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Medium-term mortality after hip fractures and COVID-19:A prospective multicentre UK study

Chinese Journal of Traumatology 2022年第3期25卷 161-165页

作者： Gareth Chan Ashish Narang Arash Aframian Zaid Ali joseph bridgeman Alastair Carr Laura Chapman Henry Goodier Catrin Morgan Chang Park Sarah Sexton Kapil Sugand Thomas Walton Michael Wilson Ajay Belgaumkar Kieran Gallagher Koushik Ghosh Charles Gibbons Joshua Jacob Andrew Keightley Zuhair Nawaz Khaled Sarraf Christopher Wakeling William Kieffer Benedict Rogers Brighton&Sussex University Hospitals NHS Trust Brighton&Sussex Medical SchoolFainter CampusBrighton UK Surrey&Sussex Healthcare NHS Trust Canada&venueRedhillUK Chelsea&Westminster Hospital NHS Foundation Trust LondonUK Ashford&St frier's Hospital NHS Foundation TrustChertseyUK Western Sussex Hospitals NHS Foundation Trust(Sr Richard's Hospital)ChichesterUK Poole General Hospital&the Royal Bournemouth Hospital froleUK Imperial College Healthcare NHS Trust LondonUK Western Sussex Hospitals NHS Foundation Trust(Worthing Hospital) WorthingUK Royal Surrey Hospital NHS Foundation Trust GuildfordUK Frimley Health NHS Foundation Trust FrimleyUK

Purpose:The COVID-19 pandemic has caused 1.4 million deaths globally and is associated with a 3-4 times increase in 30-day mortality after a fragility hip fracture with concurrent COVID-19 ***,death from COVID-19 infection occurs between 15 and 22 days after the onset of symptoms,but this period can extend up to 8 *** study aimed to assess the impact of concurrent COVID-19 infection on 120-day mortality after a fragility hip ***:A multi-centre prospective study across 10 hospitals treating 8%of the annual burden of hip fractures in England between 1st March and 30th April,2020 was *** whose surgical treatment was payable through the National Health Service Best Practice Tariff mechanism for"fragility hip fractures"were included in the ***'120-day mortality was assessed relative to their perioperative COVID-19 *** analysis was performed using SPSS version ***:A total of 746 patients were included in this study,of which 87(11.7%)were COVID-19 *** rates at 30-and 120-day were significantly higher for COVID-19 positive patients relative to COVID-19 negative patients(p<0.001).However,mortality rates between 31 and 120-day were not significantly different(p=0.107),16.1%and 9.4%respectively for COVID-19 positive and negative patients,odds ratio 1.855(95%CI 0.865-3.978).Conclusion:Hip fracture patients with concurrent COVID-19 infection,provided that they are alive at day-31 after injury,have no significant difference in 120-day *** the growing awareness and concern of "long-COVID"and its widespread prevalence,this does not appear to increase mediumterm mortality rates after a hip fracture.

关键词： Hip fractures Femoral fractures COVID-19 Coronavirus Mortality

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HIV-1 particles transfer the antiviral second messenger cGAMP between cells

HIV-1 particles transfer the antiviral second messenger cGAM...

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第九届全国免疫学学术大会

作者： Anne bridgeman Jonathan Maelfait Tamara Davenne Jan Rehwinkel Medical Research Council Human Immunology Unit Medical Research Council Weatherall Institute of Molecular MedicineRadcliffe Department of MedicineUniversity of Oxford

Cyclic GMP-AMP synthase(cGAS)is a sensor for cytosolic DNA delivered into cells during virus *** stimulator of interferon genes(STING),which induces an antiviral *** signals to STING via synthesis of a diffusible second messenger,cyclic GMP-AMP(cGAMP).We explored the implications of this unique signaling mechanism.

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Nitrogen Constrains the Growth of Late Summer Cyanobacterial Blooms in Lake Erie

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Advances in Microbiology 2013年第6期3卷 16-26页

作者： Justin D. Chaffin Thomas B. bridgeman Darren L. Bade Department of Environmental Sciences and Lake Erie Center University of Toledo Toledo USA

