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HOP co-chaperones contribute to GA signaling by promoting the accumulation of the F-box protein SNE in Arabidopsis

Plant Communications 2023年第3期4卷 244-257页

作者： Silvina mangano Alfonso Muñoz Lourdes Fernández-Calvino M.Mar Castellano Centro de Biotecnología y Genómica de Plantas Universidad Politécnica de Madrid(UPM)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria(INIA/CSIC)Campus Montegancedo UPM28223 Pozuelo de Alarcón(Madrid)Spain Fundación Instituto Leloir and Instituto de Investigaciones Bioquímicas de Buenos Aires(IIBA CONICET)Av.Patricias Argentinas 435Buenos Aires C1405BWEArgentina Departamento de Botánica Ecologíay Fisiología VegetalCampus de RabanalesEdificio Severo OchoaUniversidad de Córdoba14071 CórdobaSpain

Gibberellins(GAs)play important roles in multiple developmental processes and in plant response to the *** the GA pathway,a central regulatory step relies on GA-dependent degradation of the DELLA transcriptional ***,the relevance of the stability of other key proteins in this pathway,such as SLY1 and SNE(the F-box proteins involved in DELLA degradation),remains ***,we take advantage of mutants in the HSP70-HSP90 organizing protein(HOP)co-chaperones and reveal that these proteins contribute to the accumulation of SNE in ***,HOP proteins,along with HSP90 and HSP70,interact in vivo with SNE,and SNE accumulation is significantly reduced in the hop ***,greater accumulation of the DELLA protein RGA is observed in these *** agreement with these molecular phenotypes,hop mutants show a hypersensitive response to the GA inhibitor paclobutrazol and display a partial response to the ectopic addition of GA when GA-regulated processes are *** mutants also display different phenotypes associated with alterations in the GA pathway,such as reduced germination rate,delayed bolting,and reduced hypocotyl elongation in response to warm ***,ectopic overexpression of SNE reverts the delay in germination and the thermally dependent hypocotyl elongation defect of the hop1 hop2 hop3 mutant,revealing that SNE accumulation is the key aspect of the hop mutant ***,these data reveal a pivotal role for HOP in SNE accumulation and GA signaling.

关键词： HSP70-HSP90 organizing protein seed germination thermomorphogenesis RGA protein folding protein stability

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Age-dependent slowing of enteric axonal transport in insulin-resistant mice

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World j.urnal of Gastroenterology 2013年第4期19卷 482-491页

作者： Kathy j.LePard joseph Cellini Department of Physiology Chicago College of Osteopathic MedicineMidwestern UniversityDowners GroveIL 60515United States

AIM:To investigate retrograde tracer transport by gastric enteric neurons in insulin resistant mice with low or high glycosylated hemoglobin(Hb).METHODS:Under anesthesia,the retrograde tracer fluorogold was superficially inj.cted into the fundus or antrum using a microsyringe in KK Cg-Ay/j.mice prior to onset of type 2 diabetes mellitus(T2DM;4 wk of age),at onset of T2DM(8 wk of age),and after 8,16,or 24 wk of untreated T2DM and in age-matched KK/HIj.*** days later,mice were sacrificed by CO 2 narcosis followed by *** were removed and *** from fundus,corpus and antrum were excised and mounted on a glass ***-labeled neurons were viewed using a microscope and manually *** were expressed as the number of neurons in short and long descending and ascending pathways and in local fundus and antrum pathways,and the number of neurons in all regions labeled after inj.ction of tracer into either the fundus or the ***:By 8 wk of age,body weights of KKAy mice(n=12,34±1 g) were heavier than KK mice(n=17,29±1 g;F(4,120)=4.414,P=0.002] and glycosylated Hb was higher [KK:(n=7),4.97%±0.04%;KKAy:(n=6),6.57%±0.47%;F(1,26)=24.748,P<0.001].The number of tracer labeled enteric neurons was similar in KK and KKAy mice of all ages in the short descending pathway [F(1,57)=2.374,P=0.129],long descending pathway [F(1,57)=0.922,P=0.341],local fundus pathway [F(1,53)=2.464,P=0.122],local antrum pathway [F(1,57)=0.728,P=0.397],and short ascending pathway [F(1,53)=2.940,P=0.092].In the long ascending pathway,fewer tracer-labeled neurons were present in KKAy as compared to KK mice [KK:(n=34),302±17;KKAy:(n=29),230±15;F(1,53)=8.136,P=0.006].The number of tracer-labeled neurons was decreased in all mice by 16 wk as compared to 8 wk of age in the short descending pathway [8 wk:(n=15),305±26;16 wk:(n=13),210±30;F(4,57)=9.336,P<0.001],local antrum pathway [8 wk:(n=15),349±20;16 wk:(n=13),220±33;F(4,57)=8.920,P<0.001],short ascending pathway [

