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Value of cardiac magnetic resonance on the risk stratification of cardiomyopathies

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World Journal of Cardiology 2023年第10期15卷 487-499页

作者： Rafael Vidal-Perez Mariana Brandao Wael Zaher Ruben Casado-Arroyo Alberto Bouzas-Mosquera Ricardo Fontes-Carvalho jose Manuel Vazquez-Rodriguez Servicio de Cardiologia Unidad de Imagen y Funcion CardiacaComplexo Hospitalario Universitario A Coruña Centro de Investigacion Biomedica en Red de Enfermedades Cardiovasculares(CIBERCV)A Coruna 15006GaliciaSpain Department of Cardiology Centro Hospitalar de Vila Nova de Gaia/EspinhoVila Nova de Gaia 4434-502Portugal Department of Cardiology Hôpital ErasmeUniversite Libre de BruxellesBrussels 1070BrusselsBelgium Cardiovascular R&D Centre-UnIC@RISE Department of Surgery and PhysiologyFaculty of Medicine of the University of PortoPorto 4200-319Portugal Servicio de Cardiología Complexo Hospitalario Universitario A CoruñaA Coruña 15006A CoruñaSpain

Cardiomyopathies represent a diverse group of heart muscle diseases with varying etiologies,presenting a diagnostic challenge due to their heterogeneous *** evaluation using cardiac imaging techniques is impera-tive as symptoms can evolve over *** imaging approaches are pivotal for accurate diagnosis,treatment planning,and optimizing prognostic *** these,cardiovascular magnetic resonance(CMR)stands out for its ability to provide precise anatomical and functional *** manuscript ex-plores the significant contributions of CMR in the diagnosis and management of patients with cardiomyopathies,with special attention to risk ***’s high spatial resolution and tissue characterization capabilities enable early detec-tion and differentiation of various cardiomyopathy ***,it offers valuable insights into myocardial fibrosis,tissue viability,and left ven-tricular function,crucial parameters for risk stratification and predicting adverse cardiac *** integrating CMR into clinical practice,clinicians can tailor patient-specific treatment plans,implement timely interventions,and optimize long-term *** non-invasive nature of CMR reduces the need for invasive procedures,minimizing patient *** review highlights the vital role of CMR in monitoring disease progression,guiding treatment decisions,and identifying potential complications in patients with *** utilization of CMR has significantly advanced our understanding and management of these complex cardiac conditions,leading to improved patient outcomes and a more personalized approach to care.

关键词： Cardiac magnetic resonance Cardiomyopathies Prognosis Dilated cardiomyopathy hypertrophic cardiomyopathy Restrictive cardiomyopathy

Electron Donor Systems to Facilitate Development of Assays for Two Flavoproteins Involved in Tetrahydromethanopterin Biosynthesis

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Advances in Microbiology 2020年第6期10卷 275-294页

作者： Chao Pang jose Moscaira Jenny Gong Madeline E. Rasche Department of Chemistry and Biochemistry California State University at Fullerton Fullerton CA USA

Methane production by archaea depends on tetrahydromethanopterin (h4MPT), a pterin-containing cofactor that carries one-carbon units. Two redox reactions within the nine steps of h4MPT side chain biosynthesis have bee... 详细信息

Methane production by archaea depends on tetrahydromethanopterin (H4MPT), a pterin-containing cofactor that carries one-carbon units. Two redox reactions within the nine steps of H4MPT side chain biosynthesis have been hypothesized. Biochemical assays have demonstrated that the archaeal iron-sulfur flavoprotein dihydromethanopterin reductase X (DmrX or MM1854) catalyzes the final reaction of the pathway, the reduction of dihydromethanopterin to H4MPT, using dithiothreitol (DTT) as an artificial electron donor. The crystal structure of DmrB, a bacterial DmrX homolog that lacks iron-sulfur clusters, has led to a proposed ping-pong mechanism of electron transfer between FMNH2 and the FMN prosthetic group of DmrB. However, an enzymatic assay to test the hypothetical DmrB mechanism is lacking because a suitable electron donor has not previously been identified. Furthermore, a second uncharacterized archaeal flavoprotein (MM1853) has been hypothesized to function in H4MPT side chain biosynthesis. In this work, to facilitate the development of assays to elucidate the functions of DmrB and MM1853, we tested a variety of electron donors, including dithiothreitol, ferredoxin, and a system consisting of NADH and an NADH-dependent fla

关键词： Methanopterin Coenzyme Biosynthesis Dihydromethanopterin Reductase Flavoprotein Archaea Methanogenesis

