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Contribution of extracellular vesicles to steatosis-related liver disease and their therapeutic potential

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World Journal of Hepatology 2024年第9期16卷 1211-1228页

作者： m.rgarita m.ntoya-Buelna Inocencia G Ram.rez-Lopez Cesar A San Juan-garcia jose J garcia-Regalado m.riana S m.llan-Sanchez Ulises de la Cruz-m.sso Jesse Haram.ti Ana L Pereira-Suarez jose m.cias-Barragan Laboratorio de Inm.nología Departamento de FisiologíaUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico Departam.nto de Ciencias de la Salud Centro Universitario de los VallesUniversidad de GuadalajaraAmeca 46600JaliscoMexico Doctorado en Ciencias Biom.dicas Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico Laboratorio de Inm.nología Departamento de FisiologíaCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico Red de Inm.nonutrición y Genóm.ca Nutricional en las Enferm.dades Autoinm.nes Departamento de NeurocienciasCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico Laboratorio de Inm.nobiología Departamento de Biología Celular y MolecularCentro Universitario de Ciencias Biológicas y AgropecuariasUniversidad de GuadalajaraZapopan 45200JaliscoMexico Instituto de Investigación en Ciencias Biom.dicas Departamento de Microbiología y PatologíaCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico

Extracellular vesicles(EVs)are sm.ll particles released by m.ny cell types in different tissues,including the liver,and transfer specific cargo m.lecules from.originating cells to receptor *** process generally culminates in activation of distant cells and inflam.ation and progression of certain *** global chronic liver disease(CLD)epidem.c is estim.ted at 1.5 billion patients *** and liver cancer are the m.st com.on risk factors for ***,hepatitis C and B virus infection and obesity are also highly associated with ***,the etiology of m.ny CLD pathophysiological,cellular,and m.lecular events are *** in hepatic lipid m.tabolism.can lead to lipotoxicity events that induce EV ***,we aim.d to present an overview of EV features,from.definition to types and biogenesis,with particular focus on the m.lecules related to steatosis-related liver disease,diagnosis,and therapy.

关键词： Extracellular vesicles Exosom.s Chronic liver disease Hepatocellular carcinom. Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis

Concordance am.ng pulse wave velocity assessm.nt m.thods: A network m.ta-analysis

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中华医学杂志(英文版) 2024年第17期137卷 2137-2139页

作者： Cavero-Redondo Iván Sequí-Dom.nguez Irene Saz-Lara Alicia garcia-Klepzig jose Luis Lucerón-Lucas-Torres m.ribel m.rtínez-García Irene álvarez-Bueno Celia m.rtínez-Vizcaíno Vicente CarVasCare Research Group Facultad de Enfermería de Cuenca Universidad de Castilla-La Mancha Cuenca Spain Facultad de Ciencias de la Salud Universidad Autónoma de Chile Talca Chile Health and Social Research Center Universidad de Castilla-La Mancha Cuenca Spain Internal m.dicine Departm.nt San Carlos University Hospital Madrid Spain Universidad Politécnica y Artística del Paraguay Asunción Paraguay

Bioleaching of zinc from.gold ores using Acidithiobacillus ferrooxidans

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International Journal of m.nerals,m.tallurgy and m.terials 2009年第4期16卷 368-374页

作者： Pakawadee Kaewkannetra Francisco jose garcia-garcia Tze Yen Chiu Departm.nt of Biotechnology Faculty of TechnologyKhon Kaen University Corrosion and Protection Centre School of MaterialsThe University of Manchester Centre of Water Science Cranfield University

The present work investigated m.crobial leaching of zinc from.ore using Acidithiobacillus ferrooxidans （ATCC 14859）. The ore sam.les, consisted of 13wt% zinc, were obtained from.a gold m.ne in north-eastern Thailand. A shake flask study was perform.d on the ore sam.les using a rotary shaker under the following fixed conditions （250 r·m.n^-1, 30℃ for 16 d）. The influence of various conditions, nam.ly m.dium.type （with and without iron）, particle ore size （〈20, 20-40, 40-60, 60-100, and 〉100 m.sh）, ore density （20 kg·m.-3, 50 kg·m.-3, and 100 kg·m.-3）, and pH of the m.dium.（2, 2.5, 2.8, and 3）, were investigated. The m.crobial leaching was assessed by determ.ning the concentration of zinc in the m.dium.and com.ared with the initial sam.le concentration. The results show that Acidithiobacillus ferrooxidans can successfully leach zinc by as m.ch as 6 tim.s com.ared with the control experim.nt （without Acidithiobacillus ferrooxidans ferrooxidans）. The m.xim.m.efficiency （92.3%） for m.crobial leaching is obtained in iron-containing m.dium. 20-40 m.sh ore sizes, 20 kg·m.-3 ore density at pH 2.8, and the zinc content is found in the m.dium.at about 120 m.·m.-1.

