检索结果-南通市图书馆

慢性中耳炎手术的罕见并发症眶周肿胀的病因分析

在线全文

学校读者我要写书评

暂无评论

慢性中耳炎手术的罕见并发症眶周肿胀的病因分析

EVOLUTION AND INTERACTION OFδ-WAVES IN THE ZERO-PRESSURE GAS DYNAMICS SYSTEM

2010全国耳鼻咽喉头颈外科中青年学术会议

作者：赵宇吕晓攀秦学玲 joseph b.roberson 四川成都国学巷37号四川大学华西医院耳鼻咽喉头颈外科

目的传统的慢性化脓性中耳炎手术并发症中,未见眼部并发症。在我们的临床实践中,观察到慢性化脓性中耳炎术后出现罕见并发症眶周肿胀,我们就其临床表现特点和可能的病因进行探讨。

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Acta Mathematica Scientia 2024年第5期44卷 1801-1836页

作者： Abhishek DAS K.T.joseph Centre for Data Science Institute of Technical Education and Research(ITER)Siksha‘O’Anusandhan(Deemed to be University)BhubaneswarOdisha751030India Centre for Applicable Mathematics Tata Institute of Fundamental ResearchSharada NagarBangalore560065KarnatakaIndia

Evolution and interaction of plane waves of the multidimensional zero-pressure gas dynamics system leads to the study of the corresponding one dimensional *** this paper,we study the initial value problem for one dimensional zero-pressure gas dynamics *** the first equation is the burgers equation and the second one is the continuity *** consider the solution with initial data in the space of bounded borel *** we prove a general existence result in the algebra of generalized functions of *** we study in detail special solutions withδ-measures as initial *** study interaction of waves originating from initial data concentrated on two point sources and interaction with classical shock/rarefaction *** gives an understanding of plane-wave interactions in the multidimensional *** use the vanishing viscosity method in our analysis as this gives the physical solution.

关键词： zero-pressure gas dynamics delta-waves interaction of waves

Advances in discovery of novel investigational agents for functional cure of chronic hepatitis b:A comprehensive review of phases II and III therapeutic agents

在线全文

学校读者我要写书评

暂无评论

World Journal of Hepatology 2024年第3期16卷 331-343页

作者： Robert Lam joseph K Lim Section of Digestive Diseases Yale University School of MedicineNew HavenCT 06520United States

Chronic hepatitis b virus(HbV)infection affects over 295 million people globally and an estimated 1.6 million people in the United *** is associated with significant morbidity and mortality due to cirrhosis,liver failure,and liver *** therapy with oral nucleos(t)ide analogues is associated with high rates of virologic suppression,which in turn has been associated with a decreased risk of liver ***,current antiviral regimens are limited by concerns with adverse effects,adherence,resistance,long-term treatment,and ongoing risk for liver *** investigational agents are currently in development and are targeted at achieving functional cure with sustained hepatitis b surface antigen(HbsAg)loss and suppression of HbV *** we review key evidence from phases II and III trials defining the efficacy and safety profiles for key investigational agents for functional cure of chronic hepatitis b,including core/capsid inhibitors,entry inhibitors,RNA interference(siRNA/ASO),HbsAg inhibitors,Toll-like receptor agonists,checkpoint inhibitors,and therapeutic vaccines.

关键词： Hepatitis b virus Treatment Clinical trials RNA interference Entry inhibitors Core inhibitors Immunomodulators

The Sigma-1 Receptor as a Pharmacologic Chaperone: Energetics

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of biosciences and Medicines 2024年第8期12卷 347-356页

作者： Robert b. Raffa joseph V. Pergolizzi Jr. School of Pharmacy (Emeritus) Temple University Philadelphia PA USA College of Pharmacy (Adjunct) University of Arizona Tucson AZ USA NEMA Research Naples FL USA

Initially thought to be an opioid receptor subtype, Sigma-1 receptors (S1R) are now known to be unique proteins that have chaperone-like properties. As such, they play critical roles in cellular signaling, homeostasis, and cell survival. These roles offer significant insight for understanding homeostasis of normal physiologic processes, and the pathophysiologic consequences of disruption of normal function. because of the broad nature of chaperone action, S1R agonists and antagonists represent potential drug discovery goals for the pharmacotherapeutic treatment of a variety of disorders that result from dysfunctional proteins. The present study summarizes the S1R as a pharmacologic chaperone crucial for protein folding and cellular homeostasis. Through literature review and thermodynamic analysis, it explores how S1R stabilizes target proteins, influencing neuroprotection and potential drug therapies. The binding of chaperones to target proteins is thermodynamically favorable, offering insights into treating diseases linked to protein misfolding.

关键词： Chaperone Sigma-1 Receptor Energetics Thermodynamics Isothermal Titration Microcalorimetry

The Impacts and Causes of Land Fragmentation on Farm Productivity: Case Review of East African Countries

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Ecology 2024年第5期14卷 455-482页

作者： joseph Mayindo Mayele Jacob b. Kolleh Joel Emmanuel Saburi Department of Agricultural and Resource Economics The University of Tokyo Tokyo Japan Department of Forestry and Wildlife College of Natural Resources and Environmental Studies University of Juba Juba South Sudan Department of Socio-Economic and Applied Statistics Central Agricultural Research Institute (CARI) Suakoko Liberia

