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molecular Plant 2022年第7期15卷 1084-1086页

作者： martiniano m.Ricardi jose m.Estevez Instituto de Fisiología Biología Molecular y Neurociencias(IFIBYNE-UBA-CONICET)and Facultad de Ciencias Exactas y NaturalesUniversidad de Buenos AiresCiudad UniversitariaBuenos Aires C1428EHAArgentina Fundación Instituto Leloir and IIBBA-CONICET.Av.Patricias Argentinas 435 Buenos Aires C1405BWEArgentina Centro de Biotecnología Vegetal Facultad de Ciencias de la VidaUniversidad Andres BelloSantiago 8370146Chile ANID-millennium Science Initiative Program-millennium Nucleus for the Development of Super Adaptable Plants(mN-SAP) Santiago 8370146Chile

Root hairs(RHs)grow in a polar manner as cylindrical protrusions from the root *** significantly expand the root volume in the rhizosphere to search for water and nutrients,anchor the plant,and promote interactions with several kinds of microorganisms in the ***,the epidermis cell type responsible for RH development,switch from anisotropic cell elongation to tip growth through polarization of the growth machinery to a predefined RH initiation domain(RHID)at the plasma membrane.

关键词： tip polarization cylindrical

Effects of a long-term physical exercise program with and without diet on obese boys after six-month detraining

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World Journal of Pediatrics 2014年第1期10卷 38-45页

作者： Antonio García-Hermoso jose m Saavcdra Yolanda Escalante Ana m Domíngue Faculty of Sport Sciences AFIDES Research GroupUniversity of ExtremaduraSpain

Background:most studies on physical fitness and detraining have been conducted on normal-weight *** results indicate that any gains regress to the untrained control values during the detraining ***,therefore,seems necessary to determine how detraining affects the different fitness parameters in obese *** aim of the present study was to evaluate the effects of detraining(6 months)on kinanthropometry and the components of physical fitness after an intervention(31 months)consisting of a program of exercise and/or diet for obese ***:The participants were 18 boys,aged between 8 and 11 years,divided into E and E+D groups according to the program they *** E group followed a physical exercise program(three 90-minute sessions/week),and the E+D group the same physical exercise program plus a low calorie *** fitness was assessed by the European physical fitness test battery including flamingo balance,plate tapping,sit-andreach,standing broad jump,hand-grip strength,sit-ups,bent-arm hang,10×5-metre shuttle run,and 20-metre endurance shuttle *** Kruskal-Wallis test was applied to reveal overall intergroup differences(E and E+D groups),and measurements showing significant differences were further analysed for differences between individual groups by the mann-Whitney U ***:In both groups,changes were observed in various physical fitness parameters,especially limb speed(E group,P=0.001;E+D group,P=0.002),agility(E group,Pm intervention based on the combination of exercise program and exercise program plus diet in obese boys does not affect the changes attained during the intervention.

关键词： aerobic fitness agility balance body mass index strength

Acoustic streaming and Sun's meridional circulation

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Research in Astronomy and Astrophysics 2016年第9期16卷 101-106页

作者： jose manuel Valverde Faculty of Physics University of Seville

A vast number of physical processes involving oscillations of a bounded viscous fluid are relevantly influenced by acoustic streaming. When this happens a steady circulation of fluid develops in a thin boundary adjacent to the interface. Some examples are refracted sound waves, a fluid inside a spherical cavity undergoing torsional oscillations or a pulsating liquid droplet. Steady streaming around circular interfaces consists of a hemispherically symmetric recirculation of fluid from the equatorial plane to the polar axes closely resembling the meridional circulation pattern observed in the Sun＇s convection zone that determines the solar cycle. In this paper, it is argued that the acoustic pulsations exhibited by the Sun would lead to acoustic streaming in the boundary of the convection zone. A simple estimation using a typical dominant frequency of 3 mHz and the observed surface oscillation amplitude yields a steady streaming velocity Us - 10 m s^-1, which is on the order of the meridional circulation velocity observed in the Sun＇s convection zone.

