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Obesity is associated with decreased risk of microscopic colitis in women

World Journal of Gastroenterology 2022年第2期28卷 230-241页

作者： Robert S Sandler Temitope O Keku John T Woosley Dale P Sandler joseph a galanko Anne F Peery Department of Medicine University of North CarolinaChapel HillNC 27514-7555United States Department of Medicine University of North CarolinaChapel HillNC 27514-7555United States Department of PathologyUniversity of North CarolinaChapel HillNC 27514United States Department of Health and Human Services National Institute of Environmental Health SciencesDurhamNC 27709United States

BACKGROUND Microscopic colitis is a leading cause of diarrhea in the older *** is limited information about risk *** hypothesized that obesity would be associated with microscopic *** To examine the association between obesity and microscopic colitis in men and women undergoing *** We conducted a case-control study at the University of North Carolina *** identified and enrolled men and women referred for elective,outpatient colonoscopy for chronic *** excluded patients with a past diagnosis of Crohn’s disease or ulcerative colitis.A research pathologist reviewed biopsies on every patient and classified them as microscopic colitis cases or non-microscopic colitis *** provided information on body weight,height and exposure to medications via structured interviews or Internet based *** analysis included 110 patients with microscopic colitis(cases)and 252 nonmicroscopic colitis *** analyses were performed using logistic regression to estimate odds ratios and 95%confidence *** Cases were older and more likely than controls to be white *** subjects were well educated,but cases were better educated than *** with microscopic colitis had lower body mass index than controls and reported more weight loss after the onset of *** to patients who were normal or under-weight,obese(BMI>30 kg/m2)patients were substantially less likely to have microscopic colitis after adjusting for age and education,adjusted OR(aOR)0.35,95%confidence interval(CI)0.18-0.66).When stratified by sex,the association was limited to obese women,aOR 0.21,95%CI:*** with microscopic colitis were more likely to report weight loss after the onset of *** stratifying by weight loss,there remained a strong inverse association between obesity and microscopic colitis,aOR 0.33,95%CI:0.10-1.11 among the patients who did not lose *** use of birth

关键词： Colitis Microscopic/epidemiology Humans Diarrhea/epidemiology Obesity

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