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Cortical columns(barrels)display normal size in the brain’s primary somatosensory cortex of mice carrying null mutations of the insulin receptor substrate 1 gene:A preliminary report

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Advances in Bioscience and Biotechnology 2013年第10期4卷 945-948页

作者： Marta Lopez-Santibanez Guevara Eileen Uribe-Querol Alma Lilia fuentes farias Esperanza Melendez-Herrera Agustine joseph D’Ercole Gabriel Gutierrez-Ospina Departamento de Biologia Celular y fisiologia Instituto de Investigaciones BiomedicasUniversidad Nacional Autonoma de MexicoMexico D.F.Mexico Division de Estudios de Posgrado e Investigacion Facultad de OdontologiaUniversidad Nacional Autonoma de MexicoMexico D.F.Mexico Departamento de Zoologia Instituto de Investigaciones sobre los Recursos NaturalesUniversidad Michoacana de San Nicolas de HidalgoMoreliaMexico Department of Pediatrics The University of North Carolina at Chapel HillChapel HillUSA Coordinacion de Psicofisiologia Facultad de PsicologiaUniversidad Nacional Autonoma de MexicoMexico D.F.Mexico

Circuits in barrels of the rodent brain’s primary somatosensory (S1) cortex build up following constructivist rules. Previous evidence in mice supports that the precise addition of barrel neuropil is promoted by insulin-like growth factor-1 (IGf-1). The signaling cascades mediating this response remain undetermined. To address whether the effects of IGf-1 upon the growth of S1 circuits are mediated by insulin receptor substrate-1 (IRS-1), we studied barrel size in adult mice having the IRS-1 gene knocked out (IRS-1 ko). Our results reveal that barrel size is similar between wild type and IRS-1 ko mice suggesting that IRS-1 is not essential for barrel circuitry growth. Hence, investigations aimed at exploring other substrates activated by IGf-1, namely IRS-2 and IRS-4, are needed to reveal signaling pathways that mediate the precise addition of S1 neuronal circuitry.

关键词： Barrel Cortex Neuronal Circuit Assemblage Trophic Interactions Constructivism

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QBC ParaLens^(TM) LED fluorescent microscope attachment with QBC f.A.S.T.^(TM) AfB staining system

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Journal of Tuberculosis Research 2013年第3期1卷 40-43页

作者： Kouassi N’Guessan Brian joseph Hnatkovich N’Guetta Aka Armand Achy-Brou Bakary Coulibaly Jean Marc Assande Philomene Mohoudi Mireille Dosso Departement de Bacteriologie-Virologie Institut Pasteur de Cote d’IvoireAbidjanCote d’Ivoire QBC Diagnostics Inc.Port MatildaUSA Departement d’Epidemiologie Institut Pasteur de Cote d’IvoireAbidjanCote d’Ivoire

This study was designed to evaluate the QBC ParaLensTM LED fluorescent microscope attachment and the QBC *** AfB staining system for the detection of Acid fast Bacilli in pathological samples in Abidjan, Cote d’Ivoire. A total of 50 patients were tested using direct smear specimens with both Ziehl-Neelsen (ZN) light microscopy and LED fluorescence microscopy with QBC f.A.S.T. AfB stain. The samples were also cultured and tested using an immunochromatograpic test for detection of antigen MPT 64 and the results were compared to direct examination. ZN light microscopy detected 20 positive cases and LED fluorescent microscopy with QBC f.A.S.T. AfB stain detected 21. The sensitivity and specificity of ZN light microscopy was determined to be 84.2% and 87.1% respectively. The sensitivity and specificity of LED fluorescent microscopy with QBC f.A.S.T. AfB stain was determined to be 94.7% and 90.3% respectively. Compared to ZN light microscopy, LED fluorescent microscopy with QBC f.A.S.T. AfB stain increased the sensitivity of direct examination without concentration by 10.5%.

关键词： Tuberculosis AfB Ziehl-Neelsen LED fluorescence QBC ParaLens QBC f.A.S.T.

