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再生工程(英文) 2023年第3期4卷 257-264页

作者： joseph Khoury Ti Zhang David b.Earle M.Laird Forrest Exogenesis Corporation BillericaMA 01821USA Department of Pharmaceutical Chemistry School of PharmacyThe University of KansasLawrenceKS 66047USA Surgical Services Tufts UniversityLowell General HospitalLowellMA 01854USA

Infections at the placement site of biomaterial-based devices and subsequent scar formation results in morbidity,which may require revision *** intended for permanent implantation in the body need to be biologically inert to avoid excessive foreign body response and to reduce bacterial *** this study,we show that polymeric materials commonly used in medical devices,including polyetheretherketone(PEEK)and polypropylene,treated by gas cluster ion beam(GCIb)or by accelerated neutral atom beam(ANAb)result in a nanoscale-modified surface topography that changes the ability of extracellular proteins to *** leads to decreased bacterial attachment and an attenuated inflammatory response using both in vitro and in vivo *** adsorption of extracellular proteins to the polymeric surface improved the competitive attachment of osteoblasts over bacteria,without resorting to growth factor of antibiotic use.

关键词： biofilm formation Surgical mesh biomaterial surface biomedical device Inflammation

Treatment of Nonalcoholic Fatty Liver Disease: The Role of Medical, Surgical, and Endoscopic Weight Loss

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Journal of Clinical and Translational Hepatology 2015年第3期3卷 230-238页

作者： Violeta b.Popov joseph K.Lim Division of Gastroenterology New York University School of Medicine New York NY USA Yale Liver Center Section of Digestive Diseases Yale University School of Medicine New Haven CT USA

Nonalcoholic fatty liver disease (NAFLD) represents a rapidly growing cause of chronic liver disease in the United States and is associated with significant morbidity and mortality,including progression to liver cirrhosis and hepatocellular *** comprises a spectrum of liver conditions,ranging from simple steatosis to steatosis with inflammation (steatohepatitis) and progressive *** loss represents a first line therapeutic modality for the management of ***,we review the evidence base for medical,surgical,and endoscopic approaches to weight loss and their potential impact on the natural history of NAFLD.

关键词： Fatty liver Nonalcoholic steatohepatitis Weight loss Exercise Pharmacotherapy Endoscopic therapy bariatric surgery

Toll-like receptor signaling in hematopoietic homeostasis and the pathogenesis of hematologic diseases

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Frontiers of Medicine 2015年第3期9卷 288-303页

作者： joseph Cannova biochemistry and Molecular biology Program Loyola University Chicago Maywood IL 60153 USA Stritch School of Medicine Loyo& University Chicago Maywood IL 60153 USA Oncology Institute Loyola University Chicago Maywood IL 60153 USA Department of Pathology Loyola University Chicago Maywood IL 60153 USA Department of biology Loyola University Chicago Chicago IL 60660 USA Department of Molecular and Cellular Physiology Loyola University Chicago Maywood IL 60153 USA

Toll-like receptors （TLRs）, which are found in innate immune cells, are essential mediators of rapid inflammatory responses and appropriate T-cell activation in response to infection and tissue damage. Accumulating evidence suggests that TLR signaling is involved in normal hematopoiesis and specific hematologic pathologies. Particular TLRs and their downstream signaling mediators are expressed not only in terminally differentiated innate immune cells but also in early hematopoietic progenitors. Sterile activation of TLR signaling is required to generate early embryonic hematopoietic progenitor cells. In adult animals, TLR signaling directly or indirectly promotes differentiation of myeloid cells at the expense of that of lymphoid cells and the self renewal of hematopoietic stem cells during infection and tissue damage. Activating mutations of the MyD88 gene, which codes for a key adaptor involved in TLR signaling, are commonly detected in b-cell lymphomas and other b-cell hematopathologies. Dysregulated TLR signaling contributes to the pathogenesis of many hematopoietic disorders, including bone marrow failure, myelodysplastic syndrome, and acute myeloid leukemia. Complete elucidation of the molecular mechanisms by which TLR signaling mediates the regulation of both normal and pathogenic hematopoiesis will prove valuable to the development of targeted therapies and strategies for improved treatment of hematopoietic disorders.

关键词： TLR MyD88 hematopoiesis bone marrow failure leukemia myelodysplastic syndrome

Modeling some long-term implications of CO_2 fertilization for global forests and forest industries

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Forest Ecosystems 2016年第1期3卷 13-25页

作者： joseph buongiorno Department of Forest and Wildlife Ecology University of Wisconsin-Madison

background： This paper explored the long-term, ceteris-paribus effects of potential CO2 fertilization on the global forest sector. based on the findings of Norby et al. （PNAS 2005, 102（50）） about forest response to elevated [CO2]. Methods： Forest productivity was increased in the Global Forest Products Model （GFPM） in proportion to the rising [CO2] projected in the IPCC scenario A1b, A2, and 132. Projections of the forest area and forest stock and of the production, consumption, prices, and trade of products ranging from fuelwood to paper and paperboard were obtained with the GFPM for each scenario, with and without CO2 fertilization beginning in 2011 and up to 2065. Results： CO2 fertilization increased wood supply, leading to lower wood prices which in turn induced modest lower prices of end products and higher global consumption. However, production and value added in industries decreased in some regions due to the relative competitive advantages and to the varying regional effects of CO2 fertilization. Conclusion： The main effect of CO2 fertilization was to raise the level of the world forest stock in 2065 by 9 to 10 % for scenarios A2 and b2 and by 20 % for scenario A1b. The rise in forest stock induced by fertilization was in part counteracted by its stimulation of the wood supply which resulted in lower wood prices and increased harvests.

