检索结果-南通市图书馆

HOP co-chaperones contribute to GA signaling by promoting the accumulation of the F-box protein SNE in Arabidopsis

Plant Communications 2023年第3期4卷 244-257页

作者： Silvina Mangano Alfonso Muñoz Lourdes fernández-Calvino M.mar Castellano Centro de Biotecnología y Genómica de Plantas Universidad Politécnica de Madrid(UPM)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria(INIA/CSIC)Campus Montegancedo UPM28223 Pozuelo de Alarcón(Madrid)Spain Fundación Instituto Leloir and Instituto de Investigaciones Bioquímicas de Buenos Aires(IIBA CONICET)Av.Patricias Argentinas 435Buenos Aires C1405BWEArgentina Departamento de Botánica Ecologíay Fisiología VegetalCampus de RabanalesEdificio Severo OchoaUniversidad de Córdoba14071 CórdobaSpain

Gibberellins(GAs)play important roles in multiple developmental processes and in plant response to the *** the GA pathway,a central regulatory step relies on GA-dependent degradation of the DELLA transcriptional ***,the relevance of the stability of other key proteins in this pathway,such as SLY1 and SNE(the F-box proteins involved in DELLA degradation),remains ***,we take advantage of mutants in the HSP70-HSP90 organizing protein(HOP)co-chaperones and reveal that these proteins contribute to the accumulation of SNE in ***,HOP proteins,along with HSP90 and HSP70,interact in vivo with SNE,and SNE accumulation is significantly reduced in the hop ***,greater accumulation of the DELLA protein RGA is observed in these *** agreement with these molecular phenotypes,hop mutants show a hypersensitive response to the GA inhibitor paclobutrazol and display a partial response to the ectopic addition of GA when GA-regulated processes are *** mutants also display different phenotypes associated with alterations in the GA pathway,such as reduced germination rate,delayed bolting,and reduced hypocotyl elongation in response to warm ***,ectopic overexpression of SNE reverts the delay in germination and the thermally dependent hypocotyl elongation defect of the hop1 hop2 hop3 mutant,revealing that SNE accumulation is the key aspect of the hop mutant ***,these data reveal a pivotal role for HOP in SNE accumulation and GA signaling.

关键词： HSP70-HSP90 organizing protein seed germination thermomorphogenesis RGA protein folding protein stability

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tandem pore TWIK-related potassium channels and neuroprotection

引用

Neural Regeneration Research 2019年第8期14卷 1293-1308页

作者： J.Antonio Lamas Diego fernández-fernández Laboratory of Neuroscience Biomedical Research Center (CINBIO) University of Vigo

TWIK-related potassium channels (TREK) belong to a subfamily of the two-pore domain potassium channels family with three members, TREK1, TREK2 and TWIK-related arachidonic acid-activated potassium channels. The two-pore domain potassium channels is the last big family of channels being discovered, therefore it is not surprising that most of the information we know about TREK channels predominantly comes from the study of heterologously expressed channels. Notw让hstanding, in this review we pay special attention to the limited amount of information available on native TREK-like channels and real neurons in relation to neuroprotection. Mainly we focus on the role of free fatty acids, lysophospholipids and other neuroprotective agents like riluzole in the modulation of TREK channels, emphasizing on how important this modulation may be for the development of new therapies against neuropathic pain, depression, schizophrenia, epilepsy, ischemia and cardiac complications.

关键词： TREK channels TREK-1 TREK-2 TRAAK neuroprotection free fatty acids lysophospholipids riluzole

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Distribution of DNA damage in the human sperm nucleus:implications of the architecture of the sperm head

引用

Asian Journal of Andrology 2020年第4期22卷 401-408页

作者： Silvia González-Rojo Cristina fernández-Díez mar.a Lombó mar.a Paz Herráez Department of Molecular Biology Faculty of BiologyUniversidad de LeónCampus de Vegazana s/n LeónLeón 24071Spain

