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Laparoscopic liver resection in the cirrhotic patient

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Hepatoma Research 2016年第1期2卷 248-252页

作者： Ben Robichaux Jesse Sulzer joseph f.buell Department of Surgery Louisiana State University School of MedicineBaton RougeLA 70803USA Tulane Transplant Institute Departments of SurgeryTulane University School of MedicineNew OrleansLA 70112USA

Aim:The adoption of laparoscopic liver resection has been expansive in the last 2 decades with the exception of cirrhotic *** current study examines the outcomes of our cirrhotic resections to determine the potential limitations of this ***:Retrospective analysis of 114 cirrhotic ***-five(65.8%)laparoscopic resections were compared to 39 open ***-six(66.7%)resections in the series were minor resections(less than 3 segments).Surgical approach and extent of resection were analyzed using student’s t test and regression multivariate analysis with ***:The laparoscopic group had lower operative times(2.4 vs.4.8 h;Pf stay(4.4 vs.10.1 days;P=0.013)a nd c omplications(28%vs.48%;P=0.028).Subset analysis by technique and extent of resection identified the laparoscopic group lost the advantage in blood loss and lengths of stay when utilized in major *** regression analysis for blood loss further confirmed open resection(P=0.014)a nd major resection(P=0.026)a s significant i ndicators of bleeding and ***:Laparoscopic liver resection in cirrhotic patients is safe and ***,the significant variability in outcomes for major resections in cirrhotics leads us to recommend further examination of the learning curve and significant caution in the selection of cirrhotics requiring major hepatic resections.

关键词： Laparoscopic liver resection cirrhosis complications outcomes

Stem cell biology in thyroid cancer: Insights for novel therapies

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World Journal of Stem Cells 2014年第5期6卷 614-619页

作者： Parisha Bhatia Koji Tsumagari Zakaria Y Abd Elmageed Paul friedlander joseph f buell Emad Kandil Departments of Surgery Tulane University School of Medicine New Orleans LA 70112 United States Departments of Otolaryngology Tulane University School of Medicine New Orleans LA 70112 United States

Currently, thyroid cancer is one of the most common endocrine cancer in the United States. A recent involvement of sub-population of stem cells, cancer stem cells, has been proposed in different histological types of thyroid cancer. Because of their ability of self-renewal and differentiation into various specialized cells in the body, these putative cells drive tumor genesis, metastatic activity and are responsible to provide chemo- and radioresistant nature to the cancer cells in the thyroid gland. Our Review was conducted from previously published literature to provide latest apprises to investigate the role of embryonic, somatic and cancer stem cells, and discusses the hypothesis of epithelial-mesenchymal transition. Different methods for their identification and isolation through stemness markers using various in vivo and in vitro methods such as flow cytometry, thyrosphere formation assay, aldehyde dehydrogenase activity and ATP-binding cassette sub-family G member 2 efflux-pump mediated Hoechst 33342 dye exclusion have been discussed. The review also outlines various setbacks that still remain to target these tumor initiating cells. future perspectives of therapeutic strategies and their potential to treat advanced stages of thyroid cancer are also disclosed in this review.

关键词： Stem cells Cancer Stem cells Thyroid Neoplasms Carcinogenesis Cell Differentiation Epithelial-Mesenchymal transition

Effect of obesity on perioperative outcomes after laparoscopic hepatectomy

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Hepatoma Research 2016年第1期2卷 323-327页

作者： Seeyuen J.Lee Adam Hauch Erica Kane Christoper DuCoin Michael Darden Geoffrey Parker Emad Kandil joseph f.buell Departments of Surgery Louisiana State University School of MedicineNew OrleansLA 70112USA Departments of Surgery Tulane University School of MedicineNew OrleansLA 70112USA Department of Economics Tulane UniversityNew OrleansLA 70112USA Tuck School of Business Administration Dartmouth CollegeHanoverNH 03755USA

