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In Vivo Subacute Liver Toxicity of “Attoté”: A Herbal Drink

American Journal of Molecular Biology 2025年第1期15卷 39-52页

作者： Kouakou Serge Kouassi Irié Lou Bohila Emilie Kamo Aka Edwige Ayebe Gouely Fidèle Blimne Ouagnonan Ismael Soro Allico joseph Djaman Biology and Health Laboratory Flix Houphout-Boigny University Abidjan Cte dIvoire Department of Microbiology The Institut Pasteur de Cte dIvoire Abidjan Cte dIvoire Department of Fundamental Clinical and Biochemistry The Institut Pasteur de Cte dIvoire Abidjan Cte dIvoire

The herbal drink “Attoté” has been widely used in the Abidjan district to treat a number of illnesses, notably erectile dysfunction. Despite the popularity of its therapeutic effects, very few studies have been carried out on its effects on the health of users. The aim of this study was to identify the constituents contained in the phytomedicinal product and to assess their potential adverse effects in vivo. Phytochemical screening was conducted to identify the bioactive molecules in “Attoté” and to evaluate its hepatic effects in vivo. Forty (40) Wistar rats, randomly divided into 4 groups, with 10 animals per group (5 males and 5 females) were used to study potential hepatotoxic effects. Group 1 animals (control group) received distilled water. Batches I, II and III received by gavage a volume of Attoté extract corresponding to 1 ml/100 g body weight at 200 mg/kg, 400 mg/kg and 800 mg/kg, respectively. Attoté extract was administered daily at the same time for 28 days, and serum was collected every two weeks to assess hepatic biochemical markers by spectrophotometry using a Cobas C311® HITACHI biochemistry system. After one month of study, the rats were euthanized by ether overdose and the livers were harvested for morphological and histopathological analysis. Phytochemical screening revealed the presence of alkaloids, polyphenols, leucoanthocyanes, anthraquinones and quinones. Hepatic biochemical and hematological parameters such as red globular, hemoglobin, alanine aminotransferase (ALAT), aspartate aminotransferase (ASAT), alkaline phosphatase (ALPs) and gamma glutamyl transferase (GGT) showed no significant change (p > 0.05) in the treated rat group compared with controls. However, these variations were moderate and transient, with values remaining almost within their standard limits. Microscopic observations of liver tissue sections from treated rats showed no liver damage or dysfunction. This study merits further investigation, with a view to gaining a bette

关键词： Herbal Drink Attoté Toxicity in Vivo Hepatic Biomarkers Abidjan

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Rhizosphere Soil Microbial Characteristics and Enzyme Activities under Cajanus cajan and Milletia laurentii Grown in Scientific Center of Brazzaville, Republic of the Congo

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Open Journal of Applied Sciences 2025年第1期15卷 220-238页

作者： Irene Marie Cécile Mboukou-Kimbatsa Angélique Esperance Lembella Boumba Alvychelle Benith Banga Augustin Aimé Lebonguy joseph Goma-Tchimbakala Ecole Nationale Suprieure dAgronomie et de Foresterie Universit Marien NGOUABI Brazzaville Rpublique du Congo Institut Nationale de Recherche en Sciences Exactes et Naturelles Brazzaville Rpublique du Congo Facult des Sciences et Techniques Universit Marien NGOUABI Brazzaville Rpublique du Congo

This study was conducted at the scientific center of Brazzaville. The objective was to assess the microbial characteristics and enzymes activities in the rhizosphere soil of Cajanus cajan and Milletia lauurentii. These plants have great importance in food and forestry. Microbial diversity management in the rhizosphere is the key for sustainable crop production or forest durability. DNA metagenomic sequencing was used to analyze the whole bacterial diversity, the microbial biomass was determinate by the fumigation-extraction method and the enzymes by the p-nitrophenol-β-D-glucoside for β-glucosidase, the p-nitrophenyl-N-acetyl-β-D-glucosaminide for β-Glucosaminidase. Dehydrogenase and acid phosphatase were quantified using 2,3,5-tryphenyl tetrazolium chloride and p-nitophenylphosphate respectively. The results show that, in Cajanus cajan culturable bacteria genera were mainly Acidobacterium, Skermanella, Rhodoplanes, Bacillus, Chloroflexus, Steroidobacter, Sphingomonas and Bradyrhizobium while in Milletia laurentii: Rhodoplanes, Bradyrhizobium, Bacillus, Sphingobacterium, Acidobacterium, Mesorhizobium, Nitrospira were the principal genera. In the two rhizosphere soils investigated, the uncultured bacteria exhibited relatively higher abundance, often for the same genera, than culturable bacteria. Metagenomic studies have revealed more bacterial diversity in each compared to when culturable bacteria were taken into account alone. The MBC and MBN were higher in the rhizosphere of Milletia than in rhizosphere of Cajanus. The same trend was observed with the enzyme activities. PCA of culturable and NMDS of unculturable soil bacteria genera shows that factors mainly involved in the carbon cycle such as MBC, members of the microbial community i.e. Acidobacterium, Skermanella, Chloroflexus, sand, C, β-glucosaminidase and dehydrogenase, were strongly correlated with Cajanus cajan. On the other hand, the MBN, Mesorhizobium, Bradyrhizobium, Burkholderia, Nitrospira, Nitratiredu

