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Harrison's Principles of Internal Medicine (2 Vol Set) 17th ed.

2008年

作者： Anthony S. Fauci Eugene Braunwald Dennis L. Kasper Stephen L. Hauser Dan L. Longo J. Larry Jameson joseph loscalzo

ISBN: (纸本)9780071476911

Introducing the most dramatically revised edition of Harrison's ever!Now with NEW bonus DVD with 37 chapters and more than 500 brand new images and video clips! MORE THAN TRUSTED, BEYOND ESSENTIAL . . . !The #1 selling medical textbook worldwide, Harrison's has defined internal medicine for millions of clinicians and students. The new Seventeenth Edition retains Harrison's acclaimed balance of pathobiology, cardinal signs and manifestations of disease, and best approaches to patient management, yet has been massively updated to give you an innovative array of bold new features and content. If ever there was one must-have resource for clinicians and students - this is it!UNMATCHED EXPERTISE AT YOUR FINGERTIPS!As an unprecedented amount of medical information bombards you and your patients, where do you go to sort it out and make sense of it all? When your patients request clarification on something they've “printed off” where do you turn for expert explanations? The same trusted resource physicians and students have turned to for over fifty years: Harrison's Principles of Internal Medicine. Now more than ever, trust Harrison's to filter and clarify the exploding knowledge base, to highlight the breakthroughs, and to deliver a clear, balanced distillation of the best and most current information on which to base clinical *** MOST EXCITING AND EXTENSIVELY REVISED EDITION EVER!Here are just a few of the reasons why the new 17th Edition of Harrison's is the best edition yet:A) Bonus companion DVD featuring:- 37 new “e-chapters"- over 500 brand-new radiological, laboratory- clinical images, including complete atlases- state-of-the-art video clips- an Image Bank of nearly all the illustrations contained in the parent textB) Expanded, modernized illustration program with more than 800 brand-new, additional illustrations-a 60% increase over the previous editionC) Dozens of brand new chapters on vital topics in medical education and clinical practice: Global Issues

关键词： Internal medicine. Internal Medicine.

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基因编码的高时空分辨NADH探针

基因编码的高时空分辨NADH探针

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第十届全国酶学学术讨论会

作者：赵玉政金晶呼庆勋周海梦易静于振行徐磊王雪杨弋 joseph loscalzo 华东理工大学生物反应器工程国家重点实验室药学院清华大学生命科学院教育部蛋白质科学重点实验室上海交通大学医学院基础医学院教育部细胞分化与凋亡重点实验室 China National Center for Biotechnology Development Cardiovascular Division Department of MedicineBrigham and Women's HospitalHarvard Medical SchoolBostonMA 02115USA.

还原型烟酰胺腺嘌呤二核苷酸(NADH)及其氧化型(NAD)是细胞内的氧化还原反应最重要的辅酶,广泛参与了细胞内的信号转导与基因调控,与许多人类重要疾病关系密切。由于NADH在代谢和信号转导中的中心作用及其在疾病诊疗中的重要性,对组织与... 详细信息

还原型烟酰胺腺嘌呤二核苷酸(NADH)及其氧化型(NAD)是细胞内的氧化还原反应最重要的辅酶,广泛参与了细胞内的信号转导与基因调控,与许多人类重要疾病关系密切。由于NADH在代谢和信号转导中的中心作用及其在疾病诊疗中的重要性,对组织与细胞内NADH的分布进行生物成像将为相关研究提供重要的信息。长期以来应用的NADH自发荧光成像的方法存在局限,国际上对于NADH尚无有效的高时空分辨的在体检测方法,特别是没有高灵敏度、可以定位于亚细胞结构的荧光蛋白探针,

关键词： NADH 脱氢酶基因编码荧光探针活细胞成像

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Influence of surface modified mixed metal oxide nanoparticles on the electrochemical and mechanical properties of polyurethane matrix

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Frontiers of Chemical Science and Engineering 2023年第1期17卷 1-14页

作者： joseph Raj Xavier Department of Chemistry Saveetha School of EngineeringSaveetha Institute of Medical and Technical SciencesChennai-602105India