Aim:Laparoscopic hepatectomy is increasing in utilization,however the procedure has not been adequately examined in the obese *** study aims to analyze the effect of obesity on perioperative outcomes after laparoscopic ***:Retrospective analysis of 396 laparoscopic hepatectomies in normal[body mass index(BMI)factors for post-operative ***:Normal BMI(n=78;20%),overweight(n=209;52%),obese(n=86;22%),and severely obese(n=23;6%).Demographics were similar except for a higher American Society of Anesthesiologists(ASA)score in the obese *** blood loss and operating time were greatest in the overweight group,while length of stay and complications were statistically similar between *** analysis identified that complications were associated with weight class,ASA score,blood loss,and resection;multivariate analysis revealed ASA and transfusion were best correlated with ***:Obese and overweight patients have similar complication profiles to normal BMI patients while severely obese patients have a higher incidence of complications that are primarily limited to Clavien-Dindo class I and II.

关键词： Liver resection laparoscopy obesity

The evolving role of laparoscopic ablation

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Hepatoma Research 2015年第1期1卷 49-49页

作者： joseph f.buell Tulane Transplant Institute Tulane UniversityNew OrleansLA 70118USA

In the last two decades,the etiology of hepatocellular cancer has shifted from hepatitis B to hepatitis C with the incidence of nonalcoholic steatohepatitis(NASH)rising *** sudden rise in NASH and newly diagnosed cases of hepatocellular cancer may represent the tip of an *** recommendations for patients with chronic hepatitis B or hepatitis C infections should be screened with routine use of *** this Surveillance,Epidemiology,and End Results,data would suggest that the average size of newly diagnosed hepatocellular cancer is beyond the Milan criteria at the time of *** the setting of fatty liver disease and NASH,an early serologic diagnosis is not evident.

关键词： routine diagnosis cancer

Portal vein thrombosis in liver transplantation: radiologic evaluation, risk factors, and occult diagnosis

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Hepatoma Research 2016年第1期2卷 36-41页

作者： Adam Hauch Carl Winkler Eric Katz Peter W.Lundberg Mary Killackey Anil S.Paramesh Luis A.Balart Nathan J.Shores Martin Moehlen Ward Miller Douglas P.Slakey joseph f.buell Bob H.Saggi Tulane Transplant Institute Tulane University School of MedicineNew OrleansLA 70112USA Department of Gastroenterology Section of HepatologyTulane University School of MedicineNew OrleansLA 70112USA

Aim:Portal vein thrombosis(PVT)in the liver transplant recipient poses many ***,the risk factors and effects on outcomes of PVT are not ***:This study analyzed the experience with PVT in liver transplant program from 2007 to *** included the effectiveness of PVT diagnostics and its risk factors using logistical *** primary endpoints were Kaplan-Meir patient and graft *** secondary endpoints were the length of stay(LOS),transfusion rate,and overall *** predictors of survival were identified using a Cox’s proportional hazards ***:Two hundred and sixteen consecutive liver transplant recipients were examined,and 30(13.8%)had either a total or partial *** hundred and five patients had imaging within 1 year of liver transplantation with only 7(23.3%)of the 30 PVTs identified *** sensitivity(4.8-50%)and negative predictive values(10.5-22.2%)were ***,age significantly predicted PVT[P=0.037/hazard ratio(HR)=0.95].Ninety-day-patient and graft survival for PVT was similar at 6 months,although 1-year survival was significantly lower.“Occult”PVT was not associated with inferior *** for end-stage liver disease score>25(P=0.001,HR=0.49/P=0.004,HR=0.52)and age>60 years(P=0.017,HR=0.64/P=0.013,HR=0.67)were significant predictors of patient and graft *** the transfusion rate was significantly greater with PVT,LOS,and morbidity were ***:Older recipients had a greater likelihood of *** studies were not effective at excluding PVT,and occult diagnosis did not affect the *** was not an independent predictor of mortality or graft loss,but was associated with greater blood loss but not increased LOS or morbidity.

