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Modulation of brainstem reflexes induced by non-invasive brain stimulation: is there a future?

Neural Regeneration Research 2021年第10期16卷 2004-2005页

作者： Hatice Kumru Markus Kofler josep valls-sole Institut Guttmann Institut Universitari de Neurorehabilitacióadscrit a la UAB089M6 Badalona–BarcelonaSpain Univ Autonoma de Barcelona 08M93 Bellaterra(Cerdanyola del Vallès)Spain FundacióInstitut d’Investigacióen Ciències de la Salut Germans Trias i Pujol BadalonaBarcelonaSpain Department of Neurology Hochzirl HospitalZirlAustria EMG Unit NeurologyHospital Clinic-IDIBAPSBarcelonaSpain

Kumru et al.(2019)have recently reported significant reduction of the R2 component of the trigeminal blink reflex following highfrequency(20 Hz)repetitive transcranial magnetic stimulation(rTMS)over the vertex in both,healthy subjects and in patients with spinal cord injury(SCI)(Figure 1).The modulatory influence of non-invasive brain stimulation(NIBS)on brainstem reflexes has been only scarcely studied.

关键词： stimulation brainstem al.

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Applicability of the PRECISE-DAPT score in elderly patients with myocardial infarction

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Journal of Geriatric Cardiology 2018年第12期15卷 713-717页

作者： Albert Ariza-sole Francesc Formiga Manuel Martinez-Selles Maria T Vidan Jaime Aboal department of Cardiology Hospital Universitari de BellvitgeL'Hospitalet de LlobregatBarcelona Geriatrics Medicine Unit Internal Medicine Department.Hospital Universitari de BellvitgeL'Hospitalet de LlobregatBarcelona Department of Cardiology Hospital General Universitario Gregorio MaranonMadrid Geriatrics Medicine Department Hospital General Universitario Gregorio MarahonMadrid Department of Cardiology Hospital Universitari Josep TruetaGirona

Background Elderly patients with acute coronary syndromes(ACS)are at higher risk both for ischemic and bleeding *** guidelines recommend the PRECISE-DAPT score for bleeding risk stratification in this setting,but no study assessed its applicability in elderly *** study aimed to assess the performance of the PRECISE-DAPT score in a series of non-selected elderly patients with ACS from routine clinical *** The IFFANIAM registry included prospectively patients aged>75 years with ST segment elevation myocardial infarction(STEMI).Main outcome measured was the incidence of relevant bleeding after discharge(bleeding leading to hospital readmission,need for transfusion,intervention,stop of antithrombotic drugs or death).Bleeding risk was classified:(A)according to PRECISE-DAPT values above or not the recommended cut-off point(>25);and(B)according to the quartiles of PRECISE-DAPT values observed in the IFFANIAM series(QI:45).Results A total of 208 patients were *** age was 81.9±4.5 *** patients(92.6%)had a PRECISE-DAPT value>25.A total of 25 patients(12.0%)had bleeding events and 49 patients(23.6%)*** significant differences regarding the incidence of bleeding were observed according to the recommended cutt of point>***,a progressive increase in the incidence of bleeding was observed across PRECISE-DAPT quartiles observed in this series(P=0.038).Conclusions The vast majority of elderly patients have PRECISE-DAPT values above the recommended cut-off point for bleeding *** different cut-off points could be a more rational approach for predicting bleeding risk in these complex patients.

关键词： Acute coronary syndromes Bleeding Prognosis The elderly

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A T follicular helper cell origin for T regulatory type 1 cells

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Cellular & Molecular Immunology 2023年第5期20卷 489-511页

作者： Patricia Solé Jun Yamanouchi josep Garnica Muhammad Myn Uddin Robert Clarke Joel Moro Nahir Garabatos Shari Thiessen Mireia Ortega Santiswarup Singha Debajyoti Mondal César Fandos Julio Saez-Rodriguez Yang Yang Pau Serra Pere Santamaria Institut D'investigacions Biomediques August Pi i Sunyer BarcelonaSpain Department of Microbiology Immunology and Infectious DiseasesSnyder Institute for Chronic DiseasesCumming School of MedicineUniversity of CalgaryCalgaryABCanada Institute of Computational Biomedicine Faculty of MedicineHeidelberg University HeidelbergGermany Department of Biochemistry and Molecular Biology Cumming School of MedicineUniversity of CalgaryCalgaryABCanada.

