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Super-Resolution Displacement Spectroscopic Sensing over a Surface“Rainbow”

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Engineering 2022年第10期17卷 75-81页

作者： Lyu Zhou Nan Zhang Chang Chieh Hsu Matthew Singer Xie Zeng Yizheng Li Haomin Song josep Jornet Yun Wu Qiaoqiang Gan Department of Electrical Engineering The State University of New York at BuffaloBuffaloNY 14260USA Department of Biomedical Engineering The State University of New York at BuffaloBuffaloNY 14260USA Department of Electrical and Computer Engineering Northeastern UniversityBostonMA 02115USA Material Science Engineering Program King Abdullah University of Science and TechnologyThuwal 23955-6900Saudi Arabia

Subwavelength manipulation of light waves with high precision can enable new and exciting applications in spectroscopy,sensing,and medical *** these applications,miniaturized spectrometers are desirable to enable the on-chip analysis of spectral *** particular,for imaging-based spectroscopic sensing mechanisms,the key challenge is to determine the spatial-shift information accurately(i.e.,the spatial displacement introduced by wavelength shift or biological or chemical surface binding),which is similar to the challenge presented by super-resolution ***,we report a unique"rainbow"trapping metasurface for on-chip spectrometers and *** with super-resolution image processing,the low-setting 4×optical microscope system resolves a displacement of the resonant position within 35 nm on the plasmonic rainbow trapping metasurface with a tiny area as small as0.002 *** unique feature of the spatial manipulation of efficiently coupled rainbow plasmonic resonances reveals a new platform for miniaturized on-chip spectroscopic analysis with a spectral resolution of 0.032 nm in wavelength *** this low-setting 4×microscope imaging system,we demonstrate a biosensing resolution of 1.92×109exosomes per milliliter for A549-derived exosomes and distinguish between patient samples and healthy controls using exosomal epidermal growth factor receptor(EGFR)expression values,thereby demonstrating a new on-chip sensing system for personalized accurate bio/chemical sensing applications.

关键词： Rainbow trapping Metasurface Surface plasmon polaritons Super-resolution displacement On-chip biosensing

Detection of hyper-conserved regions in hepatitis B virus X gene potentially useful for gene therapy

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World Journal of Gastroenterology 2018年第19期24卷 2095-2107页

作者： Carolina González David Tabernero Maria Francesca Cortese josep Gregori Rosario Casillas Mar Riveiro-Barciela Cristina Godoy Sara Sopena Ariadna Rando Marcal Yll Rosa Lopez-Martinez josep Quer Rafael Esteban Maria Buti Francisco Rodríguez-Frías Liver Pathology Unit Departments of Biochemistry and MicrobiologyHospital Universitari Vall d’HebronUniversitat Autònoma de BarcelonaBarcelona 08035Spain Liver Unit Liver Disease Laboratory-Viral HepatitisVall d’Hebron Institut Recerca-Hospital Universitari Vall d’HebronUniversitat Autònoma de BarcelonaBarcelona 08035Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(CIBERehd) Instituto de Salud Carlos IIIMadrid 28029Spain Roche Diagnostics SL Sant Cugat del Vallès 08174Spain Liver Unit Department of Internal MedicineHospital Universitari Vall d'HebronUniversitat Autònoma de BarcelonaBarcelona 08035Spain

AIM To detect hyper-conserved regions in the hepatitis B virus(HBV) X gene(HBX) 5' region that could be candidates for gene *** The study included 27 chronic hepatitis B treatmentnaive patients in various clinical stages(from chronic infection to cirrhosis and hepatocellular carcinoma, both HBeA g-negative and HBeA g-positive), and infected with HBV genotypes A-F and H. In a serum sample from each patient with viremia > 3.5 log IU/m L, the HBX 5' end region [nucleotide(nt) 1255-1611] was PCRamplified and submitted to next-generation sequencing(NGS). We assessed genotype variants by phylogenetic analysis, and evaluated conservation of this region by calculating the information content of each nucleotide position in a multiple alignment of all unique sequences(haplotypes) obtained by NGS. Conservation at the HBx protein amino acid(aa) level was also *** NGS yielded 1333069 sequences from the 27 samples, with a median of 4578 sequences/sample(2487-9279, IQR 2817). In 14/27 patients(51.8%), phylogenetic analysis of viral nucleotide haplotypes showed a complex mixture of genotypic variants. Analysis of the information content in the haplotype multiple alignments detected 2 hyper-conserved nucleotide regions, one in the HBX upstream non-coding region(nt 1255-1286) and the other in the 5' end coding region(nt 1519-1603). This last region coded for a conserved amino acid region(aa 63-76) that partially overlaps a Kunitz-like *** Two hyper-conserved regions detected in the HBX 5' end may be of value for targeted gene therapy, regardless of the patients' clinical stage or HBV genotype.

