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HVEM,a cosignaling molecular switch,and its interactions with BTLA,CD160 and LIGHT

Cellular & Molecular Immunology 2019年第7期16卷 679-682页

作者： jose Ignacio Rodriguez-Barbosa Pascal Schneider Andreas Weigert Kyung-Mi Lee Tae-Jin Kim jose-antonio perez-simon Maria-Luisa del Rio Transplantation Immunobiology Section Research Institutes of the University of LeonCampus of Vegazana s/n24071 LeonSpain Leon Regional Transplantation Coordination Center Leon University HospitalLeonSpain Acción Estratégica en Salud Consorcio CIBER-ONCSevilleSpain Department of Biochemistry University of Lausanne1066 EpalingesSwitzerland Institute of Biochemistry I Faculty of MedicineGoethe-University Frankfurt60590 FrankfurtGermany Department of Biochemistry and Molecular Biology Korea University College of MedicineSeoul 02841Republic of Korea Department of Biomedical Engineering Center for Bio-Integrated ElectronicsSimpson Querrey Institute for BioNanotechnologyNorthwestern UniversityEvanstonIL 60208USA Department of Hematology Virgen del Rocio University HospitalBiomedical Institute of SevillaSevillaSpain

Temporal and spatial expression of cosignaling receptors and their ligands regulates the early stages of T-cell activation(signal 1,T-cell receptor(TCR)signaling and signal 2,costimulation/coinhibition),clonal expansion and T-cell survival during their differentiation towards effector T *** the inflammatory stimulus is eliminated,effector T cells return to homeostasis after undergoing a contraction phase by activation-induced cell death and the intervention of ligands for coinhibitory receptors,leaving a population of long-term memory T *** expression of ligands for coinhibitory receptors on hematopoietic cells and,more importantly,on non-hematopoietic cells of peripheral tissues is a key process in tuning the functional activity of effector T cells to prevent excess tissue inflammation that may lead to immunopathology and subsequent tissue dysfunction.

关键词： stimulation homeostasis inflammation

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D-患者输注D＋红细胞输血政策的前瞻性研究

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国际输血及血液学杂志 2009年第2期32卷 175-177页

作者： Gonzalez-Porras JR Graciani IF perez-simon JA 韩浙东(译) 不详浙江省血液中心浙江杭州310006

红细胞成分是有限的资源，因此应开发新的政策和输血准则以优化其使用。在理想情况下，D-患者应该输注D-红细胞。遗憾的是在一些情况下，如大量输血或者D-红细胞短缺时，D-病人需要输注D＋红细胞，这样发生D-同种免疫就相当常见。健康D... 详细信息

红细胞成分是有限的资源，因此应开发新的政策和输血准则以优化其使用。在理想情况下，D-患者应该输注D-红细胞。遗憾的是在一些情况下，如大量输血或者D-红细胞短缺时，D-病人需要输注D＋红细胞，这样发生D-同种免疫就相当常见。健康D-志愿者输注D＋红细胞后，发生抗D同种免疫风险高于80％。最近的研究表明，

关键词：红细胞输血 D-患者输注 D+红细胞 D同种免疫红细胞成分理想情况大量输血

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Bacteria in cancer therapy: beyond immunostimulation

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Journal of Cancer Metastasis and Treatment 2018年第1期4卷 44-68页

作者： Wheeler Torres Victor Lameda Luis Carlos Olivar Carla Navarro Jorge Fuenmayor Adrian perez Andres Mindiola Milagros Rojas Maria Sofia Martinez Manuel Velasco joselyn Rojas Valmore Bermudez Endocrine and Metabolic Diseases Research Center the University of ZuliaMaracaibo 4001Venezuela Miami Veterans Affairs Medical Center Geriatric Research Education and Clinical Center(GRECC)Miami 33125FLUSA Departme nt of Pharmacology "JM Vargas"Medical SchoolCentral University of VenezuelaCaracas 1050Venezuela Division of Pulmonary and Critical Care Medicine Brigham and Women's HospitalHarvard Medical SchoolBoston 02115MAUSA Advaneed Frontier Studies Research Group(ALEF) Simon Bolivar UniversityCucuta 540006Colombia

Currently,conventional therapies in cancer are improving;chemotherapy,radiotherapy and surgery have increased survival *** therapies have arisen with the same goal;immunotherapy has appeared as a promising option in the fight against cancer stimulating the immune system by inducing innate and adaptive *** responses include release of pro-inflammatory cytokines,making the immune system capable to eliminate or protect against multiple ***,many of these therapies are being used in clinical settings,such as checkpoint inhibitors,monoclonal anti cytotoxic T-Lymphocyte associated protein 4(CTL-4)and programmed death protein 1(PD1),with inspiring results;however,they may decrease immunotolerance,limiting their *** the same time,chemotherapy works by passive transport across the cell membrane,limiting its capacity to penetrate in tumor *** these reasons,bacteria employment represents one of the best candidates for cancer *** can surpass these barriers with their selective colonization which also has an oncolytic effect by increasing proliferation and immunostimulation in the tumor *** strains,such as Mycobacterium bovis,Clostridium,Salmonella typhimirium and Listeria monocytogenes have been studied showing promising results in experimental ***,their application in clinical trials has shown the need to maximize their therapeutic *** engineering and synthetic biology are necessary to prove the scope that this novel approach has against cancer due to implications of cancer therapy and public health.

关键词： Bacterium cancer selective colonization salmonella clostridium listeria

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