Chronic antigenic stimulation can trigger the differentiation of antigen-experienced CD4+T cells into T regulatory type 1(TR1)cells,a subset of interleukin-10-producing Treg cells that do not express *** identities of the progenitor(s)and transcriptional regulators of this T-cell subset remain ***,we show that the peptide-major histocompatibility complex class Il(pMHCll)monospecific immunoregulatory T-cell pools that arise in vivo in different genetic backgrounds in response to pMHCll-coated nanoparticles(pMHCll-NPs)are invariably comprised of oligoclonal subpools of T follicular helper(TFH)and TR1 cells with a nearly identical clonotypic composition but different functional properties and transcription factor expression *** analyses of scRNAseq data and multidimensional mass cytometry revealed progressive downregulation and upregulation of TFH and TR1 markers,***,pMHCIl-NPs trigger cognate TR1 cell formation in TFH cell-transfused immunodeficient hosts,and T-cell-specific deletion of Bcl6 or Irf4 blunts both the TFH expansion and TR1 formation induced by *** contrast,deletion of Prdm1 selectively abrogates the TFH-to-TR1 ***6 and Prdm1 are also necessary for anti-CD3 mAbinduced TR1 ***,TFH cells can differentiate into TR1 cells in vivo,and BLIMP1 is a gatekeeper of this cellular reprogramming event.

关键词： T-regulatory type 1(TR1)cells autoimmunity T follicular helper(TFH)cells transdifferentiation nanomedicine

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Anemia in patients with high-risk acute coronary syndromes admitted to Intensive Cardiac Care Units

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Journal of Geriatric Cardiology 2020年第1期17卷 35-42页

作者： Victoria Lorente Jaime Aboal Cosme Garcia Jordi Sans-Rosello Antonia Sambola Rut Andrea Carlos Tomas Gil Bonet David Vinas Nabil el Ouaddi Santiago Montero Javier Cantalapiedra Margarida Pujol Isabel Hernandez Maria Perez-Rodriguez Isaac Llao Jose C Sanchez-Salado Miquel Gual Albert Ariza-sole 无 Hospital Universitari de Bellvitge L’Hospitalet de LlobregatBarcelonaSpain Hospital Unversitari josep Trueta GironaSpain Hospital Universitari Germans Trias i Pujol Badalona BarcelonaSpain Hospital de la Santa Creu i Sant Pau Instituto de Investigación Biomedica IIB Sant PauUniversitat Autonoma de Barcelona(UAB)BarcelonaSpain Hospital Universitari de la Vall d’Hebron BarcelonaSpain Hospital Clinic i Provicial BarcelonaSpain Hospital Arnau de Vilanova LleidaSpain Hospital Joan XXIII TarragonaSpain the Grup de Treball de Cures Agudes Cardiologiques de la Societat Catalana de Cardiologia

Background Little information exists about the role of anemia in patients with acute coronary syndromes(ACS)admitted to Intensive Cardiac Care Units(ICCU).The aim of this study was to assess the prevalence of anemia and its impact on management and outcomes in this clinical *** All consecutive patients admitted to eight different ICCUs with diagnosis of non-ST segment elevation ACS(NSTEACS)were prospectively *** was defined as hemoglobin<130 g/L in men and<120 g/L in *** association between anemia and mortality or readmission at six months was assessed by the Cox regression *** A total of 629 patients were *** age was 66.6 years.A total of 197 patients(31.3%)had *** angiography was performed in most patients(96.2%).Patients with anemia were significantly older,with a higher prevalence of comorbidities,poorer left ventricle ejection fraction and higher GRACE score *** with anemia underwent less often coronary angiography,but underwent more often intraaortic counterpulsation,non-invasive mechanical ventilation and renal replacement *** ICCU and hospital stay were significantly longer in patients with *** the incidence of mortality(HR=3.36,95%CI:1.43–7.85,P=0.001)and the incidence of mortality/readmission were significantly higher in patients with anemia(HR=2.80,95%CI:2.03–3.86,P=0.001).After adjusting for confounders,the association between anemia and mortality/readmission remained significant(P=0.031).Conclusions Almost one of three NSTEACS patients admitted to ICCU had *** patients underwent coronary *** was independently associated to poorer outcomes at 6 months.

关键词： Acute coronary syndromes Anemia Intensive cardiac care units Prognosis

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