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Serotypes of Bacteria Encountered in Childhood Purulent Meningitis in Children in Parakou (Benin) in 2011

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Open Journal of Pediatrics 2016年第1期6卷 109-119页

作者： joseph Agossou Julien Didier Adédémy Alphonse Noudamadjo Mahougnon Rachelle Mariette Houessou Pierre Tsawlassou Rolande Assogba Godonou Gracien Sagbo Honorat francis Lalya Maroufou Jules Alao Honoré Bankolé f. Hounsou Rock Aristide Sossou José Biey Martin Antonio Claire Oluwalana Jarju Sheikh Sikiratou Adéothy-Koumakpaï Ayélèrou Simon Akpona Blaise Ayivi Department of Mother and Child Faculty of Medicine University of Parakou Parakou Benin Borgou Regional University Teaching Hospital Parakou Benin Department of Mother and Child Faculty of Health Sciences University of Abomey-Calavi Abomey-Calavi Benin Ministry of Health of Benin Cotonou Benin WHO/Benin Cotonou Benin Medical Research Council Laboratories Banjul Gambia Department of fundamental Sciences and Clinical Biochemistry Teaching & Research Unit Faculty of Medicine University of Parakou Parakou Benin

Introduction: In the North-Benin, there are three agents causing pediatric purulent meningitis outside the neonatal period. These are: Streptococcus pneumoniae, Neisseria meningitidis and Haemophilus influenzae type b. The aim of this research work was to investigate bacteria serotypes that caused childhood purulent meningitis in the pediatric unit of the Borgou à Regional University Teaching Hospital (CHUD-Borgou) located in Parakou (North-Benin). Patients and Methods: Through a prospective and descriptive study centered on children aged 0 to 5 years old suspected of meningitis and hospitalized, the cerebrospinal fluid (CSf) samples of those children were analyzed at the WHO reference laboratory in Banjul for serotyping by real time polymerase chain reaction (RT/PCR). Results: Among the 1396 children hospitalized during that period, 366 were suspected of meningitis and had benefitted from lumbar puncture. Among those 366 suspected cases, 51 cases of purulent meningitis were confirmed after CSf cytobacteriological and biochemical test at the CHUD-Borgou laboratory. Among 51 CSf samples in which purulent meningitis was confirmed, 44 were sent to Banjul. In addition, 310 CSf samples from non-confirmed cases of meningitis were also sent to Banjul. In the whole set of samples sent for real time PCR, 151 cases of Streptococcus pneumoniae (42.7%) were found, 5 cases of Neisseria meningitidis (1.4%) and 1 case of Haemophilus influenzae (0.3%) were also encountered. As regards Streptococcus pneumonia, the serotypes encountered were: 1, 3, 4, 5, 7f, 8, 9V, 9V/9A, 9N/9L, 14, 18C, 19A, 23f, 33f as well as non typed and non typable serotypes. As for Neisseria meningitidis, only serogroup A was found in it. for Haemophilus influenzae, only serotype b was identified. Conclusion: four non vaccine serotypes (8, 9V/9A, 9N/9L and 33f), non typed and non typable serotypes which are not covered by 13-valent pneumococcal conjugate vaccine (PCV 13) were identified. This highlights the ne

关键词： Purulent Meningitis Children Bacteria Serotypes Benin

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Evaluation of Glutathione Peroxidase Enzymatic Activity in Seminal Plasma of Patients Treated at the Institute Pasteur in Cote d’Ivoire

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Advances in Reproductive Sciences 2023年第4期11卷 116-126页

作者： Marie florence N’Guessan Bi Bali Sery foua Jonas Vanié Bi N’Gbesso Amos Ekissi Youzan ferdinand Djohan founzégué Amadou Coulibaly Allico joseph Djaman Biochemistry Unit Physiology of Reproductive Cells Institute Pasteur in Ivory Coast Abidjan Cote d’Ivoire The Laboratory of The Medical Sciences Training and Research Unit Felix Houphouet-Boigny University Abidjan Cote d’Ivoire Medical Sciences Training and Research Unit Department of Basic and Bioclinical Sciences Abidjan Felix Houphouet-Boigny Uni-versity Abidjan Cote d’Ivoire Laboratory of Biotechnology Agriculture and Valorization of Biological Resources Departement Biosciences University Félix Hou-phouet-Boigny Abidjan Cote d’Ivoire Agriculture Fishery Resources and Agro-Industry Training and Research Unit University of San-Pedro San-Pedro Cote d’Ivoire Departement of Clinical and fundamental Biochemistry Institute Pasteur in Cote d’Ivoire Abidjan Cote d’Ivoire

Glutathione peroxidase (GPx) is an antioxidant that plays an important role in the maintenance of male fertility. The aim of this study was to compare the profile of enzymatic activity of glutathione peroxidase in the seminal plasma of normozoosperm and those of pathological sperm. Thus, the activity of glutathione peroxidase was determined in the seminal plasma of 20 normozoosperms, 9 azoosperms and 31 oligoasthenoteratozoosperms. It was 37.58 ± 3.14 U/L in normozoosperms, 39.39 ± 2.27 U/L in oligoasthenoteratozoosperms, and 29.77 ± 2.62 U/L in azoosperms. The mean GPx enzyme activity of normozoosperms did not differ significantly from that of oligoasthenoteratozoosperms and azoosperms. In contrast, comparison of enzyme activity between abnormal sperms gave a significant difference. This study showed that glutathione peroxidase enzymatic activity is not related to sperm quality.