Agro-Industrial Waste as a Source of Raw Material:Eggshell and Ash of Agave salmiana Useful for the Synthesis of hydroxyapatite

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Journal of Renewable Materials 2022年第12期10卷 3559-3572页

作者： Nora Elizondo-Villarreal Luz hVerástegui-Dominguez jose JQuijano-Briones Francisco JVázquez-Rodríguez Eden Rodríguez-Castellanos Enrique López-Cuellar Ernesto Torres-Lopez Victor MCastaño-Meneses Universidad Autónoma de Nuevo León Facultad de Ciencias Fisico MatemáticasCiudad UniversitariaSan Nicolás de los GarzaNuevo LeónMéxico Universidad Autónoma de Nuevo León Facultad de ArquitecturaCiudad UniversiariaSan Nicolás de los GarzaNuevo LeónMéxico Universidad Autónoma de Nuevo León Facultad de Ingeniería Mecainicay EléctricaCiudad UniversitariaSan Nicolás de los GarzaNuevo LeónMéxico Centro de Física Aplicada y Tecnología Avanzada Universidad Nacional Autonoma de MéxicoQuerétaroMéxico

Agave salmiana ash and poultry eggshell powder as CaO sources were used for obtaining nanostructured hydro-xyapatite(hAP).The synthesis was carried out by the Green Chemistry hydrothermal Biosynthesis at 180℃ with a ph of 5,by reacting CaO from Agave Salmiana ash and Eggshell powder,with dibasic caldium phosphate(Cah-PO_(4)+2h_(2)O)in an aqueous solution,with Aloe barbadensis *** product was characterized by X-ray dif-fraction,Fourier transform infrared spectroscopy(FT-IR),Scanning Electron Microscopy(SEM),and Transmission Electron Microscopy(TEM).The size and shape of the hydroxyapatite particles changed dramati-cally in the presence of Aloe *** crystals of hydroxyapatite were observed when Eggshell powder and Agave salmiana ash were used as raw materials in the presence of the Aloe barbadensis *** with shapes of ribbons and plates from 1 micrometers to 8 micrometers were observed when using the eggshell powder in the presence of Aloe bar badensis and,in the case of Agave salmiana ash in the presence of Aloe bar-badensis,crystals with shapes of quadra ngular prisms and hexagonal(polyhedra)with sizes from 2 micrometers to 20 micrometers were *** was therefore successfully biosynthesized by a green and sus-tainable method that reduces the environmental impact.

关键词： hydroxyapatite raw materials Agave salmiana eggshell Aloe barbadensis surfactant

Low prevalence of germline hMSh6 mutations in colorectal cancer families from Spain

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World Journal of Gastroenterology 2005年第37期11卷 5770-5776页

作者： Ana Sánchez de Abajo Miguel de la hoya Alicia Tosar Javier Godino Juan Manuel Fernández jose Lopez Asenjo Beatriz Perez Villamil Pedro Perez Segura Eduardo Diaz-Rubio Trinidad Caldes Laboratorio de Oncología Molecular hospital Clinico San Carlos Madrid Spain Servicio de Anatomía Patológica hospital Clinico San Carlos Madrid Spain Servicio de Oncología Médica hospital Clinico San Carlos Madrid Spain

AIM: To investigate the prevalence and penetrance of hMSh6 mutations in Spanish hNPCC families that was negative for mutation in hMLh1 or ***: We used PCR-based DGGE assay and direct Sequencing to screen for hMSh6 gene in 91 hNPCC ***: we have identified 10 families with germ-line mutations in the DNA sequence. These mutations included two intronic variation, three missense mutation, one nonsense mutation, and four silent mutations. Among the 10 germ-line mutations identified in the Spanish cohort,8 were novel, perhaps, suggesting different mutational spectra in the Spanish population. Detailed pedigrees were constructed for the three families with a possible pathogenic hMSh6 mutation. The two silent mutations h388h and L758L, detected in a person affected of colorectal cancer at age 29, produce loss of the wild-type allele in the tumor sample. Immunohistochemical analysis showed that expression of MSh6 protein was lost only in the tumors from the carriers of V878A and Q263X ***: Altogether, our results indicate that disease-causing germ-line mutations of hMSh6 are very less frequent in Spanish hNPCC families.