关键词： Hepatitis B virus Hepatitis B X gene Hepatitis B X protein Gene therapy Next-generation sequencing HBV conserved regions Small interference RNA

Modeling,Oscillation Analysis and Distributed Stabilization Control of Autonomous PV-based Microgrids

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CSEE Journal of Power and Energy Systems 2023年第3期9卷 921-936页

作者： Zhuoli Zhao Jindian Xie Shaoqing Gong Xi Luo Yuewu Wang Chun Sing Lai Ping Yang Loi Lei Lai josep M.Guerrero Department of Electrical Engineering School of AutomationGuangdong University of TechnologyGuangzhou 510006China School of Automation Guangxi University of Science and TechnologyLiuzhou 545006China Department of Electronic and Electrical Engineering Brunel University LondonLondon UB83PHUK Key Laboratory of Clean Energy Technology of Guangdong Province South China University of TechnologyGuangzhou 510640China Department of Energy Technology Aalborg University9220 AalborgDenmark

Driven by rising energy demand and the goal of carbon neutrality,renewable energy generations(REGs),especially photovoltaic(PV)generations,are widely used in the urban power energy *** the intelligent control of microgrids(MG)brings economic and efficient operation,its potential stability problem cannot be *** date,most of the research on modeling,analyzing and enhancing the stability of MG usually assume the DC-link as an ideal voltage ***,this practice of ignoring the dynamics of DC-link may omit the latent oscillation phenomena of autonomous PV-based ***,this paper establishes a complete dynamic model of autonomous PV-based MG including PV panels and *** from previous conclusions of idealizing DC-link dynamics,participation factor analysis finds the potential impact of DClink dynamics on system dynamic performance,and different influence factors including critical control parameters and nonlinear V-I output characteristic of PV array are considered to further reveal oscillation ***,based on the average consensus algorithm,a distributed stabilization controller with strong robustness is proposed to enhance stability of the PVbased MG,which does not affect the steady-state performance of the ***,the correctness of all theoretical analysis and the effectiveness of the proposed controller are verified by time domain simulation and hardware-in-loop tests.

关键词： Average consensus algorithm distributed stabilization microgrid oscillation photovoltaic(PV)generation stability analysis

Usefulness of Impella support in different clinical settings in cardiogenic shock

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Journal of Geriatric Cardiology 2022年第2期19卷 115-124页

作者： María Isabel Barrionuevo-Sánchez Albert Ariza-Solé Daniel Ortiz-Berbel JoséGonzález-Costello Joan Antoni Gómez-Hospital Victòria Lorente Oriol Alegre Isaac Llaó JoséCarlos Sánchez-Salado josep Gómez-Lara Arnau Blasco-Lucas josep Comin-Colet Cardiology Department Intensive Cardiac Care UnitBellvitge University HospitalL’Hospitalet de LlobregatBarcelonaSpain Cardiac Surgery Department Heart Disease InstituteBellvitge University HospitalL’Hospitalet de LlobregatBarcelonaSpain

BACKGROUND The Impella pump has emerged as a promising tool in patients with cardiogenic shock(CS).Despite its attractive properties,there are scarce data on the specific clinical setting and the potential role of Impella devices in CS patients from routine clinical *** This is an observational,retrospective,single center,cohort *** consecutive patients with diagnosis of CS and undergoing support with Impella 2.5?,Impella CP?or Impella 5.0?from April 2015 to December 2020 were *** characteristics,management and outcomes were assessed according to CS severity,age and cause of *** outcome measured was in-hospital *** A total of 50 patients were included(median age:59.3±10 years).The most common cause of CS was acute coronary syndrome(ACS)(68%),followed by decompensation of previous cardiomyopathy(22%).A total of 13 patients(26%)had profound *** patients(54%)improved pulmonary congestion at 48 h after Impella support.A total of 19 patients(38%)presented significant ***-hospital mortality was 42%.Among patients with profound CS(n=13),five patients were previously supported with venoarterial extracorporeal membrane oxygenation.A total of eight patients(61.5%)died during the admission,and no patient achieved ventricular *** patients(≥67 years,n=10)had more comorbidities and the highest mortality(70%).Among patients with ACS(n=34),35.3%of patients had profound CS;and in most cases(52.9%),Impella support was performed as a bridge to *** contrast,only one patient from the decompensated cardiomyopathy group(n=11)presented with profound *** 90.9%of these cases,Impella support was used as a bridge to cardiac *** were no cases of *** In this cohort of real-life CS patients,Impella devices were used in different settings,with different clinical profiles and *** a significant rate of complications,mortality was acceptable and lower than those observed

