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Characterization of hepatitis B virus X gene quasispecies complexity in mono-infection and hepatitis delta virus superinfection

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World Journal of Gastroenterology 2019年第13期25卷 1566-1579页

作者： Cristina Godoy David Tabernero Sara Sopena josep Gregori maria Francesca Cortese Carolina González Rosario Casillas mar?al Yll Ariadna Rando Rosa López-martínez josep Quer Gloria González-Aseguinolaza Rafael Esteban mar Riveiro-Barciela maria Buti Francisco Rodríguez-Frías Liver Pathology Unit Departments of Biochemistry and Microbiology Hospital Universitari Vall d’Hebron Universitat Autònoma de Barcelona Liver Unit Liver Disease Laboratory-Viral Hepatitis Vall d’Hebron Institut Recerca-Hospital Universitari Vall d'Hebron Universitat Autònoma de Barcelona Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd) Instituto de Salud Carlos Ⅲ Roche Diagnostics SL Centro de Investigación médica Aplicada (CImA) Universidad de Navarra Liver Unit Department of Internal MedicineHospital Universitari Vall d’Hebron Universitat Autònoma de Barcelona (UAB)

Hepatitis delta virus(HDV) seems to strongly suppress hepatitis B virus(HBV)replication, although little is known about the mechanism of this interaction. Both these viruses show a dynamic distribution of mutants, resulting in viral quasispecies. Next-generation sequencing is a viable approach for analyzing the composition of these mutant spectra. As the regulatory hepatitis B X protein(HBx) is essential for HBV replication, determination of HBV X gene(HBX)quasispecies complexity in HBV/HDV infection compared to HBV monoinfection may provide information on the interactions between these two *** To compare HBV quasispecies complexity in the HBX 5' region between chronic hepatitis delta(CHD) and chronic HBV mono-infected *** Twenty-four untreated patients were included: 7/24(29.2%) with HBeAgnegative chronic HBV infection(CI, previously termed inactive carriers), 8/24(33.3%) with HBeAg-negative chronic hepatitis B(CHB) and 9/24(37.5%) with CHD. A serum sample from each patient was first tested for HBV DNA *** HBX 5' region [nucleotides(nt) 1255-1611] was then PCR-amplified for subsequent next-generation sequencing(miSeq, Illumina, United States). HBV quasispecies complexity in the region analyzed was evaluated using incidencebased indices(number of haplotypes and number of mutations), abundancebased indices(Hill numbers of order 1 and 2), and functional indices(mutation frequency and nucleotide diversity). We also evaluated the pattern of nucleotide changes to investigate which of them could be the cause of the quasispecies *** CHB patients showed higher median HBV-DNA levels [5.4 logIU/mL,interquartile range(IQR) 3.5-7.9] than CHD(3.4 logIU/mL, IQR 3-7.6)(P = n.s.)or CI(3.2 logIU/mL, IQR 2.3-3.5)(P mplexity was significantly greater in CI than CHB. A similar trend was observed in CHD patients, although only Hill numbers of order 2 showed

关键词： Hepatitis B virus Hepatitis delta virus Hepatitis B X gene Next-generation sequencing Viral quasispecies Hepatitis B virus-hepatitis delta virus interaction

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基于SmC的交直流混合微电网接口换流器控制策略

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科技导报 2016年第2期34卷 299-304页

作者：苏小玲韩民晓 josep m.Guerrero 赵鑫华北电力大学新能源电力系统国家重点实验室北京102206 奥尔堡大学能源技术系

根据交直流混合微电网拓扑和并网运行特点,建立了接口换流器的数学模型,设计了基于滑模控制(sliding-mode control,SmC)的接口换流器控制系统,并通过设计趋近律规定了滑模控制过程中系统在正常运动阶段的状态轨迹,保证滑模控制的品质。... 详细信息

根据交直流混合微电网拓扑和并网运行特点,建立了接口换流器的数学模型,设计了基于滑模控制(sliding-mode control,SmC)的接口换流器控制系统,并通过设计趋近律规定了滑模控制过程中系统在正常运动阶段的状态轨迹,保证滑模控制的品质。为证明控制系统在实际应用中的可行性,在d SPACE 1006平台上建立了实验模型。仿真和实验结果表明,该控制系统可以提高接口换流器在不确定和非线性条件下的鲁棒性和快速响应性,保证微电网稳定运行。

