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急性缺血性脑血管病人长期服用抗血小板药物对血小板...

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中华神经精神科杂志 1991年第1期24卷 21-23页

作者：韩思吉 jose.,r

Modeling Groundwater Levels on the Calera Aquifer region in Central Mexico Using ModFIow

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Journal of Agricultural Science and Technology(B) 2012年第1期2卷 52-61页

作者： Jairo E. Hernandez Prasanna H. Gowda Terry A. Howell Jean L. Steiner Francisco Mojarro Ernesto P.Nfifiez jose. r. Avila Department of Civil Engineering Boise State University Boise ID 83725-2060 USA USDA-ArS-Conservation and Production research Laboratory Bushland TX 79012-0010 USA USDA-ArS-Grazinglands research Laboratory St. E1 Reno OK 73036 USA Universidad Aut6noma de Zacatecas Zacatecas C.P. 98000 Mexico Universidad A ut6noma de Zacatecas Calzada de la Universidad 108 Col Progreso Zacatecas C.P. 98058 Mexico

A conceptual model for the Calera Aquifer has been created to represent the aquifer system beneath the Calera Aquifer region （CAr） in the State of Zacatecas, Mexico. The CAr area was uniformly partitioned into a 500 x 500 m grid generating a high resolution model that represented the natural boundaries of the aquifer. A computer model was calibrated and validated to verify output from the model corresponding to situations that matched the historical aquifer performance. Predicted groundwater levels were compared with measured data collected from nine observation wells between 1954 and 2004 to evaluate model performance. The main objective of this study was to develop and evaluate a groundwater modeling system using ModFlow-2000 for the CAr. Performance statistics indicated that the model performed well in simulating historic groundwater levels in the central part of the CAr where irrigated agriculture was concentrated. results evaluation yielded average coefficients of determination of 0.81 and 0.67 and root mean square error values lower than 25.1 m and 25.9 m for the calibration and validation processes, respectively. These results are indicative of a good agreement between predicted and observed groundwater levels. However, further improvements in the conceptual model may be needed to improve predictions in other parts of the CAr for evaluating alternative groundwater management strategies.

关键词： Water management irrigation groundwater modeling ModFlow Calera aquifer.

Unveiling the brain’s symphony:exploring the necessity and sufficiency of neural networks in behavior control

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Neural regeneration research 2025年第1期20卷 186-187页

作者： Fernando jose.Bustos Instituto de Ciencias Biomedicas Facultad de Medicina y Facultad de Ciencias de la VidaUniversidad Andres BelloSantiagoChile Millennium Nucleus of Neuroepigenetics and Plasticity(EpiNeuro) SantiagoChile

Since the pioneering work by Broca and Wernicke in the 19th century,who examined individuals with brain lesions to associate them with specific behaviors,it was evident that behaviors are complex and cannot be fully attributable to specific brain areas ***,they involve connectivity among brain areas,whether close or *** that time,this approach was considered the optimal way to dissect brain circuitry and *** pioneering efforts opened the field to explore the necessity or sufficiency of brain areas in controlling behavior and hence dissecting brain ***,the connectivity of the brain and the mechanisms through which various brain regions regulate specific behaviors,either individually or collaboratively,remain largely *** animal models,researchers have endeavored to unravel the necessity or sufficiency of specific brain areas in influencing behavior;however,no clear associations have been firmly established.

关键词： behavior connectivity neural

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白内障对全自动视野计测定结果的影响

中华眼科杂志 1993年第1期29卷 13-15页

作者： jose.,FI 姚克杭州，浙江医科大学附属第二医院眼科 310009 瑞士巴塞尔大学眼科医院

在分析视野结果时,应排除白内障的影响。我们用晶体混浊度测定仪(Opacity Lensmeter 701)和Octopus全自动视野计G1程序对58例(58只眼)白内障及人工晶体手术病人进行术前晶体混浊度定量测定和术前后视野比较。视野结果显示术前后平均缺损... 详细信息

