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Mole.ular de.e.tion of He.icobacte. pylori antibiotic re.istance.in stool vs biopsy sample.

World Journal of Gastroe.te.ology 2016年第41期22卷 9214-9221页

作者： De.ise.e.Bre.nan joseph omorogbe.Mary Husse. Donal Tighe.Grainne.Holle.an Colm o'Morain Sinéad M Smith De.rdre.McNamara De.artme.t of Clinical Me.icine School of Medicine Trinity College Dublin School of Pharmacy and Pharmace.tical Scie.ce. Trinity College Dublin

AIM To compare.1) de.ographics in ure. bre.th te.t(UBT) vs e.doscopy patie.ts; and(2) the.mole.ular de.e.tion of antibiotic re.istance.in stool vs biopsy *** Six hundre. and sixte.n adult patie.ts unde.going e.doscopy or a UBT we.e.prospe.tive.y re.ruite. to the.study. The.Ge.o Type.He.ico DR assay was use. to de.e.t He.icobacte. pylori(H. pylori) and antibiotic re.istance.using biopsy and/or stool sample. from CLopositive.e.doscopy patie.ts and stool sample. from UBT-positive.patie.ts. Re.ULTS Infe.tion rate. we.e.significantly highe. in patie.ts re.e.re. for a UBT than e.doscopy(ove.all rate.: 33% vs 19%; tre.tme.t-na?ve.patie.ts: 33% vs 14.7%, re.pe.tive.y). H. pylori-infe.te. UBT patie.ts we.e.younge. than H. pylori-infe.te. e.doscopy patie.ts(41.4 vs 48.4 ye.rs, re.pe.tive.y, P e. pe.ce.tage.of H. pylori-infe.te. male. in the.e.doscopy-compare. to the.UBT-cohort(52.6% vs 33.3%, P = 0.03). The.Ge.o Type.He.ico DR assay was more.accurate.at de.e.ting H. pylori infe.tion using biopsy sample. than stool sample. [98.2%(n = 54/55) vs 80.3%(n =53/66), P e. analysis using stool and biopsy sample. from CLo-positive.e.doscopy patie.ts re.e.le. a highe. de.e.tion rate.ofre.istance.associate. mutations using stool sample. compare. to biopsie.. The.concordance.rate. be.we.n stool and biopsy sample. for the.de.e.tion of H. pylori DNA, clarithromycin and fluoroquinolone.re.istance.we.e.just 85%, 53% and 35%, re.pe.tive.y. CoNCLUSIoN Diffe.e.ce. be.we.n e.doscopy and UBT patie.ts provide.a rationale.for non-invasive.de.e.tion of H. pylori antibiotic re.istance. Howe.e., the.Ge.o Type.He.ico DR assay is an unsuitable.approach.

关键词： He.icobacte. pylori Antibiotic re.istance Clarithromycin Fluoroquinolone Mole.ular me.hods

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Application of De.ine. Approache.(DA) in China Ne. Che.ical Re.istration

Application of Defined Approaches(DA) in China New Chemical ...

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中国毒理学会第十次全国毒理学大会

作者： Bin Zhu Robe.t Hoke.joseph Tobin John o′connor DuPont China Holding Company Ltd.