关键词：混合微电网接口换流器滑模控制趋近律鲁棒性

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西南极利文斯顿岛汉那角火山岩地质及火山活动

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南极研究 1994年第2期6卷 1-12页

作者：郑祥身 Francesc Sabat josep m Casas Ranimon Pallas 中国科学院地质研究所岩石圈构造演化开放研究实验室巴塞罗那大学地质系

本文以野外地质资料为基础，并结合岩相学特征，论述了西南极南设得兰群岛利文斯顿岛汉那角（ＨａｎｎａｈＰｏｉｎｔ）火山岩地层及岩石的基本特征，初步讨论了该地火山活动过程。该地互层状产出的火山角砾岩和熔岩，为南极半岛火山岩... 详细信息

本文以野外地质资料为基础，并结合岩相学特征，论述了西南极南设得兰群岛利文斯顿岛汉那角（ＨａｎｎａｈＰｏｉｎｔ）火山岩地层及岩石的基本特征，初步讨论了该地火山活动过程。该地互层状产出的火山角砾岩和熔岩，为南极半岛火山岩组的一部分。剖面上出露的三个火山岩地层旋回分别是三期火山作用的产物。第一、二旋回岩层产状的变化记录了火山作用过程中的一次活动间歇。第一旋回的英安岩和含有流纹岩质熔岩夹层的凝灰角砾岩仅为第一期火山活动末的产物；第二旋回为三次较强喷发活动的产物，从安山岩质火山碎屑岩为主，经玄武岩－安山岩质熔岩为主，过渡为含有安山岩或流纹岩质熔浆团的火山角砾岩。第三期火山活动可能更强烈，大面积分布的厚层玄武质熔岩无论从产状上还是在岩石学特征方面都有别于其他旋回。火山岩地层总体产状稳定，平缓地倾向北西，表明该区未受到过明显的构造影响，火山活动中心可能有逐步向北西迁移的趋势，与南设得兰群岛岩浆弧演变趋势一致。次火山岩主要为玄武岩质小岩墙，集中在第二旋回底部。第一、二旋回接触界线两侧凝灰角砾岩表现较强的沸石化。这些现象说明该接触面附近为一薄弱带，侵入活动和蚀变均较易发生。

关键词：火山岩地层火山活动岩相学利文斯顿岛

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Lysosome-mediated chemoresistance in acute myeloid leukemia

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Cancer Drug Resistance 2022年第1期5卷 233-244页

作者： Laia Cuesta-Casanovas Jennifer Delgado-martinez josep ***-masana Jose m.Carbo Lise Clement-Demange Ruth m.Risueno josep Carreras Leukaemia Research Institute(IJC) Barcelona 08916Spain Faculty of Biosciences Autonomous University of BarcelonaBellaterra(Cerdanyola del Valles)08193Spain Faculty of Pharmacy University of BarcelonaBarcelona 08028Spain Leukos Biotech Muntaner383Barcelona 08036Spain

Despite the outstanding advances in understanding the biology underlying the pathophysiology of acute myeloid leukemia(AmL)and the promising preclinical data published lastly,AmL treatment still relies on a classic chemotherapy regimen largely unchanged for the past five ***,new drugs have been approved for AmL,but the real clinical benefit is still under ***,primary refractory and relapse AmL continue to represent the main clinical challenge,as the majority of AmL patients will succumb to the disease despite achieving a complete remission during the induction *** such,treatments for chemoresistant AmL represent an unmet need in this *** great efforts have been made to decipher the biological basis for leukemogenesis,the mechanism by which AmL cells become resistant to chemotherapy is largely *** identification of the signaling pathways involved in resistance may lead to new combinatory therapies or new therapeutic approaches suitable for this subset of *** mechanisms of chemoresistance have been identified,including drug transporters,key secondary messengers,and metabolic ***,no therapeutic approach targeting chemoresistance has succeeded in clinical trials,especially due to broad secondary effects in healthy *** research has highlighted the importance of lysosomes in this ***’key role in resistance to chemotherapy includes the potential to sequester drugs,central metabolic signaling role,and gene expression *** results provide further evidence to support the development of new therapeutic approaches that target lysosomes in AmL.