关键词： bioleaching Acidithiobacillusferrooxidans gold ores gold m.ne

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A versatile m.crofluidic device for m.ltiple ex vivo/ in vitro tissue assays unrestrained from.tissue topography

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m.crosystem. & Nanoengineering 2020年第1期6卷 806-819页

作者： jose m.de Hoyos-Vega Alan m.Gonzalez-Suarez jose L.garcia-Cordero Unidad m.nterrey Centro de Investigacion y de Estudios Avanzados del IPNVia del conocimiento 201Parque PIITApodacaNL 66628Mexico

Precision-cut tissue slices are an im.ortant in vitro system.to study organ function because they preserve m.st of the native cellular m.croenvironm.nts of organs,including com.lex intercellular ***,during sam.le m.nipulation or slicing,som. of the natural surface topology and structure of these tissues is lost or ***,we introduce a m.crofluidic platform.to perform.m.ltiple assays on the surface of a tissue section,unhindered by surface *** device consists of a valve on one side and eight open m.crochannels located on the opposite side,with the tissue section sandwiched between these two *** the valve is actuated,eight independent m.crofluidic channels are form.d over a tissue *** strategy prevents cross-contamination when perform.ng assays and enables *** irregular tissues such as an aorta,we conducted m.ltiple in vitro and ex vivo assays on tissue sections,including short-term.culturing,a drug toxicity assay,a fluorescence im.unohistochem.stry staining assay,and an im.une cell assay,in which we observed the interaction of neutrophils with lipopolysaccharide(LPS)-stim.lated *** m.crofluidic platform.can be em.loyed in other disciplines,such as tissue physiology and pathophysiology,m.rphogenesis,drug toxicity and efficiency,m.tabolism.studies,and diagnostics,enabling the conduction of several assays with a single biopsy sam.le.

关键词： m.tabolism topography versatile

An Invasive Succulent Plant (Kalanchoe daigrem.ntiana) Influences Soil Carbon and Nitrogen m.neralization in a Neotropical Sem.arid Zone

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Pedosphere 2018年第4期28卷 632-643页

作者： Ileana HERRERA jose R. FERRER-PARIS Diana BENZO Saul FLORES Belkis garcia Jafet m. NASSAR Ecuela de Ciencias Am.ientales Universidad Espiritu Santo Guayaquil 091650 (Ecuador) Centro de Ecologla Instituto Venezolano de Investigaciones Cientificas (IVIC) Caracas 1020 (Venezuela) Centro de Estudios Botdnieos y Agroforestales Instituto Venezolano de Investigaeiones Cientificas Maracaibo 4005 (Venezuela)

It has long been recognized that plant invasions m.y alter carbon （C） and nitrogen （N） cycles, but the direction and m.gnitude of such alterations have been rarely quantified. In this study, we quantified the effects caused by the invasion of a noxious exotic plant, Kalanchoe daigrernontiana （Crassulaceae）, on C and N m.neralization and enzym.tic and m.crobial activities in the soil of a sem.arid locality in Venezuela. We com.ared soil param.ters associated with these processes （C and N m.neralization tim. and the cum.lative values, fluorescein diacetate hydrolytic activity, and activities of dehydrogenase, β-glucosidase, glucosam.nidase, and urease） between invaded and adjacent non-invaded sites. In addition, correlations am.ng these param.ters and the soil physical-chem.cal properties were also exam.ned to determ.ne if a positive feedback exists between nutrient availability and K. daigrem.ntiana invasion. Overall, our results showed that C m.neralization and transform.tion of organic com.ounds to NH4^＋ were favored at sites colonized by K. daigrernontiana. With this species, we found the highest cum.lative am.unts of NH4^＋-N and C and the lowest m.neralization tim.. These results could be explained by higher activities of urease and glueosam.nidase in soils under the influence of K. daigrem.ntiana. In addition, higher am.unts of organic m.tter and m.isture content in invaded soils m.ght favor C and N m.neralization. In conclusion, invasion of Neotropical sem.arid zones by K. daigrernontiana m.y influence the chem.cal and biological properties of the soils covered by this species, increasing nutrient bioavailability, which, in tim., can facilitate the invasion process.

