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Is metastatic pancreatic cancer an untargetable malignancy?

World Journal of Gastrointestinal Oncology 2016年第3期8卷 297-304页

作者： Hampig Raphael Kourie joseph gharios Fadi Elkarak Joelle Antoun Marwan Ghosn Department of Oncology Faculty of Medicine Saint Joseph University

Metastatic pancreatic cancer(MPC) is one of the most aggressive malignancies, known to be chemo-resistant and have been recently considered resistant to some targeted therapies(TT). Erlotinib combined to gemcitabine is the only targeted therapy that showed an overall survival benefit in MPC. New targets and therapeutic approaches, based on new-TT, are actually being evaluated in MPC going from immunotherapy, epigenetics, tumor suppressor gene and oncogenes to stromal matrix regulators. We aim in this paper to present the major causes rendering MPC an untargetable malignancy and to focus on the new therapeutic modalities based on TT in MPC.

关键词： Pancreatic cancer Tumor suppressor genes Targeted therapies Immunotherapy Epigenetics

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Complete Remission by Primary Chemotherapy of Advanced Non-Seminomatous Germ Cell Tumor in an Intra-Abdominal Testis

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Open Journal of Urology 2014年第8期4卷 105-108页

作者： Pierre Sarkis Hampig Raphael Kourie joseph gharios joseph Kattan Saint-joseph Hospital Raymond and Aida Najjar Medical Center Saint-Joseph University Beirut Lebanon

Ectopic testis predisposes to a high risk of germ cell tumor development. Treatment of advanced testicular germ cell tumor developing in an uncorrected abdominal testis is based on primary chemotherapy followed by removal of the testis along with residual masses. However, persistence of viable tumor particularly in the testis is always noted since testis penetration of chemotherapeutic agents is reduced. We report a case of complete pathological remission of a patient with advanced non-seminomatous germ cell tumor in intra-abdominal testis by primary chemotherapy alone, with a review of the literature.

关键词： Germ Cell Tumors Intra-Abdominal Testis Non-Seminomatous Germ Cell Tumors

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Is There Any Indication for Prophylactic Brain Irradiation in the Management of Small Cell Prostate Cancer?

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Journal of Cancer Therapy 2013年第4期4卷 1-2页

作者： joseph Kattan Hampig Kourie Pierre Sarkis joseph gharios Joelle Antoun Saint joseph Hospital Raymond and Aida Najjar Medical Center Saint Joseph University Beirut Lebanon

Small cell prostate carcinoma (SCPC) is an extremely rare pathology with an aggressive behavior, characterized by early brain metastases. We describe three cases of SCPC where brain metastases occurred despite response to chemotherapy. The benefit of prophylactic brain irradiation (PBI), as part of the management of SCPC, is discussed and compared to its indications in small cell lung cancer.

关键词： Small Cell Carcinoma Prostate Cancer Brain Metastases Prophylactic Brain Irradiation

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