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Robotic4all project:Results of a hands-on robotic surgery training program

Laparoscopic, Endoscopic and Robotic Surgery 2023年第1期6卷 1-8页

作者： Mario Rui Gonçalves jose Novo de Matos Antonio Oliveira Ricardo Marinho Irene Cadime Palmira Carlos alves Salvador Morales-Conde Miguel Castelo-Branco Faculty of Health Sciences University of Beira InteriorCovilha 6200-506Portugal Centro Hospitalar Universitario Lisboa Central Hospital de Sao JoseLisboa 1150-199Portugal Centro Hospitalar de Tras-os-Montes e Alto Douro Vila Real 5000-508Portugal Centro Hospitalar de Leiria Hospital de Santo AndreLeiria 2410-197Portugal Centro de Investigaçao em Psicologia Escola de Psicologia-Universidade do MinhoBraga 4710-057Portugal Departamento de Estudos Curriculares e Tecnologia Educativa Instituto de Educaçao-Universidade do MinhoCampus de GualtarBraga 4710-093Portugal Unit of Innovation in Minimally Invasive Surgery University Hospital Virgen del RocioUniversity of SevillaSeville 41013Spain

Objective Although robotic surgery adoption and its indications are growing worldwide,for multiple factors,including costs,there is a lack of training and *** aim was to study the impact of a robotic introduction training program on gesture performance,such as suturing,in robot-naive *** Using the DaVinci robot,a 2-hour program was based on virtual reality and anatomical model *** participants performed 3 repetitions of virtual reality exercises on the virtual simulator,and then performed and were assessed on 2 tests,ie robot and laparoscopic training *** the course,the participants were surveyed for this training *** Twenty-seven residents and surgeons were enrolled in the training *** only 2 hours of training,all of the participants were able to complete the training program,thus learning generic and specific skills in robotic *** virtual reality exercise,the scores of the 3 exercises increased significantly with every repetition(p<0.001)and the size of the increase was *** completion time on the robot platform was 2.6 times faster(169.33±28.28 s vs.447.96±156.55 s,p<0.001)than that in the laparoscopic box,and the difference between both types of tests was large(pη2=0.797).The centralization and passage of the needle were significantly better on the robot platform(5 vs.3,p<0.001,r=0.47;5 vs.4,p<0.001,r=0.59)than in the laparoscopic *** the intracorporeal stitch+knot test,every participant was able to perform the exercise on the robot but only 85.2%(23/27)in the laparoscopic ***-one participants answered the survey,and 13(61.9%)of them considered robotic performance independent of laparoscopic *** Surgeons are interested and seek training in robotic *** implemented the first hands-on robotic surgery training program in Portugal and participants considered it was important and adequate for its *** participants,even without robotic experience,lear

关键词： Simulation Education Laparoscopic suture Laparoscopy Robotic surgery

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Current impact of viral hepatitis on liver cancer development: The challenge remains

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World Journal of Gastroenterology 2021年第24期27卷 3556-3567页

作者： Ângelo Zambam de Mattos jose D Debes Andre Boonstra Ju-Dong Yang Domingo C Balderramo Giovana D P Sartori Angelo alves de Mattos Department of Gastroenterology and Hepatology Federal University of Health Sciences of Porto AlegrePorto Alegre 90020-090Brazil Gastroenterology and Hepatology Unit Irmandade Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90050-170Brazil Department of Medicine Division of Gastroenterology and Infectious DiseasesUniversity of MinnesotaMinneapolisMN 55455United States Department of Gastroenterology and Hepatology Erasmus Medical CenterRotterdam NL-3015Netherlands Division of Digestive and Liver Diseases Department of MedicineCedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Gastroenterology Hospital Privado Universitario de CórdobaCórdoba 5016Argentina Department of Medicine Instituto Universitario de Ciencias Biomédicas de CórdobaCórdoba 5016Argentina Department of Internal Medicine Hospital Nossa Senhora da ConceiçãoPorto Alegre 91350-200Brazil

Chronic infections due to hepatitis B and hepatitis C viruses are responsible for most cases of hepatocellular carcinoma(HCC)worldwide,and this association is likely to remain during the next ***,viral hepatitis-related HCC imposes an important burden on public health in terms of disability-adjusted life *** order to reduce such a burden,some major challenges must be *** vaccination against hepatitis B virus,especially in the neonatal period,is probably the most relevant primary preventive measure against the development of ***,considering the large adult population already infected with hepatitis B and C viruses,it is also imperative to identify these individuals to ensure their access to *** hepatitis B and C currently have highly effective therapies,which are able to diminish the risk of development of liver ***,it is essential for individuals at high-risk of HCC to be included in surveillance programs,so that tumors are detected at an early *** with hepatitis B or C and advanced liver fibrosis or cirrhosis benefit from being followed in a surveillance *** hepatitis B virus is oncogenic and capable of leading to liver cancer even in individuals with early stages of liver fibrosis,other high-risk groups of patients with hepatitis B are also candidates for *** effort is required concerning these strategies in order to decrease the incidence and the mortality of viral hepatitis-related HCC.

