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ANTI-TUMOR RESPONSES INDUCED BY LASER IRRADIATION AND IMMUNOLOGICAL STIMULATION USING A MOUSE MAMMARY TUMOR MODEL

Journal of Innovative Optical Health Sciences 2013年第4期6卷 49-55页

作者： fEIfAN ZHOU XIAOSONG LI SHENG SONG joseph T.ACQUAVIVA III ROMAN f.WOLf ERIC W.HOWARD WEI R.CHEN MOE Key Laboratory of Laser Life Science&Institute of Laser Life Science South China Normal University Guangzhou P.R.China Department of Oncology The first A±liated Hospital of Chinese PLA General Hospital Beijing 100048 P.R.China Department of Engineering and Physics University of Central Oklahoma Edmond OklahomaUSA Department of Comparative Medicine College of Medicine University of Oklahoma Health Sciences Center 940 S.L.Young Blvd.Oklahoma City OklahomaUSA Department of Cell Biology University of Oklahoma Health Sciences Center 940 S.L.Young Blvd. Oklahoma City OklahomaUSA

Anti-tunor immunological response induced by local intervention is ideal for treatment of metastatic *** immunot herapy was developed to synergize photot hermal interaction with immunological stimulation for cancer *** an infrared laser,indocyanine green(ICG,as a light abeorbing agent),and glycated chitosan(GC,as an immunostimulant),.laser imm unot herapy has resulted in tumor suppression and anti-tumor responses in pre-clinical as well as clinical *** further understand the mechanism of laser immunotherapy,the efects of laser and GC treatment without specifc enhancement of laser absorption were *** adoptive immunity transfer was perfomed using splenocytes as immune *** cells harvested from tumor-bearing mice treated by laser+GC provided 60%immunity in naive ***,cytotoxicity and TNf-ar secretion by splenocytes from treated mice also indicated that laser+GC induced immunity was *** high level of infiltrating T cells in tumors after laser+GC treatment furt her confirned a specific anti-tumor immune ***,laser+GC could prove to be a promisi ng selective local trea tment modality that induces a systemic anti-tumor response,with appropriate laser parameters and GC doses.

关键词： Laser immunotherapy glycated chitosan anti-tumor immunity metastatic cancers

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Artificial intelligence in gastroenterology:where are we heading?

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frontiers of Medicine 2020年第4期14卷 511-517页

作者： joseph JY Sung Nicholas CH Poon Institute of Digestive Disease Faculty of MedicineThe Chinese University of Hong KongHong KongChina Big Data Decision Analytic Cancer The Chinese University of Hong KongHong KongChina

Artificial intelligence(AI)is coming to medicine in a big *** making diagnosis in various medical conditions,following the latest advancements in scientific literature,suggesting appropriate therapies,to predicting prognosis and outcome of diseases and conditions,AI is offering unprecedented possibilities to improve care for *** is a field that AI can make a significant *** is partly because the diagnosis of gastrointestinal conditions relies a lot on image-based investigations and procedures(endoscopy and radiology).AI-assisted image analysis can make accurate assessment and provide more information than conventional *** integration of genomic,epigenetic,and metagenomic data may offer new classifications of gastrointestinal cancers and suggest optimal personalized *** managing relapsing and remitting diseases such as inflammatory bowel disease,irritable bowel syndrome,and peptic ulcer bleeding,convoluted neural network may formulate models to predict disease outcome,enhancing treatment *** and surgical robots can also assist surgeons in conducting gastrointestinal *** the advancement and new opportunities are exciting,the responsibility and liability issues of AI-assisted diagnosis and management need much deliberations.

关键词： artificial intelligence endoscopy robotics gastrointestinal diseases

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Defect detection in freight railcar tapered-roller bearings using vibration techniques

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Railway Engineering Science 2021年第1期29卷 42-58页

作者： Constantine Tarawneh joseph Montalvo Brent Wilson University Transportation Center for Railway Safety(UTCRS) University of Texas Rio Grande Valley(UTRGV)EdinburgTXUSA Hum Industrial Technology IncSt.LouisMOUSA

Currently,there are two types of defect detection systems used to monitor the health of freight railcar bearings in service:wayside hot-box detection systems and trackside acoustic detection *** systems have proven to be inefficient in accurately determining bearing health,especially in the early stages of defect *** that end,a prototype onboard bearing condition monitoring system has been developed and validated through extensive laboratory testing and a designated field test in 2015 at the Transportation Technology Center,*** Pueblo,*** devised system can accurately and reliably characterize the health of bearings based on developed vibration thresholds and can identify defective taperedroller bearing components with defect areas smaller than 12.9 cm2 while in service.