关键词： Metagenomic Microbial Diversity Uncultured Bacteria Microbial Biomass Enzyme

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联邦快递开启新篇章

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商业周刊(中文版) 2025年第3期 60-67页

作者： Devin Leonard Kiel Porter joseph Ross(图) 许诺(翻译) 不详

2024年2月,福克斯新闻网(Fox News)“特别报道”栏目一向言辞尖刻的主持人布雷特·拜尔(Bret Baier)在节目开场先播报了几条美国总统乔·拜登的短消息,说他向公众保证工资会上涨、通胀会下降。拜尔随后介绍的一位嘉宾却表示,实际上美国... 详细信息

2024年2月,福克斯新闻网(Fox News)“特别报道”栏目一向言辞尖刻的主持人布雷特·拜尔(Bret Baier)在节目开场先播报了几条美国总统乔·拜登的短消息,说他向公众保证工资会上涨、通胀会下降。拜尔随后介绍的一位嘉宾却表示,实际上美国经济形势并不乐观。“在过去几年里,我们其实一直是寅吃卯粮在花我们子孙的钱,并且入不敷出,”联邦快递公司(FedEx)创始人弗雷德里克·史密斯(Frederick Smith)用他那慢悠悠但直截了当的南方腔调说。

关键词：联邦快递公司新闻网弗雷德里克短消息拜尔特别报道通胀史密斯

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Cytotoxicity and Hepatic Effects in Vivo of the Phytomedicinal Antipalu Used by the Population of Abidjan

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American Journal of Molecular Biology 2025年第1期15卷 25-38页

作者： Kouakou Serge Kouassi Aka Edwige Ayebe Irié Lou Bohila Emilie Kamo Djenabou Kamagate Ouagnonan Ismael Soro Gnogbo Alexis Bahi Allico joseph Djaman Biology and Health Laboratory Universit Flix Houphout-Boigny Abidjan Cte dIvoire Department of Clinical and Fundamental Biochemistry The Institut Pasteur de Cte dIvoire Abidjan Cte dIvoire Department of Microbiology The Institut Pasteur de Cte dIvoire Abidjan Cte dIvoire

Antipalu is a phytomedicinal medicinal beverage that is popular in the District of Abidjan, particularly for the treatment of malaria. However, Antipalu could present potential health effects on patients, and few toxicological studies have been conducted before its use. In order to determine the cytotoxicity of Antipalu, two complementary tests, LDH activity and the MTT cell proliferation assay, were used using Vero cells. Vero cells were exposed to increasing concentrations of Antipalu and incubated for 24, 48 and 72 hours. In addition, forty (40) rats distributed randomly into 4 groups, including 10 animals per group (5 males and 5 females) were used for the potential hepatoxic effects. Animals in group 1 received distilled water and were used as a control group. On the other hand, Lot I, II and III received by gavage a volume of the Antipalu extract corresponding to 1 ml/100 g of body weight at 200 mg/kg, 400 mg/kg, 800 mg/kg, respectively. The extract was administered daily at the same time for 28 days and serum was collected once a week to evaluate hepatic biochemical markers. After 28 days of study, all rats were euthanized by an overdose of ether and the liver of the rats was removed for gross morphological and histopathological analysis. The results of the cell supernatant assay showed an increasing extracellular LDH enzyme activity with lethal concentrations at 10% and 50% (LC10 = 111 µg/mL and LC50 = 555 µg/mL, respectively). In addition, the MTT assay showed a decrease in mitochondrial activity and thus cell proliferation after 24, 48 and 72 H of incubation. Our study showed that Antipalu caused alterations in the plasma membranes of the cells, resulting in the release of lactase dehydrogenase (LDH) into the external environment and a decrease in the mitochondrial activity of the Vero cells. The biochemical parameters ALT, ASAT, ALPs, and GGT showed no significant change (P > 0.05) in the group of treated rats compared to the controls. However, these vari

