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现代生物医学进展 2017年第4期17卷 I0004-I0004页

作者： Brian Finan Christoffer Clemmensen Zhimeng Zhu Kerstin stemmer Karine Gauthier Luisa M uuml ller Meri De Angelis Kristin Moreth Frauke Neff Diego Perez-Tilve Katrin Fischer Dominik Lutter Miguel A. s aacute nchez-Garrido Peng Liu Jan Tuckermann Mohsen Malehmir Marc E. Healy Achim Weber Mathias Heikenwalder Martin Jastroch Maximilian Kleinert sigrid Jall sara Brandt Fr eacute d eacute ric Flamant Karl-Werner schramm Heike Biebermann Yvonne D ouml ring Christian Weber Kirk M. Habegger Michaela Keuper Vasily Gelfanov Fa Liu josef K ouml hrle Jan Rozman Helmut fuc.s Valerie Gailus-Durner Martin Hrabě de Angelis susanna M. Hofmann Bin Yang Matthias H. Tsch ouml p Richard DiMarchi Timo D. M uuml ller Institute for Diabetes and Obesity Helmholtz Diabetes Center at Helmholtz Zentrum München German Research Center for Environmental Health (GmbH) 85764 Neuherberg Germany Department of Chemistry Indiana University Bloomington IN 47405 USA Institut de Génomique Fonctionnelle de Lyon Université de Lyon Centre National de la Recherche Scientifique (CNRS) Institut National de la Recherche Agronomique (INRA) École Normale Supérieure de Lyon 69364 Lyon France Molecular EXposomics Helmholtz Zentrum München German Research Center for Environmental Health (GmbH) 85764 Neuherberg Germany German Mouse Clinic Institute of Experimental Genetics Helmholtz Zentrum München German Research Center for Environmental Health 85764 Neuherberg Germany Division of Endocrinology Department of Internal Medicine Metabolic Diseases Institute University of Cincinnati College of Medicine Cincinnati OH 45237 USA Institute of Comparative Molecular Endocrinology University of Ulm 89081 Ulm Germany Department of Pathology and Molecular Pathology University Zurich and University Hospital Zurich 8091 Zurich Switzerland Institute of Virology Technische Universität München 81675 Munich Germany Institute of Experimental Pediatric Endocrinology Charité-Universitätsmedizin Berlin Berlin 13353 Germany Department of Medicine Institute for Cardiovascular Prevention Ludwig-Maximilians-Universität München 80336 Munich Germany Comprehensive Diabetes Center and Department of Medicine-Endocrinology Diabetes & Metabolism University of Alabama at Birmingham Birmingham AL 35294 USA Institute for Diabetes and Regeneration Helmholtz Diabetes Center at Helmholtz Zentrum München German Research Center for Environmental Health (GmbH) Neuherberg 85764 Germany Calibrium LLC Carmel IN 46032 USA Institute for Experimental Endocrinology Charité-Universitätsmedizin Berlin Berlin 13353 Germany German Center for Diabetes Research (DZD) 85764 Neuherberg Germany

肥胖和糖尿病持续上升代表着我们的社会所面临的一个重大的负担。脂肪肝和动脉粥样硬化是这些代谢疾病常见的后果，但是开发一种高效且又安全的能够逆转肥胖、胰岛素抵抗性、脂肪肝和动脉粥样硬化的药物仍然是全球头等的一项重大的科学... 详细信息

肥胖和糖尿病持续上升代表着我们的社会所面临的一个重大的负担。脂肪肝和动脉粥样硬化是这些代谢疾病常见的后果，但是开发一种高效且又安全的能够逆转肥胖、胰岛素抵抗性、脂肪肝和动脉粥样硬化的药物仍然是全球头等的一项重大的科学挑战。

关键词：脂肪肝 Cell 动脉粥样硬化血液肝脏清除分子代谢疾病

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基于小波的时间分辨CT灌注脑血管成像数据分析

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国际医学放射学杂志 2015年第5期 504-505页

作者： L.Havla K.M.Thierfelder s.E.Beyer W.H.sommer O.Dietrich 曲方园 josef-Lissner-Laboratory for Biomedical Imaging Institute for Clinical RadiologyLudwig-Maximilians-University Hospital Munich

摘要目的评价在CT灌注数据中应用小波变换重建血管成像的新方法。方法连续15例可疑脑卒中病人进行多层CT检查,得到99层(总层厚99 mm)动态32期(Δt=1.5 s)影像,扫描参数为80 k V/200 m As。注射35 m L碘美普尔350,流率4.5 m L/s。利用时... 详细信息

