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Exploring the Feasibility of Text Messaging Intervention in Intimate Partner Violence

Open Journal of Nursing 2014年第7期4卷 528-537页

作者： Rose Constantino Linden Wu Dominique de la Cruz joseph burroughs JuHae Grace Hwang Amanda Henderson Betty Braxter Department of Health and Community Systems University of Pittsburgh School of Nursing Pittsburgh USA Department of Health Promotion and Development University of Pittsburgh School of Nursing Pittsburgh USA UPMC Shadyside Emergency Department University of Pittsburgh School of Nursing Pittsburgh USA

Introduction: Intimate Partner Violence (IPV) is defined as controlling, abusive, and aggressive behavior in a romantic relationship. Women between the ages 16 and 24 experience the highest rate of IPV. IPV costs US society at least $13.6 billion annually and is expected to rise to $15.6 billion by 2021. The purpose of this study is to explore the feasibility of Text Messaging Intervention (TMI) in recognizing, responding and preventing IPV among college students. The research questions are: Will TMI 1) improve participant knowledge of warning signs of IPV? (Knowledge) and 2) improve participant confidence to intervene in IPV? (Confidence). Methods: A mixed methods design in data collection and data analysis was used. One-way ANOVA and Chi-square test were used to analyze quantitative data from the pre and post TMI survey. Results of the qualitative data analysis are included verbatim. Results: Results showed that knowledge level pre to post test increased from 2.00 ± 1.00 to 2.7 ± 0.48 (p < 0.001) and confidence level pre to post test increased from 2.89 ± 0.60 to 3.30 ± 0.68 (p < 0.001). Conclusions: Further research is needed in evaluating the feasibility and effectiveness of IPV prevention programs that uses mobile devices to create the best optimal health outcomes.

关键词： Disruptive Innovations (DI) Intimate Partner Violence (IPV) Primary Prevention Strategy Text Messaging Intervention (TMI) Violence Prevention

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Can non-invasive measurements aid clinical assessment of volume in patients with cirrhosis?

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World Journal of Hepatology 2013年第8期5卷 433-438页

作者： Andrew Davenport Banwari Argawal Gavin Wright Konstantinos Mantzoukis Rumyana Dimitrova joseph Davar Panayota Vasianopoulou Andrew K burroughs UCL Center for Nephrology Royal Free Hospital Intensive care Unit Royal Free Hospital Sheila Sherlock centre for hepatic diseases Royal Free Hospital Department of Cardiology Royal Free Hospital

AIM:To evaluate the non-invasive assessments of volume status in patients with ***:Echocardiography and multifrequency bioimpedance analysis measurements and short synacthen tests were made in 20 stable and 25 acutely decompensated patients with ***:Both groups had similar clinical assessments,cortisol response and total body water(TBW),however the ratio of extracellular water(ECW)/TBW was significantly greater in the trunk(0.420±0.004 vs0.404±0.005),and limbs(R leg 0.41±0.003 vs 0.398±0.003,P<0.05,and L leg 0.412±0.003 vs 0.399±0.003)with decompensated cirrhosis compared to stable cirrhotics,P<0.05).Echocardiogram derived right atrial and ventricular filling and end diastolic pressures and presence of increased left ventricular end diastolic volume and diastolic dysfunction were similar in both *** decompensated group had lower systemic blood pressure,mean systolic 101.8±4.3 vs122.4±5.3 and diastolic 58.4±4.1 mmHg vs 68.8±3.1 mmHg respectively,P<0.01,and serum albumin30(27-33)vs 32(31-40.5)g/L,P<***:Decompensated cirrhotics had greater leg and truncal ECW expansion with lower serum albumin levels consistent with intravascular volume depletion and increased vascular permeability.

关键词： Cirrhosis Bioimpedance Echocardiography Extracellular water Ascites Cortisol

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Curcumin-loaded polymeric nanoparticles for neuro-protection in neonatal rats with hypoxic-ischemic encephalopathy

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Nano Research 2018年第10期11卷 5670-5688页

作者： Andrea joseph Thomas Wood Chih-Chung Chen Kylie Corry Jessica M. Snyder Sandra E. Juul Pratik Parikh Elizabeth Nance Department of Chemical Engineering University of Washington Seattle WA 98195 USA Division of Neonatology Department of Pediatrics University of Washington Seattle WA 98195 USA Department of Comparative Medicine University of Washington Seattle WA 98195 USA Department of Radiology University of Washington Seattle WA 98195 USA

Hypoxic-ischemic encephalopathy is the leading cause of permanent brain injury in term newborns and currently has no cure. Inflammatory processes play a key role in the progression of this disease and may be amenable to a targeted pharmaceutical intervention. Curcumin is a dietary compound with potent anti-inflammatory, antioxidant, and antiapoptotic properties but is limited in therapeutic applications due to its low aqueous solubility, low bioavailability, and rapid first-pass hepatic metabolism. To address these limitations, loading curcumin into poly（lactic-co-glycolic acid）-poly（ethylene glycol）（PLGA-PEG） nanoparticles may increase relevant pharmacokinetic parameters and allow for effective drug delivery to the brain. Using the Vannucci model of unilateral hypoxic-ischemic brain injury in neonatal rats, we studied the in vivo effect of curcumin-loaded PLGA-PEG nanoparticles on brain uptake and diffusion of curcumin and on neuroprotection. The curcumin-loaded nanoparticles were able to overcome the impaired blood-brain barrier, diffuse effectively through the brain parenchyma, localize in regions of injury, and deliver a protective effect in the injured neonatal brain. The application of curcumin and PLGA-PEG nanoparticle-mediated delivery to a clinically relevant model of neonatal brain injury provides greater opportunities for clinical translation of targeted therapies for hypoxic-ischemic encephalopathy.

关键词： drug delivery neuroprotection brain penetrating neonatal hypoxia-ischemia curcumin nanotherapeutics

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Cell Stem Cell：利用干细胞制造出的心肌细胞有助精准心血管医疗取得进展

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现代生物医学进展 2016年第32期16卷 I0001-I0002页

作者： Elena Matsa Paul W. Burridge Kun-Hsing Yu John H. Ahrens Vittavat Termglinchan Haodi Wu Chun Liu Praveen Shukla Nazish Sayed Jared M. Churko Ningyi Shao Nicole A. Woo Alexander S. Chao joseph D. Gold Ioannis Karakikes Michael P. Snyder joseph C. Wu Biomedical Informatics Training Program Stanford University School of Medicine Stanford CA 94305 USA

在一项新的研究中。来自美国斯坦福大学医学院的研究人员发现利用人诱导性多能干细胞（iPS细胞）制造的心肌细胞忠实地反映供者天然的心脏组织中关键基因的表达模式。因此，这些细胞能够被用来预测病人是否可能经历药物相关的心脏损伤... 详细信息

在一项新的研究中。来自美国斯坦福大学医学院的研究人员发现利用人诱导性多能干细胞（iPS细胞）制造的心肌细胞忠实地反映供者天然的心脏组织中关键基因的表达模式。因此，这些细胞能够被用来预测病人是否可能经历药物相关的心脏损伤。相关研究结果在线发表在Cell Stem Cell期刊上。论文标题为＂Transcriptome Profiling of Patient -Specific Human iPSC - ardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro＂.

关键词：多能干细胞 Cell 心肌细胞 Stem 制造利用心血管美国斯坦福大学

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