关键词： Phytomedicinal Antipalu Cytotoxicity Vero Cells Hepatic Biomarkers

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Empirical Study on Factors Influencing Residents’ Behavior of Separating Household Wastes at Source

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Chinese Journal of Population,Resources and Environment 2007年第2期5卷 20-27页

作者： murray Haight School of Planning Environmental Studies University of Waterloo Waterloo Canada

Source separation is the basic premise for making effective use of household wastes. In eight cities of China, how- ever, several pilot projects of source separation finally failed because of the poor participation rate of residents. In order to solve this problem, identifying those factors that influence residents’ behavior of source separation becomes crucial. By means of questionnaire survey, we conducted descriptive analysis and ex- ploratory factor analysis. The results show that trouble-feeling, moral notion, environment protection, public education, environment value and knowledge deficiency are the main factors that play an important role for residents in deciding to separate their household wastes. Also, according to the contribution percentage of the six main factors to the total behavior of source separation, their influencing power is analyzed, which will provide suggestions on household waste management for policy makers and decision makers in China.

关键词： source separation influencing factors behavior household waste management

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Ship behavior prediction via trajectory extraction-based clustering for maritime situation awareness

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Journal of Ocean Engineering and Science 2022年第1期7卷 1-13页

作者： Brian murray LokukalugePrasad Perera UiT The Arctic University of Norway TromsøNorway

This study presents a method in which historical AIS data are used to predict the future trajectory of a se-lected *** is facilitated via a system intelligence-based approach that can be subsequently utilized to provide enhanced situation awareness to navigators and future autonomous ships,aiding proactive col-lision *** evaluating the historical ship behavior in a given geographical region,the method applies machine learning techniques to extrapolate commonalities in relevant trajectory *** commonalities represent historical behavior modes that correspond to the possible future behavior of the selected ***,the selected vessel is classified to a behavior mode,and a trajectory with respect to this mode is *** is achieved via an initial clustering technique and subsequent tra-jectory *** extracted trajectories are then compressed using the Karhunen-Loéve transform,and clustered using a Gaussian Mixture *** approach in this study differs from others in that tra-jectories are not clustered for an entire region,but rather for relevant trajectory *** such,the extracted trajectories provide a much better basis for clustering relevant historical ship behavior modes.A selected vessel is then classified to one of these modes using its observed *** predic-tions are facilitated using an enhanced subset of data that likely correspond to the future behavior of the selected *** method yields promising results,with high classification accuracy and low prediction ***,vessels with abnormal behavior degrade the results in some situations,and have also been discussed in this study.

关键词： Maritime situation awareness Ship navigation Trajectory prediction Collision avoidance Machine learning Unsupervised learning AIS

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Real-time ore sorting using color and texture analysis

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International Journal of Mining Science and Technology 2023年第6期33卷 659-674页

作者： David G.Shatwell Victor murray Augusto Barton Hochschild Mining PLC La Colonia 180Lima 15023Peru Department of Electrical Engineering Universidad de Ingenieria y Tecnologia-UTECLima 15063Peru John A.Paulson School of Engineering and Applied Sciences Harvard UniversityCambridge 02134USA Department of Electrical and Computer Engineering University of New MexicoAlbuquerque 87131USA

Sensor-based ore sorting is a technology used to classify high-grade mineralized rocks from low-grade waste rocks to reduce operation *** ore-sorting algorithms using color images have been proposed in the past,but only some validate their results using mineral grades or optimize the algorithms to classify rocks in *** paper presents an ore-sorting algorithm based on image processing and machine learning that is able to classify rocks from a gold and silver mine based on their *** algorithm is composed of four main stages:(1)image segmentation and partition,(2)color and texture feature extraction,(3)sub-image classification using neural networks,and(4)a voting system to determine the overall class of the *** algorithm was trained using images of rocks that a geologist manually classified according to their mineral content and then was validated using a different set of rocks analyzed in a laboratory to determine their gold and silver *** proposed method achieved a Matthews correlation coefficient of 0.961 points,higher than other classification algorithms based on support vector machines and convolutional neural networks,and a processing time under 44 ms,promising for real-time ore sorting applications.