关键词： Glutathione Peroxidase Antioxidant Oligoasthenoteratozoospermia Azoospermia Normozoospermia

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丙泊酚通过脊髓腹根GABA通路产生制动作用

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麻醉与镇痛 2010年第5期6卷 10-16页

作者： Gudrun Kungys, MD JongBun Kim, MD, PhD Steven L. Jinks, MD Richard J. Atherley, BS joseph f. Antognini, MD 饶竹青(译) 高梅(译) 钱燕宁(校) Department of Anesthesiology and Pain Medicine and Section of Neurobiology Physiology and Behavior University of California Davis Davis California Department of Anesthesia and Pain Medicine Catholic University of Korea Seoul Korea 不详

背景我们探讨了丙泊酚和异氟烷对脊髓神经元感受伤害性刺激的作用。方法我们检测了丙泊酚（1个ED50）和异氟烷（1个MAC）麻醉前和麻醉中的去大脑大鼠腰髓背根（〈1200txm）和腹根（〉1200μm）神经元对伤害性刺激的反应。在记录腹根神... 详细信息

背景我们探讨了丙泊酚和异氟烷对脊髓神经元感受伤害性刺激的作用。方法我们检测了丙泊酚（1个ED50）和异氟烷（1个MAC）麻醉前和麻醉中的去大脑大鼠腰髓背根（〈1200txm）和腹根（〉1200μm）神经元对伤害性刺激的反应。在记录腹根神经元时，我们输注木防己苦毒素以验证异氟烷和丙泊酚对GABA。受体的作用是否不同。我们也研究了去大脑是否影响丙泊酚产生制动作用所需剂量。结果去大脑没有影响丙泊酚的用量。非去大脑大鼠和去大脑大鼠的丙泊酚ED50值分别是497±58μg·k^-1·min^-1和420±65μg·k^-1·min^-1（P〉0．05），所对应的血清丙泊酚浓度分别为8．1±1．1μg／ml和7．3±1．1μg／ml（P〉0．05）。丙泊酚不能显著抑制背根神经元反应，但异氟烷能抑制此反应至对照组的56％（P〈0．05）。与对照组相比，丙泊酚能抑制腹根神经元反应的47％，而异氟烷能抑制20％。木防己苦毒素能显著逆转丙泊酚对腹根神经元反应的抑制作用（对照组的79％，差异无显著性）。异氟烷对腹根神经元的制动作用不受木防己苦毒素的影响（对照组的26％）。结论丙泊酚作用于脊髓产生制动作用。这种抑制反应发生于腹根，主要通过GABA。受体介导。异氟烷也作用于腹根GABA。受体神经元；但其作用不是太弱就是被其他作用掩盖。

关键词：脊髓神经元制动作用 GABA 丙泊酚腹根神经元反应伤害性刺激通路

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麻醉设备故障的处理：以模拟故障评估麻醉住院医师的应对技能

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麻醉与镇痛 2010年第5期6卷 94-100页

作者： William B. Waldrop, MD David J. Murray, MD JohnR Boulet, PhD joseph f. Kras, DDS, MD 张晓怡(译) 周仁龙(校) 杭燕南(校) Departments of Anesthesiology Washington University School of Medicine St. Louis Missouri foundation for Advancement of International Medical Education and Research Philadelphia Pennsylvania 不详

背景手术中麻醉设备故障是；j起麻醉死亡的原因之一，本研究目的在于：（1）设计一套模拟场景以评估麻醉医师应对手术中麻醉设备相关故障的处理能力。（2）评估各研究场景所得结论的可靠性和有效性。方法共设有8个场景来评估麻醉住院医... 详细信息