关键词： Hepatitis B virus Hepatitis C virus Hepatocellular carcinoma Epidemiology Vaccination Surveillance

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The influence of soil on vegetation structure and plant diversity in different tropical savannic and forest habitats

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Journal of Plant Ecology 2018年第2期11卷 226-236页

作者： Priscyla Maria Silva Rodrigues Carlos Ernesto Gonçalves Reynaud Schaefer Jhonathan de Oliveira Silva Walnir Gomes ferreira Júnior Rubens Manoel dos Santos Andreza Viana Neri Universidade Federal do Vale do São Francisco Campus Senhor do BonfimColegiado de EcologiaAv.Tomaz GuimarãesS/NBairro Santos DumontSenhor do BonfimBACEP 48.970-000Brazil Universidade Federal de Viçosa Departamento de SolosCampus UniversitárioViçosaMGCEP 36570-900Brazil Instituto Federal de Educação Ciência e Tecnologia do Sul de Minas GeraisRodovia Machado-ParaguaçuKm 3MachadoMGCEP 37750-000Brazil Universidade Federal de Lavras Departamento de Ciências FlorestaisLaboratório de Conservação e Manejo da BiodiversidadeCampus UniversitárioLavrasMGCEP 37200-000Brazil Universidade Federal de Viçosa Departamento de Biologia VegetalLaboratório de Ecologia e Evolução de PlantasCampus UniversitárioViçosaMGCEP 36570-900Brazil

Aims Soil plays an important role in the formation and heterogene-ity of habitats and thus can cause changes in vegetation struc-ture and plant *** differentiation between Cerrado/savanna and forest is well known,but the relationship between soil and habitats from savannic or forest formations still needs to be better understood,particularly in tropical ecotonal *** studied the association between attributes of plant com-munities,namely structure and diversity,and physicochemical characteristics of soils in the Caatinga domain at the transition to Cerrado in *** Chemical and physical analyses of soils were performed in samples of 38 plots from savannic formations and 30 plots from forest *** was characterized floristically and structurally in all plots,five habitats being assessed in each plant *** features and vegetation parameters were highly distinct among the different *** Findingsin general,forest habitats were more nutrient rich than savannic ***,soil variables showed effects both on vegetation structure and on its species diversity,more pronouncedly in the savannic *** were structurally distinct,and diversity differed between savannic and forest communities;however,a higher differentiation occurred when the savannic formation habitats were compared among *** plant diversity did not differ among forest formation habitats,soil attributes showed a close relationship with edaphic factors and can contribute for similar *** soil-vegetation relationship in highly diverse ecotonal landscapes is important from the conservation biology point of view and aid in the execution of proactive plans for the maintenance of ***,we noticed that diversity and soil behaves distinctly between savannic and forest communities.

关键词： Cerrado dry forest edaphic variation vegetation-soil relationship ecotone

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Hepatic“pregnancy”:hepatocellular carcinoma with extensive extrahepatic growth

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Hepatobiliary Surgery and Nutrition 2023年第4期12卷 641-642页

作者： Ana Rita ferreira Bárbara Castro jose Daniel Martins João Varanda Alexandre Costa Bela Pereira Manuel Oliveira General Surgery Centro Hospitalar Vila Nova de Gaia/EspinhoVila Nova de GaiaPortugal

A female in her 50s,no previous personal history,presented to the Emergency Department with a 7 months history of progressively worsening abdominal diffuse pain associated with increasing abdominal *** physical examin... 详细信息

关键词： pregnancy Hepatic Figure

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Functional and structural changes in internal pudendal arteries underlie erectile dysfunction induced by androgen deprivation

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Asian Journal of Andrology 2017年第5期19卷 526-532页