关键词： Sun general -- Sun helioseismology -- Sun granulation -- Sun oscillations -- Sun fun-damental parameters -- Sun activity

Paclitaxel-loaded hollow-poly（4-vinylpyridine） nano- particles enhance drug chemotherapeutic efficacy in lung and breast cancer cell lines

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Nano Research 2017年第3期10卷 856-875页

作者： Rafael Contreras-Caceres maria C. Leiva Raul Ortiz Amelia Diaz Gloria Perazzoli miguel A.Casado-Rodriguez Consolacion melguizo jose m. Baeyens Juan m. Lopez-Romero jose Prados Department of Organic Chemistry Faculty of Science University of Mdlaga 29071 Malaga Spain Institute of Biopathology and Regenerative medicine (IBImER) Center of Biomedical Research (CIBM) University of Granada 18100 Granada Spain Department of Anatomy and Embryology Faculty of Medicine University of Granada 18071 Granada Spain Biosanitary Institute of Granada (IBS. GRANADA) SAS-Universidad de Granada 18014 Granada Spain Department of Health Science University of Jaen 23071 Jadn Spain Department of Pharmacology Institute of Neuroscience Biomedical Research Center (CIBM) University of Granada 18100 Granada Spain

Paclitaxel （PTX）, one of the most effective cytotoxins for the treatment of breast and lung cancer, is limited by its severe side effects and low tumor selectivity. In this work hollow-poly（4-vinylpyridine）（hollow-p4VP） nanoparticles （NPs） have been used for the first time to generate PTX@p4VP NPs, employing a novel technique in which a gold core in the center of the NP is further oxidized to produce the hollow structure into which PTX molecules can be incorporated. The hollow-p4VP NPs exhibit good physicochemical properties and displayed excellent biocompatibility when tested on blood （no hemolysis） and cell cultures （no cytotoxicity）. Interestingly, PTX@p4VP NPs significantly increased PTX cytotoxicity in human lung （A-549） and breast （mCF-7） cancer cells with a significant reduction of PTX ICs0 （from 5.9 to 3.6 nm in A-549 and from 13.75 to 4.71 nm in mCF-7）. In addition, PTX@p4VP caused a decrease in volume of A-549 and mCF-7 multicellular tumor spheroids （mTS）, an in vitro system that mimics in vivo tumors, in comparison to free PTX. This increased antitumoral activity is accompanied by efficient cell internalization and increased apoptosis, especially in lung cancer mTS. Our results offer the first evidence that hollow- p4VP NPs can improve the antitumoral activity of PTX. This system can be used as a new nanoplatform to overcome the limitations of current breast and lung cancer treatments.

关键词： paclitaxel poly(4-vinylpyridine)(p4VP) nanoparticles lung cancer breast cancer cytotoxicity multicellular tumorspheroids

Culturable aerobic and facultative bacteria from the gut of the polyphagic dung beetle Thorectes lusitanicus

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Insect Science 2015年第2期22卷 178-190页

作者： Noemi Hernandez jose A. Escudero Alvaro San millan Bruno Gonzalez-Zorn Jorge m. Lobo jose R. Verdu monica Suarez Department Sanidad Animal Facultad de Veterinaria Universidad Complutense de Madrid Avenida Puerta de Hierro sin Madrid CP28040 Department Biogeografia y Cambio Global Museo Nacional de Ciencias Naturales CSIC Jose Gutierrez Abascal 2 Madrid28006 I.U.I. CIBIO (Centro Iberoamericano de la Biodiversidad) Universidad de Alicante Carretera de San Vicente del Raspeigsin Alicante 03080 Spain