关键词： CO2 fertilization Climate change Prices Supply Demand International trade

Hypoestoxide inhibits tumor growth in the mouse CT26 colon tumor model

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World Journal of Gastroenterology 2007年第34期13卷 4586-4588页

作者： Emmanuel A Ojo-Amaize Howard b Cottam Olusola A Oyemade joseph I Okogun Emeka J Nchekwube Immune Modulation Inc. 2273B South Cactus Avenue Bloomington California 92316 United States

AIM: To evaluate the effect of the natural diterpenoid, hypoestoxide (HE) on the growth of established colon cancer in mice. METHODS: The *** mouse colon carcinoma cell line was grown and expanded in vitro. Following the expansion, bALb/c mice were inoculated s.c. with viable tumor cells. After the tumors had established and developed to about 80-90 mm3, the mice were started on chemotherapy by oral administration of HE, 5-fluorouracil (5-FU) or combination. RESULTS: The antiangiogenic HE has previously been shown to inhibit the growth of melanoma in the b16F1 tumor model in C57bL/6 mice. Our results demonstrate that mean volume of tumors in mice treated with oral HE as a single agent or in combination with 5-FU, were significantly smaller (> 60%) than those in vehicle control mice (471.2 mm3 vs 1542.8 mm3, P burden resulted in pronounced mean survival times (MST) and increased life spans (ILS) in the treated mice. CONCLUSION: These results indicate that HE is an effective chemotherapeutic agent for colorectal cancer in mice and that HE may be used alone or in combination with 5-FU.

关键词： Hypoestoxide 5-Fluorouracil Colon, Cancer Mice

Audits of Death in HIV-Infected Children and Adolescents Followed up in the Pediatric Department of the Regional Teaching Hospital of borgou/Alibori from 2005 to 2020

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Open Journal of Pediatrics 2024年第2期14卷 285-296页

作者： Alphonse Noudamadjo Mohamed Falilatou Agbeille Dénagan Kévin Amoussou Médétinmè Gérard Kpanidja Lahanatou Séidou Chantal Chabi Réckya Kilaya Julien Didier Adédémy Agossou joseph Mother and Child Department Faculty of Medicine University of Parakou Parakou Benin Pediatric Department Regional Teaching Hospital of Borgou/Alibori Parakou Benin

Introduction: Human immunodeficiency virus (HIV) is a major public health problem with high morbidity and mortality among children. The objective of this work was to audit the deaths of children and adolescents with HIV infection followed up in the pediatric department of the Regional Teaching Hospital of borgou/Alibori (CHUDb/A) the from 2005 to 2020. Patients and Method: This was a retrospective and descriptive study conducted in the pediatric department of CHUD/b-A in Parakou. All children with HIV infection who died from January 1, 2005 to August 31, 2020 were included. Data collection was carried out in three stages: a phase of medical records processing, a phase of community survey and a phase of death audits. The variables studied were sociodemographic, clinical, biological, therapeutic and evolutionary. Results: Over the study period, the data of 464 infected children were recorded, including 92 deaths, representing a case fatality rate of 19.83%. Severe acute malnutrition (69.23%), gastro-intestinal tract infections (43.58%) and serious opportunistic pulmonary infections (24.36% pulmonary tuberculosis and 19.23% pneumocystis) were the main causes of death. The main dysfunctions found were: the delayed diagnosis of HIV infection (79.35%), the absence or delay in consultation when the child’s clinical condition deteriorates (32.61% and 47.83%), delayed initiation of antiretroviral treatment (42.39%) and non-adherence to treatment (38.04%). Non-adherence to treatment was predominant in adolescents (90.49%). Conclusion: Specific interventions for early detection, adequate nutritional care, psychosocial support for adolescents and mothers of children are necessary to reduce mortality due to HIV among children and adolescents.