背景手术中麻醉设备故障是；j起麻醉死亡的原因之一，本研究目的在于：（1）设计一套模拟场景以评估麻醉医师应对手术中麻醉设备相关故障的处理能力。（2）评估各研究场景所得结论的可靠性和有效性。方法共设有8个场景来评估麻醉住院医师应对设备故障的能力。有56名住院医师参与这项研究。按接受培训时间分为4组（1年住院医师-4年住院医师）分别参加模拟设备故障评估。每个场景按照处理故障的关键措施及所用的时间评分。结果随着年资的增加，得分也增加。高年资医师（R3和R4组）表现优于低年资医师（R1和R2）。尽管各医师都要经过相同的培训过程，但培训内容逐年加深。8个评估场景的总体得分能很好地反映麻醉住院医师的应对技能（无论按关键措施还是按完成所需时间来评分）。结论模拟手术中突发设备故障情况能较好反映麻醉住院医师的应对技能。所用多种场景评估能有效反映个体处理危机的水平。按年资得到的总结性结果可作为评价目前住院医师技能培训成效的参考。

关键词：住院医师设备故障术中麻醉技能培训评估模拟培训时间低年资医师

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影响力大师

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2018年

作者： (美)约瑟夫·格雷尼(joseph Grenny)[等]

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不平等的代价

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作者： (Stiglitz joseph E.)斯蒂格利茨

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Synthesis, Growth and Characterization of Sodium Mixed Cadmium Oxalate Crystals

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Journal of Crystallization Process and Technology 2016年第2期6卷 11-20页

作者： f. Daisy Selasteen S. Alfred Cecil Raj A. Alagappa Moses f. Emalda Prince R. Esther Getsy R. Elakkiya Department of Physics Bishop Heber College Tiruchirappalli India Department of Physics St. Joseph’s College Tiruchirappalli India Department of Environmental Sciences Bishop Heber College Tiruchirappalli India

The newly synthesized CdNa2?2C2O4?2H2O crystals having a size of 0.30 × 0.25 × 0.20 mm3 were grown by the single-diffusion reaction method in the silica gel medium at 28?C temperature. The crystalline nature of crystals was determined in 20 days by 1) varying the concentrations of the feed solutions and the gel pH level, 2) changing the specific gravity of the feed solution, and 3) changing the gel aging period. The crystals were characterized by using the methods such as powder X-ray diffraction, fTIR, UV, SEM-EDAX, TGA/DTA, and micro-hardness test. The structure of as-grown crystals was determined by the powder crystal XRD patterns. fTIR & SEM-EDAX spectral analyses were used to confirm the presence of the required functional groups of as grown crystals. UV absorption spectrum, the absorption peaks at 224.64 nanometer, determined the energy gap. TGA/DTA thermo gram was used to detect the thermal stability of sodium mixed cadmium oxalate dihydrate crystals. The present grown crystals were brittle and also plastic in nature was identified by Vickers micro-hardness test.

关键词： CdNa2?2C2O4?2H2O Crystal Growth XRD fTIR UV TGA/DTA SEM-EDAX Micro Hardness

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Outcomes and Quality of Life of Patients with a Digestive Stoma in Sub-Saharan Africa: Case of the Yaounde Central Hospital, Cameroon

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Surgical Science 2021年第11期12卷 381-389页

作者： Georges Bwelle Motto Guy Aristide Bang joseph Cyrille Chopkeng Ngoumfe Yannick Mahamat Ekani Boukar Raissa Larissa Kom de Sendjong Bernadette Ngo Nonga Maurice Aurélien Sosso Department of Surgery and Specialties Faculty of Medicine and Biomedical Sciences The University of Yaoundé I Yaoundé Cameroon Department of Visceral and Digestive Surgery Yaoundé Central Hospital Yaoundé Cameroon Department of Surgery University of Buea Buea Cameroon

Introduction: The installation of a digestive stoma involves changes affecting all aspects of the patients’ lives. The objective of this study was to determine the impact of a digestive stoma on the quality of life of patients operated on at the Yaounde Central Hospital (YCH). Patients and Methodology: We conducted a prospective descriptive study over a period of 12 months from June 2018 to May 2019 in all patients with a digestive stoma for at least 3 months operated on at the YCH. The follow-up was done within 12 months. Quality of life was assessed using the stoma QOL (quality of life) and self-image using the BIS (Body Image Scale). font-family:"">Results: We collected a total of 34 patients, of whom 22 were male, giving an M/F sex ratio of 1.8. The average age of the patients was 42.8 years. The indications were tumoral in 44.11% of cases (n = 15) and non-tumoral in 55.88% of cases (n = 19). The colon was the most frequently ablated organ (n

关键词： Stoma Quality of Life Self-Image Cameroon

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