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Anti-tumor response induced by immunologically modified carbon nanotubes and laser irradiation using rat mammary tumor model

2003年

作者： Hair joseph f.

来源：畅想之星图书光盘版（南... 评论

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Journal of Innovative Optical Health Sciences 2015年第4期8卷 97-104页

作者： joseph T.Acquaviva III Cody f.Bahavar feifan Zhou Xiaosong Li Eric W.Howard Liz C.Bullen Ricardo P.Silvy Wei R.Chen Biophotonics Research Laboratory Center for Interdisciplinary Biomedical Education and Research University of Central Oklahoma EdmondOklahoma 73034USA South West Nano Technologies NormanOklahoma 73071USA Department of Oncology The first Affiliated Hospital of Chinese PLA General Hospital Fucheng Road 51 BeijingP.R.China University of Oklahoma Health Sciences Center 940 Stanton.L.Young Blvd. BMSB Rm.513 Oklahoma City Oklahoma 73104USA

The ideal treatment modality for metastatic cancer would be a local treatment that can destroy primary tumors while inducing an effective systemic anti-tumor *** this end,we de-veloped laser immunotherapy,combining photothermal laser application with an immunoadju-vant for the treatment of metastatic ***,to enhance the selective photothermal effect,we integrated light-absorbing nanomaterials into this innovative ***,we developed an immunologically modified carbon nanotube combining single-walled carbon nanotubes(SWNTs)with the immunoadjuvant glycated chitosan(GC).To determine the ef-fectiveness of laser iradiation,a series of experiments were performed using two different irra-diation durations-5 and 10 *** were inoculated with DMBA-4 cancer cells,a metastatic cancer cell *** treatment group of rats receiving laser irradiation for 10 min had a 50%long-term survival rate without residual primary or metastatic *** treatment group of rats receiving laser irradiation for 5 min had no long-term survivors;all rats died with multiple metastases at several distant ***,Laser+SWNT-GC treatment with 10 min of laser irradiation proved to be efective at reducing tumor size and inducing long-term anti-tumor immunity.

关键词： Anti-tumor immune response laser immunotherapy single-walled carbon nanotubes glycated chitosan laser irradiation

Influence of harvest date on seed yield and quality in forage kochia

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frontiers of Agricultural Science and Engineering 2018年第1期5卷 71-79页

作者： Cody f.CREECH Blair L.WALDRON Corey V.RANSOM Dale R.ZOBELL joseph Earl CREECH Department of Plants Soils and Climate Utah State University USDA-ARS Forage and Range Research Laboratory Department of Animal Dairy and Veterinary Sciences Utah State University

forage kochia(Bassia prostrata) is used for rangeland reclamation and livestock and wildlife forage,but limited research has been conducted on its seed production. Therefore, this research evaluated the effect of harvest date on seed weight, germination, and seed yield of forage kochia subspecies virescens and grisea. Seed was harvested from individual plants for 3 years during October, November, and December. October harvest had the lightest 100-seed weights, with the November harvest slightly heavier than December, for most *** Snowstorm and breeding line Sahsel, both subsp. grisea, had the greatest 100-seed weights in November, 155 and 143 mg, respectively, whereas, ***(subsp. virescens), the standard for forage kochia, ranked among the least for 100-seed weight. for most accessions, germination was lowest from the October harvest(11%–43%), with greater germination with November and December harvested seeds(43%–64%).Viable seed yields were greatest in November with the exception of two accessions, which peaked in October,indicating earlier maturity. Results indicate that forage kochia usually reaches optimum seed maturity by early November, after plants are exposed to freezing temperatures; however, earlier maturing accessions exist in both subspecies virescens and grisea.

关键词： forage rangeland seed germination seed quality

Combination therapy with androgen deprivation for hormone sensitive prostate cancer: A new frontier

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Asian Journal of Urology 2019年第1期6卷 57-64页

作者： Tyler Etheridge Shivashankar Damodaran Adam Schultz Kyle A.Richards joseph Gawdzik Bing Yang Vincent Cryns David f.Jarrard Department of Urology University of Wisconsin-MadisonMadisonWIUSA Department of Medicine University of Wisconsin-MadisonMadisonWIUSA University of Wisconsin-Madison Carbone Cancer CenterUniversity of Wisconsin-MadisonMadisonWIUSA

Androgen deprivation therapy(ADT)has been the standard of care for the last 75 years in metastatic hormone sensitive prostate cancer(PCa).However,this approach is rarely *** clinical trials have demonstrated that ADT combined with other agents,notably docetaxel and abiraterone,lead to improved *** mechanisms surrounding this improved cancer outcomes are incompletely *** response of cancer cells to ADT includes apoptosis and cell death,but a significant fraction remains *** laboratory has demonstrated both in vitro and in vivo that cellular senescence occurs in a subset of these *** senescence is a phenotype characterized by cell cycle arrest,senescenceassociated b-galactosidase(SA-b-gal),and a hypermetabolic *** features of cellular senescence include growth arrest and immune stimulation,although persistence may release cytokines and growth factors that are *** tumor cells generate a catabolic state with increased glycolysis,protein turnover and other metabolic changes that represent targets for drugs,like metformin,to be applied in a synthetic lethal *** review examines the response to ADT and the putative role of cellular senescence as a biomarker and therapeutic target in this context.

