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There’s a World Going on Underground—Infant Mortality and Fracking in Pennsylvania

j.urnal of Environmental Protection 2017年第4期8卷 381-393页

作者： Christopher Busby joseph j. mangano Environmental Research SIA 1117 Latvian Academy of Sciences Riga Latvia Radiation and Public Health Proj.ct New York NY USA

Background: There has been a rapid global development of the horizontal drilling and hydraulic fracturing process termed fracking. This involves the dispersion of “produced water” which contains naturally occurring radioactive material (NORM) which may contaminate surface water and pose a health risk. Obj.ctives: To investigate association between early (0-28 days) infant mortality by county in Pennsylvania and fracking. Methods: We compared early infant mortality for 2007-2010 after fracking developed with a control period 2003-2006, contrasting a group of the 10 most heavily fracked counties with the rest of Pennsylvania. Results: Whilst early infant deaths decreased by 2.4% in the State over the period, in the 82,558 births in the 10 fracked counties there was a significant increase in mortality (238 vs 193;RR = 1.29;95% CI 1.05, 1.55;p = 0.011). For the five north east fracked counties Bradford, Susquehanna, Lycoming, Wyoming and Tioga the combined early infant mortality increased from 34 deaths to 60 (RR 1.66;1.05, 2.51;p = 0.014), whereas in the south western 5 counties Washington, Westmoreland, Fayette, Butler and Greene the increase was modest, 157 to 178 (RR 1.18;0.95, 1.46;p = 0.13). Increased risk was associated with exposure to groundwater, expressed as the county ratio of water wells divided by the number of births. Conclusions: Fracking appears to be associated with early infant mortality in populations living in counties where the process is carried out. There is some evidence that the effect is associated with private water well density and/or environmental law violations.

关键词： Fracking Hydraulic Fracturing Unconventional Gas Infant Mortality Radioactivity Pennsylvania Radium Uranium

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Elevated airborne beta levels in Pacific/West Coast US States and trends in hypothyroidism among newborns after the Fukushima nuclear meltdown

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Open j.urnal of Pediatrics 2013年第1期3卷 1-9页

作者： joseph j. mangano j.nette D. Sherman Radiation and Public Health Proj.ct New York USA

Various reports indicate that the incidence of congenital hypothyroidism is increasing in developed nations, and that improved detection and more inclusive criteria for the disease do not explain this trend entirely. One risk factor documented in numerous studies is exposure to radioactive iodine found in nuclear weapons test fallout and nuclear reactor emissions. Large amounts of fallout disseminated worldwide from the meltdowns in four reactors at the Fukushima-Dai-ichi plant in j.pan beginning March 11, 2011 included radioiodine isotopes. j.st days after the meltdowns, I-131 concentrations in US precipitation was measured up to 211 times above normal. Highest levels of I-131 and airborne gross beta were documented in the five US States on the Pacific Ocean. The number of congenital hypothyroid cases in these five states from March 17-December 31, 2011 was 16% greater than for the same period in 2010, compared to a 3% decline in 36 other US States

关键词： Congenital Hypothyroidism Fukushima-Dai-Ichi Iodine Nuclear

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Compost Input Effect on Dryland Wheat and Forage Yields and Soil Quality

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Pedosphere 2018年第3期28卷 451-462页

作者： Francisco j. CALDERON Merle F. VIGIL joseph BENj.MIN United States Department of Agriculture-Agricultural Research Service (USDA-ARS) Central Great Plains Research Station Akron80720 CO( USA)