关键词： Railcar health monitoring Onboard condition monitoring systems Bearing defect detection Bearing vibration signatures Bearing spectral analysis

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Single and multiplexed gene repression in solventogenic Clostridium via Cas12a-based CRISPR interference

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Synthetic and Systems Biotechnology 2023年第1期8卷 148-156页

作者： Rochelle Carla joseph Nicholas R.Sandoval Department of Chemical and Biomolecular Engineering Tulane UniversityNew OrleansLA70118United States

The Gram-positive,spore-forming,obligate anaerobic firmicute species that make up the Clostridium genus have broad feedstock consumption capabilities and produce value-added metabolic products,but genetic manipulation is difficult,limiting their broad ***-Cas systems have recently been applied to Clostridium species,primarily using Cas9 as a counterselection marker in conjunction with plasmid-based homologous *** interference is a method that reduces gene expression of specific genes via precision targeting of a nuclease deficient Cas effector ***,we develop a dCas12a-based CRISPR interference system for transcriptional gene repression in multiple mesophilic Clostridium *** show the francisella novicida Cas12a-based system has a broader applicability due to the low GC content in Clostridium species compared to CRISPR Cas systems derived from other *** demonstrate>99%reduction in transcript levels of targeted genes in Clostridium acetobutylicum and>75%reduction in Clostridium *** also demonstrate multiplexed repression via use of a single synthetic CRISPR array,achieving 99%reduction in targeted gene expression and elucidating a unique metabolic profile for their reduced ***,this work builds a foundation for high throughput genetic screens without genetic editing,a key limitation in current screening methods used in the Clostridium community.

关键词： CRISPR Cas12a Clostridium CRISPRi

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A Direct Calculation of first-Order Wave function of Helium

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Communications in Theoretical Physics 2010年第10期54卷 647-650页

作者： Boniface Otieno Ndinya joseph Akeyo Omolo Department of Physics and Materials Science Maseno University

We develop a simple analytic calculation for the first order wave function of helium in a model in which nuclear charge screening is caused by repulsive coulomb interaction. The perturbation term, first-order correlation energy, and first-order wave function are divided into two components, one component associated with the repulsive coulomb interaction and the other proportional to magnetic shielding. The resulting first-order wave functions are applied to calculate second-order energies within the model. We find that the second-order energies are independent of the nuclear charge screening constant in the unperturbed Hamiltonian with a central coulomb potential.

关键词： nuclear charge screening first-order wave function and second-order energy

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Stability and Time-Step Constraints of Implicit-Explicit Runge-Kutta Methods for the Linearized Korteweg-de Vries Equation

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Communications on Applied Mathematics and Computation 2024年第1期6卷 658-687页

作者： joseph Hunter Zheng Sun Yulong Xing Department of Mathematics The Ohio State UniversityColumbusOH43210USA Department of Mathematics The University of AlabamaTuscaloosaAL35487USA

This paper provides a study on the stability and time-step constraints of solving the linearized Korteweg-de Vries(KdV)equation,using implicit-explicit(IMEX)Runge-Kutta(RK)time integration methods combined with either finite difference(fD)or local discontinuous Galerkin(DG)spatial *** analyze the stability of the fully discrete scheme,on a uniform mesh with periodic boundary conditions,using the fourier *** the linearized KdV equation,the IMEX schemes are stable under the standard Courant-friedrichs-Lewy(CfL)conditionτ≤λ***,λis the CfL number,τis the time-step size,and h is the spatial mesh *** study several IMEX schemes and characterize their CfL number as a function ofθ=d/h^(2)with d being the dispersion coefficient,which leads to several interesting *** also investigate the asymptotic behaviors of the CfL number for sufficiently refined meshes and derive the necessary conditions for the asymptotic stability of the IMEX-RK *** numerical experiments are provided in the paper to illustrate the performance of IMEX methods under different time-step constraints.

