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Modulation of tau phosphorylation by environmental copper

Translational Neurodegeneration 2014年第1期3卷 169-178页

作者： Kellen Voss Christopher Harris Martina Ralle Megan Duffy Charles Murchison joseph f Quinn Department of Neurology and Parkinson’s Disease Research Education and Clinical Care Center(PADRECC) Portland Veterans Affairs Medical CenterPortlandORUSA Department of Neurology Oregon Health and Sciences University3181 SW Sam Jackson Park RoadPortlandOR 97201USA Department of Molecular and Medical Genetics Oregon Health and Sciences UniversityPortlandORUSA

Background:The transition metal copper enhances amyloidβaggregation and neurotoxicity,and in models of concomitant amyloid and tau pathology,copper also promotes tau *** it is not clear if the effects of environmental copper upon tau pathology are dependent on the presence of pathological amyloidβ,we tested the effects of copper overload and complexing in disease models which lack pathological amyloidβ.Methods:We used cell culture and transgenic murine models to test the effects of environmental copper on tau *** used oral zinc acetate as a copper lowering agent in mice and examined changes in blood and brain metals through inductively coupled plasma mass *** effects of copper lowering were assessed with Morris water maze and novel object recognition *** in tau phosphorylation were examined by phosphorylation specific antibodies on Western ***:In human neuroblastoma cells,excess copper promoted tau phosphorylation and a copper complexing agent,tetrathiomolybdate,attenuated tau *** a transgenic mouse model expressing wild type human tau,copper-lowering by oral zinc suppressed plasma and brain levels of copper,and resulted in a marked attenuation of tau *** significant changes in behavior were observed with copper lowering,but a trend to improved recognition of the novel object was observed in zinc acetate treated ***:We propose that reduction of brain copper by blocking uptake of copper from the diet may be a viable strategy for modulating tau pathology in Alzheimer’s *** potential benefits of this approach are tempered by the absence of a behavioral benefit and by the health risks of excessive lowering of copper.

关键词： Copper Alzheimer’s disease Tau protein Transgenic mice

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Mission impossible completed:unlocking the nomenclature of the largest and most complicated subgenus of Cortinarius,Telamonia

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fungal Diversity 2020年第5期104卷 291-331页

作者： Kare Liimatainen Tuula Niskanen Bálint Dima joseph f.Ammirati Paul M.Kirk Ilkka Kytövuori Jodrell Laboratory Royal Botanic GardensKewSurrey TW93ABUK Botanical Museum University of HelsinkiP.O.Box 700014 HelsinkiFinland Department of Plant Anatomy Institute of BiologyEötvös Loránd UniversityPázmány Péter sétány 1/C1117 BudapestHungary Department of Biology University of WashingtonBox 351800SeattleWA 98195-1800USA

So far approximately 144,000 species of fungi have been named but sequences of the majority of them do not exist in the public ***,the quality and coverage of public barcode databases is a bottleneck that hinders the study of *** is the largest genus of Agaricales with thousands of species *** most diverse subgenus in Cortinarius is Telamonia and its species have been considered one of the most taxonomically challenging in the *** high diversity combined with convergent,similar appearing taxa have earned it a reputation of being an impossible group to *** this study a total of 746 specimens,including 482 type specimens representing 184 species were ***,a significant number of old types were successfully sequenced,105 type specimens were over 50 years old and 18 type specimens over 100 years ***,20 epi-or neotypes are proposed for recently commonly used older *** study doubles the number of reliable DNA-barcodes of species of *** Telamonia in the public sequence *** is also the first extensive phylogenetic study of the subgenus.A majority of the sections and species are shown in a phylogenetic context for the first *** study shows that nomenclatural problems,even in difficult groups like *** Telamonia,can be solved and consequently identification of species based on ITS barcodes becomes an easy task even for non-experts of the genus.