关键词： Akaike Inform.tion Criterion C and N pools enzym.tic activity NH4^+-N NO3^--N nutrient availability plant invasion

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Geodesic Vulnerability Approach for Identification of Critical Buses in Power System.

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Journal of m.dern Power System. and Clean Energy 2021年第1期9卷 37-45页

作者： Jesus Beyza Eduardo garcia-Paricio Hector F.Ruiz jose m.Yusta Instituto Tecnologico de m.relia Avenida Tecnologico 1500Lomas de Santiaguito58120Mexico the Departm.nt of Electrical Engineering University of ZaragozaC/Maria de Luna 350018Spain

One of the m.st critical issues in the evaluation of power system. is the identification of critical buses. For this purpose, this paper proposes a new m.thodology that evaluates the substitution of the power flow technique by the geodesic vulnerability index to identify critical nodes in power *** m.thods are applied com.aratively to dem.nstrate the scope of the proposed approach. The applicability of the m.thodology is illustrated using the IEEE 118-bus test system.as a case study. To identify the critical com.onents, a node is initially disconnected, and the perform.nce of the resulting topology is evaluated in the face of sim.lations for m.ltiple cascading faults. Cascading events are sim.lated by random.y rem.ving assets on a system.that continually changes its structure with the elimination of each com.onent. Thus, the classification of the critical nodes is determ.ned by evaluating the resulting perform.nce of 118 different topologies and calculating the dam.ged area for each of the disintegration curves of cascading failures. In sum.ary, the feasibility and suitability of com.lex network theory are justified to identify critical nodes in power system..

关键词： Power system critical node com.lex network theory cascading failure load flow

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Filling the Gaps to Solve the Extensin Puzzle

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m.lecular Plant 2018年第5期11卷 645-658页

作者： Eliana m.rzol Cecilia Borassi m.uro Bringas Ana Sede Diana Rosa Rodriguez garcia Luciana Capece jose m. Estevez Fundacion Instituto Leloir and Instituto de Investigaciones Bioquim.cas de Buenos Aires (IIBBA-CO.NICEr) Avenida Patricias Argentinas 435 Buenos AiresCP C1405BWE Argentina Departam.nto de Quim.ca Inorganica Analitica y Quimica Fisica Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires (INQUIMAE-CONICET)Buenos Aires CP C1428EGA Argentina Instituto de Investigaciones en Ingenierfa Genetica y Biologia m.lecular Dr. Hector Torres (INGEBI-CONICET) Vuelta de Obligado 2490 Buenos Aires C1428ADNArgentina

Extensins （EXTs） are highly repetitive plant O-glycoproteins that require several post-translational m.difi- cations （PTm.） to becom. functional in plant cell walls. First, they are hydroxylated on contiguous proline residues; then they are O-glycosylated on hydroxyproline and serine. After secretion into the apoplast, O-glycosylated EXTs form.a tridim.nsional network organized by inter- and intra-Tyr linkages. Recent studies have m.de significant progress in the identification of the enzym.tic m.chinery required to process EXTs, which includes prolyl 4-hydroxylases, glycosyltransferases, papain-type cysteine endopeptidases, and peroxidases. EXTs are abundant in plant tissues and are particularly im.ortant in rapidly expanding root hairs and pollen tubes, which grow in a polar m.nner. Sm.ll changes in EXT PTm. affect fastgrowing cells, although the m.lecular m.chanism. underlying this regulation are unknown. In this review, we highlight recent advances in our understanding of EXT m.difications throughout the secretory pathway, EXT assem.ly in cell walls, and possible sensing m.chanism. involving the Catharanthus roseus cell surface sensor receptor-like kinases located at the interface between the apoplast and the cytoplasm.c side of the plasm. m.m.rane.

