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Antinephrotoxic and antihyperlipidaemic activities of Cucurbita maxima leaf supplemented diets in stz-induced diabetic rats

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Toxicology Advances 2023年第4期5卷 24-32页

作者： Job Itanyi Onuche Arowora Kayode Adebisi joseph ikwebe Michael Sunday Abu Department of Biochemistry Faculty of Pure and Applied SciencesFederal University Wukari.Wukari ***Taraba StateNigeria

Background:Cucurbita maxima plant materials are frequently used to manage a number of disorders,according to previous ***:The goal of the present report was to look into further possible effects of this plant on kidney disorder in rats brought on by diabetes as well as the related abnormalities in lipid ***:To assess the ameliorative effect of the plant,streptozotocin(STZ)(45 mg/kg/day)was given as a single dosage to cause type 1 *** then,diabetic rats received supplemented diets of Cucurbita maxima for four weeks at 5%,10%,15%and 20%ad ***,in another experiment to evaluate the preventive capacity of Cucurbita maxima,the STZ-induction came at the end of four weeks *** and kidney tissues were obtained at the end of the treatments and ***,the analysis of kidney function and lipid profile was made using serum obtained from the blood *** change in kidney was also observed using haematoxylin and eosin stain Results:Our findings demonstrated that Cucurbita maxima drastically(P<0.05)decreased the elevated kidney indicators such as urea and creatinine in the blood,and restored the electrolytes and lipid profiles anomalies as compared to the normal ***,the alteration of biochemical parameters in the STZ-induced diabetic control remained unchanged throughout as compared to the normal *** above mentioned biochemical changes that took place in kidney tissues were further corroborated by histological ***:The results suggest that Cucurbita maxima leaves supplemented diets reversed STZ-induced renal disorder and abnormal lipid metabolism,and that these effects may be mediated by interacting with multiple receptors to raise the levels of antioxidant enzymes in the system.

关键词： antinephrotoxic antihyperlipidaemic Cucurbita maxima supplementation STZ-induced diabetes

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Potential of <i>Dictyosphaerium</i>sp. LC172264 Concomitant Remediation of Cassava Wastewater and Accumulation of Lipids for Biodiesel Production

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Advances in Bioscience and Biotechnology 2021年第8期12卷 257-274页

作者： Innocent Okonkwo Ogbonna joseph ikwebe Otsai Otsima Okpozu Chijioke Nwoye Eze James Chukwuma Ogbonna Department of Microbiology Federal University of Agriculture Makurdi Nigeria Department of Biochemistry Federal University Wukari Nigeria Environmental Science Unit Federal University of Agriculture Makurdi Nigeria Department of Science Laboratory Technology University of Nigeria Nsukka Nigeria Department of Microbiology University of Nigeria Nsukka Nigeria

As a way of making algal feedstock feasible for biofuel production, simultaneous utilization of microalga Dictyosphaerium sp. LC172264 for cassava wastewater remediation and accumulation of lipids for biodiesel production was investigated. The algal biomass, lipid contents and composition were measured from the autotrophic, heterotrophic and mixotrophic cultured algal cells. Physicochemical parameters of the cassava wastewater and bioremediation potentials were measured. Biodiesel properties were deduced and compared with the standards. The results showed that mixotrophic culture was the best for both biomass accumulation (1.022 g/L) and lipid contents (24.53%). Irrespective of the culture condition, the predominant fatty acids were similar and included 11-Octadecenoic acid (vaccenic acid (C19H36O2), oleic acid (C18H34O2) and 14-methyl pentadecanoic acid (isopalmitic acid (C17H34O2). The percentage reduction of total dissolved solids was 79.32% and 89.78% for heterotrophy and mixotrophy respectively. Biochemical oxygen demand was 72.95% and 89.35%, chemical oxygen demand was 72.19% and 84.03% whereas cyanide contents reduced from the initial value of 450 mg/L to 93.105 (79.31%) and 85.365 mg/L (81.03%) respectively. Dictyosphaerium sp. showed good growth and lipid production under mixotrophic condition and produced good quality biodiesel under the three cultivation modes. Even though both mixotrophic and heterotrophic conditions had good promise of cassava wastewater remediation by Dictyosphaerium sp., mixotrophy showed superiority.

关键词： Biodiesel Production Cassava Wastewater Dictyosphaerium sp. Fatty Acid Profile

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Potential of Dictyosphaerium ***172264 Concomitant Remediation of Cassava Wastewater and Accumulation of Lipids for Biodiesel Production

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Advances in Bioscience and Biotechnology 2021年第8期

作者： Innocent Okonkwo Ogbonna joseph ikwebe Otsai Otsima Okpozu Chijioke Nwoye Eze James Chukwuma Ogbonna

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