Newly synthesized functional nanoparticles,3-amino-1,2,4-triazole(ATA)/SiO_(2)—TiO_(2)were introduced to the polyurethane(PU)*** techniques were used to investigate the barrier properties of the synthesized PU—ATA/SiO_(2)—TiO_(2)nanocomposite coated steel *** natural seawater,electrochemical impedance spectroscopy experiments indicated outstanding protective behaviour for the PU—ATA/SiO_(2)—TiO_(2)coated *** coating resistance(Rcoat)of PU—ATA/SiO_(2)—TiO_(2)was determined to be 2956.90 kΩ·cm^(−2).The Rcoat of the PU—ATA/SiO_(2)—TiO_(2)nanocomposite coating was found to be over 50%higher than the PU *** current measured along the scratched surface of the PU—ATA/SiO_(2)—TiO_(2)coating was found to be very low(1.65 nA).The enhanced ATA/SiO_(2)—TiO_(2)nanoparticles inhibited the entry of electrolytes into the coating interface,as revealed by scanning electron microscopy/energy dispersive X-ray spectroscopy and X-ray diffraction analysis of the degradation *** contact angle testing validated the hydrophobic nature of the PU—ATA/SiO_(2)—TiO_(2)coating(θ=115.4°).When the concentration of ATA/SiO_(2)—TiO_(2)nanoparticles was 2 wt%,dynamic mechanical analysis revealed better mechanical ***,the newly synthesised PU—ATA/SiO_(2)—TiO_(2)nanocomposite provided excellent barrier and mechanical properties due to the addition of ATA/SiO_(2)—TiO_(2)nanoparticles to the polyurethane,which inhibited material degradation and aided in the prolongation of the coated steel’s life.

关键词： SiO_(2)/TiO_(2)nanoparticle nanocomposite coatings dynamic mechanical analysis electrochemical techniques corrosion colloids and interfaces

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SoNar,一个高度响应的NAD+/NADH探针,允许抗肿瘤剂的高通量代谢筛选

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科学新闻 2016年第1期 71-71页

作者：赵玉政 Qingxun Hu Feixiong Cheng Ni Su Aoxue Wang Yejun Zou Hanyang Hu Xianjun Chen Hai-Meng Zhou Xinzhi Huang Kai Yang Qian Zhu Xue Wang Jing Yi Linyong Zhu Xuhong Qian Lixin Chen Yun Tang joseph loscalzo 杨弋华东理工大学药学院中国生物化学与分子生物学会中国生化学会酶学专业委员会上海市细胞生物学学会华东理工大学生物反应器工程国家重点实验室

文章简介肿瘤细胞的代谢发生变异,从而使之获得生存与增殖的优势。研究表明,靶向这样的代谢变化是一种有用的肿瘤治疗策略。研究团队发展了一个高亮度、快速响应、pH不敏感、大动态范围的遗传编码的代谢荧光探针。该探针命名为SoNar,可... 详细信息

文章简介肿瘤细胞的代谢发生变异,从而使之获得生存与增殖的优势。研究表明,靶向这样的代谢变化是一种有用的肿瘤治疗策略。研究团队发展了一个高亮度、快速响应、pH不敏感、大动态范围的遗传编码的代谢荧光探针。该探针命名为SoNar,可以追踪细胞胞浆内与活体内NAD+与NADH氧化还原状态。SoNar探针可以实时响应细胞能量代谢中各途径的细微扰动,并允许抗肿瘤剂的高通量代谢筛选。在5500种独特的化合物中,研究人员发现,化合物KP372-1是强效NQO1介导的氧化还原循环剂,可产

关键词： NADH SoNar 遗传编码

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On Two Classes of Finite Inseparable p-Groups

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Acta Mathematica Sinica,English Series 2015年第7期31卷 1203-1214页

作者： joseph KIRTL Department of Mathematics Marist College

A finite group is inseparable, it does not split over any proper nontrivial normal subgroup; that is, if it has no nontrivial semidirect product decompositions. This paper investigates two classes of finite inseparabl... 详细信息

关键词： p-group inseparable splitting

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Toll-like receptor signaling in hematopoietic homeostasis and the pathogenesis of hematologic diseases

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Frontiers of Medicine 2015年第3期9卷 288-303页

作者： joseph Cannova Biochemistry and Molecular Biology Program Loyola University Chicago Maywood IL 60153 USA Stritch School of Medicine Loyo& University Chicago Maywood IL 60153 USA Oncology Institute Loyola University Chicago Maywood IL 60153 USA Department of Pathology Loyola University Chicago Maywood IL 60153 USA Department of Biology Loyola University Chicago Chicago IL 60660 USA Department of Molecular and Cellular Physiology Loyola University Chicago Maywood IL 60153 USA

