Eric Senneville Dane K.Wukich Nicolaas C.Schaper on behalf of the International Working Group on the Diabetic Foot 张会峰(译) 许樟荣(审校) Department of Rehabilitation medicine Amsterdam UMCLocation University of AmsterdamAmsterdamthe Netherlands Amsterdam movement Sciences Program RehabilitationAmsterdamthe Netherlands Department of Endocrinology University Hospital of MalmöMalmöSweden Joondalup Health Campus Ramsay HealthcareSydneyAustralia Faculty of Health University of TasmaniaHobartAustralia School of Health Sciences Western Sydney UniversitySydneyAustralia Faculty of Health and medical Sciences University of AdelaideAdelaideAustralia Vascular and Endovascular Service Royal Adelaide HospitalAdelaideAustralia Department of Diabetes and Endocrinology University Hospitals of Derby and Burton NHS Foundation TrustDerbyUK Department of Vascular Surgery University of BristolBristolUK School of Public Health and Social Work Queensland University of TechnologyBrisbaneAustralia Allied Health Research Collaborative The Prince Charles HospitalBrisbaneAustralia michael E.DeBakey Department of Surgery Division of Vascular Surgery and Endovascular TherapyBaylor College of MedicineHoustonTexasUSA Portuguese Red Cross School of Health–Lisbon LisbonPortugal mEDCIDS–Departamento de medicina da Comunidade Informação e Decisão em Saúde Faculty of Medicine of the University of PortoPortoPortugal RISE@CINTESIS Faculty of Medicine Oporto UniversityPortoPortugal Department of Internal medicine Amsterdam UMCVrije Universiteit AmsterdamSection of Infectious DiseasesAmsterdamthe Netherlands Department of Orthopaedic Surgery University of Texas Southwestern Medical CenterDallasTexasUSA Department of Infectious Diseases Gustave Dron Hospital Tourcoing Univ-lilleTourcoingFrance Div.Endocrinology MUMC+CARIM and CAPHRI InstituteMaastrichtThe Netherlands 不详河南省人民医院内分泌科河南郑州450003 战略支援部队特色医学中心北京100101

糖尿病相关的足病管理涉及多个学科,通用的专业词汇对于各学科间准确沟通交流至关重要。国际糖尿病足工作组(IWGDF)对相关文献进行了系统综述,构成了制定IWGDF指南的基础,并且明确了糖尿病相关的足病的一系列定义、标准及名词解释。本... 详细信息

糖尿病相关的足病管理涉及多个学科,通用的专业词汇对于各学科间准确沟通交流至关重要。国际糖尿病足工作组(IWGDF)对相关文献进行了系统综述,构成了制定IWGDF指南的基础,并且明确了糖尿病相关的足病的一系列定义、标准及名词解释。本文介绍2023年IWGDF对这些定义和标准的更新,并建议在临床实践和研究中一致使用,以利于世界各地不同学科人员针对糖尿病相关的足病的专业性交流。

关键词：定义糖尿病糖尿病相关的足病国际糖尿病足工作组

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Successful management of a mixed epithelial and stromal renal tumor masquerading as lower pole renal cyst:A laparoscopic deroofing approach

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UroPrecision 2024年第1期2卷 36-39页

作者： Alain m.mukendi Emelia K.C.de Heer-menlah Phaladi Charles E.mathye Department of Surgery Division of UrologyHelen Joseph HospitalUniversity of the WitwatersrandJohannesburgSouth Africa

Background:Renal cysts are common in clinical practice,but some may harbor rare pathological entities such as mixed epithelial and stromal tumors(mEST).Imaging studies are crucial for accurate *** laparoscopic deroofing is an established approach for symptomatic renal cysts,encountering mEST within a cyst is *** Presentation:We present the case of a 37-year-old female who presented with persistent left flank *** revealed a large renal cyst in the lower pole of the left kidney,classified as Bosniak *** analgesia,the patient's symptoms persisted,leading to a laparoscopic deroofing *** examination postprocedure revealed a *** patient reported complete resolution of symptoms at the 3-month ***:This unique case presents the successful identification and surgical management of a mEST masquerading as a lower pole renal cyst through laparoscopic *** also contributes to the existing literature by highlighting the importance of considering rare pathological entities in the evaluation of renal cysts and the value of laparoscopic techniques in their management.