关键词： hNPCC MMR hMSh6 MSI IhC SPANISh

Characterization of fungal pathogens associated with grapevine trunk diseases in Arkansas and Missouri

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Fungal Diversity 2012年第1期52卷 169-189页

作者： jose Ramon Urbez-Torres Francesca Peduto R.K.Striegler K.E.Urrea-Romero J.C.Rupe R.D.Cartwright W.D.Gubler Pacific Agri-Food Research Centre 4200 Highway 97Box 5000SummerlandBC V0H1Z0Canada Department of Plant Pathology University of California DavisDavisCA 95616USA Institute for Continental Climate Viticulture&Enology University of MissouriColumbiaMO 65211USA

Grapevine trunk diseases are a major concern to the wine-and table-grape industries worldwide,limiting both vineyard longevity and *** surveys conducted throughout the grape-growing regions of Arkansas and Missouri revealed the presence of three economically important grapevine trunk diseases including,Botryosphaeria canker,Eutypa dieback and *** studies along with multi-gene phylogenetical analyses confirmed the identification of 15 different fungal taxa associated with different vascular *** include Botryosphaeria dothidea,Diatrypella sp.,Diplodia seriata,Dothiorella americana,Eutypa lata,Eutypella vitis,Lasiodiplodia missouriana,Lasiodiplodia viticola,Neofusicoccum ribis,Neofusicoccum vitifusiforme,Pestalotiopsis sp.,Pestalotiopsis uvicola,Phaeomoniella chlamydospora,Phomopsis viticola,Schyzophyllum commune,and Togninia *** of these represent new records on grapevines in Arkansas and *** americana,*** and *** are described as new species,and both *** and *** are first reported as grapevine pathogens in North ***’s postulates confirmed the pathogenicity of all fungal species except *** in the interspecific hybrids Vignoles,Chambourcin,Norton,and *** spp.,***,and *** were the most virulent fungi,while ***,*** and *** were considered to be weak *** research highlights the importance that grapevine trunk diseases have on grapevine health in growing regions where,due to different climatological conditions,interspecific hybrid cultivars are predominantly grown.

关键词： Botryosphaeriaceae Canker Diatrypaceae Eutypa dieback Esca Grape hybrid Multi-gene phylogeny Phomopsis viticola Vitis vinifera

XRD Characterization of Crystallinity of human Tooth Enamel under Influence of Mechanical Grinding

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Materials Sciences and Applications 2015年第6期6卷 464-472页

作者： jose Reyes-Gasga Olga Koudriavtseva Raul herrera-Becerra Arturo Escobosa Instituto de Física UNAM Circuito de la Investigación s/n Ciudad Universitaria México D.F. México Dep. Ingeniería Eléctrica—SEES CINVESTAV—IPN México D.F. México

Crystallinity refers to the degree of structural order in a solid and has a big influence on hardness, density, transparency and diffusion. Even within materials that are crystalline completely, the degree of structural perfection can vary, reflecting size and elastic strain of many independent crystalline regions (grains or crystallites) of which these materials are composed. In this work it was attempted to reduce the crystallinity of human enamel using a technique of mechanical grinding (MG) with an ultra-compact FRITSCh Mini-Mill PULVERISETTE 23 machine. Variation in the crystallinity through the MG was monitored by X-ray diffraction (XRD) by broadening of the diffraction peak and examined using the Williamson-hall plot method. Crystallites in human enamel are regularly arranged and oriented (in the [001] direction) perpendicularly to the interface of enameldentin junction. The results showed an anisotropic feature in crystallinity. Reduction of the crystallinity along the a-axis is due to the crystal strain rather than to the refinement of crystal, and vice versa along the c-axis. After 230 h of the MG, the length of crystallites decreased from 100 nm to 30 nm and width from 40 nm to 37 nm approximately.

关键词： human Tooth Enamel Crystal Structure Mechanical Grinding X-Ray Diffraction Crystallites

LJItrasensitive h2S gas sensors based on p-type WS2 hybrid materials

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Nano Research 2018年第8期11卷 4215-4224页

作者： Georgies Alene Asrest jose J. Baldovi Aron Dombovari Topias Jarvinen Gabriela Simone Lorite Melinda Mohl Andrey Shchukarev Alejandro Perez Paz Lede Xian Jyri-Pekka Mikkola Anita Lloyd Spetz heli Jantunen Angel Rubio Krisztian Kordas Microelectronics Research Unit Faculty of Information Technology and Electrical Engineering University of Oulu P.O. Box 4S00FI-90014 Oulu Finland Max Planck Institute for the Structure and Dynamics of Matter Luruper Chaussee 149 22761 Hamburg Germany Nano-Bio Spectroscopy Group European Theoretical Spectroscopy Facifity (ETSF) Universidad del Pals Vasco CFM SCIC-UPV/EHU-MPC DIPC A venida Tolosa 72 20018 San Sebastian Spain Technical Chemistry Department of Chemistry Chemical-Biological Centre Umea University SE-90187 Umea Sweden School of Chemical Sciences and Engineering School of Physics and Nanotechnology Yachay Tech University Urcuquf Ecuador Industrial Chemistry & Reaction Engineering Department of Chemical Engineering Johan Gadolin Process Chemistry Centre AboAkademi University FI-20500 Abo-Turku Finland Sensor and Actuator Systems Department of Physics Chemistry and Biology Link~ping University SE-58183 LinkOping Sweden