关键词： Autonomic neuropathy Retrograde transport KKAy mice Fluorogold Type 2 diabetes mellitus

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Sodium modification of zirconia catalysts for ethanol coupling to 1-butanol

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j.urnal of Energy Chemistry 2013年第1期22卷 58-64页

作者： joseph T. Kozlowski Robert j. Davis Department of Chemical Engineering University of Virginia

The influences of adding sodium to zirconia on the acid-base properties of the surface and on the catalytic conversion of ethanol and acetone were investigated. The rates of ethanol dehydration, dehydrogenation and coupling were evaluated in a fixed-bed flow reactor operating at temperatures from 613 to 673 K. The rate of acetone condensation was evaluated in the same reactor operating at 473-573 K. Addition of 1.0 wt% Na to ZrO2 decreased the rate of ethanol dehydration by more than an order of magnitude, which was consistent with a neutralization of acid sites evaluated by ammonia adsorption microcalorimetry. Addition of 1.0 wt% Na to ZrO2 also increased the base site density quantified by carbon dioxide adsorption microcalorimetry and the rate of acetone condensation. Although the rate of ethanol coupling was not increased by the addition of Na, the overall selectivity of ethanol to butanol was improved over the 1.0 wt% Na/ZrO2 sample because of the significant inhibition of ethanol dehydration.

关键词： Guerbet reaction alcohol condensation zirconia microcalorimetry acetone condensation

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Superior growth performance in broiler chicks fed chelated compared to inorganic zinc in presence of elevated dietary copper

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j.urnal of Animal Science and Biotechnology 2016年第4期7卷 561-569页

作者： j.nmei Zhao Robert B. Shirley j.lia j. Dibner Karen j. Wedekind Frances Yan Paula Fisher Thomas R. Hampton joseph L. Evans Mercedes Vazquez-Anon research and development novus international20 Research Park DriveSaint CharlesMO 63304USA current affiliation:poultry technical services adisseo usaAlpharettaGA 30022USA

Background： The goal of this study was to compare the antagonism of elevated dietary Cu （250 mg/kg） from CuS04 on three different Zn sources （ZnS04. H20; [Zn bis（-2-hydroxy-4-（methylthio）butanoic acid）], Zn（HMTBa）2 a chelated Zn methionine hydroxy analogue; and Zn-Methionine）, as measured using multiple indices of animal performance in ROSS 308 broilers. Methods： Three experiments were conducted in broiler chicks fed a semi-purified diet. All birds were fed a Zn-deficient diet （8.5 mg/kg diet） for 1 wk, and then provided with the experimental diets for 2 wks. Results： Experiment 1 was a 2 x 2 factorial design with two levels of Cu （8 vs. 250 mg/kg diet from CuSO4） and two Zn sources at 30 mg/kg [ZnSO4. H20 vs. Zn（HMTBa）2]. Elevated Cu impaired growth performance only in birds fed ZnSO4. Compared to ZnSO4. H20, Zn（HMTBa）2 improved feed intake （12 %; P 〈 0.001） and weight gain （12 %, P 〈 0.001） and the benefits were more pronounced in the presence of 250 mg/kg diet Cu. Experiment 2 was a dose titration of ZnSO4- H20 and Zn（HMTBa）2 at 30, 4,5, 60, and 75 mg/kg diet in the presence of 250 mg/kg CuSO4. Feed：gain was decreased and tibia Zn was increased with increasing Zn levels from 30 to 75 mg/kg. Birds fed Zn（HMTBa）2 consumed more food and gained more weight compared to birds fed ZnSO4, especially at lower supplementation levels （30 and 45 mg/kg; interaction P 〈 0,05）. Experiment 3 compared two organic Zn sources （Zn（HMTBa）2 vs. Zn-Methionine） at 30 mg/kg with or without 250 mg/kg CuSO4. No interactions were observed between Zn sources and Cu levels on performance or tissue mineral concentrations. High dietary Cu decreased weight gain （P 〈 0.01）. Tibia Cu and liver Cu were significantly increased with 250 mg/kg dietary Cu supplementation （P 〈 0.01）. No difference was observed between the two Zn sources. Conclusions： Dietary 250 mg/kg Cu significantly impaired feed intake and weight gain in birds fed ZnSO4. H20, but had less impact in birds fed Zn（HMTBa）2. No difference