The sperm nucleus is prone to sustain DNA damage before and after *** of the damage is not homogeneous,and the factors determining differential sensitivity among nuclear regions have not yet been *** sperm chromatin contains three structural domains,two of which are considered the most susceptible to DNA damage:the histone bound domain,harboring developmental related genes,and the domain associated with nuclear matrix *** a quantitative polymerase chain reaction(qPCR)approach,we analyzed the number of lesions in genes homeobox A3(HOXA3),homeobox B5(HOXB 5),sex-determining region Y(SRY)-box 2(SOX2),β-GLOBIN,rDNA 18S,and rDNA 28S in human sperm after ultraviolet irradiation(400μW cm−2,10 min),H2O2treatment(250 mmol l−1,20 min),and cryopreservation,which showed differential susceptibility to genetic *** vulnerability is dependent on the genotoxic agent and independent of the sperm nuclear proteins to which the chromatin is bound and of accessibility to the transcription *** of 8-hydroxy-2'-deoxyguanosine(8-OHdG)showed that the highest level of oxidation was observed after *** distribution of oxidative lesions also differed depending on the genotoxic agent.8-OHdG did not colocalize either with histone 3(H3)or with type IIα+βtopoisomerase(TOPO IIα+β)after H2O2treatment but matched perfectly with peroxiredoxin 6(PRDX6),which is involved in *** study reveals that the characteristics of the sperm head domains are responsible for access of the genotoxicants and cause differential degree of damage to nuclear areas,whereas chromatin packaging has a very limited *** histone-enriched genes analyzed cannot be used as biomarkers of oxidative DNA damage.

关键词： biomarkers DNA damage human sperm oxidative stress sperm chromatin sperm quality

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Challenges and improvement strategies in the hospitalization of chronic multimorbid patients

引用

World Journal of Clinical Cases 2025年第3期13卷 35-41页

作者： Andres Fontalba-Navas Francisco Pozo Muñoz Rogelio Garcia Cisneros mar.a jose Garcia Larrosa mar.a del mar Callejon Gil Ignacio Garcia Delgado mar.a Belen Jimenez martinez Antequera Hospital Northern Málaga Integrated Healthcare AreaAntequera 29200AndalusiaSpain Department of Public Health and Psychiatry University of MálagaMálaga 29010Spain Antequera Hospital Northern Málaga Antequera Integrated Healthcare AreaAntequera 29200MálagaSpain

BACKGROUND Addressing the growing challenge of hospitalizing chronic multimorbid patients,this study examines the strain these conditions impose on healthcare systems at a local level,focusing on a pilot *** diseases and complex patients require comprehensive management strategies to reduce healthcare burdens and improve patient *** proven effective,this pilot model has the potential to be replicated in other healthcare settings to enhance the management of chronic multimorbid *** To evaluate the effectiveness of the high complexity unit(HCU)in managing chronic multimorbid patients through a multidisciplinary care model and to compare it with standard hospital *** The study employed a descriptive longitudinal approach,analyzing data from the Basic Minimum Data Set(BMDS)to compare hospitalization variables among the HCU,the Internal Medicine Service,and other services at Antequera Hospital throughout *** HCU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity *** The study employed a descriptive longitudinal approach,analyzing data from the BMDS to compare hospitalization variables among the HCU,the Internal Medicine Service,and other services at Antequera Hospital throughout *** HCU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity *** This study demonstrates the effectiveness of the HCU in managing patients with complex chronic diseases through a multidisciplinary *** coordinated care provided by the HCU results in improved patient outcomes,reduced unnecessary hospitalizations,and better management of patient *** superiority of the HCU compared to standard care is evident in key outcomes such as fewer readmissions and higher patient satisfaction,reinforcing its value as a model of ca

关键词： High complexity unit Chronic multimorbidity Patient-centered care Integrated care Healthcare management

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

“Second-generation” stem cells for cardiac repair

引用

World Journal of Stem Cells 2015年第2期7卷 352-367页

作者： Alberto Núez García Ricardo Sanz-Ruiz mar.a Eugenia fernández Santos Francisco fernández-Avilés Instituto parala Investigación Biomédica del Hospital General Universitario Gregorio mara?ón Department of Internal Medicine Complutense University-School of Medicine Department of Cardiology Hospital General Universitario Gregorio Mara?ón Laboratory of Bioartificial Organs and Scaffolds Hospital General Universitario Gregorio Mara?ón