Organic agricultural systems rely on organic amendments to achieve crop fertility requirements, and weed control must be achieved without synthetic herbicides. Our obj.ctive was to determine the crop yield and soil quality as affected by a transition from grass to dryland organic agriculture in the Central Great Plains of North America. This study evaluated three beef feedlot compost(BFC)treatments in 2010–2015 following biennial application rates: 0(control), 22.9, and 108.7 t ha^(-1) on two dryland organic cropping systems: a wheat(Triticum aestivum)-fallow(WF) rotation harvested for grain and a triticale(Triticosecale)/pea(Pisum sativum)-fallow(T/P-F) rotation harvested for forage. The triticale + pea biomass responded positively to the 108.7-t ha^(-1) BFC treatment,but not the 22.9-t ha^(-1) BFC treatment. The wheat biomass was not affected by BFC addition, but biomass N content *** feedlot compost input did not increase wheat grain yields, but had a positive effect on wheat grain Zn content. Soil total C and N contents increased with the rate of 108.7 t ha^(-1) BFC after three applications, but not with 22.9 t ha^(-1) BFC. Soil enzyme activities associated with N and C cycling responded positively to the 108.7-t ha^(-1) BFC treatment. Saturated salts were high in the soil receiving 108.7 t ha^(-1) of BFC, but did not affect crop yields. These results showed that BFC was effective in enhancing forage yields, wheat grain quality, and soil C and N, as well as specific microbial enzymes important for nutrient cycling. However, the large rates of BFC necessary to elicit these positive responses did not increase grain yields, and resulted in an excessive buildup of soil P.

关键词： organic agriculture soil C soil enzyme activity soil N pea triticale

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Increases in Mortality for All Causes and All Cancers Combined before and after Startup of a Nuclear Power Plant in New j.rsey, USA

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j.urnal of Environmental Protection 2019年第4期10卷 488-499页

作者： joseph mangano j.nette Sherman Radiation and Public Health Proj.ct New York NY USA

The Salem/Hope Creek nuclear plant in southern New j.rsey is one of j.st four U.S. plants with three large reactors (all others consist of one or two). These reactors started operations in 1976, 1980, and 1986 and routinely released toxic radioactive gases and particles into the environment. Only a single study has been performed by federal officials on cancer near nuclear plants—a study now 30 years old. A review of official mortality data using four-year periods shows the Salem County cancer death rate was consistently j.st below that of other New j.rsey counties up to the mid-1980s. However, from 1983-1986 to 2015-2017, the county rate soared from -5.4% below the rest of the state to +32.6% above. The county/state mortality ratio for all causes also increased rapidly in these periods, from +0.6% above to +28.4% above the state. Salem now has the highest cancer death rate, and the 2nd highest total death rate of any New j.rsey county. Had the 1983-1986 county-state ratios not changed in the following 31 years, 3493 fewer deaths (1018 of them from cancer) would have occurred among Salem County residents. The lack of any apparent etiologies that could have caused such a dramatic and unexpected change, plus the fact that the Salem/Hope Creek reactors are aging, corroding, and more prone to leaking radionuclides, emphasizes the immediate need for more studies of this type, and the inclusion of local health as a crucial factor in public decisions on the plant’s future.

关键词： Radiation Nuclear Power Nuclear Reactors Radioactivity Cancer

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Rising Thyroid Cancer Incidence Proximate to a New York City-Area Nuclear Power Plant

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j.urnal of Environmental Protection 2017年第12期8卷 1446-1459页

作者： joseph mangano j.nette Sherman Radiation and Public Health Proj.ct New York NY USA

Thyroid cancer incidence has risen steadily in the US for several decades. While any cause of this trend has yet to be clearly identified, most analyses have concluded that there are factors other than improved detection accounting for the increase. Since exposure to radioactive iodine is the only acknowledged root cause of thyroid cancer, a review of temporal trends in incidence since the late 1970s near the Indian Point nuclear power plant, j.st 23 miles from the New York City border, was conducted. Rates in the four counties closest to Indian Point, where virtually the entire population resides within 20 miles of the plant, were compared with national trends in the US. The relative ratio in the local area was 0.778 in the period 1976-1981, or 22.2 percent lower than the national rate. This ratio increased steadily, to 1.579 (57.9 percent greater than the US) by the period 2000-2004, which slightly declined to 1.515 (51.5 percent greater) in the latest period available (2010-2014). Significant increases occurred for both males and females, and in each of the four counties. Annual new cases diagnosed among residents of the four counties increased from 51 to 412 between 1976-1981 and 2010-2014. Because the two large reactors at Indian Point began operations in 1973 and 1976, and exposures to radioiodine isotopes can manifest as cancer from five years to several decades after exposure, iodine emissions from Indian Point emissions should be considered as a potential factor in these trends. More studies near Indian Point and other nuclear installations should be conducted to further explore this potential association.