Phosphorus (P) is generally considered to be the main limiting nutrient to freshwater phytoplankton productivity. However, recent research is drawing attention to the importance of nitrogen (N) in freshwater eutrophication and N often constrains growth of cyanobacteria in small lakes. In this study we determined phytoplankton nutrient limitation in a large lake, Lake Erie during two growing seasons. During 2010 and 2011, nutrient enrichment bioassays (+P, +N and, +P and N) were conducted monthly from June through September with water collected in Maumee Bay (site MB18) and in the center of the western basin (site WBC). Nutrient concentrations were monitored every other week. At MB18, total P concentration was often >3 mmol/L and nitrate concentration decreased from >250 mmol/L in early summer to mmol/L in late summer. Nitrogen and P levels were about five-fold less at WBC. Bioassays indicated that phytoplankton nutrient limitation varied in summer, spatially, and even among phytoplankton groups. For site MB18, +P increased chlorophyll concentration in one of the eight bioassays, indicating that P did not typically limit production. For site WBC, +P increased chlorophyll concentration in six of the eight bioassays. As a result of very low ambient nitrate concentration (mmol/L) in late summer, +N (without P) increased chlorophyll concentration, suggesting symptoms of N-limitation. The N-fixing cyanobacterium Anabaena became dominant following N-limitation. This study highlights the need to reduce P loading to restore water quality. Furthermore, due to low nitrate concentration, the severity of the cyanobacterial blooms could be worse if not for N-limitation in western Lake Erie.

关键词： Cyanobacteria Eutrophication Nitrogen Phosphorus Phytoplankton

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Interactive Effects of Temperature, Nitrogen, and Zooplankton on Growth and Protein and Carbohydrate Content of Cyanobacteria from Western Lake Erie

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Journal of Water Resource and Protection 2014年第12期6卷 1139-1153页

作者： Deepesh Bista Scott A. Heckathorn Thomas bridgeman Justin D. Chaffin Sasmita Mishra Department of Environmental Sciences University of Toledo Toledo USA F.T. Stone Laboratory The Ohio State University Columbus USA

Harmful algal blooms (HABs) in freshwater ecosystems, especially of cyanobacterial species, are becoming more frequent and expanding geographically, including in Lake Erie in North America. HABs are the result of complex and synergistic environmental factors, though N or P eutrophication is a leading cause. With global mean temperatures expected to increase an additional 2°C - 5°C by 2100, cyanobacterial blooms are predicted to increase even more, given their typically-high temperature optimum for growth. We investigated how increases in temperature and nitrogen, singly or in combination, affect the growth, food quality, and herbivory of Lake Erie cyanobacteria. Algal community samples collected from Lake Erie, and isolated non-N-fixing (Microcystis aeruginosa) and N-fixing (Anabaena flos-aquae) cyanobacterial species, were cultured at 20°C, 25°C, or 30°C, and at 5, 50, 150, or 250 μM N, and then analyzed for growth and (for isolates) content of total protein and non-structural carbohydrates (NSC). Temperature and N both affected algal growth, and there were temperature × N interactions, which were sometimes affected by presence/absence of zooplankton. For example, cyanobacteria (but not green algae) growth increased with both temperature and N, especially from 25°C to 30°C, but N and herbivore presence increased cyanobacterial growth primarily only at 30°C. In general, temperature and N had little consistent effect on NSC, but increasing temperature and N tended to increase protein content in Microcystis and Anabaena (temperature effects mostly at higher N levels). In Anabaena, increases in N did not increase growth or protein at 20°C or 25°C, but did increase both at 30°C, indicating that N fixation is damaged at high temperatures and that high NO3 can overcome this damage. These results indicate that future global warming and continued eutrophication will increase cyanobacterial growth, as well influence algal herbivory and competition between N-fixing and non-N-

关键词： Cyanobacteria Great Lakes Harmful Algal Blooms Nitrogen Temperature

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Role of Suspended Sediments and Mixing in Reducing Photoinhibition in the Bloom-Forming Cyanobacterium Microcystis

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Journal of Water Resource and Protection 2012年第12期4卷 1029-1041页

作者： Justin D. Chaffin Thomas B. bridgeman Scott A. Heckathorn Ann E. Krause Lake Erie Center and Department Environmental Sciences University of Toledo Oregon USA