关键词： Prostate cancer Cellular senescence Androgen deprivation therapy Combination therapy Synthetic lethal targeting Metformin Statins

Modeling Water Adsorption and Retention of Building Materials from Pore Size Distribution

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Journal of Renewable Materials 2019年第6期7卷 547-556页

作者： Abdelkrim Trabelsi Zakaria Slimani Akli Younsi joseph Virgone Rafik Belarbi Univ Lyon CNRSINSA-LyonUniversitéClaude Bernard Lyon 1CETHIL UMR5008F-69621VilleurbanneFrance University of La Rochelle CNRSLaSIEUMR-7356Avenue Michel Crépeau17042 La Rochelle Cedex 1France

Water adsorption and capillarity are key phenomena involved during heat and moisture transfer in porous building *** account for interaction between solid matrix,liquid water and moist *** are considered through Water Vapor Adsorption Isotherm(WVAI)and Retention Curve(RC)functions which are constitutive laws characterizing water activity within a porous *** objective of this paper is to present a water vapor adsorption and retention models built from multimodal Pore Size Distribution function(PSDf)and to see how its parameters modify moisture storage for hygroscopic and near saturation *** microstructure of the porous medium is represented statistically by a bundle of tortuous parallel pores through its ***,the influence of contact angle and temperature on storage properties were ***,a parametric study was performed to see the influence of the PSDf shape on storage *** cases were studied considering the number of modalities,the weight of each modality and the dispersion around mean ***,as a validation,the proposed model for WVAI were compared to existing model from literature showing a good *** study showed that the proposed models are capable to reproduce various shapes of storage *** also highlighted the link between microstructure and adsorption-retention phenomena.

关键词： Water vapor adsorption capillarity pore size distribution WVAI and RC modeling porous building materials

An Ensemble-Based Hotel Reviews System Using Naive Bayes Classifier

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Computer Modeling in Engineering & Sciences 2023年第10期137卷 131-154页

作者： joseph Bamidele Awotunde Sanjay Misra Vikash Katta Oluwafemi Charles Adebayo Department of Computer Science Faculty of Information and Communication SciencesUniversity of IlorinIlorin240003Nigeria Department of Computer Science and Communication Otfold University CollegeHaldenNorway

The task of classifying opinions conveyed in any form of text online is referred to as sentiment *** emergence of social media usage and its spread has given room for sentiment analysis in our daily *** media applications and websites have become the foremost spring of data recycled for reviews for sentimentality in various *** subject matter can be encountered on social media platforms,such as movie product reviews,consumer opinions,and testimonies,among others,which can be used for sentiment *** rapid uncovering of these web contents contains divergence of many benefits like profit-making,which is one of the most vital of them *** to a recent study,81%of consumers conduct online research prior to making a *** the reviews available online are too huge and numerous for human brains to process and ***,machine learning classifiers are one of the prominent tools used to classify sentiment in order to get valuable information for use in companies like hotels,game companies,and so *** the sentiments of people towards different commodities helps to improve the services for contextual promotions,referral systems,and market ***,this study proposes a sentiment-based framework detection to enable the rapid uncovering of opinionated contents of hotel reviews.A Naive Bayes classifier was used to process and analyze the dataset for the detection of the polarity of the *** dataset from Datafiniti’s Business Database obtained from Kaggle was used for the experiments in this *** performance evaluation of the model shows a test accuracy of 96.08%,an f1-score of 96.00%,a precision of 96.00%,and a recall of 96.00%.The results were compared with state-of-the-art classifiers and showed a promising performance andmuch better in terms of performancemetrics.

关键词： Sentiment analysis hotel reviews Naive Bayes algorithm consumer opinions web 2.0 machine learning

Existence and Nonexistence for Semilinear Equations on Exterior Domains

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Journal of Partial Differential Equations 2017年第4期30卷 299-316页

作者： IAIA joseph A. University of North Texas P.O. Box 311430 Denton Texas 76203-5017 USA

In this paper we prove the existence of an infinite number of radial solutions of △u ＋K（r）f（u） = 0 on the exterior of the ball of radius R 〉 0 centered at the origin in RN where f is odd with f 〈 0 on （0,β）, f 〉 0 on （β,3）, f ≡ 0 for u 〉 δ, and where the function K（r） is assumed to be positive and K（r） → 0 as r→ ∞. The primitive f（u） = fuf（S） ds has a ＂hilltop＂ at u =δ which allows one to use the shooting method to prove the existence of solutions.

关键词： Semilinear hilltop.