关键词： Impella clinical routine

Land use effects on terrestrial carbon sources and sinks

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Science China(Life Sciences) 2002年第Z1期45卷 1-9页

作者： josep G. Canadell Global Carbon Project GCTE CSIRO Land and Water PO Box 1666 Australia

Current and past land use practices are critical in determining the distribution and size of global terrestrial carbon (C) sources and sinks. Althoughfossil fuel emissions dominate the anthropogenic perturbation of the global C cycle, land use still drives the largest portion of anthropogenic emissions in a number of tropical regions of Asia. The size of the emission flux owing to land use change is still the biggest uncertainty in the global C budget. The Intergovernmental Panel on Climate Change (IPCC) reported a flux term of 1.7 PgC@a-1 for 1990-1995 but more recent estimates suggest the magnitude of this source may be only of 0.96 PgC@a-1 for the 1990s. In addition, current and past land use practices are now thought to contribute to a large degree to the northern hemisphere terrestrial sink, and are the dominant driver for some regional sinks. However, mechanisms other than land use change need to be invoked in order to explain the inferred C sink in the tropics. Potential candidates are the carbon dioxide (CO2) fertilization and climate change; fertilization due to nitrogen (N) deposition is believed to be small or nil. Although the potential for managing C sinks is limited, improved land use management and new land uses such as reforestation and biomass fuel cropping, can further enhance current terrestrial C sinks. Best management practices in agriculture alone could sequester 0.4-0.8 PgC per year in soils if implemented globally. New methodologies to ensure verification and permanency of C sequestration need to be developed.

关键词： land use, terrestrial carbon, carbon emissions, sink mechanisms.

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基于相互作用关系的中国省际人口流动研究

地理研究 2018年第9期37卷 1848-1861页

作者：豆晓 ARELLANO Blanca ROCA josep 山东农业大学城市管理系泰安271018 加泰罗尼亚理工大学建筑学院西班牙巴塞罗那08028

基于2000年、2010年人口普查及2005年、2015年人口抽样调查数据,采用相互作用关系模型计算了中国"人口流动系统"和"单向相互作用关系值"。结果表明:(1)人口流动具有明显的凝聚性,东部地区对流动人口的吸引力依然具有绝对优势;(2)省际人... 详细信息

基于2000年、2010年人口普查及2005年、2015年人口抽样调查数据,采用相互作用关系模型计算了中国"人口流动系统"和"单向相互作用关系值"。结果表明:(1)人口流动具有明显的凝聚性,东部地区对流动人口的吸引力依然具有绝对优势;(2)省际人口流动呈"非对称双向迁移模式",人口回流的趋势已不容忽视;(3)长三角地区逐渐代替珠三角成为新的人口流动中心,人口流动开始北移;(4)中西部地区的人口流动分中心某种意义上已经出现,人口就近转移日渐凸显。将2010-2015年间省际人口流动新规律和特征与1995-2010年进行动态对比,对于制定未来人口和区域发展政策,继续缩小东西部地区之间的差距,最终实现区域协调发展具有重要意义。

关键词：省际人口流动人口流动系统相互作用关系中国

破碎化景观格局中热带干旱森林的结构、多样性与保护价值

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Journal of Plant Ecology 2023年第1期16卷 163-176页

作者： Oscar R.Lanuza Fernando Casanoves Sergio Vílchez-Mendoza josep Maria Espelta josep Peñuelas Guille Peguero Facultad Regional Multidisciplinaria Estelí Universidad Nacional Autónoma de Nicaragua(UNAN Managua/FAREM Estelí)49EstelíNicaragua CREAF E08193 BellaterraCerdanyola del VallèsSpain Global Ecology Unit CSICCREAF‐CSIC‐UAB08193 BellaterraCataloniaSpain CATIE-Centro Agronómico Tropical de Investigación y Enseñanza 30501TurrialbaCosta RicaSpain Departament de Biologia Animal Biologia Vegetal i EcologiaUniversitat Autònoma de Barcelona08193 BellaterraSpain

尽管热带干旱森林是世界上退化和破碎化程度最严重的生物群落之一,但我们对它们的基本生态特征和保护状况仍然知之甚少,尤其是在新热带地区。在本研究中,我们对尼加拉瓜破碎化景观格局中的热带干旱森林的多样性、组成、结构和保护价值... 详细信息