Toxic cyanobacterial blooms are becoming a global problem. Previous research of cyanobacterial bloom development has examined how high nutrient concentrations promote cyanobacteria dominance, and how positive buoyancy provides an ecological advantage over sinking phytoplankton. Tributaries responsible for loading nutrients into lakes often simultaneously contribute high concentrations of suspended sediments. High concentrations of suspended sediments may also influence blooms by affecting the ambient light climate, reducing photodamage, and increasing the efficiency of photosynthesis. We examined the effects of sediments and vertical mixing in potentially reducing photodamage to Microcystis by measuring photosynthetic parameters and pigment content of Microcystis in western Lake Erie during the 2008 bloom and in laboratory experiments. Photosynthetic efficiency increased with increasing sediment concentration in the lake and laboratory experiment. Content of photo-protective carotenoid pigments per dry weight decreased with increasing sediment concentrations, while the light-harvesting pigments, chl a and phycocyanin, increased with sediments. These results indicate that suspended sediments reduce photoinhibition for Microcystis. Further, photosynthetic damage was higher when Microcystis was concentrated on the surface compared to a mixed water column. Measurements of Microcystis abundance and light were also recorded, in addition to photosynthetic measurements. Greatest Microcystis abundances in Lake Erie were recorded during light-limiting conditions, which offer Microcystis both physiological and ecological benefits by reducing photoinhibition and increasing Microcystis’ advantage in light competition via buoyancy. Efforts to reduce cyanobacterial blooms may include reducing suspended sediments loads in combination with reducing nutrient loading.

关键词： Chlorophyll Fluorescence Cyanobacteria Harmful Algae Bloom Lake Erie Microcystis Suspended Sediments

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追寻莫奈的阳光与色彩大陆首次“印象派大师·莫奈特展”55件法国国宝级藏品震撼来沪

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旅游世界 2014年第3期 106-107页

作者： Musee Marmottan Monet Paris bridgeman-Giraudon/presse

由巴黎马莫丹莫奈美术馆、上海天协文化发展公司可K11 Art Foundation联合主办、上海市对外文化交流协会特别支持“印象派大师’莫奈特展”将于2014年3月18日-6月15日在上海K11购物艺术中心B3层CHI K11 art space展出。本次展览将作为... 详细信息

由巴黎马莫丹莫奈美术馆、上海天协文化发展公司可K11 Art Foundation联合主办、上海市对外文化交流协会特别支持“印象派大师’莫奈特展”将于2014年3月18日-6月15日在上海K11购物艺术中心B3层CHI K11 art space展出。本次展览将作为“中法建叫50周年”重要庆典活动之一，也是中国大陆第一次莫奈专题特展。

关键词：中国大陆莫奈奈特色彩阳光藏品国宝法国

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流光溢彩·印象永驻大陆首次“印象派大师·莫奈特展”55件法国国宝级藏品震撼来沪

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旅游世界 2014年第5期 92-95页

作者： "Musée Marmottan Monet,Paris,bridgeman-Giraudon/presse" 严磊

轻轻触摸色彩、线条、光影所留下的印象，探索光色与空气的表现效果，莫奈就是这样一位印象派大师，常常在不同的时间和光线下，对同一对象作多幅的描绘，从自然的光色变幻中抒发瞬间的感觉。而当真正直面大师作品之时，那种瞬间感受所... 详细信息

轻轻触摸色彩、线条、光影所留下的印象，探索光色与空气的表现效果，莫奈就是这样一位印象派大师，常常在不同的时间和光线下，对同一对象作多幅的描绘，从自然的光色变幻中抒发瞬间的感觉。而当真正直面大师作品之时，那种瞬间感受所爆发出的感动，才是这些艺术品真正为人所动容的地方。在K11的莫奈画展中，初次与大师在中国上海邂逅，那种穿越时空的交流，本身就让人感动，而当近距离触摸大师身平印记之后，思想交流所撞出的火花，更能让人去思考其画作背后想要传达给世人的深意。让我们跟随着大师的画作，去揭开莫奈这一生的传奇。

关键词：印象派大师藏品国宝法国奈特大陆思想交流

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三维荧光光谱法测定市政污水中有机污染物

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环境监测管理与技术 2017年第5期29卷 37-39,71页

作者：易莹周艳伟 bridgeman J 孔伟杨昌达毛海荣王知兵中国电器科学研究院有限公司广东广州510300 伯明翰大学工程与物理科学学院

采用三维荧光光谱法和传统水质分析法分别测定广州某城市污水厂污水处理过程中不同节点的污水水质,并分析荧光特性与传统分析方法获得的数据之间的关系。结果表明,随着污水水质情况的改善,污水样本的特征峰荧光强度呈现出明显的下降趋势... 详细信息

采用三维荧光光谱法和传统水质分析法分别测定广州某城市污水厂污水处理过程中不同节点的污水水质,并分析荧光特性与传统分析方法获得的数据之间的关系。结果表明,随着污水水质情况的改善,污水样本的特征峰荧光强度呈现出明显的下降趋势,且污水荧光强度与COD、BOD5值存在较好的相关性,可通过直接分析污水的荧光特性来判断污水的有机污染情况;相较于过滤处理的污水样本,未过滤水样的特征峰荧光强度与污水COD、BOD5值之间具有更强的线性关系。