关键词： ITS Type study Barcode Neotype Phylogeny Section

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Printable Aligned Single-Walled Carbon Nanotube film with Outstanding Thermal Conductivity and Electromagnetic Interference Shielding Performance

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Nano-Micro Letters 2022年第11期14卷 143-156页

作者： Zhihui Zeng Gang Wang Brendan f.Wolan Na Wu Changxian Wang Shanyu Zhao Shengying Yue Bin Li Weidong He Jiurong Liu joseph W.Lyding Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of EducationSchool of Materials Science and EngineeringShandong UniversityShandongJinan 250061People’s Republic of China Department of Electrical and Computer Engineering Beckman Institute for Advanced Science and TechnologyUniversity of Illinois at Urbana-ChampaignUrbanaIL 61801USA Department of Chemistry Swiss Federal Institute of Technology in Zurich(ETH Zürich)8092 ZurichSwitzerland School of Materials Science and Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore Empa Swiss Federal Laboratories for Materials Science and TechnologyÜberland Strasse 1298600 DübendorfSwitzerland Institute for Advanced Technology Shandong UniversityJinan 250061People’s Republic of China

Ultrathin,lightweight,and flexible aligned single-walled carbon nanotube(SWCNT)films are fabricated by a facile,environmentally friendly,and scalable printing *** aligned pattern and outstanding intrinsic properties render“metal-like”thermal conductivity of the SWCNT films,as well as excellent mechanical strength,flexibility,and ***,the aligned cellular microstructure promotes the electromagnetic interference(EMI)shielding ability of the SWCNTs,leading to excellent shielding effectiveness(SE)of~39 to 90 dB despite a density of only~0.6 g cm^(−3) at thicknesses of merely 1.5-24μm,*** ultrahigh thickness-specific SE of 25693 dB mm^(−1) and an unprecedented normalized specific SE of 428222 dB cm^(2)g^(−1) are accomplished by the freestanding SWCNT films,significantly surpassing previously reported shielding *** addition to an EMI SE greater than 54 dB in an ultra-broadband frequency range of around 400 GHz,the films demonstrate excellent EMI shielding stability and reliability when subjected to mechanical deformation,chemical(acid/alkali/organic solvent)corrosion,and high-/low-temperature *** novel printed SWCNT films offer significant potential for practical applications in the aerospace,defense,precision components,and smart wearable electronics industries.

关键词： Aligned film Single-walled carbon nanotube Lightweight flexible Thermal conductivity Electromagnetic interference shielding

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Effect of body mass index on functional outcome in primary total knee arthroplasty——a single institution analysis of 2180 primary total knee replacements

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World Journal of Orthopedics 2016年第10期7卷 664-669页

作者： Shane C O'Neill joseph S Butler Adam Daly Darren f Lui Patrick Kenny Department of Orthopaedics Cappagh National Orthopaedic Hospital

AIM To evaluate the effect of body mass index(BMI) on short-term functional outcome and complications in primary total knee arthroplasty. METHODS All patients undergoing primary total knee arthroplasty at a single institution between 2007 and 2013 were identified from a prospective arthroplasty database. 2180 patients were included in the study. Age, gender, BMI, pre- and post-operative functional scores [Western Ontario and Mc Master University Arthritis Index(WOMAC) and Sf-36], complications and revision rate were recorded. Patients were grouped according to the WHO BMI classification. The functional outcome of the normal weight cohort(BMI formed comparing all five WHO BMI groups; Normal weight, overweight, class 1 obese, class 2 obese and class 3 *** With a mean age of 67.89(28-92), 2180 primary total knee replacements were included. 64.36%(1403) were female. The mean BMI was 31.86(18-52). Ninty-three percent of patients were either overweight or obese. Mean follow-up 19.33 mo(6-60 mo). There was no significant difference in pre or post-operative WOMAC score in the normal weight(BMI 0.05). Sub-group analysis revealed significantly worse WOMAC scores in class 2 obese 30.80 compared to overweight 25.80(P ficantly worse Sf-36 scores in class 2 obese 58.16 compared to overweight 63.93(P ficial infections, 9(0.41%) deep infections and 19(0.87%) revisions overall with no complications or revisions in the normal weight cohort(BMI functional outcome was not influenced by BMI comparing normal weight individuals with BMI > 25. Patients should not be denied total knee arthroplasty based solely on weight alone.