尽管热带干旱森林是世界上退化和破碎化程度最严重的生物群落之一,但我们对它们的基本生态特征和保护状况仍然知之甚少,尤其是在新热带地区。在本研究中,我们对尼加拉瓜破碎化景观格局中的热带干旱森林的多样性、组成、结构和保护价值进行了评估。我们在河流廊道、次生林、绿篱和林间牧地之中和沿线地区建立了31处样地和样带。我们使用希尔数(Hill number)对胸高处直径≥2.5 cm的所有树木进行了记录,并对每种森林类型中树木的丰富性和多样性进行了估算,接着计算了种级分类和科级分类上的重要值指数(Importance Value Index,IVI),最后则使用Bray-Curtis相似性指数进行了非度量多维标度(Non-Metric Multidimensional Scaling,NMDS)排序和相似性分析(Analysis of Similarities,ANOSIM)。不同森林类型之间在多样性上存在差异,但物种丰富度却不存在差异。豆科植物的IVI值最高,其次是桑科植物和锦葵科植物。Vachellia pennatula、Guazuma ulmifolia和Bursera simaruba的IVI值都>30%,其中前两种是所有森林类型中最为丰富的树木。对群落的相似性进行分析后可知每种森林类型都有着不同的组成,从而凸显了对所有这些不同类型的土地覆盖开展保护的重要性。

关键词：豆科植物破碎化希尔数(Hill number) 重要值指数河流廊道热带干旱森林

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分布式多变流器型微电网无互联线潮流控制

电网技术 2014年第9期38卷 2363-2370页

作者：唐芬吴丹周啸 Guerrero josep M. 贾利民北京交通大学国家能源主动配电网技术研发中心北京交通大学轨道交通安全与控制国家重点实验室北京市100044 丹麦奥尔堡大学能源技术系丹麦奥尔堡9220

当储能系统接口变流器的视在功率一定时,分布式多变流器型微电网系统内无功功率需求越大,储能系统对电源与负荷之间有功供需平衡的调节能力越弱。针对该问题,提出了一种无互联线潮流控制方法。该方法利用微电网系统内所有潜在的分布式... 详细信息

当储能系统接口变流器的视在功率一定时,分布式多变流器型微电网系统内无功功率需求越大,储能系统对电源与负荷之间有功供需平衡的调节能力越弱。针对该问题,提出了一种无互联线潮流控制方法。该方法利用微电网系统内所有潜在的分布式无功补偿源提供负荷所需无功,以期减小储能系统功率调节压力。并通过下垂控制与倒下垂相结合的方法来实现电压控制模式与电流控制模式变流器间功率的合理分配。同时,分析了影响功率分配精度的因素,提出基于虚拟阻抗与自适应空载电压补偿相结合的方法改善无功功率分配精度。最后通过实时硬件在环平台验证了所提控制策略的可行性。

关键词：微电网自治功率分配虚拟阻抗协调控制

FPGA-based Digital Implementation of Flexible Power Control for Three-phase to Single-phase MMC-based Advanced Co-phase Traction Power Supply System

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Journal of Modern Power Systems and Clean Energy 2023年第6期11卷 2015-2027页

作者： Jiangpeng Yang Hongjian Lin Haotian Zhu Zeliang Shu Lan Ma Changsong Cai Pengcheng Zhang Li He Ruoyu Li Shasha Song josep M.Guerrero National Rail Transportation Electrification and Automation Engineering Technology Research Center Chengdu 611756China School of Electrical Engineering Southwest Jiaotong UniversityChengdu 611756China IEEE Department of Electrical Engineering City University of Hong KongHong KongChina School of Electrical Engineering and Automation Wuhan UniversityWuhan 430072China Department of Electrical Engineering Tsinghua UniversityBeijing 100084China Department of Energy Technology Aalborg UniversityAalborg 9220Denmark

A three-phase to single-phase modular multilevel converter based advanced co-phase traction power supply(MMC-ACTPS) system is an effective structure to address the concerns of phase splitting and poor power quality of the conventional electrified railway. Due to the large number of MMCACTPS system modules, I/O resources and computing speed have high requirements on processors. Moreover, the module capacitor balance is challenging because the sorting time is too long when the traditional sorting algorithm for voltage balance is used. To solve the above issues, a digital implementation scheme of flexible power control strategy for three-phase to single-phase MMC-ACTPS system based on field programmable gate array(FPGA), which has sufficient I/O resources, has been proposed. Due to the parallel execution characteristics of the FPGA, the execution time of the controller and the modulator can be greatly reduced compared with a digital signal processor(DSP) + FPGA or DSpace. In addition, an improved sorting algorithm is proposed to reduce the sorting time and the implementation steps are analyzed. Finally, simulation and experimental results are presented to demonstrate the effectiveness and correctness of the proposed control strategy.

关键词： Advanced co-phase power traction supply(ACTPS)system modular multilevel converter(MMC) digital implementation flexible power transmission circulating current mitigation