关键词： Thyroid Cancer Radiation Iodine Nuclear Power Nuclear Reactor

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The Salicylic Acid Receptor NPR3 Is a Negative Regulator of the Transcriptional Defense Response during Early Flower Development in Arabidopsis

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Molecular Plant 2013年第3期6卷 802-816页

作者： Zi Shi Siela Maximova Yi Liu joseph Verica Mark j. Guiltinan The Huck Institutes of the Life Sciences Pennsylvania State University University Park PA 16802 USA Department of Plant Science Pennsylvania State University University Park PA 16802 USA

Arabidopsis NON-EXPRESSOR OF PR1 （NPR1） is a transcription co-activator that plays a central role in regulating the transcriptional response to plant pathogens. The NPR family consists of NPR1 and five NPRl-like genes. The NPR1 paralog NPR3 has recently been shown to function as a receptor of the plant hormone salicylic acid and to mediate proteosomal degradation of NPR1. The function of NPR3 protein during early flower development was revealed through a detailed molecular-genetic analysis including promoter transcriptional fusion analysis, phenotype characterization of npr3-3 mutants/overexpressors, and whole-plant fitness analysis. The physical interaction between NPR3 and NPR1/ TGA2 was explored using bimolecular fluorescence complementation analysis in onion epidermal cells, Here, we show that NPR3 expression was strongest in the petals and sepals of developing flowers and declined after flower opening. Consistently with this observation, an npr3 knockout mutant displayed enhanced resistance to Pseudomonas syringae infection of immature flowers, but not leaves. Developing npr3 flowers exhibited increased levels of basal and induced PR1 transcript accumulation. However, the npr3 mutant showed lower fitness compared to Col-0 in the absence of pathogen. Moreover, NPR3 was shown to interact with NPR1 and TGA2 in vivo. Our data suggest that NPR3 is a negative regulator of defense responses during early flower development and it may function through the association with both NPR1 and TGA2.

关键词： plant defense NPR3 negative regulator Arabidopsis flower.

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Changes in confirmed plus borderline cases of congenital hypothyroidism in California as a function of environmental fallout from the Fukushima nuclear meltdown

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Open j.urnal of Pediatrics 2013年第4期3卷 370-376页

作者： joseph mangano j.nette Sherman Christopher Busby Green Audit Aberystwyth UK Radiation and Public Health Proj.ct New York USA

Radiation exposure has been linked to increased risk of congenital hypothyroidism (CH) for decades. CH is a relatively uncommon condition, occurring in about 1 of 2000 US births. Thyroid Stimulating Hormone (TSH) levels for each child born in California permitted an analysis of combined confirmed and borderline CH cases. Borderline/confirmed CH cases are more than seven times greater than j.st confirmed cases. Airborne levels of gross beta nuclear radiation in the US were elevated in the period starting several days after the Fukushima nuclear meltdown, especially in west coast states like California. The borderline/confirmed CH rate for newborns during the last 9.5 months in 2011 (exposed to Fukushima in utero) vs. births during other periods in 2011 and 2012 (not exposed) was significantly elevated, suggesting that adverse health effects to the newborn thyroid were not restricted to j.st a small number of confirmed CH cases. The sensitivity of the fetus to radiation exposure, plus the presence of thyroid-seeking radioiodine, suggest further analysis of Fukushima’s potential to cause adverse health effects in newborns is needed.