关键词： Total knee replacement Body mass index Total knee arthroplasty

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Accurate nanoelectrode recording of human pluripotent stem cell-derived cardiomyocytes for assaying drugs and modeling disease

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Microsystems & Nanoengineering 2017年第1期3卷 382-388页

作者： Ziliang Carter Lin Allister f.McGuire Paul W.Burridge Elena Matsa Hsin-Ya Lou joseph C.Wu Bianxiao Cui Department of Applied Physics Stanford UniversityStanfordCA 94305USA Department of Chemistry Stanford UniversityStanfordCA 94305USA Stanford Cardiovascular Institute Stanford UniversityStanfordCA 94305USA Department of Pharmacology and Center for Pharmacogenomics Northwestern UniversityChicagoIL 60611USA

The measurement of the electrophysiology of human pluripotent stem cell-derived cardiomyocytes is critical for their biomedical applications,from disease modeling to drug ***,a method that enables the high-throughput intracellular electrophysiology measurement of single cardiomyocytes in adherent culture is not *** address this area,we have fabricated vertical nanopillar electrodes that can record intracellular action potentials from up to 60 single beating *** access is achieved by highly localized electroporation,which allows for low impedance electrical access to the intracellular ***,we demonstrate that this method provides the accurate measurement of the shape and duration of intracellular action potentials,validated by patch clamp,and can facilitate cellular drug screening and disease modeling using human pluripotent stem *** study validates the use of nanopillar electrodes for myriad further applications of human pluripotent stem cell-derived cardiomyocytes such as cardiomyocyte maturation monitoring and electrophysiology-contractile force correlation.

关键词： cardiomyocytes drug screening electrophysiology human pluripotent stem cells multielectrode array

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Nanoseparation-lnspired Manipulation of the Synthesis of CdS Nanorods

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Nano Research 2011年第2期4卷 226-232页

作者： Xiaoming Sun Xiuju Ma Lu Bai Junfeng Liu Zheng Chang David G. Evans Xue Duan Jiaou Wang joseph f. Chiang State Key Laboratory of Chemical Resource Engineering RO. Box 98 Beijing University of Chemical Technology Beijing 100029 China Institute of High Energy Physics Beijing 100039 China Department of Chemistry and Biochemistry SUNY-Oneonta Oneonta NY 13820 USA

CdS nanorods have been sorted by length using a density gradient ultracentrifuge rate separation method. The fractions containing longer rods showed relatively stronger oxygen-related surface trap emission, while the shorter ones had dominant band-edge emission. These results suggest that the final length distribution of CdS nanorods is not a result of random nucleation and growth, but is related to the local synthesis conditions. Inspired by these findings, different synthesis environments （N2, air, and 02） have been employed in order to tailor the length distribution. In addition to the rod length, the photoluminescence properties of CdS nanorods can also be manipulated. Increasing the oxygen partial pressure significantly changed the growth behavior of CdS nanorods by improving the anisotropic growth.

关键词： Nanoseparation quantum rods CdS photoluminescence controlled synthesis

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Effect of benzaldehyde on the electrodeposition and corrosion properties of Ni–W alloys

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International Journal of Minerals,Metallurgy and Materials 2015年第10期22卷 1060-1066页

作者： U.Pramod Kumar C.joseph Kennady Department of Chemistry Karunya Institute of Technology and SciencesKarunya NagarCoimbatore 641114Tamil NaduIndia

The effect of different concentrations of benzaldehyde on the electrodeposition of Ni–W alloy coatings on a mild steel substrate from a citrate electrolyte was investigated in this study. The electrolytic alkaline bath(p H 8.0) contained stoichiometric amounts of nickel sulfate, sodium tungstate, and trisodium citrate as precursors. The corrosion resistance of the Ni–W-alloy-coated specimens in 0.2 mol/L H2SO4 was studied using various electrochemical techniques. Tafel polarization studies reveal that the alloy coatings obtained from the bath containing 50 ppm benzaldehyde exhibit a protection efficiency of 95.33%. The corrosion rate also decreases by 21.5 times compared with that of the blank. A higher charge-transfer resistance of 1159.40 ?·cm2 and a lower double-layer capacitance of 29.4 μf·cm-2 further confirm the better corrosion resistance of the alloy coating. X-ray diffraction studies reveal that the deposits on the mild steel surface are consisted of nanocrystals. A lower surface roughness value(Rmax) of the deposits is confirmed by atomic force microscopy.