作者： Rheure alves-Lopes Karla B Neves Marcondes AB Silva Vania C Olivon Silvia G Ruginsk jose Antunes-Rodrigues Leandra NZ Ramalho Rita C Tostes Fernando Silva Carneiro Department of Pharmacology Ribeirao Preto Medical School University of Sao Paulo Ribeirao Preto SP Brazil Department of Physics and Chemistry Faculty of Pharmaceutical Sciences of Ribeirao Preto University of Sao Paulo Ribeirao Preto SP Brazil Department of Physiological Sciences Biomedical Sciences InstituteFederal University of Alfenas Alfenas MG Brazil Department of Physiology Ribeirao Preto Medical School University of Sao Paulo Ribeirao Preto SP Brazil Department of Pathology and Legal Medicine Ribeirao Preto Medical School University of Sao Paulo Ribeirao Preto SP Brazil

Androgen deficiency is strongly associated with erectile dysfunction （ED）. Inadequate penile arterial blood flow is one of the major causes of ED. The blood flow to the corpus cavernosum is mainly derived from the internal pudendal arteries （IPAs）; however, no study has evaluated the effects of androgen deprivation on IPA＇s function. We hypothesized that castration impairs IPAs reactivity and structure, contributing to ED. In our study, Wistar male rats, 8-week-old, were castrated and studied 30 days after orchiectomy. Functional and structural properties of rat IPAs were determined using wire and pressure myograph systems, respectively. Protein expression was determined by Western blot and immunohistochemistry. Plasma testosterone levels were determined using the IMMULITE 1000 Immunoassay System. Castrated rats exhibited impaired erectile function, represented by decreased intracavernosal pressure/mean arterial pressure ratio. IPAs from castrated rats exhibited decreased phenylephrine- and electrical field stimulation （EFS）-induced contraction and decreased acetylcholine- and EFS-induced vasodilatation. IPAs from castrated rats exhibited decreased internal diameter, external diameter, thickness of the arterial wall, and cross-sectional area. Castration decreased nNOS and α-actin expression and increased collagen expression, p38 （Thr180/ryr182） phosphorylation, as well as caspase 3 cleavage. In conclusion, androgen deficiency is associated with impairment of IPA reactivity and structure and increased apoptosis signaling markers. Our findings suggest that androgen deficiency-induced vascular dysfunction is an event involving hypotrophic vascular remodeling of IPAs.

关键词： androgen castration internal pudendal artery

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Crisis challenges of small firms in Macao during the COVID-19 pandemic

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Frontiers of Business Research in China 2020年第4期14卷 403-425页

作者： jose Calves Tan Cheng Lok Yubo Luo and Wei Hao City University of Macao 4th FloorLuso-Chinese BuildingAvenida Padre Tomas PereiraMacaoChina

This research develops a framework that combines crisis stages,stakeholder engagement and crisis *** framework is applied to small firms in Macao during the 2019 novel coronavirus disease(COVID-19)pandemic *** conduct a qualitative study based on semi-structured interviews with the leaders of six small firms in *** findings suggest that the COVID-19 pandemic has turned into a"normal"context,which blurs the traditional crisis termination *** also find that participating firms engage more with internal stakeholders than external *** strategies adopted by small firms include flexible human resource(HR)practices,cost reduction,enhancing customer relations,and using government support *** strategies are effective in the short term;firms need to pay attention to diversity and learning for the long term.

关键词： Crisis development Crisis strategies Small firms 2019 novel coronavirus disease(COVID-19) Macao

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CFD predictions for hazardous area classification

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Chinese Journal of Chemical Engineering 2019年第1期27卷 21-31页

作者： Andrey Oliveira de Souza Aurélio Moreira Luiz Ant?nio Tavernard Pereira Neto Ant?nio Carlos Brandao de Araujo Heleno Bispo da Silva Sidinei Kebler da Silva jose Jailson Nicacio alves Federal Institute of Education Science and Technology of Paraiba Petrobras-Petróleo Brasileiro S.A. Federal University of Campina Grande

This study aimed to describe a Computational Fluid Dynamics(CFD) procedure using the ANSYS CFX software 16.1 and Design of Experiments for the determination of volume and extension of explosive atmospheres due to fugitive emissions of flammable *** multidimensional statistical sampling technique Latin Hypercube was used, which defined 100 simulations of random methane gas leak *** CFD model proved to be robust in predicting the extension and volume of the explosive atmosphere for orifice diameters from 0.1 to2.5 mm, pressure from 0.1 MPa to 12 MPa and temperatures from 0 ℃ to 400 ℃.It was found that the calculation domain must be parameterized 8 m in length for each millimeter of the diameter of the source of release to ensure the *** order not to lose precision for very small diameters, the mesh was parameterized with 50 elements along the orifice *** was proved that gravity does not influence the extension and volume of the explosive atmosphere at sonic *** deviation from the ideal gas behavior in the reservoir,achieved by applying the Soave–Redlich–Kwong equation of state, also has not significantly influenced the extension and volume of the explosive *** results showed that the size of the explosive atmosphere varies directly with the diameter of the source emission and reservoir pressure, and inversely with the temperature of the *** diameter of the source is the parameter that has the major effect on the extension of the explosive atmosphere, followed by the pressure and lastly the temperature of the reservoir.