Toll-like receptors （TLRs）, which are found in innate immune cells, are essential mediators of rapid inflammatory responses and appropriate T-cell activation in response to infection and tissue damage. Accumulating evidence suggests that TLR signaling is involved in normal hematopoiesis and specific hematologic pathologies. Particular TLRs and their downstream signaling mediators are expressed not only in terminally differentiated innate immune cells but also in early hematopoietic progenitors. Sterile activation of TLR signaling is required to generate early embryonic hematopoietic progenitor cells. In adult animals, TLR signaling directly or indirectly promotes differentiation of myeloid cells at the expense of that of lymphoid cells and the self renewal of hematopoietic stem cells during infection and tissue damage. Activating mutations of the MyD88 gene, which codes for a key adaptor involved in TLR signaling, are commonly detected in B-cell lymphomas and other B-cell hematopathologies. Dysregulated TLR signaling contributes to the pathogenesis of many hematopoietic disorders, including bone marrow failure, myelodysplastic syndrome, and acute myeloid leukemia. Complete elucidation of the molecular mechanisms by which TLR signaling mediates the regulation of both normal and pathogenic hematopoiesis will prove valuable to the development of targeted therapies and strategies for improved treatment of hematopoietic disorders.

关键词： TLR MyD88 hematopoiesis bone marrow failure leukemia myelodysplastic syndrome

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Modeling some long-term implications of CO_2 fertilization for global forests and forest industries

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Forest Ecosystems 2016年第1期3卷 13-25页

作者： joseph Buongiorno Department of Forest and Wildlife Ecology University of Wisconsin-Madison

Background： This paper explored the long-term, ceteris-paribus effects of potential CO2 fertilization on the global forest sector. Based on the findings of Norby et al. （PNAS 2005, 102（50）） about forest response to elevated [CO2]. Methods： Forest productivity was increased in the Global Forest Products Model （GFPM） in proportion to the rising [CO2] projected in the IPCC scenario A1B, A2, and 132. Projections of the forest area and forest stock and of the production, consumption, prices, and trade of products ranging from fuelwood to paper and paperboard were obtained with the GFPM for each scenario, with and without CO2 fertilization beginning in 2011 and up to 2065. Results： CO2 fertilization increased wood supply, leading to lower wood prices which in turn induced modest lower prices of end products and higher global consumption. However, production and value added in industries decreased in some regions due to the relative competitive advantages and to the varying regional effects of CO2 fertilization. Conclusion： The main effect of CO2 fertilization was to raise the level of the world forest stock in 2065 by 9 to 10 % for scenarios A2 and B2 and by 20 % for scenario A1B. The rise in forest stock induced by fertilization was in part counteracted by its stimulation of the wood supply which resulted in lower wood prices and increased harvests.

关键词： CO2 fertilization Climate change Prices Supply Demand International trade

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Current perspectives and the future of disease-modifying therapies in type 1 diabetes

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World Journal of Diabetes 2025年第1期16卷 12-21页

作者： Sunetra Mondal joseph M Pappachan Department of Endocrinology NRS Medical College and HospitalKolkata 700014West BengalIndia Department of Endocrinology and Metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Department of Endocrinology Kasturba Medical CollegeManipal 576104India

Use of immunomodulating agents to prevent the progression of autoimmuneβ-cell damage leading to type 1 diabetes mellitus(T1DM)is an interesting area for *** include non-specific anti-inflammatory agents,immunologic vaccination and anti-inflammatory agents targeting specific immune cells or *** is an anti-CD3-molecule that binds to and leads to the disappearance of the CD3/TCR complex and rendering the T cell anergic to its target *** and clinical trials have demonstrated its efficacy in reducing the decline in serum C-peptide levels and the need for insulin therapy if used early in the disease process of *** benefits have been apparent as early as six months to as long as seven years after *** has recently been approved by the Food and Drug Administration to delay the onset of clinical(stage 3)type 1 diabetes in children above 8 years of *** their recent metaanalysis published in the World Journal of Diabetes,Ma et al found that those in the teplizumab treatment group have a greater likelihood of reduction in insulin use,change in C-peptide response,and better glycemic control compared to the control group with a good safety ***,all the included randomized control trials have been conducted in high-income *** cost of therapy and unknown utility of the molecule in stage 3 disease limit its widespread use.