关键词： laparoscopic deroofing mixed epithelial and stromal tumor renal cyst renal tumor

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Posterior reversible encephalopathy syndrome following uneventful clipping of an unruptured intracranial aneurysm:A case report

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World Journal of Clinical Cases 2023年第19期11卷 4723-4728页

作者： joseph Hwang Won-Ho Cho Seung-Heon Cha Jun-Kyueng Ko Department of Neurosurgery Biomedical Research InstitutePusan National University HospitalSchool of MedicinePusan National UniversityBusan 49241South Korea

BACKGROUND Posterior reversible encephalopathy syndrome(PRES)is characterized mainly by occipital and parietal lobe involvement,which can be reversible within a few ***,we report a rare case of PRES that developed after craniotomy for an unruptured intracranial aneurysm(UIA).CASE SUmmARY A 59-year-old man underwent clipping surgery for the treatment of UIA arising from the left middle cerebral *** surgery was performed uneventfully,and he regained consciousness quickly immediately after the *** the 4th hour after surgery,he developed a disorder of consciousness and *** resonance imaging revealed cortical and subcortical T2/FLAIR hyperintensities in the parietal,occipital,and frontal lobes ipsilaterally,without restricted diffusion,consistent with unilateral *** conservative treatment,his symptoms and radiological findings almost completely disappeared within *** our case,the important causative factor of PRES was suspected to be a sudden increase in cerebral perfusion pressure associated with temporary m1 *** Our unique case highlights that,to our knowledge,this is the second report of PRES developing after craniotomy for the treatment of *** must keep PRES in mind as one of the causes of perioperative neurological abnormality following clipping of an UIA.

关键词： Clipping magnetic resonance imaging Posterior reversible encephalopathy syndrome Unruptured intracranial aneurysm Case report

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Tattoos as a window to the psyche:How talking about skin art can inform psychiatric practice

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World Journal of Psychiatry 2017年第3期7卷 148-158页

作者： Hannah Roggenkamp Andrew Nicholls joseph m Pierre mental Illness Research Education and Clinical CenterVA Puget Sound Healthcare System VA Greater Los Angeles Healthcare System Department of Psychiatry and Biobehavioral Sciences David Geffen School of Medicine at UCLA

Tattooing the skin as a means of personal expression is a ritualized practice that has been around for centuries across many different ***,the symbolic meaning of tattoos has evolved over time and is highly individualized,from both the internal perspective of the wearer and the external perspective of an *** modern Western societies through the 1970 s,tattoos represented a cultural taboo,typically associated with those outside of the mainstream such as soldiers,incarcerated criminals,gang members,and others belonging to marginalized and counter-cultural *** paper aims to review the more recent epidemiology of tattoos in Western culture in order to establish that tattooing has become a mainstream *** then review psychological and psychiatric aspects of tattoos,with a goal of revising outmoded stigmas about tattooing and helping clinicians working with tattooed patients to facilitate an exploration of the personal meaning of skin art and *** suggest that as a kind of augmentation of the physical exam,looking at and talking to patients about their tattoos can provide a valuable window into the psyche,informing clinical practice.

关键词： Tattoos military psychiatry Deviance Skin art Psychopathology Psychology

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Climate Change in the Subtropical Jetstream during 1950–2009

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Advances in Atmospheric Sciences 2015年第1期32卷 140-148页

作者： B.ABISH P.V.joseph Ola.m.JOHANNESSEN Nansen Environmental Research Centre India Department of Atmospheric Sciences Cochin University of Science and Technology Nansen Environmental and Remote Sensing Center Nansen Scientific Society

A study of six decades（1950–2009） of reanalysis data reveals that the subtropical jetstream（STJ） of the Southern（Northern） Hemisphere between longitudes 0°E and 180°E has weakened（strengthened） during both the boreal winter（January,February） and summer（July, August） seasons. The temperature of the upper troposphere of the midlatitudes has a warming trend in the Southern Hemisphere and a cooling trend in the Northern Hemisphere. Correspondingly, the north–south temperature gradient in the upper troposphere has a decreasing trend in the Southern Hemisphere and an increasing trend in the Northern Hemisphere, which affects the strength of the STJ through the thermal wind relation. We devised a method of isotach analysis in intervals of 0.1 m s-1in vertical sections of hemispheric mean winds to study the climate change in the STJ core wind speed, and also core height and latitude. We found that the upper tropospheric cooling of the Asian mid-latitudes has a role in the strengthening of the STJ over Asia, while throughout the rest of the globe the upper troposphere has a warming trend that weakens the STJ. Available studies show that the mid-latitude cooling of the upper troposphere over Asia is caused by anthropogenic aerosols（particularly sulphate aerosols） and the warming over the rest of the global mid-latitude upper troposphere is due to increased greenhouse gases in the atmosphere.

关键词： subtropical jetstream upper troposphere greenhouse gases aerosols

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metabolic complications of hepatitis C virus infection

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World Journal of Gastroenterology 2021年第13期27卷 1267-1282页

作者： Rahul Chaudhari Sherouk Fouda Ashik Sainu joseph m Pappachan Department of medicine Pennsylvania Hospital of the University of PennsylvaniaPennsylvaniaPA 19104United States School of Health and Biomedical Sciences RMIT UniversityMelbourne VIC 3000Australia Department of Gastroenterology and Hepatology Aster Oman HospitalAl GhubraMuscat OM 133Oman Department of Endocrinology and metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom

Hepatitis C virus(HCV) infection is a systemic disease that is implicated in multiple extrahepatic organ dysfunction contributing to its protean manifestations. HCV is associated with diverse extrahepatic disorders including atherosclerosis, glucose and lipid metabolic disturbances, alterations in the iron metabolic pathways, and lymphoproliferative diseases over and above the traditional liver manifestations of cirrhosis and hepatocellular carcinoma. The orchestration between HCV major proteins and the liver-muscle-adipose axis, poses a major burden on the global health of human body organs, if not adequately addressed. The close and inseparable associations between chronic HCV infection, metabolic disease, and cardiovascular disorders are specifically important considering the increasing prevalence of obesity and metabolic syndrome, and their economic burden to patients, the healthcare systems, and society. Cellular and molecular mechanisms governing the interplay of these organs and tissues in health and disease are therefore of significant interest. The coexistence of metabolic disorders and chronic hepatitis C infection also enhances the progression to liver fibrosis and hepatocellular carcinoma. The presence of metabolic disorders is believed to influence the chronicity and virulence of HCV leading to liver disease progression. This comprehensive review highlights current knowledge on the metabolic manifestations of hepatitis C and the potential pathways in which these metabolic changes can influence the natural history of the disease.

关键词： Chronic hepatitis C infection Insulin resistance metabolic syndrome Cardiovascular diseases Fatty liver Diabetes mellitus

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Anal intraepithelial neoplasia: A review of diagnosis and management

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World Journal of Gastrointestinal Oncology 2017年第2期9卷 50-61页

作者： joseph R Roberts Lacey L Siekas Andrew m Kaz Department of medicine Division of Gastroenterology University of Washington School of Medicine Gastroenterology Section VA Puget Sound Health Care System

Anal intraepithelial neoplasia(AIN) is a premalignant lesion of the anal mucosa that is a precursor to anal cancer. Although anal cancer is relatively uncommon, rates of this malignancy are steadily rising in the United States, and among certain high risk populations the incidence of anal cancer may exceed that of colon cancer. Risk factors for AIN and anal cancer consist of clinical factors and behaviors that are associated with the acquisition and persistence of human papilloma virus(HPV) infection. The strongest HPV-associated risk factors are HIV infection, receptive anal intercourse, and high risk sexual behavior. A history of HPVmediated genital cancer, which suggests infection with an oncogenic HPV strain, is another risk factor for AIN/anal cancer. Because progression of AIN to anal cancer is known to occur in some individuals over several years, screening for AIN and early anal cancer, as well as treatment of advanced AIN lesions, is reasonable in certain high-risk populations. Although randomized controlled trials evaluating screening and treatment outcomes are lacking, experts support routine screening for AIN in high risk populations. Screening is performed using anal cytological exams, similar to those performed in cervical cancer screening programs, along with direct tissue evaluation and biopsy via high resolution anoscopy. AIN can be treated using topical therapies such as imiquimod, 5-flurouracil, and trichloroacetic acid, as well as ablative therapies such as electrocautery and laser therapy. Reductions in AIN and anal cancer rates have been shown in studies where high-risk populations were vaccinated against the oncogenic strains of HPV. Currently, the CDC recommends both high-risk and average-risk populations be vaccinated against HPV infection using the quadrivalent or nonavalent vaccines. It is important for clinicians to be familiar with AIN and the role of HPV vaccination, particularly in high risk populations.

关键词：肛门癌症肛门 intraepithelial 瘤形成肛门有鳞的房间癌人的乳头状瘤病毒疫苗人的乳头状瘤病毒

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Comparative study of mechanical, corrosion and erosion-corrosion properties of cast hyper-duplex and super-duplex stainless steels

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International Journal of minerals,metallurgy and materials 2020年第7期27卷 954-961页

作者： P.Nithin Raj P.K.Navaneethkrishnan K.Sekar m.A.joseph Department of mechanical Engineering National Institute of TechnologyCalicutIndia

Duplex stainless steels(DSSs)used in subsea structures and desalination industries require high corrosion and erosion resistance as well as excellent mechanical *** newly introduced cast duplex grade ASTm A8907 A has a unique composition and is expected to have a much better resistance to corrosion and erosion compared with the super-duplex grades 5 A and 6 *** work is a comparative study of the mechanical properties,corrosion,and erosion-corrosion resistance of super-duplex grades 5 A and 6 A and the hyper-duplex grade 7 *** three DSSs exhibited equiaxial austenite islands in the ferrite matrix and balanced phase *** hardness of the grade 7 A was nearly 15%higher than those of the super-duplex grades,which is attributed to the effect of the higher contents of W and mn in 7 *** impact toughness of grade 7 A was found to be lower than those of the super-duplex grades due to the carbide precipitation resulting from the partial substitution of mo with *** oxide layer strengthening effect of rare earth elements and the higher pitting resistance equivalent number(PREN)of grade7 A resulted in higher corrosion *** harder and more passive grade 7 A showed a 35%lower material loss during erosion-corrosion.

关键词： hyper-duplex stainless steels erosion−corrosion electrochemical corrosion marine environment super-duplex stainless steels

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