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Hyperglycemia and reduced adiposity of streptozotocin-induced diabetic mice are not alleviated by oral benzylamine supplementation

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World Journal of Diabetes 2022年第9期13卷 752-764页

作者： Christian Carpéné Kristiyan Stiliyanov Atanasov Francisco Les josep mercader barcelo Institut des Maladies Métaboliques et Cardiovasculaires INSERM UMR 1297Toulouse 31432France Molecular Biology and One Health research group Department of Fundamental Biology and Health SciencesUniversity of the Balearic IslandsPalma 07122Spain Department of Pharmacy Faculty of Health SciencesUniversidad San JorgeVillanueva de GállegoZaragoza 50830Spain

BACKGROUND Benzylamine(Bza)oral administration delays the onset of hyperglycemia in insulin-resistant db-/-mice;a genetic model of obesity and type 2 *** To extend the antihyperglycemic properties of oral benzylamine to a model of insulin-deficient type 1 *** Male Swiss mice were rendered diabetic by streptozotocin treatment(STZ)and divided in two groups:one received 0.5%Bza as drinking solution for 24 d(STZ Bza-drinking)while the other was drinking water ad *** groups were constituted in age-matched,nondiabetic *** intake,liquid intake,body weight gain and nonfasting blood glucose levels were followed during *** the end of treatment,fasted glycemia,liver and white adipose tissue(WAT)mass were measured,while glucose uptake assays were performed in *** STZ diabetic mice presented typical features of insulin-deficient diabetes:reduced body mass and increased blood glucose *** altered parameters were not normalized in the Bza-drinking group in spite of restored food and water *** consumption could not reverse the severe fat depot atrophy of STZ diabetic *** the nondiabetic mice,no difference was found between control and Bza-drinking mice for any *** isolated adipocytes,hexose uptake was partially activated by 0.1 mmol/L Bza in a manner that was obliterated in vitro by the amine oxidase inhibitor phenelzine and that remained unchanged after Bza *** of 0.1 mmol/L Bza in WAT was lower in STZ diabetic than in normoglycemic *** Bza supplementation could not normalize the altered glucose handling of STZ diabetic mice with severe WAT ***,its antidiabetic potential in obese and diabetic rodents does not apply to lipoatrophic type 1 diabetic mice.

关键词： Diabetes Adipocytes Amine oxidases Insulin-like agents Glucose transport Polydipsia

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