Over the last years, stem cell therapy has emerged asan inspiring alternative to restore cardiac function after myocardial infarction. A large body of evidence has been obtained in this field but there is no conclusive data on the efficacy of these treatments. Preclinical studies and early reports in humans have been encouraging and have fostered a rapid clinical translation, but positive results have not been uniformly observed and when present, they have been modest. Several types of stem cells, manufacturing methods and delivery routes have been tested in different clinical settings but direct comparison between them is challenging and hinders further research. Despite enormous achievements, major barriers have been found and many fundamental issues remain to be resolved. A better knowledge of the molecular mechanisms implicated in cardiac development and myocardial regeneration is critically needed to overcome some of these hurdles. Genetic and pharmacological priming together with the discovery of new sources of cells have led to a "second generation" of cell products that holds an encouraging promise in cardiovascular regenerative medicine. In this report, we review recent advances in this field focusing on the new types of stem cells that are currently being tested in human beings and on the novel strategies employed to boost cell performance in order to improve cardiac function and outcomes after myocardial infarction.

关键词： Stem cells Cardiac repair Myocardialinfarction Heart failure Second generation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Seed provenance determines germination responses of Rumex crispus (L.) under water stress and nutrient availability

引用

Journal of Plant Ecology 2019年第6期12卷 949-961页

作者： mar.a Pérez-fernández Carole PElliott Alex Valentine JoséAntonio Oyola Ecology Area University Pablo de OlavideCarretera de Utrera Km 141013 SevillaSpain Kings Park Science Botanic Garden and Parks AuthorityDepartment of BiodiversityConservation and AttractionsKattidj CloseKings ParkWA 6005Australia School of Biological Science The University of Western AustraliaCrawleyWA 6009Australia Department of Botany and Zoology Stellenbosch UniversityPrivate Bag X1Matieland 7602South Africa Physics Department University of ExtremaduraAvenida de Elvas s/n06006 BadajozSpain

Aims Seeds of Rumex crispus from six provenances were studied in relation to their germination under drought and presence of nitrogen in the germination and emergence *** also investigated whether adaptation to soil increases the ability of the species to colonize and establish in contrasting environments along a longitudinal gradient in western Spain by means of a reciprocal transplantation *** We conducted a germination trial in the lab to test for the germination responses to water scarcity along a polyethylene glycol gradient and to varying concentrations of nitrogen *** reciprocal transplantations experiment was conducted,where seeds from six provenances were grown in the soils from the very same *** emergence,survivorship and fitness-related variables were measured in all *** Findings We found that *** has a cold-stratification requirement that enhances its *** differences between the six provenances were detected for time-to-germination,total seedling emergence,plant mortality and reproductive effort in all the *** differences between provenances with respect to germination were confirmed by the significant statistical analyses of the variance,thus providing evidence that seeds from parent plants grown in different environmental conditions have an intrinsically different abilities to germinate and *** nitrogen content where seed germination and seedlings establish also play an important role in their performance in terms of survivorship and reproduction,being the higher levels of inorganic nitrogen and of microbial biomass those that increased biomass production,enhanced inflorescence formation and reduced plant *** conclude that one of the main reasons for the spread and maintenance of *** would be the increased levels of nitrogen in agricultural soils.

关键词： seed provenance germination latitudinal gradient drought N-compounds soil properties

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The power of“touch”and early enriched stimulation:neuroplasticity effects in rodents and preterm infants

引用

Neural Regeneration Research 2022年第6期17卷 1248-1250页

作者： Alberto fernández-Teruel Department of Psychiatry and Forensic Medicine&Institute of Neurosciences School of MedicineAutonomous University of BarcelonaBellaterraBarcelonaSpain

Early postnatal stimulation,e.g.,neonatal handling(NH)in its most frequent form,and environmental enrichment(EE,the exposure of juvenile animals,usually during several weeks,to environments involving rich and variable sensory stimulation)produce profound and long-lasting behavioral and neurobiological *** treatments reduce anxiety and stress sensitivity,and improve neurodevelopment and learning/memory in unconditioned and conditioned tasks in laboratory rodents.