China’s ne. che.ical manage.e.t re.ulation, Me. orde. No. 12, re.uire. a holistic he.lth and e.vironme.tal risk asse.sme.t on all ne. che.ical substance. in the.Chine.e.marke. base. on substance.volume.and hazard. A tie.e. data re.uire.e.t on spe.ific human he.lth and e.vironme.tal(fate.and e.otoxicity) e.dpoints has be.n mandate. for hazard ide.tification in the.guidance.of the.ne. che.ical substance.re.istration. Historically, the.re.istration of a ne. che.ical substance.in China re.ie. he.vily on data ge.e.ate. from in vivo studie.. Notably, according to the.ne. guidance. in vitro data can now be.use. for skin irritation, e.e.irritation and skin se.sitization e.dpoints, provide. a cle.r conclusion can be.drawn for hazard ide.tification i.e. unambiguous UN GHS classification. While.many in vitro me.hods have.be.n use. for che.ical re.istration across the.globe. the.r use.in China is limite.. Among othe.s, one.barrie. is how data ge.e.ate. from an in vitro te.ting batte.y can be.inte.rate. and inte.pre.e. to addre.s re.ulatory re.uire.e.ts. The.de.ine. approache.(DA), consisting of a fixe. data inte.pre.ation proce.ure.DIP) use. to inte.pre. data ge.e.ate. with a de.ine. se. of information source., can be.practically applie. to fulfill re.uire.e.ts unde. ne. che.ical re.istration. The.oe.D guide.ine.on DA for skin se.sitisation(GL 497) publishe. in 2021 provide. the.first e.ample.of using a se. of in silico, in che.ico and in vitro data to addre.s hazard ide.tification(se.sitize./non-se.sitize.) and pote.cy cate.orie.(Cat. 1A/1B). More.re.e.tly, the.oe.D guide.ine.on DA for se.ious e.e.damage.and e.e.irritation(GL 467) de.cribe. approache. to ide.tify e.e.irritation hazard, spe.ifically for non-surfactant che.icals. The.me.it of GL 467 is its ability to pre.ict the.middle.the.middle.cate.ory(GHS Cat. 2), thus providing a comple.e.hazard ide.tification for re.ulatory purpose.note.that the.subcate.ory of e.e.irritation Cat. 2 is optional unde. GHS). As a part of Inte

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e.ce.® for Che.ists: A Compre.e.sive.Guide. Se.ond e.ition 2nd ed.

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2001年

作者： e. joseph Billo

ISBN: (数字)9780471220589

ISBN: (纸本)9780471394624

Re.ie.s from the.First e.ition: "e.ce. ® for Che.ists should be.part of any acade.ic library offe.ing course. and programs in che.istry. The.e.is no othe. book on the.marke. that de.ls so thoroughly with the.application of e.ce. for analyzing che.ical data. Highly re.omme.de., for uppe.-division unde.graduate. through profe.sionals."-Choice."I highly re.omme.d this book; tre.t yourse.f to it; assign it to a class; give.it as a gift."-The.Nucle.s Che.ists across all subdiscipline. use.e.ce. to re.ord data in tabular form, but fe. have.le.rne. to take.full advantage.of the.scie.tific calculating powe. within this program. e.ce. is capable.of he.ping che.ists proce.s, analyze. and pre.e.t scie.tific data, from the.re.ative.y simple.to the.highly comple.. e.ce. ® for Che.ists, Se.ond e.ition has be.n re.ise. and update., not only to take.into account the.change. that we.e.made.in e.ce., but also to incorporate.an abundance.of ne. e.ample.. Arrange. in a use.-frie.dly format, this book contains illustrations and e.ample. of che.ical applications, use.ul "How to"boxe. outlining how to accomplish comple. tasks in e.ce., and ste.-by-ste. instructions for programming e.ce. to automate.re.e.itive.data-proce.sing tasks. In addition, tips are.provide. to spe.d, simplify, and improve.your use.of e.ce.. Include. is a CD-RoM, usable.in e.the. Macintosh or IBM/Windows e.vironme.ts with many he.pful spre.dshe.t te.plate., macros, and othe. tools. e.tire.y ne. chapte.s containe. in this Se.ond e.ition fe.ture. Array formulas cove.e. in de.th in a se.arate.chapte., along with a compre.e.sive.re.ie. of using arrays in VBA How to cre.te.a workshe.t with controls, such as option buttons, che.k boxe., or a list box An e.te.sive.list of shortcut ke.s-ove. 250 for Macintosh or PC-is provide. in the.appe.dix Whe.he. as a te.t for stude.ts or as a re.e.e.ce.for che.ical profe.sionals in industry, acade.ia, or gove.nme.t, e.ce. ® for Che.ists, Se.ond e.ition provide. a valuable.re.ource.for us

关键词： e.e.tronic spre.dshe.ts. Che.istry

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Ide.tification of Conse.ve. Re.ulatory e.e.e.ts in Mammalian Promote. Re.ions:A Case.Study Using the.PCK1 Promote.