关键词： Lysosome chemoresistance AmL lysosomotropic drug lysosomal sequestration refractory AmL

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Using compositional data analysis to explore accumulation of sedentary behavior,physical activity and youth health

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Journal of Sport and Health Science 2022年第2期11卷 234-243页

作者： Simone J.J.m.Verswijveren Karen E.Lamb josep A.martín-Fernández Elisabeth Winkler Rebecca m.Leech Anna Timperio Jo Salmon Robin m.Daly Ester Cerin David W.Dunstan Rohan m.Telford Richard D.Telford Lisa S.Olive Nicola D.Ridgers Institute for Physical Activity and Nutrition School of Exercise and Nutrition SciencesDeakin UniversityGeelongVIC 3216Australia melbourne School of Population and Global Health University of MelbourneParkvilleVIC 3053Australia Department of Computer Science Applied Mathematics and StatisticsUniversity of GironaGirona 17003Spain School of Public Health University of QueenslandHerstonQLD 4006Australia mary macKillop Institute for Health Research Australian Catholic UniversityFitzroyVIC 3065Australia School of Public Health University of Hong KongHong KongChina Baker Heart and Diabetes Institute MelbourneVIC 3004Australia Research Institute for Sport and Exercise University of CanberraBruceACT 2617Australia School of Psychology Deakin UniversityBurwoodVIC 3125Australia ImPACT Research Institute Deakin UniversityBurwoodVIC 3125Australia ANU medical School Australian National UniversityGarranACT 2605Australia

Purpose:The study aimed to describe youth time-use compositions,focusing on time spent in shorter and longer bouts of sedentary behavior and physical activity(PA),and to examine associations of these time-use compositions with cardiometabolic ***:Accelerometer and cardiometabolic biomarker data from 2 Australian studies involving youths 7-13 years old were pooled(complete cases with accelerometry and adiposity marker data,n=782).A 9-component time-use composition was formed using compositional data analysis:time in shorter and longer bouts of sedentary behavior;time in shorter and longer bouts of light-,moderate-,or vigorous-intensity PA;and"other time"(i.e.,non-wear/sleep).Shorter and longer bouts of sedentary time were defined asmin and>5 min,*** bouts of light-,moderate-,and vigorous-intensity PA were defined asmin;longer bouts were defined as≥1 *** models examined associations between overall time-use composition and cardiometabolic ***,associations were derived between ratios of longer activity patterns relative to shorter activity patterns,and of each intensity level relative to the other intensity levels and"other time",and cardiometabolic ***:Confounder-adjusted models showed that the overall time-use composition was associated with adiposity,blood pressure,lipids,and the summary ***,more time in longer bouts of light-intensity PA relative to shorter bouts of light-intensity PA was significantly associated with greater body mass index z-score(zBmI)(β=1.79;SE=0.68)and waist circumference(β=18.35,SE=4.78).When each activity intensity was considered relative to all higher intensities and"other time",more time in light-and vigorous-intensity PA,and less time in sedentary behavior and moderate-intensity PA,were associated with lower waist ***:Accumulating PA,particularly light-intensity PA,in frequent short bursts may be more beneficial for limiting adi

关键词： Accumulation patterns Cardiometabolic health Children Compositional data analysis Time-use

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Can We Predict De Novo Urge Incontinence by Perineal Ultrasound?

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Open Journal of Obstetrics and Gynecology 2018年第3期8卷 185-197页

作者： Judith Lleberia josep Pubill montserrat mestre Emma Garcia Jose m. Gris Eduardo Bataller Hospital Parc Taulí Sabadell Spain

Introduction: Urinary incontinence affects over 200 million people worldwide [1]. Tension free vaginal tape is the standard surgical treatment for stress urinary incontinence. De novo urge urinary incontinence is a long-term complication of this treatment with a significant impact in the quality of life of these patients. Objective: The major aim of this study is to assess the correlation between perineal ultrasonography findings and the incidence of de novo urge urinary incontinence. material and methods: A prospective observational study was designed. Patients with stress urinary incontinence diagnosed by clinical and urodynamic findings submitted to a tension-free vaginal tape surgery were included. International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF) and introital perineal ultrasound were performed before surgical intervention (I-STOP©). Clinical and ultrasound re-evaluation were executed six months after surgery. Stress urinary incontinence was defined according to the ICS-IUGA. Data were recorded using a microsoft Access database and statistical analysis using SAS©. Results: Bladder thickness equal to or below 6 mm has a low positive predictive value (PPV, 0.55), but a negative predictive power (NPP) of 0.72. Following surgery, a slight increase in postvoid residue is observed. Considering demographic data, an increase of 5 points in body mass index (BmI) resulted in an odds ratio (OR) of 1.74 of presenting de novo urge urinary in continence. Conclusions: In patients submitted to a tension-free vaginal tape surgery, high BmI seems to be associated with a higher rate of de novo urge urinary incontinence. Preoperative bladder wall thickness below 6 mm seems predict absence of this complication.