关键词： Teplizumab Type 1 diabetes mellitus Disease modifying therapy β-cell function C-peptide Immunotherapy

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Nonlinearly Coupled KdV Equations Describing the Interaction of Equatorial and Midlatitude Rossby Waves

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Chinese Annals of Mathematics,Series B 2009年第5期30卷 483-504页

作者： joseph A. BIELLO Department of Mathematics University of California at Davis

Amplitude equations governing the nonlinear resonant interaction of equatorial baroclinic and barotropic Rossby waves were derived by Majda and Biello and used as a model for long range interactions （teleconnections） between the tropical and midlatitude troposphere. An overview of that derivation is nonlinear wave theory, but not in atmospheric presented and geared to readers versed in sciences. In the course of the derivation, two other sets of asymptotic equations are presented： the long equatorial wave equations and the weakly nonlinear, long equatorial wave equations. A linear transformation recasts the amplitude equations as nonlinear and linearly coupled KdV equations governing the amplitude of two types of modes, each of which consists of a coupled tropical/midlatitude flow. In the limit of Rossby waves with equal dispersion, the transformed amplitude equations become two KdV equations coupled only through nonlinear fluxes. Four numerical integrations are presented which show （i） the interaction of two solitons, one from either mode, （ii） and （iii） the interaction of a soliton in the presence of different mean wind shears, and （iv） the interaction of two solitons mediated by the presence of a mean wind shear.

关键词： Coupled KdV equations Equatorial Rossby waves Solitary waves Atmospheric teleconnections

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Analgesic effects of JCM-16021 on neonatal maternal separation-induced visceral pain in rats

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World Journal of Gastroenterology 2010年第7期16卷 837-845页

作者： joseph JY Sung Faculty of Medicine The Chinese University of Hong Kong

AIM:To investigate the pharmacological effect of JCM-16021,a Chinese herbal formula,and its underlying ***:JCM-16021 is composed of seven herbal plant *** raw materials of the formula were examined according to the quality control criteria listed in the Chinese Pharmacopeia(2005).In a neonatal maternal separation(NMS)model,male SpragueDawley rats were submitted to daily maternal separation from postnatal day 2 to day 14,or no specific handling(NH).Starting from postnatal day 60,rats were administered JCM-16021(2,4,8 g/kg per day)orally twice a day for 28 *** threshold pressure and electromyographic activities of external oblique muscles in response to colorectal distention recorded with a Power Lab System(AD Instruments International),were tested as pain *** in serotonin(5-HT)and 5-hydroxyindoleacetic acid(5-HIAA)concentrations in the colon of rats were analyzed;the enterochromaffin cell numbers and serotonin transporter in the colon of rats were also evaluated with an immunohistochemistry ***:NMS treatment significantly reduced pain threshold pressure(37.4±1.4 mmHg),as compared to that of NH rats(57.7±1.9 mmHg,P<0.05).After JCM-16021 treatment,the pain threshold pressure significantly increased when compared to that before treatment(34.2±0.9 mmHg vs 52.8±2.3 mmHg in the high dose group,40.2±1.6 mmHg vs 46.5±1.3 mmHg in the middle dose group,and 39.3±0.7 mmHg vs 46.5±1.6 mmHg in the low dose group,P<0.05).Also JCM-16021 significantly and dose-dependently decreased electromyographic activity to the graded colorectal distension(CRD),(the meanΔAUC values were:0.17±0.03,0.53±0.15,1.06±0.18,1.22±0.24 in the high dose group;0.23±0.04,0.68±0.17,1.27 ±0.26,1.8±0.3 in the middle dose group;and 0.29 ±0.06,0.8±0.16,1.53±0.24,2.1±0.21 in the low dose group for the pressures 20,40,60,80 mmHg),as compared to the NMS vehicle *** meanΔAUC values were:0.57±0.12,1.33±0.18,2.57±0.37,3.08±0.37 for the pressures 20,40,60,80 mmHg(P

关键词： Analgesia effect Neonatal maternal separation Visceral hyperalgesia Herbal medicine Serotonin pathway

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