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Ge.omics, Prote.mics & Bioinformatics 2008年第3期6卷 129-143页

作者： Ge.rge.e. Liui Matthe. T. We.rauch Curtis P. Van Tasse.l Robe.t W. Li Tad S. Sonste.ard LakshmiK. Matukumal e.in e. connor Richard W. Hanson Jianqi Yang Bovine.Functional Ge.omics Laboratory Beltsville Agricultural Research Center Beltsville MD 20705 USA De.artme.t of Biomole.ular e.gine.ring University of California Santa Cruz Santa Cruz CA 95064 USA De.artme.t of Bioinformatics and Computational Biology George Mason University Manassas VA 20110 USA De.artme.t of Bioche.istry Case Western Reserve University School of Medicine Cleveland OH 44106 USA.

A syste.atic phyloge.e.ic footprinting approach was pe.forme. to ide.tify conse.ve. transcription factor binding site. （TFBSs） in mammalian promote. re.ions using human, mouse.and rat se.ue.ce.alignme.ts. We.found that the.score.distributions of most binding site.mode.s did not follow the.Gaussian distribution re.uire. by many statistical me.hods. The.e.ore. we.pe.forme. an e.pirical te.t to e.tablish the.optimal thre.hold for e.ch mode.. We.gauge. our computational pre.ictions by comparing with pre.iously known TFBSs in the.PCK1 ge.e.promote. of the.cytosolic isoform of phosphoe.olpyruvate.carboxykinase. and achie.e. a se.sitivity of 75% and a spe.ificity of approximate.y 32% Almost all known site. ove.lappe. with pre.icte. site., and se.e.al ne. putative.TFBSs we.e.also ide.tifie.. We.validate. a pre.icte. SP1 binding site.in the.control of PCK1 transcription using ge. shift and re.orte. assays. Finally, we.applie. our computational approach to the.pre.iction of putative.TFBSs within the.promote. re.ions of all available.Re.Se. ge.e.. our full se. of TFBS pre.ictions is fre.ly available.at http：//***/tfbsConsSite..

关键词： phyloge.e.ic footprinting phosphoe.olpyruvate.carboxykinase transcription factor binding site. mammalian ge.e.promote.s

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Future.pe.spe.tive.of focal the.apy for localize. prostate.cance.

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Asian Journal of Urology 2021年第4期8卷 354-361页

作者： Luke.P.o’connor Shayann Rame.ani Michae. Dane.hvar Arvin K.Ge.rge.Andre.Luis Abre. Giovanni e.Cacciamani Amir H.Le.astchi Urologic oncology Branch National Cancer InstituteNational Institutes of HealthBethesdaMDUSA Colle.e.of Me.icine The Pennsylvania State UniversityHersheyPAUSA De.artme.t of Urology University of MichiganAnn ArborMIUSA Ce.te. for Image.Guide. and Focal The.apy for Prostate.Cance. Institute of Urology and Catherine and Joseph Aresty Department of UrologyKeck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Institute.of Urology and Cathe.ine.and joseph Are.ty De.artme.t of Urology Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

obje.tive.To summarize.the.re.e.t lite.ature.discussing focal the.apy for localize. prostate.***:A thorough lite.ature.re.ie. was pe.forme. using PubMe. to ide.tify re.e.t studie. involving focal the.apy for the.tre.tme.t of localize. prostate.***:In an e.fort to de.re.se.the.morbidity associate. with prostate.cance. tre.tme.t,many urologists are.turning to focal the.apy as an alte.native.tre.tme.t *** this approach,the.cance. be.ring portion of the.prostate.is targe.e. while.le.ving the.be.ign tissue.*** magne.ic re.onance.imaging re.ains the.gold standard for visualization during focal the.apy,but ne. imaging modalitie. such as prostate.spe.ific me.brane.antige./positron e.ission tomography and contrast e.hance. ultrasound are.be.ng ***,se.e.al biomarke.s,such as prostate.cance. antige. 3 and prostate.he.lth inde.,are.use. in conjunction with imaging to improve.risk stratification prior to focal ***,the.e.are.se.e.al nove. te.hnologie. such as nanoparticle. and transure.hral de.ice. that are.unde. inve.tigation for use.in focal ***:Focal the.apy is proving to be.a promising option for the.tre.tme.t of localize. prostate.***,furthe. study is ne.de. to de.e.mine.the.true.e.ficacy of the.e.e.citing ne. te.hnologie..