关键词： Stress Urinary Incontinence De Novo Urge Tension Free Sling Perineal Ultrasound Bladder Thickness Residual Postvoid BmI

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ASTROSAT/UVIT Near and Far Ultraviolet Properties of the m31 Bulge

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International Journal of Astronomy and Astrophysics 2021年第2期11卷 151-174页

作者： Denis Leahy Cole morgan josep Postma megan Buick Department of Physics and Astronomy University of Calgary Calgary Canada

AstroSat has surveyed m31 with the UVIT telescope from 2017 to 2019. The central bulge of m31 was observed in 2750 - 2850 A, 2000 - 2400 A, 1600 - 1850 A, 1450 - 1750 A, and 1200 - 1800 A filters. A radial profile analysis, averaged along elliptical contours which approximate the bulge shape, was carried out in each filter. The profiles follow a Sersic function with an excess for the inner ~8" in all filters, or can be fitted with two Sersic functions (including the excess). The ultraviolet colours of the bulge are found to change systematically with radius, with the center of the bulge bluer (hotter). We fit the UVIT spectral energy distributions (SEDs) for the whole bulge and for 10 elliptical annuli with single stellar population (SSP) models. A combination of two SSPs fits the UVIT SEDs much better than one SSP, and three SSPs fit the data best. The properties of the three SSPs are age, metallicity (m>Zm>) and mass of each SSP. The best fit model is a dominant old, metal-poor (1010 yr, mg src="Edit_***" alt="" />, with mg src="Edit_***" alt="" /> the solar metallicity) population plus a 15% contribution from an intermediate (109.5 yr, ) population plus a small contribution (~2%) from a young high-metallicity (108.5 yr, mg src="Edit_***" alt="" />) population. The results are consistent with previous studies of m31 in optical: both reveal an active merger history for m31.

关键词： UV Astronomy Galaxies: m31

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Global variations in critical drought thresholds that impact vegetation

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National Science Review 2023年第5期10卷 180-193页

作者： Xiangyi Li Shilong Piao Chris Huntingford josep Pe?uelas Hui Yang Hao Xu Anping Chen Pierre Friedlingstein Trevor F.Keenan Stephen Sitch Xuhui Wang Jakob Zscheischler miguel D.mahecha Sino-French Institute for Earth System Science College of Urban and Environmental SciencesPeking University Key Laboratory of Alpine Ecology and Biodiversity Institute of Tibetan Plateau ResearchCenter for Excellence in Tibetan Earth ScienceChinese Academy of Sciences UK Centre for Ecology and Hydrology CSIC Global Ecology Unit CREAF-CSIC-UAB CREAF Cerdanyola de Vallès Department of Biogeochemical Integration Max Planck Institute for Biogeochemistry Department of Biology Colorado State University Graduate Degree Program in Ecology Colorado State University Department of mathematics College of Engineering Mathematics and Physical SciencesUniversity of Exeter Laboratoire de météorologie Dynamique Institut Pierre-Simon LaplaceCNRS-ENS-UPMC-XDépartement de GeósciencesEcole Normale Superieure Earth and Environmental Sciences Area Lawrence Berkeley National Laboratory Department of Environmental Science Policy&ManagementUniversity of California Berkeley Department of Geography College of Life and Environmental SciencesUniversity of Exeter Department of Computational Hydrosystems Helmholtz Centre for Environmental Research—Ufz Remote Sensing Centre for Earth System Research Leipzig University

Identifying the thresholds of drought that,if crossed,suppress vegetation functioning is vital for accurate quantification of how land ecosystems respond to climate variability and *** present a globally applicable framework to identify drought thresholds for vegetation responses to different levels of known soil-moisture deficits using four remotely sensed vegetation proxies spanning *** thresholds identified represent critical inflection points for changing vegetation responses from highly resistant to highly vulnerable in response to drought stress,and as a warning signal for substantial vegetation *** thresholds varied geographically,with much lower percentiles of soil-moisture anomalies in vegetated areas covered by more forests,corresponding to a comparably stronger capacity to mitigate soil water deficit stress in forested ***,those lower thresholds are detected in more humid ***-of-the-art land models,however,overestimated thresholds of soil moisture(*** drought impacts),especially in more humid areas with higher forest covers and arid areas with few forest *** on climate model projections,we predict that the risk of vegetation damage will increase by the end of the twenty-first century in some hotspots like East Asia,Europe,Amazon,southern Australia and eastern and southern *** data-based results will inform projections on future drought impacts on terrestrial ecosystems and provide an effective tool for drought management.