关键词： Antagonism Broilers Chelates Growth MineraLs Organic Performance

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Dark Matter and Gravitational Waves

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Natural Science 2021年第3期13卷 76-87页

作者： joseph j. Smulsky Institute of Earth’s Cryosphere Tyum. SC of SB RAS Federal Research Center Tyumen Russia

Two reviews of papers are considered. The first paper for a galaxy model uses matter consisting of neutrinos, bosons and other similar particles. It is shown that these particles were introduced as a result of an incorrect description of interactions in the Theory of Relativity. In reality, with the relative motion of interacting particles, their interactions force changes, and not their mass. It is shown that models of such stellar associations as globular clusters and galaxies should be created on the basis of the substance that exists on Earth. The second peer-reviewed paper proposes to create LIGO on the Moon. It is shown that gravitational waves do not exist. They were introduced to explain the excessive rotation of the Mercury’s perihelion. However, the excessive rotation of the Mercury’s perihelion is due to the Sun oblateness. The paper shows that gravitational waves, the Big Bang, the expanding Universe, dark matter, dark energy, etc. appeared on the basis of unfounded hypotheses. The urgent task is to eliminate them from science.

关键词： Dark Matter Gravitational Waves Hypotheses Interaction Charged Particles Newtonian Gravity

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Development of Multilayer Models of Globular Star Clusters and Study of Their Evolution

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j.urnal of Modern Physics 2024年第8期15卷 1246-1299页

作者： joseph j. Smulsky Institute of Earths Cryosphere Tyum. SC of SB RAS Federal Research Center Tyumen Russia

Usually, models of globular star clusters are created by analyzing their luminosity and other observation parameters. The goal of this work is to create stable models of globular clusters based on the laws of mechanics. It is necessary to set the coordinates, velocities and masses of the stars so that as a result of their gravitational interaction the globular cluster is not destroyed. This is not an easy task, and it has been solved in this paper. Using an exact solution of the axisymmetric gravitational interaction of N-bodies, single-layer spherical structures were created. They are combined into multilayer models of globular clusters. An algorithm and a program for their creation is described. As a result of solving the problem of gravitational interaction of N bodies, evolution of 5-, 10-, and 15-layer structures was studied. During the inter-body interaction, there proceeds a transition from the initial specially organized structure to a structure with bodies, uniformly distributed in space. The number of inter-body collisions decreases, and the globular cluster model passes into the stable form of its existence. The collisions of bodies and the acquisition of rotational motion and thermal energy by them are considered. As a result of the passage to scaled dimensions, the results were recalculated to the conditions of globular star clusters. The periods of rotation and the temperatures of merged stars are calculated. Attention is paid to a decreased central-body mass in the analyzed models of globular star clusters.