Impact of type 2 diabetes on adenoma detection in screening colonoscopies performed in disparate populations

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World Journal of Clinical Cases 2021年第11期9卷 2433-2445页

作者： Dimitri f joseph Ellen Li Samuel L Stanley III Yi-Cong Zhu Xiao-Ning Li Jie Yang Lorenzo f Ottaviano Juan Carlos Bucobo Jonathan M Buscaglia Joshua D Miller Rajesh Veluvolu Michele follen Evan B Grossman Department of Medicine Renaissance School of Medicine at Stony Brook UniversityStony BrookNY 11794-8173United States Department of Medicine Division of GastroenterologyStony Brook UniversityStony BrookNY 11794-8173United States Department of Applied Mathematics and Statistics Stony Brook UniversityStony BrookNY 11794-3600United States Department of Biostatistics and Bioinformatics Shared Resource Stony Brook Cancer CenterStony Brook UniversityStony BrookNY 11794-3600United States Department of family Populationand Preventative MedicineRenaissance School of Medicine at Stony Brook UniversityStony BrookNY 11794-8461United States Department of Medicine NYC Health and Hospitals/Kings CountyBrooklynNY 11203United States Department of Medicine SUNY Downstate Medical CenterBrooklynNY 11203United States Department of Obstetrics and Gynecology NYC Health and Hospitals/Kings CountyBrooklynNY 11203United States

BACKGROUND The Black/African Ancestry(AA)population has a higher prevalence of type 2 diabetes mellitus(T2DM)and a higher incidence and mortality rate for colorectal cancer(CRC)than all other races in the United States.T2DM has been shown to increase adenoma risk in predominantly white/European ancestry(EA)populations,but the effect of T2DM on adenoma risk in Black/AA individuals is less *** hypothesize that T2DM has a significant effect on adenoma risk in a predominantly Black/AA *** To investigate the effect of T2DM and race on the adenoma detection rate(ADR)in screening colonoscopies in two disparate *** A retrospective cohort study was conducted on ADR during index screening colonoscopies(age 45-75)performed at an urban public hospital serving a predominantly Black/AA population(92%)(2017-2018,n=1606).Clinical metadata collected included basic demographics,insurance,body mass index(BMI),family history of CRC,smoking,diabetes diagnosis,and aspirin *** dataset was combined with a recently reported parallel retrospective cohort data set collected at a suburban university hospital serving a predominantly White/EA population(87%)(2012-2015,n=2882).RESULTS The ADR was higher in T2DM patients than in patients without T2DM or prediabetes(35.2%vs 27.9%,P=0.0166,n=981)at the urban public *** analysis of the combined datasets showed that T2DM[odds ratio(OR)=1.29,95%confidence interval(CI):1.08-1.55,P=0.0049],smoking(current vs never OR=1.47,95%CI:1.18-1.82,current vs past OR=1.32,95%CI:1.02-1.70,P=0.0026),older age(OR=1.05 per year,95%CI:1.04-1.06,Pficantly associated with increased ADR on index screening colonoscopy while controlling for other factors.

关键词： Adenoma Diabetes mellitus,type 2 African continental ancestry group European continental ancestry group Colonoscopy Multivariate analysis

Sand dunes as potential sources of dust in northern China

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Science China Earth Sciences 2016年第4期59卷 760-769页

作者： Mark R SWEENEY LU HuaYu CUI MengChun joseph A MASON fENG Han XU ZhiWei Department of Earth Sciences University of South Dakota Laboratory of Earth Surface Process and Environment School of Geographic and Oceanographic Sciences Nanjing University Department of Geography University of Wisconsin-Madison

While saltation bombardment of sand grains on a fine substrate can produce considerable dust, the well-sorted nature of sand dunes tends to preclude them from consideration as major dust sources. Recent research, however, has revealed that sand dunes can, in some cases, be large sources of dust. We used the PI-SWERL(Portable In-Situ Wind Erosion Laboratory) to measure in the field the potential of sand dunes and other desert landforms to emit particulate matter f northern China. Combined with high resolution particle size measurements of the dune sand, an assessment of sand dunes as a dust source can be made. Large active transverse dunes tend to contain little to no stored PM-10, yet they produce a low dust flux. Coppice dunes stabilized by vegetation contain appreciable PM-10 and have very high dust emission potential. There is a positive correlation between the amount of PM-10 stored in a dune and its potential dust flux. Saltation liberates loose fines stored in dunes, making them very efficient dust emitters compared to landforms such as dry lake beds and washes where dust particles are unavailable for aeolian transport due to protective crusts or sediment cohesion. In cases where large dunes do not store PM-10 yet emit dust when active, two hypotheses can be considered:(1) iron-oxide grain coatings are removed during saltation, creating dust, and(2) sand grains collide during saltation, abrading grains to create dust. Observations reveal that iron oxide coatings are present on some dune sands. PI-SWERL data suggests that low dust fluxes from dunes containing no stored dust may represent an estimate for the amount of PM-10 dust produced by removal of iron oxide coatings. These results are similar to results from dunes in the United States. In addition, PI-SWERL results suggest that dust-bearing coppice dunes, which cover vast areas of China's sandy deserts, may become major sources of dust in the f

关键词： Coppice dunes Transverse dunes Dust PI-SWERL Desert