关键词： Ore sorting Image color analysis Image texture analysis Machine learning

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Lie Invariants in Two and Three Variables

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Algebra Colloquium 2014年第1期21卷 95-116页

作者： murray R. Bremner Jiaxiong Hu Department of Mathematics and Statistics University of Saskatchewan Saskatoon Canada Department of Mathematics Simon Fraser University Burnaby British Columbia Canada.

We use computer algebra to determine the Lie invariants of degree ≤ 12 in the free Lie algebra on two generators corresponding to the natural representation of the simple 3-dimensional Lie algebra sl2（C）. We then consider the free Lie algebra on three generators, and compute the Lie invariants of degree ≤ 7 corresponding to the adjoint representation of sl2（C）, and the Lie invariants of degree ≤ 9 corresponding to the natural representation of sl3（C）. We represent the action of sl2（C） and sl3（C） on Lie polynomials by computing the coefficient matrix with respect to the basis of Hall words.

关键词： free Lie algebras invariant Lie polynomials representation theory Hermitenormal form LLL algorithm

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Personality and behavioral changes in Asian elephants(Elephas maximus)following the death of herd members

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Integrative Zoology 2021年第2期16卷 170-188页

作者： Lucy RUTHERFORD Lindsay E.murray School of Psychology University of ChesterChesterUK

Elephants are highly social beings with complex individual *** know that elephants have a general interest in death,investigating carcasses,not just limited to kin;however,research does not explore in depth whether individuals change their behavior or personality following traumatic events,such as the death of a *** a captive herd of Asian elephants(Elephas maximus)housed at Chester Zoo,UK,we measured social behavior and proximity and personality using the Ten-Item Personality Inventory,and found age-related and relationship-related changes in both behavior and personality following the deaths of herd ***,the herd spent less time socializing and engaging in affiliative behaviors following the death of the adult female when compared to baseline data,yet spent more time engaging in these behaviors after the death of two *** death of the central female had a dramatic impact on her infant calf,resulting in increasingly withdrawn behavior,yet had the opposite effect on her adult daughter,who subsequently established a more integrated role within the *** Stability fell in the motherless calf but rose in an adult female,who had lost her adult daughter,but had a new calf to care *** suggest that the greater impact on the behavior and personality of surviving herd members following the deaths of calves,compared to an adult member,attests to the significance of the unifying role played by calves within an elephant herd.

关键词： captive environment death elephant grief proximity

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The Outcomes of Pregnancy in Patients with Cirrhosis in a Low-Income Country

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Open Journal of Gastroenterology 2025年第1期15卷 21-33页

作者： Kounpièlimè Sosthène Somda Ousséni Sinon Lawagoulé joseph Emile Ky Toussaint Vebamba Aboubacar Coulibaly Christiane Bere Abel Sawadogo Arsène Roger Sombie Department of Hepato-Gastroenterology Yalgado Ouedraogo University Hospital Ouagadougou Burkina Faso Department of Medicine Joseph KI ZERBO University Ouagadougou Burkina Faso

Pregnancy in cirrhotic-woman is a rare event [1] [2]. It causes particular risks related to liver disease and its treatments, with maternal and fetal consequences. The largest reported series to date is by Welton’s with 13 cases [3]. In Africa, few cases were reported. The purpose of this work was to report the hepatic and obstetric complications in pregnant women in Burkina Faso, a low-income country. It was a descriptive cross-sectional study with retrospective data collection covering the period from January 1, 2013 to December 31, 2023. All the women diagnosed with cirrhosis through clinical basis, biological and imaging arguments associated with a pregnancy confirmed by ultrasound were included. A total of ten women were included in the study. Among them, two were known cirrhotics and were being followed. In the other eight cases, cirrhosis was discovered during pregnancy. Eight women were HBsAg positive and two of them had only the contact marker of hepatitis B virus (anti- HBc antibody). The evolution was, ascitic decompensation in nine cases, digestive hemorrhage due to rupture of esophageal varices in two cases, nine cases of anemia, two cases of ascitic fluid infection and one case of conjunctival jaundice. Two cases of probable hepatocellular carcinoma were noted with one case of extensive portal thrombosis. The evolution was without maternal complications in one case. Regarding fetal and neonatal complications, there were three cases of hypotrophy, one case of prematurity, one case of acute neonatal distress, two cases of fetal death in utero and one case of fetal tachycardia. Four pregnancies had a favorable evolution without any complications. The association of cirrhosis and pregnancy is an uncommon event, and maternal and fetal complications can occur, making this pregnancy a high-risk pregnancy.

关键词： Cirrhosis Pregnancy Complications Burkina Faso

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