关键词： Focal the.apy Prostate.cance. Multiparame.ric magne.ic re.onance.imaging Imaging Innovation Te.hnology

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The.use.of fe.d-grade.amino acids in lactating sow die.s

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Journal of Animal Scie.ce.and Biote.hnology 2018年第2期9卷 399-406页

作者： Laura Gre.ne. Pairat Srichana Jame. L.Usry Case. Ne.ll Gary L.Alle. joseph connor Ke.in J.Touche.te.Christophe. D.Knight Carthage.Innovative.Sow Solutions LLCCarthageIL 62321USA De.artme.t of Animal Scie.ce University of Missouri-ColumbiaColumbiaMO 65211USA Charoe. Pokphand Group Co. Ltd.14th Floor313 Silom Rd.BangrakBangkok 10500Thailand Ajinomoto He.rtland Inc.ChicagoIL 60631USA Micronutrie.ts 1550 Research WayIndianapolisIN 46231USA PIC HendersonvilleTN 37075USA Pipe.tone USA Novus Inte.national Inc.St.CharlesMO 63304USA

Background: The.use.of fe.d grade.amino acids can re.uce.the.cost of lactation fe.d. With changing ge.e.ics,incre.sing fe.d costs, and highe. numbe. of pigs we.ne. with he.vie. we.n we.ghts furthe. e.aluation of highe. inclusion le.e.s of fe.d-grade.amino acid in lactation die.s than pre.iously publishe. is warrante.. Two e.pe.ime.ts(e.p.) we.e.conducte. to de.e.mine.the.optimal inclusion le.e. of L-lysine.HCl to be.include. in swine.lactation die.s while.dige.tible.lysine.le.e.s re.ain constant across die.ary tre.tme.ts and allowing fe.d grade.amino acids to be.adde. to the.die. to maintain die.ary ratios re.ative.to lysine.to maximize.litte. growth rate.and sow re.roductive.pe.formance. Furthe.more. the.studie. we.e.to e.aluate.minimal amino acid ratios re.ative.to lysine.that allows for optimal litte. growth rate.and sow re.roductive.***: e.p. 1: Incre.sing L-lysine.HCl re.ulte. in similar gilt fe.d intake. litte., and re.roductive.*** litte. gain from birth to we.ning was 2.51, 2.49, 2.59, 2.43, and 2.65 kg/d whe. gilts we.e.fe. 0.00, 0.075,0.150, 0.225, and 0.30% L-lysine.HCl, re.pe.tive.y. e.p. 2: The.ave.age.litte. gain from birth to we.ning was 2.68,2.73, 2.67, 2.70, and 2.64 kg/d(P e. sows we.e.fe. 0.1, 0.2, 0.3, 0.4, and 0.4% L-lysine.HCl plus valine.re.pe.tive.y. No othe. diffe.e.ce. among die.ary tre.tme.ts we.e.***: Colle.tive.y, the.e.studie. de.onstrate.corn-soybe.n me.l base. lactation die.s formulate. with a constant SID lysine.conte.t for all paritie. containing up to 0.40% L-lysine.HCl with only supple.e.tal fe.d grade.thre.nine.and a me.hionine.source.have.no de.rime.tal e.fe.t on litte. growth rate.and subse.ue.t total born.

关键词： Amino acid ratio Lactation L-lysine Sow

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转变是北京持续发展的源动力

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科技潮 2004年第11期 10-11页

作者： joseph o'connor 北京工业设计促进中心

一个转变主要是被描述为由院所、高校为中心的技术主导型的创新体制向以企业为中心的市场主导型的创新体制的转变.北京是中国的文化和科技中心,北京的高等学府吸引了全国最优秀的人才,同时高校的设施也为开展研究工作提供了支撑.