摘要目的评价在CT灌注数据中应用小波变换重建血管成像的新方法。方法连续15例可疑脑卒中病人进行多层CT检查,得到99层(总层厚99 mm)动态32期(Δt=1.5 s)影像,扫描参数为80 k V/200 m As。注射35 m L碘美普尔350,流率4.5 m L/s。利用时间滤过最大密度投影(t MIP)和每个体素时程的小波变换(Paul wavelet,order 1)对血管成像数据进行

关键词：脑血管小波变换血管成像 CT

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腹主动脉瘤腔内修复术后早期II型内漏的CT特点有助于预测动脉瘤囊状扩张

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国际医学放射学杂志 2015年第3期 275-276页

作者： R.Muller-Wille s.schotz F.Zeman W.Uller O.Guntner K.Pfister 徐甜甜 Department of Radiology University Medical Center RegensburgFranz-Josef-Strauss-Allee 1193053 Regensburg Germany

目的明确腹主动脉瘤行血管腔内修复术后囊状扩张并且早期Ⅱ型内漏的CT特点。方法该回顾性研究无需机构伦理委员会批准。回顾了56例病人的影像和临床资料

关键词： CT特点 II 囊状扩张腔内修复术内漏伦理委员会腰动脉临床资料漏血肠系膜下动脉

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幼儿成神经管细胞瘤术后的单纯化疗

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世界核心医学期刊文摘（儿科学分册） 2005年第8期1卷 2-2页

作者： Rutkowski s. Bode U. Deinlein F. 张振 Department of Pediatric Oncology Children's Hospital University of Wü rzburg Josef- Schneider- Str. 2 D- 97080 Wü rzburg Germany Dr.

BACKGROUND: The prognosis for young children with medulloblastoma is poor, an d survivors are at high risk for cognitive deficits. We conducted a trial of the treatment of this brain tumor by intensive postoperative chemotherapy alone. ME THODs: After surgery, children received three cycles of intravenous chemotherapy (cyclophosphamide, vincristine, methotrexate, carboplatin, and etoposide) and i ntraventricular methotrexate. Treatment was terminated if a complete remission w as achieved. Leukoencephalopathy and cognitive deficits were evaluated. REsULTs: Forty- three children were treated according to protocol. In children who had complete resection (17 patients), residual tumor (14), and macroscopic metastase s (12), the five- year progression- free and overall survival rates (± sE) we re 82± 9 percent and 93± 6 percent, 50± 13 percent and 56± 14 percent, and 3 3± 14 percent and 38± 15 percent, respectively. The rates in 31 patients witho ut macroscopic metastases were 68± 8 percent and 77± 8 percent. Desmoplastic h istology, metastatic disease, and an age younger than two years were independent prognostic factors for tumor relapse and survival. Treatment strategies at rela pse were successful in 8 of 16 patients. There were no major instances of unexpe cted toxicity. In 19 of 23 children, asymptomatic leukoencephalopathy was detect ed by magnetic resonance imaging. After treatment, the mean IQ was significantly lower than that of healthy controls within the same age group but higher than t hat of patients in a previous trial who had received radiotherapy. CONCLUsIONs: Postoperative chemotherapy alone is a promising treatment for medulloblastoma in young children without metastases.

关键词：成神经管细胞瘤氨甲喋呤肿瘤转移脑室内脑肿瘤认知障碍脑白质病肿瘤病灶肿瘤复发平均智商

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习惯性自然流产史女性凝血异常和高凝突变的评估

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世界核心医学期刊文摘（妇产科学分册） 2005年第4期1卷 53-53页

作者： Bussen s. Mulfinger L. Frambach T. 王雅楠 Universitts-Frauenklinik Josef-Schneider-Straβe 4 97080 Würzburg Germany

Purpose: This study was undertaken to evaluate the incidence of haemostatic abnormalities and hypercoagulation mutations in women with a history of three or more consecutive spontaneous abortions and to investigate the influence of the antiphospholipid autoantibody status. Material and Methods: 20 nonpregnant habitual aborters were analysed for prothrombin time, activated partial thromboplastin time, fibrinogen, plasminogen, protein s, protein C, antithrombin III, and antiphospholipid autoantibodies. Genetic analysis was performed to detect factor V Leiden mutation and factor II G20210A mutation. Twenty healthy nonpregnant multigravidae served as controls. Results: The incidence of haemostatic abnormalities or of factor II or V Leiden mutations did not differ significantly between women with a history of recurrent spontaneous abortion and controls. In 9 of 20 women with recurrent spontaneous abortions antiphospholipid autoantibodies (APA) were detectable. APApositive and APAnegative study patients revealed similar results with respect to the investigated coagulation values Conclusion: According to our observations a general screening for hereditary coagulation disorders or hypercoagulation mutations should not be included in the routine workup of women with a history of recurrent spontaneous abortions unless there is a history of familiar thrombophilia.