关键词： drought threshold inflection points vegetation response soil moisture drought impacts

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双边反向驱动内流过渡流特性研究（英文）

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2023年第7期 612-625页

作者：安博 josep m.BERGADà 桑为民李栋 F.mELLIBOVSKY 西北工业大学航空学院翼型、叶栅空气动力学国家重点实验室中国空气动力研究与发展中心结冰与防除冰重点实验室加泰罗尼亚理工大学流体力学系加泰罗尼亚理工大学航空航天工程部物理系

目的：探究双边驱动方腔内流流场的过渡流临界特性，捕捉各种流动分岔点，分析其对流场特性带来的改变。确定流场演化模式，解释流动现象后的流动机理。通过流场拓扑结构和涡系演化分析流场稳定性与对称性的关系。创新点：1.首次揭示驱... 详细信息

目的：探究双边驱动方腔内流流场的过渡流临界特性，捕捉各种流动分岔点，分析其对流场特性带来的改变。确定流场演化模式，解释流动现象后的流动机理。通过流场拓扑结构和涡系演化分析流场稳定性与对称性的关系。创新点：1.首次揭示驱动速度比对该流场过渡流临界特性的影响规律；2.从物理层面上阐明流动本质。方法：1.以均匀直角网格构建计算域，通过基于格子玻尔兹曼方法的数值模拟方法，计算各流动状态发生变化时的临界雷诺数。根据不同驱动速度比，绘制Hopf和Neimark-Sacker流动分岔点以及湍流临界点随速度比的函数图像（图9）;2.通过扰动衰减系数、速度相图、速度频谱分析来判断流动是否由定常变为非定常周期性流动，再由周期性流动变为准周期性流动直至演化为湍流；3.通过流场拓扑结构分析流场对称性的破坏与不稳定性的关系；4.通过能量频谱图像分析流动的能量级串现象（图11）。结论：1.跟预期一样，该流场的稳定性丧失总是伴随着Hopf流动分岔点的出现；2.相较于顶盖驱动内流流场，双边驱动内流流场的稳定性较强，说明第二条边的驱动条件可以有效提高流场的稳定性；3.当α=-0.464时，流场稳定性最强，同时当双边驱动条件相同时可以更好的提高流场稳定性；4.不管驱动速度比如何变，流场始终展现了经典的Ruelle-Takens模式，从定常流动演化至非定常周期性流动，再由周期性流动演化至准周期性流动，最终演化为湍流；5.180度的旋转对称性对于推迟湍流的出现有很大作用。

关键词：双边驱动方腔内流驱动速度比过渡流临界特性涡系拓扑结构能量级串

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Coherent ONU based on 850 μm-long cavity-RSOA for next-generation ultra-dense access network

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Chinese Optics Letters 2016年第5期14卷 19-23页

作者： Guang Yong Chu Adolfo Lerín Iván N.Cano Victor Polo josep Prat Department of Signal Theory and Communications Universitat Politècnica de Catalunya

In this Letter, an efficient bidirectional differential phase-shift keying （DPSK）--DPSK transmission for a ultra- dense wavelength division-multiplexed passive optical network is proposed. A single distributed feedback laser at the optical network unit （ONU） is used both as the local laser for downlink coherent detection and the optical carrier for uplink. Phase-shift keying is generated using a low-cost reflective semiconductor optical amplifier （RSOA） at the ONU. The RSOA chip has the bandwidth of 4.7 GHz at the maximum input power and bias current. For uplink transmission, the sensitivity of the RSOA chip reaches -48.2 dBm at the level of bit error rate = 10^-3 for back-to-back, and the penalty for 50 km transmission is less than 1 dB when using polarization diversity.

关键词： ONU RSOA Coherent ONU based on 850 m-long cavity-RSOA for next-generation ultra-dense access network

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