This report provides an overall assessment of land fragmentation problems in East Africa. Many parts of East Africa have become highly fragmented, putting development systems and activities in these areas at risk of complete collapse. Land fragmentation occurs when land gets converted for agriculture, industrialization, or urbanization, invaded by non-local plants, or enclosed for individual use and by subdividing farmlands into subsequent smaller units called parcels with varying average farm sizes. Fragmentation results from inappropriate agricultural development processes and ineffective land use planning that fails to recognize how farmland is used, and the importance of its interconnected areas. Insecurity of tenure and resource rights are key factors in making this possible. Land fragmentation is one of the key reasons why the ability of most resources in East Africa becomes scarcer, and those remaining become “privatized” by more powerful community members—keen to maintain their access to them. Such individualistic attitudes are new and disadvantage the poorest even further by affecting the traditional customary safety nets and agricultural outputs. Neither the government nor customary governance systems effectively protect resource access for the poorest. This review summary report identifies the key causes, measures, and implications, government interventions, and the common remedies to land fragmentation problems in the East African Countries of Kenya, Uganda, Rwanda, and Tanzania including neighboring Ethiopia, and the Sudan. The findings indicated from 2005 to 2015, the population kept increasing for all the named countries in East Africa with Rwanda and Uganda having a substantial increase in population density. The study review further explores the trend in the performance of agriculture by average farm sizes within the intervals of five years by highlighting their strong linkages and found that the average farm size has declined drastically, especiall

关键词： Land Fragmentation Land Consolidation Farm Productivity Industrialization Impacts Causes Average Farm Size Population East Africa

Exciton-polaritons in a 2D hybrid organic-inorganic perovskite microcavity with the presence of optical Stark effect

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics b 2024年第3期33卷 551-555页

作者： Kenneth Coker 郑楚媛 joseph Roger Arhin Kwame Opuni-boachie Obour Agyekum 张伟利 School of Information and Communication Engineering University of Electronic Science and Technology of ChinaChengdu 611731China Department of Electrical and Electronic Engineering Ho Technical UniversityHo 00233Ghana Telecommunication Engineering Department Kwame Nkrumah University of Science and TechnologyKumasi 00233Ghana

This study investigates the properties of exciton-polaritons in a two-dimensional(2D)hybrid organic-inorganic perovskite microcavity in the presence of optical Stark *** both steady and dynamic state analyses,strong coupling between excitons of perovskite and cavity photons is revealed,indicating the formation of polaritons in the perovskite ***,it is found that an external optical Stark pulse can induce energy shifts of excitons proportional to the pulse intensity,which modifies the dispersion characteristics of the polaritons.

关键词： exciton-polaritons perovskite microcavity optical Stark effect

Elucidating the Degradation Pathways of Human Insulin in the Solid State

在线全文

学校读者我要写书评

暂无评论

Journal of Analysis and Testing 2024年第3期8卷 288-299页

作者： Andrew Fagan Lorraine M.bateman joseph P.O'Shea Abina M.Crean SSPC the SFI Centre for Pharmaceutical Research School of Pharmacy University College Cork School of Pharmacy University College Cork Analytical and biological Chemistry Research Facility (AbCRF) University College Cork School of Chemistry University College Cork

While there have been significant advances in the development of peptide oral dosage forms in recent years, highlighted by the clinical and commercial success of approved peptides such as Rybelsus?, there remain several barriers in the way of broad range applicability of this approach to peptide delivery. One such barrier includes the poor physical and chemical stability inherent to their structures, which persists in the solid state although degradation typically occurs at different rates and via different pathways in comparison to the solution state. Using insulin as a model peptide, this work sought to contribute to the development of analytical techniques for investigating common insulin degradation pathways. Chemically denatured,deamidated and aggregated samples were prepared and used to benchmark circular dichroism spectroscopy, reverse phase HPLC and size exclusion chromatography methods for the investigation of unfolding, chemical modifications and covalent aggregation of the insulin molecule respectively. Solid state degraded samples were prepared by heating insulin powder at 60 °C and 75% relative humidity for 1, 3, 5 and 7 d, and the degradation profiles of the samples were evaluated and compared with those observed in solution. While no unfolding was observed to occur, significant deamidation and covalent aggregation were detected. Reductive disulfide bond cleavage using dithiothreitol allowed for separation of the insulin A-and b-chains,offering a facile yet novel means of assessing the mechanisms of deamidation and covalent aggregation occurring in the solid state.

关键词： biopharmaceutical analysis Covalent aggregation Deamidation Disulfide cleavage Insulin Solid state Stability

black hole shadows in Einstein-bel-Robinson gravity

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics C 2024年第5期48卷 272-283页

作者： b.Hamil b.C.Lütfüoğlu Laboratoire de Physique Mathématique et Subatomique Facultédes Sciences ExactesUniversitéConstantine 1ConstantineAlgeria Department of Physics University of Hradec KrálovéRokitanského 6250003 Hradec KrálovéCzechia

Gravity models given by higher-order scalar curvature corrections are believed to bear important consequences. Einstein-bel-Robinson (EbR) gravity with quartic curvature modification motivated Sajadi et al. to explore static spherically symmetric black hole solutions using perturbative methods. In this study, inspired by their work, we investigate AdS black hole shadows in EbR gravity and demonstrate how the gravity parameter alters the energy emission rate. Finally, we address the same problem in the presence of plasma, because the black holes are thought to be surrounded by a medium that changes the geodesic of photons.

关键词： black hole shadows Einstein-bel-Robinson gravity plasma

Water Vapor Information from Satellite and Its Applications

在线全文

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2024年第1期41卷 188-189页

作者： b.J.SOHN School of Earth and Environmental Sciences Seoul National UniversitySeoul 08826Korea

Water vapor is a critical component of the hydrological cycle because it plays a vital role in transporting water from one part of the cycle to *** vapor evaporated from surfaces such as oceans,lakes,and rivers conden... 详细信息

关键词： motion oceans lakes