关键词：自然流产史习惯性流产凝血异常抗磷脂自身抗体血栓形成倾向抗凝血酶Ⅲ 凝血因子遗传分析无显著性差异经产

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单纯术后化疗治疗儿童早期髓母细胞瘤

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世界核心医学期刊文摘（神经病学分册） 2005年第9期1卷 6-6页

作者： Rutkowski s. Bode U. Deinlein F. 黄卫东 Department of Pediatric Oncology Children's Hospital University of Würzburg Josef-Schneider-Str. 2 D-97080 Würzburg GermanyDr.

BACKGROUND: The prognosis for young children with medulloblastoma is poor, and survivors are at high risk for cognitive deficits. We conducted a trial of the treatment of this brain tumor by intensive postoperative chemotherapy alone. METHODs: After surgery, children received three cycles of intravenous chemotherapy (cyclophosphamide, vincristine, methotrexate, carboplatin, and etoposide) and intraventricular methotrexate. Treatment was terminated if a complete remission was achieved. Leukoencephalopathy and cognitive deficits were evaluated. REsULTs: Forty-three children were treated according to protocol. In children who had complete resection (17 patients), residual tumor (14), and macroscopic metastases (12), the five-year progression-free and overall survival rates (±sE) were 82±9 percent and 93±6 percent, 50±13 percent and 56±14 percent, and 33±14 percent and 38±15 percent, respectively. The rates in 31 patients without macroscopic metastases were 68±8 percent and 77±8 percent. Desmoplastic histology, metastatic disease, and an age younger than two years were independent prognostic factors for tumor relapse and survival. Treatment strategies at relapse were successful in 8 of 16 patients. There were no major instances of unexpected toxicity. In 19 of 23 children, asymptomatic leukoencephalopathy was detected by magnetic resonance imaging. After treatment, the mean IQ was significantly lower than that of healthy controls within the same age group but higher than that of patients in a previous trial who had received radiotherapy. CONCLUsIONs: Postoperative chemotherapy alone is a promising treatment for medulloblastoma in young children without metastases.

关键词：髓母细胞瘤甲氨蝶呤脑室内注射脑病依托泊苷无症状性毒副作用长春新碱

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克拉屈滨可用于治疗系统性肥大细胞增生症

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世界核心医学期刊文摘（皮肤病学分册） 2005年第1期1卷 29-29页

作者： schleyer V. Meyer s. Landthaler M. szeimies R.-M. 田中伟 Klin.und Poliklin.fur Dermatologie Universitt Regensburg Franz-Josef-Strauss-Allee 11 93053 Regensburg Germany Dr.

Mastocytoses are a heterogenous group of diseases characterized by proliferation and accumulation of mast cells in the skin and other *** are subdivided into cutaneous mastocytoses; systemic forms, which may appear with or without skin lesions; mast cell sarcomas and extracutaneous, localized, benign *** mastocytoses apart from the skin mainly involve bone marrow, gastrointestinal tract, bones, lymph nodes, spleen and *** indolent forms of systemic mastocytosis are mainly treated with antihistamines, glucocorticosteroids and PUVA therapy, the more aggressive forms, including mast cell leukemia, often require cytostatic chemotherapy.A 53-year old patient with beginning “smoldering systemic mastocytosis”failed to respond to high-dose systemic glucocorticosteroids and interferon-α.Treatment with cladribine led to an impressive improvement of skin lesions, a significant decrease in tryptase serum levels and stabilization of bone marrow infiltrates.

关键词：肥大细胞增生克拉屈滨肥大细胞白血病抗组胺药骨髓浸润异质性疾病化学疗法类胰蛋白酶糖皮质激素 α-干扰素

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用定量时间-密度曲线的线性组合特征对CT灌注数据区分动脉和静脉血管的方法进行验证

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国际医学放射学杂志 2015年第6期 607-607页

作者： L.Havla M.schneider K.M.Thierfelder s.E.Beyer B.Ertl-Wagner W.H.sommer 冀晓东 josef Lissner Laboratory for Biomedical Imaging Institute for Clinical RadiologyLudwig-Maximilians-University Hospital Munich

摘要目的旨在开发和评估一种新的方法,使用基于体素的CT灌注参数可靠地区分脑动脉和静脉。材料与方法采用多层CT成像系统对14例疑似脑卒中但无病理结果的病

关键词：密度曲线密度-曝光量对数曲线静脉血管静脉动脉线性组合 CT

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