关键词： N-Body Problem Solution Globular Star Clusters Properties

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New Long-Term Climate Oscillations

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Natural Science 2021年第8期13卷 354-371页

作者： joseph j. Smulsky Institute of Earth’s Cryosphere Tyum. SC of SB RAS Federal Research Center Tyumen Russia

The astronomical theory of climate change is based on the solution of differential equations describing Earth’s orbital and rotational motions. The equations are used to calculate the change in insolation over the Earth’s surface. As a result of the author’s solution of the orbital problem, the periods and amplitudes of Earth-orbit variations and their evolution have been refined. Unlike previous studies, the equations of Earth’s rotational motion are solved completely. The Earth’s rotational axis precesses relative to a direction different from the direction of the orbit’s axial precession, and oscillates with periods of half a month, half a year and 18.6 years. Also, its oscillations occur with irregular periods of several tens of thousands of years and more. All these motions lead to oscillations of the obliquity in the range of 14.7° to 32.1°, which prove to be 7 - 8 times larger than obtained by a previous theory. In the same proportion, the Earth’s insolation oscillations increase in amplitude, with insolation extremes occurring in other epochs than those in the previous theory. The amplitudes and the onset times of the extremes correlate with known paleoclimate changes. Thirteen insolation periods of paleoclimate variation over an interval of 200 thousand years are identified. From the insolation evolution calculated over a time interval of 1 million years, 6 climate gradations from very cold to very warm are identified.

关键词： Earth’s Orbit and Axis Evolution Insolation Climate Change Ice Ages

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A novel traj.ctory-based online controller design approach to fault accommodation in NREL’s 5MW wind turbine systems

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Control Theory and Technology 2014年第2期12卷 122-131页

作者： Tushar j.IN joseph j.YAME Dominique SAUTER Aalto University School of Chemical Technology P. O. Box 16100 F1-00076 Aalto Finland Centre de Recherche en Automatique de Nancy Universite de Lorraine 54506 Vandoeuvre-les-Nancy France

This paper presents a real-time mechanism to tolerate faults occurring in a wind turbine （WT） system. This system is composed of a FAST coded simulator designed by the U.S. National Renewable Energy Laboratory. The demonstrated mechanism lies under the taxonomy of active fault-tolerant control （FTC） systems, namely online redesign based approach. In the proposed approach, we do not use any a priori information about the model of the turbine in real-time. In fact, we use online measurements generated by the WT. Based on the given control specifications, and the observed measurement an occurred fault is accommodated by reconfiguring the online controller such that the WT generates rated power even under faulty conditions. Second, no explicit fault diagnosis （FD） module is used in this approach. As a result, issues of model uncertainty, false alarms, etc. associated with an integrated FD and controller reconfiguration approach to FTC systems are not experienced here.

关键词： Fault-tolerant control Behavioral theory Wind turbines Online controller redesign

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Positron imaging systems for studying particulate, granular and multiphase flows

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Particuology 2012年第2期10卷 146-153页

作者： Thomas W.Leadbeater David j.Parker joseph Gargiuli Positron Imaging Centre University of BirminghamEdgbastonBirmingham B152TTUKa

The University of Birmingham has pioneered and adapted the use of the medical imaging technique known as positron emission tomography （PET） to the study of particulate, granular and multiphase flows in industrial and physical processes, This paper provides a review of the PET and complimentary positron emission particle tracking （PEPT） techniques and details their application to the study of particulate sys- tems, The current state of the art, recent developments and example results from many of the applications to which these techniques have been applied are highlighted.

关键词： Positron emission particle tracking (PEPT)Particle dynamicsMulti-phase flow measurement

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The Influence of the Planets, Sun and Moon on the Evolution of the Earth’s Axis

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International j.urnal of Astronomy and Astrophysics 2011年第3期1卷 117-134页

作者： joseph j. Smulsky 不详

To study climate evolution, we consider the rotational motion of the Earth. The law of angular momentum change is analyzed, based on which the differential equations of rotational motion are derived. Problems with initial conditions are discussed and the algorithm of the numerical solution is presented. The equations are numerically integrated for the action of each planet, the Sun and the Moon on the Earth separately over 10 kyr. Results are analyzed and compared to solutions of other authors and to observation data.

关键词： Angular Momentum Differential Equations Numerical Solution

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