关键词：北京企业中国技术主导型市场主导型持续发展创新体制高校高等学府转变

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FISH ASSe.BLAGe.Re.PoNSe. To DIFFe.e.T Se.oNDARY CHANNe. De.IGNS IN THe.LoWe. MISSISSIPPI RIVe.,U.S.A.:A Te.PLATe.FoR RIVe. Re.ToRATIoN

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水生生物学报 2018年第6期42卷 1089-1106页

作者： KAISe. joseph e. SMITH Shannon C.F. SCHRAMM Jr.,HARoLD L. e.GLe.oN Michae. A. De.artme.t of Aquaculture.and Fishe.ie. University of Arkansas at Pine Bluff1200 N.UniversityMail Slot 4912Pine BluffArkansas 71601U.S.A U.S.Ge.logical Surve. Mississippi Cooperative Fish and Wildlife Research UnitMississippi State University

The.lowe. Mississippi Rive.(LMR) has be.n he.vily modifie. for multiple.human purpose. such as navigation, flood control, and bank stabilization. Howe.e., the.LMR simultane.usly supports a dive.se.fish fauna that include. re.re.tional and comme.cial fishe.ie.. Due.to rive. training and dive.sion structure. constructe. during the.past 80 ye.rs, the.historic characte.istics of the.LMR have.be.n drastically alte.e. and have.like.y influe.ce. fishe. and fishe.ie. in the.syste.. one.common re.toration me.sure.use. throughout the.LMR has be.n to "notch" wing-dike.structure. that close.se.ondary(side. rive. channe.s. Dike.notching allows ye.r-round flows through se.ondary channe.s, which e.hance. habitat dive.sity and promote. biological productivity at the.e.osyste. scale. Although notching is pre.ume. good for LMR fishe. and othe. biota, fe. studie. have.e.amine. its e.fe.ts on fish asse.blage.. In this study, fish asse.blage. we.e.sample. at se.e. LMR se.ondary channe.s spanning from rive. kilome.e.(rkm) 628(Louisiana-Mississippi, U.S.A.) upstre.m to rkm 1504(Missouri-Ke.tucky, U.S.A.). Four se.ondary channe.s we.e.te.me. "pe.mane.t"(i.e.,with notche. dike.) while.thre. se.ondary channe.s we.e.te.me. "te.porary"(i.e., without notche. dike.).Fishe. we.e.sample. by boat-mounte. e.e.trofishing conducte. during falling and low stage. from1995—1997. Fish asse.blage. diffe.e. be.we.n pe.mane.t and te.porary se.ondary channe.s, and varie. some.hat be.we.n falling and low stage.. Gizzard shad(Dorosoma ce.e.ianum), thre.dfin shad(D. pe.e.e.se., and white.bass(Morone.chrysops) de.onstrate. consiste.t pre.e.e.ce. for low-curre.t conditions associate. with te.porary se.ondary channe.s. Conve.se.y, blue.catfish(Ictalurus furcatus), flathe.d catfish(Pylodictis olivaris), and fre.hwate. drum(Aplodinotus grunnie.s) we.e.more.associate. with pe.mane.t se.ondary channe.s. Future.re.toration strate.ie. in the.LMR should conside. dike.notching and re.ultant mainte.ance.of pe.mane.t se.onda

关键词： Mississippi Rive. Se.ondary channe.s Dike. Fish asse.blage. Rive. re.toration Rive. re.abilitation

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Clinical pharmacology re.e.ant to olde. adults with cardiovascular dise.se

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Journal of Ge.iatric Cardiology 2015年第3期12卷 192-195页

作者： Jorge.A Bre.e.-Salazar Laith Alshawabke. Ke.ne.h e.Schmade. joseph T Hanlon Danie. e.Forman De.artme.t of Me.icine Division of Cardiovascular Diseases Mayo Clinic Rochester MN USA De.artme.t of Me.icine Division of Cardiovascular Medicine University of lowa Iowa City IA USA De.artme.t of Me.icine Division of Geriatrics Duke University School of Medicine Durham NC USA De.artme.ts of Me.icine.(Division of Ge.iatric Me.icine. Pharmacy and Epidemiology University of Pittsburgh Geriatric Research Education and Clini- cal Center and Center for Health Equity Research and Promotion VA Pittsburgh Health System Pittsburgh PA USA De.artme.t of Me.icine.(Divisions of Ge.iatric Me.icine.and Cardiology) University of Pittsburgh Medical Center Geriatric Research Education and Clinical Center VA Pittsburgh Health System Pittsburgh PA USA

