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Effectiveness of Opuntia ficus-indica mucilage as a carrier agent in microencapsulation of bioactive compounds of Amaranthus hypochondriacus var. Nutrisol

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Food Bioscience 2023年第2期52卷 468-478页

作者： Danger Tabio-Garcia Francisco Paraguay-Delgado Daniel Lardizabal Gutierrez Armando Quintero-Ramos carmen O.Melendez-Pizarro Luz A.Ochoa-Martinez Miguel A.Sanchez-Madrigal Martha G.Ruiz-Gutierrez jose c.espinoza-hicks Universidad Autonoma de chihuahua Facultad de Ciencias QuimicasCircuito Universitario s/nCampus Universitario#2ChihuahuaChihuahuaC.P.31125Mexico centro de Investigacion en Materiales Avanzados S.c. CIMAVMiguel de Cervantes 120ChihuahuaChihuahuaC.P.31136Mexico Tecnologico Nacional de Mexico/IT de Durango Division de Estudios de Posgrado de InvestigacionBlvdFelipe Pescador 1830 OteColonia Nueva VizcayaC.P.34080DurangoDgoMexico

The effectiveness of maltodextrin(10%)and cactus mucilage(cM)(0%,0.25%,0.50%,0.75%,and 1%)as carrier agents was evaluated in the encapsulation of bioactive amaranth *** drying,an efficient encapsulation method,achieved high yields(62.9%-68%).The increase in cM concentration significantly augmented the water absorption index(WAI),bulk density,and hygroscopicity of the encapsulated amaranth ***,it significantly decreased the moisture content,water activity,and water solubility index(WSI).The glass transition temperatures(>40℃),Hausner ratio(HR),and carr’s index(cI)values indicated the suitability of powders for handling and ***,no cracks were observed in the microcapsules surface,which favoured the bioactive amaranth compounds retention and ***,low degradation rate constants and long half-life time values were determined for the encapsulated amaranth powders,indicative of its storage *** of 0.75%cM was an efficient concentration to achieve high percentage retention of betacyanins(55.5%),betaxanthins(58%),total polyphenols(73.3%),amaranthine(56.8%),isoamaranthine(62.7%),individual polyphenols(44.6%-81%),and antioxidant activity(79.6%).These results demonstrated the efficiency of cM as an encapsulating agent in the food industry.

关键词： Amaranth Betalains Polyphenols cactus Mucilage Microencapsulation

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Unveiling the brain’s symphony:exploring the necessity and sufficiency of neural networks in behavior control

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Neural Regeneration Research 2025年第1期20卷 186-187页

作者： Fernando jose Bustos Instituto de ciencias Biomedicas Facultad de Medicina y Facultad de Ciencias de la VidaUniversidad Andres BelloSantiagoChile Millennium Nucleus of Neuroepigenetics and Plasticity(EpiNeuro) SantiagoChile

Since the pioneering work by Broca and Wernicke in the 19th century,who examined individuals with brain lesions to associate them with specific behaviors,it was evident that behaviors are complex and cannot be fully attributable to specific brain areas ***,they involve connectivity among brain areas,whether close or *** that time,this approach was considered the optimal way to dissect brain circuitry and *** pioneering efforts opened the field to explore the necessity or sufficiency of brain areas in controlling behavior and hence dissecting brain ***,the connectivity of the brain and the mechanisms through which various brain regions regulate specific behaviors,either individually or collaboratively,remain largely *** animal models,researchers have endeavored to unravel the necessity or sufficiency of specific brain areas in influencing behavior;however,no clear associations have been firmly established.