在分析视野结果时,应排除白内障的影响。我们用晶体混浊度测定仪(Opacity Lensmeter 701)和Octopus全自动视野计G1程序对58例(58只眼)白内障及人工晶体手术病人进行术前晶体混浊度定量测定和术前后视野比较。视野结果显示术前后平均缺损度(mean defect,MD)差异有显著性(Prrected loss variance,CLV)差异无显著性(P>0.05),提示白内障引起的视野改变仅为弥散性缺损。平均累积缺损曲线术前后平行位移亦证实了此结果。术前晶体混浊度读数视力、术前后MD差值均呈相关性(P<0.0001),提示用晶体混浊度测定仪结合视力检查可以评价白内障对视野影响的程度。

关键词：白内障视野

An in vitro and in silico study of anti-dermatophytic activity of gossypol from fruits of Thespesia populnea(L.)*** Correa

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Asian Pacific Journal of Tropical Biomedicine 2021年第12期11卷 543-552页

作者： Anuthara r Sebastian jose.Midhun Jyothis Mathew Microbiology research Lab School of BiosciencesMahatma Gandhi UniversityKottayamKeralaIndia

Objective:To isolate,purify,and characterize gossypol from the fruits of Thespesia populnea(L)*** Correa,test its antidermatophytic activity,identify its targets on the dermatophyte,and confirm the binding of gossypol with the fungal target by molecular docking ***:Gossypol from Thespesia populnea was characterized by high performance liquid chromatography,liquid chromatographmass spectrometry,Fourier transform infrared spectroscopy,and nuclear magnetic *** anti-dermatophytic activity of gossypol was tested against four different dermatophytes,*** mentagrophytes,Trichophyton rubrum,Microsporum canis,and Microsporum *** mentagrophytes was selected for further *** inhibitory mode of action of gossypol on Trichophyton mentagrophytes was determined by analyzing the modulation of gene expression in various pathways of the ***:Gossypol inhibited all the *** minimum inhibitory concentrations were 12.5μg/mL for Trichophyton mentagrophytes and Microsporum canis and 25μg/mL for Trichophyton rubrum and Microsporum *** minimum fungicidal concentrations were 50μg/mL for Trichophyton mentagrophytes,100μg/mL for Microsporum canis and Trichophyton rubrum,and 200μg/mL for Microsporum *** inhibited the mrNA expression of metalloprotease(MEP4)and isocitrate lyase(ICL).The binding of gossypol with the enzymes was confirmed by molecular docking *** best docking poses were found and the low binding energies were recorded with the two target ***:Gossypol is a potential antifungal agent and can be further explored as an anti-dermatophytic drug.

关键词： Thespesia populnea Gossypol Anti-dermatophytic activity Trichophyton mentagrophytes Mechanism of action Gene expression Molecular docking Metalloprotease MEP4 Isocitrate lyase ICL

A New Phasor Estimator for PMU Applications:P Class and M Class

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Journal of Modern Power Systems and Clean Energy 2020年第1期8卷 55-66页

作者： jose.r.razo-Hernandez Arturo Mejia-Barron David Granados-Lieberman Martin Valtierra-rodriguez jose.F.Gomez-Aguilar ENAP-research Group Facultad de IngenieríaUniversidad Autónoma de Querétaro(UAQ)San CayetanoC.P.76807México ENAP-research Group Departamento de Ingeniería ElectromecánicaInstituto Tecnológico Superior de Irapuato(ITESI)Colonia El CopalC.P.36821México CONACyT-Centro Nacional de Investigación y Desarrollo Tecnológico(CENIDET) Tecnológico Nacional de MéxicoInterior Internado Palmira S/NCol.PalmiraC.P.62490México

Phasor measurement units(PMUs)are fundamental tools in the applications of modern power systems,where synchronized phasor estimations are *** accuracy and dynamic performance requirements for phasor,frequency,and rate of change of frequency(rOCOF)estimations are established in the IEEE Std.C37.118.1-2011 along with the IEEE Std.C37.118.1 a-2014,where two PMU performances are suggested:P class filters for applications requiring fast response and M class filters for applications requiring high rejection to aliased *** this paper,a methodology to design new phasor estimators that satisfy the P class and M class requirements in PMUs is *** proposed methodology is based on finite impulse response filters,brick-wall filters,and complex filter design concepts,where frequency range,time performance,harmonic rejection and out-of-band interference requirements are considered in its design.A comparative analysis using the reference model given by the IEEE Std.C37.118.1 is *** results show the effectiveness of the phasor estimators under steady-state and dynamic conditions according to the PMU standard,making them suitable tools for applications in power systems.