Owing to their higher intrinsic electrical conductivity and chemical stability with respect to their oxide counterparts, nanostructured metal sulfides are expected to revive materials for resistive chemical sensor applications. herein, we explore the gas sensing behavior of WS2 nanowire-nanoflake hybrid materials and demonstrate their excellent sensitivity （0.043 ppm-1） as well as high selectivity towards h2S relative to CO, Nh~, h2, and NO （with corresponding sensitivities of 0.002, 0.0074, 0.0002, and 0.0046 pprn-1, respectively）. Gas response measurements, complemented with the results of X-ray photoelectron spectroscopy analysis and first-principles calculations based on density functional theory, suggest that the intrinsic electronic properties of pristine WS2 alone are not sufficient to explain the observed high sensitivity towards h2S. A major role in this behavior is also played by O doping in the S sites of the WS2 lattice. The results of the present study open up new avenues for the use of transition metal disulfide nanomaterials as effective alternatives to metal oxides in future applications for industrial process control, security, and health and environmental safety.

关键词： ws nanowire nanoflake gas sensor h2S,O doping

Effect of Thickness on Magnetic Dipolar and Exchange Interactions in SmCo/FeCo/SmCo Thin Films

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Advances in Materials Physics and Chemistry 2015年第9期5卷 368-373页

作者： Carlos Ivan Rodriguez Rodriguez jose Rurik Farias Mancilla Karla Edith Vega Chavez Francisco Espinosa Magana Sion Federico Olive Mendez jose Trinidad Elizalde Galindo Instituto de Ingenieria y Tecnologia Universidad Autonoma de Ciudad JuarezCiudad JuarezMexico Universidad Tecnologica de Ciudad Juarez Ciudad JuarezMexico Centro de Investigacion de Materiales Avanzados(CIMAV) ChihuahuaMexico

SmCo/FeCo/SmCo trilayer was deposited with two different thickness configurations for soft phase (FeCo);50 nm/10 nm/50 nm and 50 nm/25 nm/50 nm were deposited on Si (111) substrate and Ta (50 nm) seed layer by RF magnetron sputtering in a pressure, p, of 30 - 35 m Torr. After deposition the films were annealed under Ar atmosphere at temperature T equal to 923 and 973 for different times followed by quenching in water. X-ray diffraction patterns were obtained to identified phase presents and calculate average crystallite size. To study the effect of configuration thickness in soft phases, DC magnetic measurements were carried out;the measurements were done in the temperature interval of 300 - 50 K. hysteresis loops collected at low temperatures exposed an increment in coercivity with the decrease of T and at same time, presented a “knee” in the second quadrant of the demagnetization curve, which suggests that the inter-layer exchange coupling becomes less effective, being more evident for sample with 50 nm/25 nm/50 nm thickness. Moreover, δM (h) plots were calculated from magnetic measurements at three different temperatures, T, equal to 300, 150 and 50 K, which corroborates that the dipolar interactions became stronger when thickness of soft phases increases. Finally, the thickness effect is attributed to the SmCo5 phase magnetocrystalline anisotropy constant, which is responsible for the exchange coupling length.

关键词： Exchange Interactions Dipolar Interaction Anisotropy

Can the host phylogeny(Chiroptera)influence the com m unity of ectoparasite flies(Diptera)?

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Current Zoology 2020年第3期66卷 331-332页

作者： Rayanna h.S.BEZERRA Adriana BOCChIGLIERI Universidade Federal de Sergipe Programa de Pos-graduaqao em Ecologia e ConservaqaoLaboratorio de MastozoologiaCidade Universitaria Prof.Jose Aloisio de CamposSao CristovaoSEBrazil

Among the factors thar may influence parasitism are ecological and phylogenetic aspects(Krasnov et al.2005),where a host species may acquire a parasite by contact with other hosts co-occurring in a given environment or because of its ancestor(hoberg and Brooks 2008).Thus,the parasite community can be considered a reflection of the ecological characteristics and the phylogeny of the host(Krasnov et al.2005).

关键词： phylogeny Diptera