关键词： behavior connectivity neural

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The Many Faces of Plant SWI/SNF complex

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Molecular Plant 2014年第3期7卷 454-458页

作者： jose c. Reyes Molecular Biology Department Centro Andaluz de Biologia Molecular y Medicina Regenerativa (CABIMER) Consejo Superior de Investigaciones Cientificas (CSIC) Av. Americo Vespucio 41092 Seville Spain

THE SWI/SNF cOMPLEXESIn plants, as well as in metazoans, the execution of devel- opmental programs and the response to environmental stimuli depend on changes in gene transcription programs that require extensive chromatin modifications of basically two types： posttranslational modification of histones and ATP-dependent reorganization of histones-DNA interac- tions. Many different nuclear machineries are necessary to carry out chromatin modifications at the appropriate time and place.

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The Beauty of Being a Variant： H2A.Z and the SWR1 complex in Plants

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Molecular Plant 2009年第4期2卷 565-577页

作者： Rosana March-Diaz jose c. Reyes Andalusian center for Molecular Biology and Regenerative Medicine (cABIMER) CSIC Americo Vespucio s/n E-41092 Sevilla Spain

Numerous studies have shown that the nucleosome is a dynamic structure that strongly influences gene expression. Dynamism concerns different nucleosomal characteristics, including position, posttranslational modifications, and histone composition. Thus, within the nucleosome, canonical histones can be exchanged by histone variant proteins with specific functions--a process known as ‘histone replacement＇. The histone variant H2A.Z has an important function in transcription and, during the last few years, its role in plant development and immune response has become evident. compiling genetic and biochemical studies from several laboratories has revealed that plants contain a multiprotein complex, similar to the SWR1/SRcAP complex from yeast and animals, involved in H2A.Z deposition. Despite intense research in different organisms, the mechanism by which H2A.Z influences transcription is still unknown. However, recent results from Arabidopsis have shown a strong inverse correlation between H2A.Z and DNA methylation, suggesting that H2A.Z might protect genes from silencing.

关键词： chromatin structure and remodeling epigenetics gene regulation floral induction.

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Analytical solution for the size of the minimum dominating set in complex networks

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International Journal of Modeling, Simulation, and Scientific computing 2017年第1期8卷 67-82页

作者： jose c.Nacher Tomoshiro Ochiai Department of Information Science Faculty of Science Toho UniversityMiyama 2-2-1 FunabashiChiba 274-8510Japan Faculty of Social Information Studies Otsuma Women’s University 2-7-1 Karakida Tama-shiTokyo 206-8540Japan

Domination is the fastest-growing field within graph theory with a profound diversity and impact in real-world applications,such as the recent breakthrough approach that identifies optimized subsets of proteins enriched with cancer-related *** its conceptual simplicity,domination is a classical NP-complete decision problem which makes analytical solutions elusive and poses difficulties to design optimization algorithms for finding a dominating set of minimum cardinality in a large ***,we derive for the first time an approximate analytical solution for the density of the minimum dominating set(MDS)by using a combination of cavity method and ultra-discretization(UD)*** derived equation allows us to compute the size of MDS by only using as an input the information of the degree distribution of a given network.

关键词： Minimum dominating set analytical solution statistical methods complex networks

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current approach to disseminated intravascular coagulation related to sepsis-organ failure type

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World Journal of Hematology 2017年第1期6卷 11-16页

作者： jose J Zaragoza Missael V espinoza-Villafuerte Intensive care Unit Hospital Espanol

Disseminated intravascular coagulation(DIc) is a syndrome characterized by the systemic activation of blood clotting, which generates large amount of intravascular thrombin and fibrin. Various diseases may cause acceleration of the clotting cascade, inactivate the endogenous anticoagulants and modify fibrinolysis, having thus the formation of micro thrombi in the systemic circulation. The abnormalities in the hemostatic system in patients with DIc result from the sum of pathways that generate both hypercoagulability and augmented fibrinolysis. When the hypercoagulability state prevails, the main manifestation is organic failure. This subtype of DIc is often referred as "organ impairment" type, frequently seen in patients suffering from severe sepsis. To identify the underlying infection, early initiation of culture-based antimicrobial treatment, and to resolve any infection source promptly are keystone actions of DIc related to sepsis prevention and treatment. These should be combined with specific treatment related to each DIc subtype. In the context of septic shock, DIc is associated to increased severity, greater number and seriousness of organ failures, more frequent side-effects from treatment itself, and worse outcomes. Therefore, we ought to review the information available in the literature about approach and management of DIc in severe sepsis.