关键词：化学需氧量五日生化需氧量三维荧光光谱法污水

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上海风土人情录(三)

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都会遗踪 2011年第2期 136-140页

作者：裨治文邵文菁不详

这年夏天,'目击者'眼中的上海有了大变化。饥荒、乞丐、弃婴等现象有所缓和,露置的棺材、落后的防疫体系依旧是棘手的问题。鸦片战争后,国家对鸦片、走私、军事和外交领域采取的措施都影响着华洋杂处的上海。作为一个虔诚的基督徒,'目击... 详细信息

这年夏天,'目击者'眼中的上海有了大变化。饥荒、乞丐、弃婴等现象有所缓和,露置的棺材、落后的防疫体系依旧是棘手的问题。鸦片战争后,国家对鸦片、走私、军事和外交领域采取的措施都影响着华洋杂处的上海。作为一个虔诚的基督徒,'目击者'悲悯困苦的百姓,嘲讽腐败的清政府,同时也流露出鲜明的反战态度。

关键词：棘手杂处目击者外交弃婴上海华洋防疫

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Measurements of dihadron correlations relative to the event plane in Au+Au collisions at√^(S)NN=200 GeV

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Chinese Physics C 2021年第4期45卷 198-241页

作者： H.Agakishiev M.M.Aggarwal Z.Ahammed A.V.Alakhverdyants I.Alekseev J.Alford B.D.Anderson C.D.Anson D.Arkhipkin G.S.Averichev J.Balewski D.R.Beavis N.K.Behera R.Bellwied M.J.Betancourt R.R.Betts A.Bhasin A.K.Bhat H.Bichsel J.Bieleik J.Bielcikova B.Biritz L.C.Bland W.Borowski J.Bouchet E.Braidot A.V.Brandin A.bridgeman S.G.Brovko E.Bruna S.Bueltmann I.Bunzarov T.P.Burton X.Z.Cai H.Caines M.Calderon de la Barca Sanchez D.Cebra R.Cendejas M.C.Cervantes Z.Chajecki P.Chaloupka S.Chattopadhyay H.F.Chen J.H.Chen J.Y.Chen L.Chen J.Cheng M.Cherney A.Chikanian K.E.Choi W.Christie P.Chung M.J.M.Codrington R.Corliss J.G.Cramer H.J.Crawford S.Dash A.Davila Leyva L.C.De Silvat R.R.Debbe T.G.Dedovich A.A.Derevschikov R.Derradi de Souza L.Didenko P.Djawotho S.M.Dogra X.Dong J.L.Drachenberg J.E.Draper J.C.Dunlop L.G Efimov M.Elnim J.Engelage G Eppley M.Estienne L.Eun O.Evdokimov R.Fatemi J.Fedorisin A.Feng R.G.Fersch P.Filip E.Finch V.Fine Y.Fisyak C.A.Gagliardi D.R.Gangadharan A.Geromitsos F.Geurts P.Ghosh Y.N.Gorbunov A.Gordon O.Grebenyuk D.Grosnick S.M.Guertin A.Gupta W.Guryn B.Haag O.Hajkova A.Hamed L-X.Han J.W.Harris J.P.Hays-Wehle M.Heinz S.Heppelmann A.Hirsch E.Hjort G.W.Hoffmann D.J.Hofiman B.Huang H.Z.Huang T.J.Humanic L.Huo G.Igo P.Jacobs W.W.Jacobs C.Jena F.Jin J.joseph E.G.Judd S.Kabana K.Kang J.Kapitan K.Kauder H.Ke D.Keane A.Kechechyan D.Kettler D.P.Kikola J.Kiryluk A.Kisiel V.Kizka A.G.Knospe D.D.Koetke T.Kollegger J.Konzer I.Koralt L.Koroleva W.Korsch L.Kotchenda V.Kouchpil P.Kravtsov K.Krueger M.Krus L.Kumar P.Kurnadi M.A.C.Lamont J.M.Landgraf S.LaPointe J.Lauret A.Lebedev R.Lednicky J.H.Lee W.Leight M.J.LeVine C.Lil L.Li N.Li W.Li X.Li X.Li Y.Li Z.M.Li M.A.Lisa F.Liu H.Liu J.Liu T.Ljubicic W.J.Llope R.S.Longacre W.A.Love Y.Lu E.V.Lukashov X.Luo G.L.Ma Y.G.Mai D.P.Mahapatra R.Majka O.I.Mall L.K.Mangotra R.Manweiler S.Margetis C.Markert H.Masui H.S.Matis Yu.A.Matulenko D.MeDonald T.S.McShane A.Meschanin R.Milner N.G.Minaev S.Mioduszewski A.Mischke M.K.Mitrovski B.Mohanty M.M.Mondal B.Morozov D.A.Morozov M.G.Munhoz M Argonne National Laboratory Argonnellinois 60439USA Brookhaven National Laboratory UptonNew York 11973USA University of Califomia BerkeleyCaliformnia 94720USA University of California DavisCalifornia 95616USA University of Califormnia Los AngelesCalifomia 90095USA Universidade Estadual de Campinas Sao PauloBrazil University of Illinois at Chicago ChicagoIlinois 60607USA Creighton University OmahaNebraska 68178USA Czech Technical University in Prague FNSPEPrague11519Czech Republic Nuclear Physics Institute AS CR 25068 Rez/PragueCzech Republic University of Frankfurt FrankfurtGermany Institute of Physics Bhubaneswar 751005India Indian Institute of Technology MumbaiIndia Indiana University BloomingtonIndiana 47408USA Alikhanov Instiute for Theoretical and Experimental Physics MoscowRussia University of Jammu Jammu 180001India Joint Institute for Nuclear Research Dubna141980Russia Kent State University KentOhio 44242USA University of Kentucky LexingtonKentucky40506-0055USA Institute of Modern Physics LanzhouChina Lawrence Berkeley National Laboratory BerkeleyCalifornia 94720USA Massachusetts Institute of Technology CambridgeMA 02139-4307USA Mx-Planck-Institut fir Physik MunichGermany Michigan State University East LansingMichigan 48824USA Moscow Engineering Physics Institute Moscow Russia NIKHEF and Utrecht University AmsterdamThe Netherlands Ohio State University ColumbusOhio 43210USA Old Dominion University NorfolkVA23529USA Panjab University Chandigarh 160014India PennsyIvania State University University ParkPennsylvania 16802USA Institute of High Energy Physics ProtvinoRussia Purdue University West LafayetteIndiana 47907USA Pusan National University PusanRepublic of Korea University of Rajasthan Jaipur 302004India Rice University HoustonTexas 77251USA Universidade de Sao Paulo Sao PauloBrazil University of Science&Technology of China Hefei 230026.China Shandong University JinanShandong 250100China Shanghai Institute of Applied Physics Shanghai 201800Chi