关键词： stimulation neonatal enriched

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ni-based catalysts obtained from perovskites oxides for ethanol steam reforming

引用

燃料化学学报 2018年第11期46卷 1332-1341页

作者： Fabiola Nerina Agüero jose Antonio Alonso mar.a Teresa fernández-Díaz Luis Eduardo Cadus Instituto de Investigaciones en Tecnología Química(INTEQUI) UNSL-CONICETAlmirante Brown 14555700 San LuisArgentina Instituto de Ciencia de Materiales de Madrid Consejo Superior de Investigaciones CientíficasCantoblanco28049 MadridSpain Institut Laue-Langevin B.P.156F-38042 Grenoble Cedex 9France

Perovskites as host structures of cations were used in order to generate in situ active and stable catalysts for ethanol steam reforming. For this purpose,La_(1-x)Mg_xAl_(1-y)Ni_yO_3(x = 0.1; y = 0,0.1,0.2,0.3) perovskites were synthetized by the citrate *** segregation is evident for a substitution level higher than 0. 2. The segregation of Ni as NiO generated species interacts with different metal-support after the reduction step. The y = 0.1 catalyst presents the highest H_2 yield value about 85% during reaction time,with low mean values of CH_4 and CO selectivities of 3.4% and 11%,respectively and a low carbon formation. The better performance of y = 0.1 catalyst could be attributed to the minor proportion of segregated phases,thus a controlled expulsion of Ni is successfully reached.

关键词： perovskites catalyst design ethanol steam reforming

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Brillouin expanded time-domain analysis based on dual optical frequency combs

引用

Light(Science & Applications) 2024年第8期13卷 1534-1544页

作者： Jae Hyeong Youn Kwang Yong Song Sonia martin-Lopez Miguel Gonzalez-Herraez mar.a R.fernández-Ruiz Dept.of Physics Chung-Ang UniversitySeoulKorea Dept.of Electronics Universidad de AlcaláMadridSpain

Brillouin Optical Time-Domain Analysis(BOTDA)is a widely-used distributed optical fiber sensing technology employing pulse-modulated pump waves for local information retrieval of the Brillouin gain or loss *** spatial resolution of BOTDA systems is intrinsically linked to pulse duration,so high-resolution measurements demand high electronic bandwidths inversely proportional to the *** paper introduces Brillouin Expanded Time-Domain Analysis(BETDA)as a modified BOTDA system,simultaneously achieving high spatial resolution and low detection *** two optical frequency combs(OFCs)with different frequency intervals as pump and probe,local Brillouin gain spectra are recorded by their spectral beating traces in an expanded time domain.A 2-cm-long hotspot located in a 230m single-mode fiber is successfully measured in the time domain with a detection bandwidth of less than 100 kHz using dual OFCs with tailored spectral phase,line spacing,and bandwidth.

关键词： pump optical fiber

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Predictability of Plastic Parts Behaviour Made from Rapid Manufacturing

引用

Tsinghua Science and Technology 2009年第S1期14卷 100-107页

作者： mario Monzón Pedro M Hernández Antonio N Benítez mar.a D marrero ngel fernández Department of Mechanical Engineering Las Palmas de Gran Canaria University Las Palmas 35017 Spain AITIIP Foundation Cogullada Technologic Park Zaragoza 50014 Spain

One of the most important issues to resolve in parts manufactured from rapid manufacturing (RM) technologies is to know their behavior working under real conditions. Total quality manufacturing (TQM) is only possible if mechanical properties are well known in the design stage depending on the processing parameters. This work is mainly focused on testing of several samples made with different selective laser sintering (SLS) parameters and technologies. This procedure is the starting point to establish a basis for designing for RM and the standardization of RM testing. The experiments and the analysis of variance (ANOVA) analyzed the effects of several factors on mechanical properties. The SLS technologies were 3DSystem and EOS. The results show which factor has a large effect on the variables and the interaction between them. The conclusions are very useful for developing rules for designing (designing for RM) and creating new standard rules (ISO, AISI, and DIN) for RM materials and parts testing. The ANOVA gives a better knowledge of the effects of these factors and eliminates unimportant parameters.

关键词： laser sintering rapid manufacturing (RM) analysis of variance (ANOVA) rapid prototyping additive manufacturing selective laser sintering (SLS)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：