关键词： Linearized Korteweg-de Vries(KdV)equation Implicit-explicit(IMEX)Runge-Kutta(RK)method Stability Courant-friedrichs-Lewy(CfL)condition finite difference(fD)method Local discontinuous Galerkin(DG)method

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NaNbO_(3) modified BiScO_(3)-BaTiO_(3) dielectrics for high-temperature energy storage applications

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Journal of Materiomics 2022年第4期8卷 731-738页

作者： Jincymol joseph Zhenxiang Cheng Shujun Zhang Institute of Superconducting and Electronic Materials Australian Institute of Innovative MaterialsUniversity of WollongongNSW2500Australia

Among the lead-free compositions identified as potential capacitor materials, BiScO_(3)-BaTiO_(3) (BS-BT)relaxor dielectrics exhibit good energy storage performance. In this research, 0.4BS-0.6BT is consideredas the parent composition, with NaNbO_(3) (NN) addition intended to substitute the A and B site *** NN modified BS-BT ceramics exhibit excellent temperature stability in terms of their dielectricproperties, with the room-temperature dielectric constant on the order of 500e1 000 and variation lessthan 10% up to 400 C. In addition, NN has a high band-gap energy leading to increased breakdownstrength and energy storage properties in modified compositions. The highest breakdown strength wasachieved for 0.4BS-0.55BT-0.05NN, being on the order of 430 kV/cm, and a high energy density of 4.6 J/cm3 with high energy efficiency of 90% was simultaneously achieved. Of particular importance is that thevariation of the energy density was below 5% due to the temperature-insensitive dielectric constant,while ~90% energy efficiency was retained over the temperature range of 25e160 C. The improvedtemperature stability with NN addition makes this composition promising for high temperaturecapacitor and dielectric energy storage applications.

关键词： Relaxor ferroelectrics Lead-free Energy storage Temperature stability

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SOME EXACT SOLUTIONS Of 3-DIMENSIONAL ZERO-PRESSURE GAS DYNAMICS SYSTEM

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Acta Mathematica Scientia 2011年第6期31卷 2107-2121页

作者： K.T. joseph Manas R. Sahoo School of Mathematics Tata Institute of Fundamental Research

The 3-dimensional zero-pressure gas dynamics system appears in the modeling for the large scale structure formation in the universe. The aim of this paper is to construct spherically symmetric solutions to the system. The radial component of the velocity and density satisfy a simpler one dimensional problem. first we construct explicit solutions of this one dimensional case with initial and boundary conditions. Then we get special radial solutions with different behaviours at the origin.

关键词： zero-pressure gas dynamics spherically symmetric solutions

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Optical wireless information transfer with nonlinear micromechanical resonators

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Microsystems & Nanoengineering 2017年第1期3卷 163-168页

作者： joseph A.Boales farrukh Mateen Pritiraj Mohanty Department of Physics Boston University590 Commonwealth AvenueBostonMA 02215USA Department of Mechanical and Aerospace Engineering Boston University110 Cummington StreetBostonMA 02215USA

Wireless transfer of information is the basis of modern *** includes cellular,Wifi,Bluetooth,and GPS systems,all of which use electromagnetic radio waves with frequencies ranging from typically 100 MHz to a few ***,several long-standing challenges with standard radio-wave wireless transmission still exist,including keeping secure transmission of data from potential ***,we demonstrate wireless information transfer using a line-of-sight optical architecture with a micromechanical *** this fundamentally new approach,a laser beam encoded with information impinges on a nonlinear micromechanical resonator located a distance from the *** force generated by the radiation pressure of the laser light on the nonlinear micromechanical resonator produces a sideband modulation signal,which carries the precise information encoded in the subtle changes in the radiation *** this,we demonstrate data and image transfer with one hundred percent fidelity with a single 96-by-270μm silicon resonator element in an optical frequency *** mechanical approach relies only on the momentum of the incident photons and is therefore able to use any portion of the optical frequency band—a band that is 10000 times wider than the radio frequency *** line-of-sight architecture using highly scalable micromechanical resonators offers new possibilities in wireless *** to their small size,these resonators can be easily arrayed while maintaining a small form factor to provide redundancy and parallelism.

关键词： MEMS piezoelectricity radiation pressure wireless communication

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罗兰之歌

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丛书名：悦读经典·法语初级读本

2011年

作者： joseph f. Conroy改编

本书讲述的是查理曼大帝占领西班牙的沙拉古斯的战争故事。书中对词汇及短语进行了注释，同时提供了人物列表。

ISBN: (数字)9787561930366

ISBN: (纸本)9787561930366

本书讲述的是查理曼大帝占领西班牙的沙拉古斯的战争故事。书中对词汇及短语进行了注释，同时提供了人物列表。

关键词：法语史诗

来源：畅想之星图书光盘版（南... 评论

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