Unlike other dung beetles, the Iberian geotrupid, Thorectes lusitanicus, exhibits polyphagous behavior; for example, it is able to eat acorns, fungi, fruits, and carrion in addition to the dung of different mammals. This adaptation to digest a wider diet has physiological and developmental advantages and requires key changes in the composition and diversity of the beetle＇s gut microbiota. In this study, we isolated aerobic, facultative anaerobic, and aerotolerant microbiota amenable to grow in culture from the gut contents of T. lusitanicus and resolved isolate identity to the species level by sequencing 16S rRNA gene fragments. Using BLAST similarity searches and maximum likelihood phylogenetic analyses, we were able to reveal that the analyzed fraction （culturable, aerobic, facultative anaerobic, and aerotolerant） of beetle gut microbiota is dominated by the phyla Pro- teobacteria, Firmicutes, and Actinobacteria. Among Proteobacteria, members of the order Enterobacteriales （Gammaproteobacteria） were the most abundant. The main functions associated with the bacteria found in the gut of T. lusitanicus would likely include nitrogen fixation, denitrification, detoxification, and diverse defensive roles against pathogens.

关键词： actinobacteria firmicutes geotrupidae gut microbiota polyphagy,proteobacteria

Role of monovalent co-dopants on the PL emission properties of YAl_3(BO_3)_4:Ce^(3+) phosphor

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Journal of Rare Earths 2014年第10期32卷 927-932页

作者： R.Satheesh Kumar V.Ponnusamy V.Sivakumar m.T.jose Department of Physics Anna UniversityM.I.T. Campus Research and Development Laboratory Department of PhysicsSaveetha Engineering College Radiological Sefety Division Indira Gandhi Centre for Atomic Research

The cerium （Ce3＋） doped yttrium aluminium borate （YAB） phosphor was synthesized by modified solid state reaction. The phosphor＇s phase purity and its emission properties were studied using powder X-ray diffraction pattern and photoluminescence spectroscopy. The synthesized YAB had rhomobohedral crystal structure. The phosphor had two different excitation and emission spectra. By 325 nm excitation, the phosphor had emission at 373 nm and with 363 nm excitation; the phosphor gave violet-blue emission at 418 nm. The UV emission of the phosphor originated due to Ce3＋ ions at the yttrium site and violet-blue emission owing to Ce3＋ ions at non-regular sites viz., A13＋ and interstitial sites. The emission intensity of the phosphor was enhanced when monovalent ions （K＋, Na＋, and F） were added as co-dopants. The crucial role of ionic radii of monovalent co-dopants on the emission enhancement of the YAB：Ce3＋ phosphor was reported. Thermogravimetric study showed that the YAB possessed high thermal stability at up to 900 ℃.

关键词： yttrium aluminium borate cerium monovalent codopants ionic radii thermogravimetric analysis rare earths

The first meteorological observations at a tropical high elevation site:Antisana,1846

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Journal of mountain Science 2016年第6期13卷 1047-1055页

作者： Aria ma m.FARRONA Fernando DOmINGUEZ-CASTRO ma Cruz GALLEGO jose m.VAQUERO Departamento de Fisica Facultad de CienciasUniversidad de ExtremaduraBadajoz 06071Spain Instituto de Fisica de Cantabria(UC-CSIC) Santander 39005Spain Departamento de Ingenieria Civily Ambiental Escuela Politecnica NacionalQuito 170112Ecuador Instituto Nacional de meteorologiae Hidrologia Quito 170135Ecuador instituto universitario de investigación del agua cambio climático y sostenibilidad (iacys) universidad de extremaduraBadajoz 06071，Spain departamento de física centro universitario de mérida universidad de extremaduraMerida 06800Spain

Antisana is a stratovolcano with an associated glacier located in the Ecuadorian Andes. Dr Aguirre made meteorological readings every day, at every hour from sunrise to sunset, from December 1845 to December 1846, at Antisana using a meteorological station at 4060 mamsl （meters above mean sea level）. Unfortunately, only the monthly average data have been preserved. These meteorological data are here studied and compared with the closest modern stations for monthly values of temperature, rainfall, and pressure. According to these comparisons, the year 1846 was rainy and cold in comparison with the current climate. moreover, these observations have been useful to help resolve a debate about a possible E1Nifio event in 1846 with the high precipitation in Antisana and Quito in 1846 discarding the occurrence of an E1 Nifio event. The probable occurrence of a La Nifia event is discussed. These data are the earliest known systematic instrumental meteorological observations taken at above 4000 mamsl.