关键词： Septic shock Disseminated intravascular coagulation coagulation impairment Organ failure Antithrombin Sepsis

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Modern management of rectal cancer: A 2006 update

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World Journal of Gastroenterology 2006年第20期12卷 3186-3195页

作者： Glen c Balch Alex De Meo jose G Guillem colorectal Service at Memorial Sloan-Kettering cancer center New York New York 10021 United States

The goal of this review is to outline some of the important surgical issues surrounding the management of patients with early (T1/T2 and NO), as well as locally advanced (T3/T4 and/or N1) rectal cancer. Surgery for rectal cancer continues to develop towards the ultimate goals of improved local control and overall survival, maintaining quality of life, and preserving sphincter, genitourinary, and sexual function. Information concerning the depth of tumor penetration through the rectal wall, lymph node involvement, and presence of distant metastatic disease is of crucial importance when planning a curative rectal cancer resection. Preoperative staging is used to determine the indication for neoadjuvant therapy as well as the indication for local excision versus radical cancer resection. Local excision is likely to be curative in most patients with a primary tumor which is limited to the submucosa (T1N0M0), without high-risk features and in the absence of metastatic disease. In appropriate patients, minimally invasive procedures, such as local excision, TEM, and laparoscopic resection allow for improved patient comfort, shorter hospital stays, and earlier return to preoperative activity level. Once the tumor invades the muscularis propria (T2), radical rectal resection in acceptable operative candidates is recommended. In patients with transmural and/or node positive disease (T3/T4 and/or N1) with no distant metastases, preoperative chemoradiation followed by radical resection according to the principles of TME has become widely accepted. During the planning and conduct of a radical operation for a locally advanced rectal cancer, a number of surgical management issues are considered, including: (1) total mesorectal excision (TME); (2) autonomic nerve preservation (ANP); (3) circumferential resection margin (cRM); (4) distal resection margin; (5) sphincter preservation and options for restoration of bowel continuity; (6) laparoscopic approaches; and (7) postoperative qu

关键词： Rectal cancer Surgery Local surgery Total mesorectal excision Review

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Tuna classification using super learner ensemble of region-based cNN-grouped 2D-LBP models

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Information Processing in Agriculture 2022年第1期9卷 68-79页

作者： Jisha Anu jose c.Sathish Kumar S.Sureshkumar Rajiv Gandhi Institute of Technology KottayamIndia Government Engineering college IdukkiIndia Kerala University of Fisheries and Ocean Studies KochiIndia

Tuna is superior among the marine fishes that are exported in the forms of raw fish and processed *** of Tuna into their species is done in industries manually,and the process is *** work proposes an automated system for classifying Tuna spe-cies based on their *** ensemble of region-based deep neural networks is used.A sub region contrast stretching operation is applied to enhance the *** fish image is then divided into three regions and is augmented before giving as input to pre-trained convolutional neural networks(cNN).After fine-tuning the models,the output from the last convolutional layer is given to a grouped 2D-local binary pattern descriptor(G2DLBP).Statistical features from the descriptor are applied to different classifiers,and the best clas-sifier for each image region model is *** ensemble methods are subse-quently used to combine the three cNN-G2DLBP *** the ensemble techniques,super learner ensemble method with random forest(RF)classifier using 5-fold cross-validation shows the highest classification accuracy of 97.32%.The perfor-mance of different ensemble methods is analyzed in terms of accuracy,precision,recall,and *** proposed system shows an accuracy of 93.91% when evaluated with an independent test *** ensemble of region-based cNN with textural features from G2DLBP is applied for the first time for fish classification.