关键词： Advanced age graft survival patient survival post-transplant outcomes resource utilization

Phased,chromosome-scale genome assemblies of tetraploid potato reveal a complex genome,transcriptome,and predicted proteome landscape underpinning genetic diversity

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Molecular Plant 2022年第3期15卷 520-536页

作者： Genevieve Hoopes Xiaoxi Meng John P.Hamilton Sai Reddy Achakkagari fernanda de Alves freitas Guesdes Marie E.Bolger joseph J.Coombs Danny Esselink Natalie R.Kaiser Linda Kodde Maria Kyriakidou Brian Lavrijssen Natascha van Lieshout Rachel Shereda Heather K.Tuttle Brieanne Vaillancourt Joshua C.Wood Jan Mde Boer Nolan Bornowski Peter Bourke David Douches Herman Jvan Eck Dave Ellis Max J.feldman Kyle M.Gardner Johannes C.P.Hopman Jiming Jiang Walter S.De Jong joseph C.Kuhl Richard G.Novy Stan Oome Vidyasagar Sathuvalli Ek Han Tan Remco A.Ursum M.Isabel Vales Kelly Vining Richard G.f.Visser Jack Vossen G.Craig Yencho Noelle L.Anglin Christian W.B.Bachem Jeffrey B.Endelman Laura M.Shannon Martina V.Stromvik Helen H.Tai Bjorn Usadel C.Robin buell Richard finkers Department of Plant Biology Michigan State UniversityEast LansingMI 48824USA Department of Horticultural Science University of MinnesotaSt.PaulMN 55108USA Department of Plant Science McGill UniversitySainte-Anne-de-BellevueQC H9X 3V9Canada Plant Breeding Wageningen University&ResearchPlant Breeding6708 PB Wageningenthe Netherlands IBG-4 Bioinformatics Forschungszentrum JülichWilhelm Johnen Str52428 JülichGermany Department of Plant Soiland Microbial SciencesMichigan State UniversityEast LansingMI 48824USA Bayer Crop Science WoodlandCA 95695USA Averis Seeds B.V. 9640 AA Veendamthe Netherlands International Potato Center 1895 Avenida La MolinaLimaPeru USDA-ARS ProsserWA 99350USA Agriculture and Agri-food Canada fredericton Research and Development Centre FrederictonNB E3B 4Z7Canada School of Integrative Plant Science Cornell UniversityIthacaNY 14853-1901USA Department of Plant Sciences University of IdahoMoscowID 83844USA USDA-ARS Small Grains and Potato Germplasm ResearchAberdeenID 83210USA HZPC Research B.V. Edisonweg 58501 XG Jourethe Netherlands Department of Crop and Soil Science Oregon State UniversityHermistonOR 97838USA School of Biology and Ecology University of Maine5735 Hitchner Hall OronoME 04469USA Department of Horticultural Sciences Texas A&M UniversityCollege StationTX 77843-2133USA Department of Horticulture Oregon State UniversityCorvallisOR 97331USA Department of Horticultural Science North Carolina State UniversityRaleighNC 27695-7609USA Department of Horticulture University of Wisconsin-MadisonMadisonWI 53706USA Department of Horticulture Michigan State UniversityEast LansingMI 48824USA Institute for Biological Data Science Heinrich Heine UniversityDusseldorf40225 DusseldorfGermany Plant Resilience Institute Michigan State UniversityEast LansingMI 48824USA Present address:GenNovation B.V. Wageningenthe Netherlands

Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous *** assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity,including altered coding and transcript sequences,preferential allele expression,and structural variation that collectively result in a highly complex transcriptome and predicted proteome,which are distributed across the homologous *** species contribute to the extensive allelic diversity in tetraploid cultivars,demonstrating ancestral introgressions predating modern breeding *** a clonally propagated autotetraploid that undergoes limited meiosis,dysfunctional and deleterious alleles are not purged in tetraploid *** a quarter of the loci bore mutations are predicted to have a high negative impact on protein function,complicating breeder’s efforts to reduce genetic *** StCDf1 locus controls maturity,and analysis of six tetraploid genomes revealed that 12 allelic variants of StCDf1 are correlated with maturity in a dosage-dependent *** of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous,diploid potato germplasm containing favorable alleles to capitalize on heterosis in f1 hybrids.

关键词： potato allele diversity phased assembly polyploid pan-genome wild introgressions