关键词： HIV Death Children Adolescents Dysfunctions benin

Nonlinearly Coupled KdV Equations Describing the Interaction of Equatorial and Midlatitude Rossby Waves

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Chinese Annals of Mathematics,Series b 2009年第5期30卷 483-504页

作者： joseph A. bIELLO Department of Mathematics University of California at Davis

Amplitude equations governing the nonlinear resonant interaction of equatorial baroclinic and barotropic Rossby waves were derived by Majda and biello and used as a model for long range interactions （teleconnections） between the tropical and midlatitude troposphere. An overview of that derivation is nonlinear wave theory, but not in atmospheric presented and geared to readers versed in sciences. In the course of the derivation, two other sets of asymptotic equations are presented： the long equatorial wave equations and the weakly nonlinear, long equatorial wave equations. A linear transformation recasts the amplitude equations as nonlinear and linearly coupled KdV equations governing the amplitude of two types of modes, each of which consists of a coupled tropical/midlatitude flow. In the limit of Rossby waves with equal dispersion, the transformed amplitude equations become two KdV equations coupled only through nonlinear fluxes. Four numerical integrations are presented which show （i） the interaction of two solitons, one from either mode, （ii） and （iii） the interaction of a soliton in the presence of different mean wind shears, and （iv） the interaction of two solitons mediated by the presence of a mean wind shear.

关键词： Coupled KdV equations Equatorial Rossby waves Solitary waves Atmospheric teleconnections

Comparative phylogeography and niche modeling for three species complexes of SE China （Paradoxornis spp., Pycnonotus spp., Spizixos spp.）

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Current Zoology 2015年第5期61卷 943-950,I0001-I0004页

作者： Luke b. KLICKA Luke C. CAMPILLO joseph D. MANTHEY Yanhua QU biodiveristy Institute Ecology and Evolutionary Biology University of Kansas Lawrence KS 66049 USA Key Laboratory of Zoological Systematics and Evolution Institute of Zoology Chinese Academy of Sciences Beijing 100101 China

Contrasting multiple organisms with similar contemporary distributions, researchers can identify shared evolutionary patterns and provide historical context for community composition. We used three species complexes with overlapping distributions in Southeastern China and surrounding islands to explore the phylogeographic history of the region. Despite similar geographic distributions, genetic data revealed few congruent patterns, but all complexes displayed genetic divergence for Taiwan Residents populations. Additionally, niche modeling and divergence dating did not find support for diversification associated with the Last Glacial Maximum [Current Zoology 61 （5）： 943-950,2015].

关键词： Phylogeography Niche modeling Paradoxornis Pycnonotus Spizixos

An efficient approach for solving mixed-integer programming problems under the monotonic condition

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Journal of Control and Decision 2016年第1期3卷 44-67页

作者： Mikhail A.bragin Peter b.Luh joseph H.Yan Gary A.Stern Department of Electrical and Computer Engineering University of ConnecticutStorrsCTUSA Southern California Edison RosemeadCAUSA

Many important integer and mixed-integer programming problems are difficult to solve.A representative example is unit commitment with combined cycle units and transmission capacity *** transitions within combined cycle units are difficult to follow,and system-wide coupling transmission capacity constraints are difficult to *** example is the quadratic assignment *** presence of cross-products in the objective function leads to *** this study,building upon the novel integration of surrogate Lagrangian relaxation and branch-and-cut,such problems will be solved by relaxing selected coupling *** of the relaxed problem will be assumed and exploited and nonlinear terms will be dynamically *** linearity of the resulting problem will be exploited using *** achieve fast convergence,guidelines for selecting stepsizing parameters will be *** method opens up directions for solving nonlinear mixed-integer problems,and numerical results indicate that the new method is efficient.

关键词： integer monotonic programming mixed-integer monotonic programming branch-and-cut surrogate Lagrangian relaxation

Detailed characterization of kHz-rate laser-driven fusion at a thin liquid sheet with a neutron detection suite

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High Power Laser Science and Engineering 2024年第1期12卷 13-23页

作者： benjamin M.Knight Connor M.Gautam Colton R.Stoner bryan V.Egner joseph R.Smith Chris M.Orban Juan J.Manfredi Kyle D.Frische Michael L.Dexter Enam A.Chowdhury Anil K.Patnaik Department of Engineering Physics Air Force Institute of TechnologyWPAFBOHUSA Physics Department Marietta CollegeMariettaOHUSA Department of Physics The Ohio State UniversityColumbusOHUSA Department of Materials Science and Engineering and Department of Electrical and Computer ScienceThe Ohio State UniversityColumbusOHUSA Intense Energy Solutions LLCPlain CityOHUSA

We present detailed characterization of laser-driven fusion and neutron production(-10^(5)/second) using 8 mJ, 40 fs laser pulses on a thin(<1 μm) D_2O liquid sheet employing a measurement suite. At relativistic inte... 详细信息

We present detailed characterization of laser-driven fusion and neutron production(-10^(5)/second) using 8 mJ, 40 fs laser pulses on a thin(by a measurement suite with three independent detection systems: an EJ-309 organic scintillator with pulse-shape discrimination, a ~3He proportional counter and a set of 36 bubble detectors. Time-of-flight analysis of the scintillator data shows the energy of the produced neutrons to be consistent with 2.45 MeV. Particle-in-cell simulations using the WarpX code support significant neutron production from D-D fusion events in the laser±target interaction region. This high-repetition-rate laser-driven neutron source could provide a low-cost, on-demand test bed for radiation hardening and imaging applications.

关键词： high-repetition-rate laser-driven fusion laser-plasma interaction liquid target neutron detectors