关键词： Early instrumental records Glacier Pastclimate conditions

A coupled fluid FEm-DEm technique for predicting blasting operations in tunnels

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Underground Space 2018年第4期3卷 310-316页

作者： Francisco Zarate jose m.Gonzalez Juan miquel Rainald Lohner Eugenio Onate Centre Internacional de metodes Numerics en Enginyeria(CImNE) Spain Universitat Politecnica de Catalunya(UPC) Gran Capitan s/nCampus Nord08034 BarcelonaSpain George mason University USA1

We present recent developments in the coupling of the finite element method(FEm)and the discrete element method(DEm)for the analysis of rock blasting operations in *** coupled FEm-DEm technique has been proven to be an efficient procedure for pre-dicting the multiple fractures of rock induced by the loads generated in *** coupled FEm-DEm procedure is applied in tunnel construction,as well as to gas pressure blasting pyrotechnics to break rocks for the excavation of the tunnel *** the latter case,the effect of gas explosion is modeled by solving the equations of gas dynamics in the analysis domain using *** effect of gas forces in the underlying rock mass is modeled via an embedded fluid-structure interaction *** efficiency of the coupled FEm-DEm tech-nique is demonstrated in several examples of fracture tests and rock blasting problems related to tunnel *** examples pre-sented indicate that the combination of the DEm with simple three-node linear triangular elements(for two-dimensional problems)captures the onset of fractures and their evolution accurately,accounting for the penetration of gas in the failure domain(Zarate&Onate,2015;Zarate,Cornejo,&Onate,2018).

关键词： Discrete elements Finite elements Fracture mechanics FEm-DEm Gas dynamics

Profitability analysis of a femtosecond laser system for cataract surgery using a fuzzy logic approach

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International Journal of Ophthalmology(English edition) 2016年第7期9卷 1046-1050页

作者： jose Antonio Trigueros David P Pinero mahmoud m Ismail Department of Financial Economic and Accounting Miguel Hernandez University Elche 03202 Alicante Spain Department of Optics Pharmacology and AnatomyUniversity of Alicante Crta San Vicente del RaspeigAlicante 03690 Spain Al-Azhar University Cairo 11651 Egypt

AIm：To define the financial and management conditions required to introduce a femtosecond laser system for cataract surgery in a clinic using a fuzzy logic ***：In the simulation performed in the current study,the costs associated to the acquisition and use of a commercially available femtosecond laser platform for cataract surgery（VICTUS,TECHNOLAS Perfect Vision GmbH,Bausch ＆ Lomb,munich,Germany） during a period of 5y were considered.A sensitivity analysis was performed considering such costs and the countable amortization of the system during this 5y ***,a fuzzy logic analysis was used to obtain an estimation of the money income associated to each femtosecond laser-assisted cataract surgery（G）. RESULTS：According to the sensitivity analysis,the femtosecond laser system under evaluation can be profitable if 1400 cataract surgeries are performed per year and if each surgery can be invoiced more than $*** contrast,the fuzzy logic analysis confirmed that the patient had to pay more per surgery,between $661.8 and $667.4 per surgery,without considering the cost of the intraocular lens（IOL）.CONCLUSION：A profitability of femtosecond laser systems for cataract surgery can be obtained after a detailed financial analysis,especially in those centers with large volumes of *** cost of the surgery for patients should be adapted to the real flow of patients with the ability of paying a reasonable range of cost.

关键词： cataract surgery femtosecond laser fuzzy logic femto-cataract victus profitability analysis

Object-Oriented Programming (From Problem Solving to JAVA) (Programming Series) 1

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