关键词： Congenital Hypothyroidism Fukushima Dai-Ichi Nuclear Meltdown Fetal Thyroid

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Changes in Congenital Anomaly Incidence in West Coast and Pacific States (USA) after Arrival of Fukushima Fallout

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Open j.urnal of Pediatrics 2015年第1期5卷 76-89页

作者： joseph mangano j.nette D. Sherman Radiation and Public Health Proj.ct New York USA

Radioactive fallout after the March 2011 Fukushima nuclear meltdown entered the U.S. environment within days;levels of radioactivity were particularly elevated in the five western states bordering on the Pacific Ocean. The particular sensitivity of the fetus to radiation exposure, and the ability of radioisotopes to attach to cells, tissues, and DNA raise the question of whether fetuses/newborns with birth defects with the greater exposures suffered elevated harm during the period after the meltdown. We compare rates of five congenital anomalies for 2010 and 2011 births from April-November. The increase of 13.00% in the five western states is significantly greater than the 3.77% decrease for all other U.S. states combined (CI 0.030 - 0.205, p < 0.008). Consistent patterns of elevated increases are observed in the west (20 of 21 comparisons, 6 of which are statistically significant/borderline significant), by state, type of birth defect, month of birth, and month of conception. While these five anomalies are relatively uncommon (about 7500 cases per year in the U.S.), sometimes making statistical significance difficult to achieve, the consistency of the results lend strength to the analysis, and suggest fetal harm from Fukushima may have occurred in western U.S. states.

关键词： Birth Defects Fukushima Radiation Meltdown Nuclear Plant

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Cyanobacterial photo-driven mixotrophic metabolism and its advantages for biosynthesis

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Frontiers of Chemical Science and Engineering 2015年第3期9卷 308-316页

作者： Ni Wan Mary Abernathy joseph Kuo-Hsiang Tang Yinj.e j. Tang Le You Department of Energy Environmental and Chemical Engineering Washington University St. Louis MO 63130 USA Biodesign Institute Arizona State University Tempe AZ 85281 USA

Cyanobacterium offers a promising chassis for phototrophic production of renewable chemicals. Although engineered cyanobacteria can achieve similar product carbon yields as heterotrophic microbial hosts, their production rate and titer under photoautotrophic conditions are 10 to 100 folds lower than those in fast growing E. colt. Cyanobacterial factories face three indomitable bottlenecks. First, photosynthesis has limited ATP and NADPH generation rates. Second, CO2 fixation by ribulose-l,5-bisphosphate carboxylase/oxygenase （RuBisCO） has poor efficiency. Third, CO2 mass transfer and light supply are deficient within large photobioreac- tors. On the other hand, cyanobacteria may employ organic substrates to promote phototrophic cell growth, Nz fixation, and metabolite synthesis. The photo-fermenta- tions show enhanced photosynthesis, while CO2 loss from organic substrate degradation can be reused by the Calvin cycle. In addition, the plasticity of cyanobacterial path- ways （e.g., oxidative pentose phosphate pathway and the TCA cycle） has been recently revealed to facilitate the catabolism. The use of cyanobacteria as ＂green E. colt＂ could be a promising route to develop robust photobiorefineries.

关键词： CO2 mass transfer N2 fixation photosystem RuBisCO the TCA cycle

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Chinese Secret Societies and Popular Religions Revisited： An Introduction

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Frontiers of History in China 2016年第4期11卷 503-509页

作者： Robert j. Antony joseph Tse-Hei Lee Canton's Thirteen Hongs Research Center Guangzhou University Guangzhou 510006 China Department of History and Confucius Institute Pace University New York NY 10038 USA

It has been over forty years since j.an Chesneaux published his edited volume Popular Movements and Secret Societies in China, and some twenty years since David Ownby and Mary Somers Heidhues published their edited volume Secret Societies Reconsidered On popular religions, both Daniel Overmyer＇s FoItc Buddhist Religion and Susan Naquin＇s Millenarian Rebellion in China were also published almost forty years ago.1 Although there have been a number of important studies published both inside and outside of China on secret societies and popular religions since the 1990s, in recent years there has been a surge in new research, much of it still unpublished, on this important subj.ct in Chinese history.

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