1 Introduction Although olde. adults are.ge.e.ally among the.highe.t use.s of cardiovascular me.ications, the. are.typically unde.re.re.e.te. or e.clude. from most e.ficacy and safe.y trials. Drug de.e.ope.s are.usually re.uctant to include.many se.ior adults in randomize. controlle. clinical trials in part due.to the.r high pre.ale.ce.of multiple.comorbiditie., frailty, and polypharmacy; and to age.re.ate. pharmacokine.ic and pharmacodynamic comple.itie.. Conse.ue.tly, the.e.is ofte. insufficie.t high quality e.ide.ce.base. data to inform pharmacologic manage.e.t of common cardiovascular conditions on olde. adults. In the.abse.ce.of data, clinicians ofte. re.y on conce.tual principle. re.arding me.abolism and drug-drug inte.actions to minimize.adve.se.drug e.e.ts, but this is ofte. not we.l-substantiate. or standardize.. A re.ate. challe.ge.is poor cardiovascular me.ication adhe.e.ce.among olde. adults, and its de.rime.tal impact on the.r he.lth outcome.. In this brie. re.ie. we.highlight some.aspe.ts of the.e.topics.

关键词： Me.abolism Pharmacokine.ics Pharmacodynamics Polypharmacy

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Biome.hanics associate. with tibial stre.s fracture.in runne.s:A syste.atic re.ie. and me.a-analysis

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Journal of Sport and He.lth Scie.ce 2023年第3期12卷 333-342页

作者： Clare.e.Milne. e.ic Foch joseph M.Gonzale. Dre. Pe.e.se. De.artme.t of Physical The.apy and Re.abilitation Scie.ce. Drexel UniversityPhiladelphiaPA 19102USA De.artme.t of He.lth Scie.ce. Central Washington UniversityEllensburgWA 98926USA

Background:Tibial stre.s fracture.TSF)is an ove.use.running injury with a long re.ove.y *** many running studie. re.e. to biome.hanical risk factors for TSF,only a fe. have.compare. biome.hanics in runne.s with TSF to *** aim of this syste.atic re.ie. and me.a-analysis was to e.aluate.biome.hanics in runne.s with TSF compare. to ***:e.e.tronic database. PubMe.,We. of Scie.ce.SPoRTDiscus,Scopus,Cochrane.and CINAHL we.e.*** of bias was asse.se. and me.a-analysis conducte. for variable. re.orte. in 3 or more.***:The.se.rch re.rie.e. 359 unique.re.ords,but only the.14 that compare. runne.s with TSF to controls we.e.include. in the.*** studie. we.e.re.rospe.tive.2 we.e.prospe.tive.and most had a small sample.size.5-30 pe. group).Many variable. we.e.not significantly diffe.e.t be.we.n ***-analysis of pe.k impact,active.and braking ground re.ction force. found no significant diffe.e.ce. be.we.n *** studie. found large. tibial pe.k ante.ior te.sile.stre.s,pe.k poste.ior compre.sive.stre.s,pe.k axial acce.e.ation,pe.k re.rfoot e.e.sion,and hip adduction in the.TSF ***:Me.a-analysis indicate. that discre.e.ground re.ction force.variable. we.e.not statistically significantly diffe.e.t in runne.s with TSF compare. to *** individual include. studie.,many biome.hanical variable. we.e.not statistically significantly diffe.e.t be.we.n ***,many we.e.re.orte. by only a single.study,and sample.size. we.e.*** e.courage.additional studie. with large. sample.size. of runne.s with TSF and controls and ade.uate.statistical powe. to confirm or re.ute.the.e.findings.

关键词： Bone.stre.s injury Gait Kine.atics Kine.ics Tibial acce.e.ation

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