关键词： nickel–tungsten alloys benzaldehyde electrodeposit

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能量管理科学相关知识

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中国实用外科杂志 2012年第11期32卷 I0003-I0004页

作者： joseph f.Amaral 美国强生公司医疗器械与诊断部门

能量管理科学（Science of Energy）是对组织与能量外科器械之间的相互作用进行深入研究和认识的科学，它的目的是改善患者手术，提高临床疗效。

关键词：管理科学能量相互作用外科器械临床疗效

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Age-dependent slowing of enteric axonal transport in insulin-resistant mice

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World Journal of Gastroenterology 2013年第4期19卷 482-491页

作者： Kathy J LePard joseph Cellini Department of Physiology Chicago College of Osteopathic MedicineMidwestern UniversityDowners GroveIL 60515United States

AIM:To investigate retrograde tracer transport by gastric enteric neurons in insulin resistant mice with low or high glycosylated hemoglobin(Hb).METHODS:Under anesthesia,the retrograde tracer fluorogold was superficially injected into the fundus or antrum using a microsyringe in KK Cg-Ay/J mice prior to onset of type 2 diabetes mellitus(T2DM;4 wk of age),at onset of T2DM(8 wk of age),and after 8,16,or 24 wk of untreated T2DM and in age-matched KK/HIJ *** days later,mice were sacrificed by CO 2 narcosis followed by *** were removed and *** from fundus,corpus and antrum were excised and mounted on a glass ***-labeled neurons were viewed using a microscope and manually *** were expressed as the number of neurons in short and long descending and ascending pathways and in local fundus and antrum pathways,and the number of neurons in all regions labeled after injection of tracer into either the fundus or the ***:By 8 wk of age,body weights of KKAy mice(n=12,34±1 g) were heavier than KK mice(n=17,29±1 g;f(4,120)=4.414,P=0.002] and glycosylated Hb was higher [KK:(n=7),4.97%±0.04%;KKAy:(n=6),6.57%±0.47%;f(1,26)=24.748,Pf tracer labeled enteric neurons was similar in KK and KKAy mice of all ages in the short descending pathway [f(1,57)=2.374,P=0.129],long descending pathway [f(1,57)=0.922,P=0.341],local fundus pathway [f(1,53)=2.464,P=0.122],local antrum pathway [f(1,57)=0.728,P=0.397],and short ascending pathway [f(1,53)=2.940,P=0.092].In the long ascending pathway,fewer tracer-labeled neurons were present in KKAy as compared to KK mice [KK:(n=34),302±17;KKAy:(n=29),230±15;f(1,53)=8.136,P=0.006].The number of tracer-labeled neurons was decreased in all mice by 16 wk as compared to 8 wk of age in the short descending pathway [8 wk:(n=15),305±26;16 wk:(n=13),210±30;f(4,57)=9.336,Pf(4,57)=8.920,P<0.001],short ascending pathway [

关键词： Autonomic neuropathy Retrograde transport KKAy mice fluorogold Type 2 diabetes mellitus

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Long-term outcome of ketoconazole and tacrolimus coadministration in kidney transplant patients

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World Journal of Nephrology 2014年第3期3卷 107-113页

作者： Enver Khan Mary Killackey Damodar Kumbala Heather LaGuardia Yong-Jun Liu Huai-Zhen Qin Brent Alper Anil Paramesh joseph buell Rubin Zhang Section of Nephrology Department of Medicine New Orleans LA 70112 United States

AIM： To study the long-term outcome of ketoconazole and tacrolimus combination in kidney transplant recipi-ents. METHODS： from 2006 to 2010, ketoconazole was given in 199 patients and was continued for at least 1 year or until graft failure （Group 1）, while 149 patients did not receive any ketoconazole （Group 2）. A combina-tion of tacrolimus, mycophenolate and steroid was used as maintenance therapy. High risk patients received basiliximab induction. RESULTS： Basic demographic data was similar be-tween the 2 groups. The 5-year cumulative incidence of biopsy-confrmed and clinically-treated acute rejection was signifcantly higher in Group 1 than in Group 2 （34% vs 18%, P = 0.01）. The 5-year Kaplan-Meier estimated graft survival （74.3% vs 76.4%, P = 0.58） and patient survival （87.8% vs 87.5%, P = 0.93） were not different between the 2 groups. Multivariable analyses identifed ketoconazole usage as an independent risk of acute rejection （HR = 2.33, 95%CI： 1.33-4.07; P = 0.003） while tacrolimus dose in the 2nd month was protective （HR = 0.89, 95%CI： 0.75-0.96; P = 0.041）. CONCLUSION： Co-administration of ketoconazole and tacrolimus is associated with significantly higher inci-dence of acute rejection in kidney transplant recipients.

关键词： Kidney transplant Rejection Survival Tacrolimus Ketoconazole Pharmacokinetics Cytochrome P450

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