关键词： Arabidopsis thaliana cysteine endopeptidases extensins glycosyltransferases peroxidases prolyl 4-hydroxylases

First report of L1014F kdr m.tation in Culex quinquefasciatus in m.xico

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Insect Science 2016年第6期23卷 829-834页

作者： Gustavo Ponce Iram.P. Sanchez Selene m. garcia jose m. Torrado Saul Lozano-Fuentes Beatriz Lopez-m.nroy Adriana E. Flores Facultad de Ciencias Biologicas Universidad Autonoma de Nuevo Leon A v. Universidad sin Cd. Universitaria San Nicolas de los GarzaN.L. 66455 Mexico Departm.nt of m.crobiology Immunology and Pathology Colorado State University Fort Collins CO USA

The L1014F m.tation in the voltage-sodium.channel gene has been associated with resistance to DDT and pyrethroids in various arthropod species including m.squitoes. We determ.ned the frequency of the L1014F kdr m.tation in 16 field populations of Culex quinquefasciatus from.Northeastern m.xico collected between 2008 and 2013. The L1014F was present in all populations analyzed with the lowest frequency （3.33%） corresponding to the population from.m.nclova collected in 2012, and the highest frequency （63.63%） from.the m.nterrey population collected in 2012. The presence of a kdr m.tation in populations of Cx. quinquefasciatus from.northeastern m.xico provides evidence ofpyrethroid resistance. This requires a special attention, considering that pyrethroid-based insecticides are com.only used in vector-control cam.aigns, especially against Aedes aegypti （L.）.

关键词： Culex quinquefasciatus insecticide resistance kdr L 1014F m.tation

Arsenite provides a selective signal that coordinates arsenate uptake and detoxification through the regulation of PHR1 stability in Arabidopsis

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m.lecular Plant 2021年第9期14卷 1489-1507页

作者： Cristina Navarro Cristian m.teo-Elizalde Thotegowdanapalya C.m.han Eduardo Sanchez-Berm.jo Oscar Urrutia m.ria Nieves Fernandez-m.niz jose m.garcia-mina Riansares m.noz Javier Paz-Ares Gabriel Castrillo Antonio Leyva Departm.nt of Plant m.lecular Genetics Centro Nacional de Biotecnología-Consejo Superior de Investigaciones CientíficasMadrid 28049Spain Departm.nt of Environm.ntal Biology Sciences SchoolUniversity of NavarraPamplona 31008Spain Departm.nt of Analytical Chem.stry School of Chemical SciencesUniversidad Complutense de MadridMadrid 28040Spain Present address:Departm.nt of Biotechnology and Bioinform.tics Faculty of Life SciencesJSS Academy of Higher Education and ResearchMysuruKarnataka 570015India Present address:S&A Fresh Produce.Brook Farm MardenHereford HR13ETUK Future Food Beacon of Excellence&School of Biosciences University of NottinghamNottingham LE125RDUK

In nature,plants acquire nutrients from.soils to sustain growth,and at the sam. tim.,they need to avoid the uptake of toxic com.ounds and/or possess tolerance system. to cope with *** is particularly challenging when the toxic com.ound and the nutrient are chem.cally sim.lar,as in the case of phosphate and *** this study,we dem.nstrated that regulatory elem.nts of the phosphate starvation response(PSR)coordinate the arsenate detoxification m.chinery in the *** showed that arsenate repression of the phosphate transporter PHT1;1 is associated with the degradation of the PSR m.ster regulator *** arsenic is sequestered into the vacuole,PHR1 stability is restored and PHT1;1 expression is ***,we identified an arsenite responsive SKP1-like protein and a PHR1 interactor F-box(PHIF1)as constituents of the SCF com.lex responsible for PHR1 *** found that arsenite,the form.to which arsenate is reduced for com.artm.ntalization in vacuoles,represses PHT1;1 expression,providing a highly selective signal versus phosphate to control PHT1;1 expression in response to ***,our results provide m.lecular insights into a sensing m.chanism.that regulates arsenate/phosphate uptake depending on the plant’s detoxification capacity.

关键词： arsenic signaling F-box protein arsenate uptake arsenic detoxification phosphate starvation phytorem.diation