关键词： Brick-wall filter complex filter IEEE Std.C37.118.1 M class P class phasor measurement unit(PMU) phasor estimator

Secreted protein acidic and rich in cysteine(SPArC)induces epithelial-mesenchymal transition,enhancing migration and invasion,and is associated with high Gleason score in prostate cancer

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Asian Journal of Andrology 2019年第6期21卷 557-564页

作者： Fernanda Lopez-Moncada Maria jose.Torres Enrique A Castellon Hector r Contreras Department of Basic and Clinic Oncology Faculty of Medic泊eUniversity of ChileSantiago 8389100Chile

Secreted protein acidic and rich in cysteine(SPArC)is a matricellular protein highly expressed in bone tissue that acts as achemoattractant factor promoting the arrival of prostate cancer(PCa)cells to the bone ***,the contribution of SPArCduring the early stages of tumor progression remains *** this study,we show that SPArC is highly expressed in PCa tissueswith a higher Gleason *** stable knockdown and overexpression of SPArC in PC3 and LNCaP cells,respectively,here wedem on strate that en doge nous SPArC induces the epithelial-mesenchymal tran sition(EMT),decreasing E-cadheri n and cytokeratin18 and increasing N-cadheri n and vime ***,SPArC in duces the expression of EMT regulatory tran scription factors Snailfamily transcriptional repressor 1(Snail),Snail family transcriptional repressor 2(Slug),and zinc finger E-box binding homeobox 1(Zeb1).In addition,SPArC knockdown in PC3 cells decreases migration and invasion in vitro,without modifying cell *** results indicate that SPArC might facilitate tumor progression by modifying the cellular phenotype in cancer cells.

关键词： epithelial-mesenchymal transition invasion migration prostate cancer secreted protein acidic and rich in cysteine(SPArC)

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脂蛋白与动脉粥样化形成

美国医学会杂志（中文版） 1991年第4期10卷 221-227页

作者： Dani.,S jose.,LW

Challenges and improvement strategies in the hospitalization of chronic multimorbid patients

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World Journal of Clinical Cases 2025年第3期13卷 35-41页

作者： Andres Fontalba-Navas Francisco Pozo Muñoz rogelio Garcia Cisneros Maria jose.Garcia Larrosa Maria del Mar Callejon Gil Ignacio Garcia Delgado Maria Belen Jimenez Martinez Antequera Hospital Northern Málaga Integrated Healthcare AreaAntequera 29200AndalusiaSpain Department of Public Health and Psychiatry University of MálagaMálaga 29010Spain Antequera Hospital Northern Málaga Antequera Integrated Healthcare AreaAntequera 29200MálagaSpain

BACKGrOUND Addressing the growing challenge of hospitalizing chronic multimorbid patients,this study examines the strain these conditions impose on healthcare systems at a local level,focusing on a pilot *** diseases and complex patients require comprehensive management strategies to reduce healthcare burdens and improve patient *** proven effective,this pilot model has the potential to be replicated in other healthcare settings to enhance the management of chronic multimorbid *** To evaluate the effectiveness of the high complexity unit(HCU)in managing chronic multimorbid patients through a multidisciplinary care model and to compare it with standard hospital *** The study employed a descriptive longitudinal approach,analyzing data from the Basic Minimum Data Set(BMDS)to compare hospitalization variables among the HCU,the Internal Medicine Service,and other services at Antequera Hospital throughout *** HCU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity *** The study employed a descriptive longitudinal approach,analyzing data from the BMDS to compare hospitalization variables among the HCU,the Internal Medicine Service,and other services at Antequera Hospital throughout *** HCU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity *** This study demonstrates the effectiveness of the HCU in managing patients with complex chronic diseases through a multidisciplinary *** coordinated care provided by the HCU results in improved patient outcomes,reduced unnecessary hospitalizations,and better management of patient *** superiority of the HCU compared to standard care is evident in key outcomes such as fewer readmissions and higher patient satisfaction,reinforcing its value as a model of ca

关键词： High complexity unit Chronic multimorbidity Patient-centered care Integrated care Healthcare management