Dihadron azimuthal correlations containing a high transverse momentum(pr)trigger particle are sensit-ive to the properties of the nuclear medium created at RHIC through the strong interactions occurring between the traversing parton and the medium,*** measurements revealed a strong modification to di-hadron azimuthal correlations in Au+Au collisions with respect to ptp and d+Au *** modification in-creases with the collision centrality,suggesting a path-length or energy density dependence to the je-quenching *** paper reports STAR measurements of dihadron azimuthal correlations in mid-central(20%-60%)Au+Au collisions at√^(S)NN=200 GeV as a function of the trigger particle's azimuthal angle relative to the event plane,Ф_(s)=|Ф_(t)-ψ_(Ep)|.The azimuthal correlation is studied as a function of both the trigger and associated particle *** subtractions of the combinatorial background and anisotropic flow,assuming Zero Yield At Minimum(ZYAM),are *** correlation results are first discussed with subtraction of the even harmonic(elliptic and quadrangu-lar)flow *** away-side correlation is strongly modifed,and the modification varies withФ_(s),with a double-peak structure for out-of-plane trigger *** near-side ridge(long range pseudo-rapidity△_(η)correla-tion)appears to drop with increasingФ_(s)while the jet-like component remains approximately *** correla-tion functions are further studied with the subtraction of odd harmonic triangular flow background arising from *** is found that the triangular flow,while responsible for the majority of the amplitudes,is not sufficient to explain theφs-dependence of the ridge or the away-side double-peak *** dropping ridge withФ_(s)could be attributed to aФ_(s)-dependent lliptie anisotropy;however,the physics mechanism of the ridge remains an open *** with aФ_(s)-dependent elliptic flow,the away-side correlation structure

关键词： relativistic heavy ion collisions dihadron correlations jet-medium interactions anisotropic flow background event plane

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