关键词： Tuna classification convolutional neural network Grouped 2D-local binary pattern Super learner ensemble

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challenges and improvement strategies in the hospitalization of chronic multimorbid patients

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World Journal of clinical cases 2025年第3期13卷 35-41页

作者： Andres Fontalba-Navas Francisco Pozo Muñoz Rogelio Garcia cisneros Maria jose Garcia Larrosa Maria del Mar callejon Gil Ignacio Garcia Delgado Maria Belen Jimenez Martinez Antequera Hospital Northern Málaga Integrated Healthcare AreaAntequera 29200AndalusiaSpain Department of Public Health and Psychiatry University of MálagaMálaga 29010Spain Antequera Hospital Northern Málaga Antequera Integrated Healthcare AreaAntequera 29200MálagaSpain

BAcKGROUND Addressing the growing challenge of hospitalizing chronic multimorbid patients,this study examines the strain these conditions impose on healthcare systems at a local level,focusing on a pilot *** diseases and complex patients require comprehensive management strategies to reduce healthcare burdens and improve patient *** proven effective,this pilot model has the potential to be replicated in other healthcare settings to enhance the management of chronic multimorbid *** To evaluate the effectiveness of the high complexity unit(HcU)in managing chronic multimorbid patients through a multidisciplinary care model and to compare it with standard hospital *** The study employed a descriptive longitudinal approach,analyzing data from the Basic Minimum Data Set(BMDS)to compare hospitalization variables among the HcU,the Internal Medicine Service,and other services at Antequera Hospital throughout *** HcU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity *** The study employed a descriptive longitudinal approach,analyzing data from the BMDS to compare hospitalization variables among the HcU,the Internal Medicine Service,and other services at Antequera Hospital throughout *** HcU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity *** This study demonstrates the effectiveness of the HcU in managing patients with complex chronic diseases through a multidisciplinary *** coordinated care provided by the HcU results in improved patient outcomes,reduced unnecessary hospitalizations,and better management of patient *** superiority of the HcU compared to standard care is evident in key outcomes such as fewer readmissions and higher patient satisfaction,reinforcing its value as a model of ca

关键词： High complexity unit chronic multimorbidity Patient-centered care Integrated care Healthcare management

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Which Inspection Approach Is Better to Prevent Drug Fraud: Announced or Unannounced?

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Journal of Systems Science & complexity 2018年第6期31卷 1571-1590页

作者： ZHANG Manman ZHANG Juliang cHENG T.c.E. SALLAN jose Maria HUA Guowei Department of Logistics Management School of Economics and ManagementBeijing Jiaotong UniversityBeijing 100044China. Department of Logistics and Maritime Studies The Hong Kong Polytechnic UniversityHung HornKowloonHong KongChina Department d'Organizacio d'Empreses Universitat Politecnica de CatalunyaTerrassa 08222Spain.

In recent years,there are many crimes related drug fraud occuring in china and many experts think that the main cause is that china Food and Drug Administration (cFDA)adopts announced inspection (AI).In order to circumvent this difficulty,cFDA has exploited unannounced inspection (UI)since *** this paper,the authors study the problem of which one performs better, AI or ***,the authors consider a supervisor,which decides the inspection approach,inspection strength and punishment to force the firm to put self-inspection effort to meet the requirements of Good Manufacturing Practice,and a firm,which produces a drug and decides its self-inspection effort. The authors use game theory to model this problem,characterize the equilibrium policies under AI, and compare the effects of the two approaches on preventing drug fraud under complete and incomplete *** results show that under the complete information,UI performs better if the firm's technical level and the inspection cost are low and AI performs better *** the supervisor doesn't know the firm's technical level,if the low technical level is high,AI performs ***, UI performs better if the inspection cost is low and AI performs better if the inspection cost is high.

关键词： Drug inspection game theory healthcare incomplete information public policy.

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