关键词： Computational Fluid Dynamics Computer simulation Safety Fugitive emissions Classified area Flammable gas cloud

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Glycoproteogenomics: Setting the Course for Next-generation Cancer Neoantigen Discovery for Cancer Vaccines

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Genomics, Proteomics & Bioinformatics 2021年第1期19卷 25-43页

作者： José Alexandre ferreira Marta Relvas-Santos Andreia Peixoto AndréM.N.Silva Lúcio Lara Santos Experimental Pathology and Therapeutics Group Portuguese Institute of OncologyPorto 4200-072Portugal Institute of Biomedical Sciences Abel Salazar University of PortoPorto 4050-313Portugal Porto Comprehensive Cancer Center(P.ccc) Porto 4200-072Portugal REQUIMTE-LAQV Department of Chemistry and BiochemistryFaculty of Sciences of the University of PortoPorto 4169-007Portugal

Molecular-assisted precision oncology gained tremendous ground with high-throughput next-generation sequencing(NGS),supported by robust *** quest for genomicsbased cancer medicine set the foundations for improved patient stratification,while unveiling a wide array of neoantigens for *** pre-clinical and clinical studies have successfully used tumor-specific peptides in vaccines with minimal off-target ***,the low mutational burden presented by many lesions challenges the generalization of these solutions,requiring the diversification of neoantigen *** utilizing customized databases for protein annotation by mass spectrometry(MS)is a powerful tool toward this *** the concept toward exploring proteoforms originated from post-translational modifications(PTMs)will be decisive to improve molecular subtyping and provide potentially targetable functional nodes with increased cancer *** through the path of systems biology,we highlight that alterations in protein glycosylation at the cell surface not only have functional impact on cancer progression and dissemination but also originate unique molecular fingerprints for targeted ***,we discuss the outstanding challenges required to accommodate glycoproteomics in oncoproteogenomics *** envisage that such rationale may flag a rather neglected research field,generating novel paradigms for precision oncology and immunotherapy.

关键词： Glycoproteogenomics Oncoproteogenomics Cancer neoantigens Glycosylation Precision oncology

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Hydrological Structure, Circulation and Water Mass Transport in the Gulf of Cadiz

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International Journal of Geosciences 2011年第4期2卷 432-456页

作者： jose Miguel Rodrigues alves Xavier Carton Isabel Ambar 不详

Hydrological and LADCP data from four experiments at sea (Semane 1999, 2000/1 2000/3, 2001) are used to describe the structure and circulation of Mediterranean Water in the Gulf of Cadiz. These data were gathered on meridional sections along 8?20′W and 6?15′W and between these longitudes on a zonal section along 35?50′N. The mesoscale and the submesoscale structures (Mediterranean Water Undercurrents, meddies, cyclones) observed along these sections are characterized in terms of thermohaline properties and of velocity. The transports of mass and salt in each class of density (North Atlantic Central Water, Mediterranean Water, North Atlantic Deep Water) are computed with an inverse model. The model indicates a general eastward flux in the Central Water layer, and a westward flux in the Mediterranean Water layer, but there is also a horizontal recirculation and entrainment in these two layers, as well as strong transports associated with the meddy and cyclone found during Semane 1999.

关键词： Mediterranean Water Gulf of Cadiz Hydrology Water Masses Regional Scale Circulation Inverse Model Transport

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精细复合含碳坯体的胶态成型与生态设计(英文)

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应用基础与工程科学学报 2004年第2期12卷 179-186页

作者：徐利华连芳夏雯姚云 jose M F ferreira 北京科技大学无机非金属材料系北京100083

研究了SL型聚合(高分子)电解质分散剂对含石墨掺杂高岭土粉体的胶体稳定性影响.结果表明该分散剂能使碳易在水中溶解并使溶液粘度快速降低,同样在高岭土水系统中也发现类似现象.通过粒度分布的分析,所测试的粉体均具有多峰行为,其有利... 详细信息

研究了SL型聚合(高分子)电解质分散剂对含石墨掺杂高岭土粉体的胶体稳定性影响.结果表明该分散剂能使碳易在水中溶解并使溶液粘度快速降低,同样在高岭土水系统中也发现类似现象.通过粒度分布的分析,所测试的粉体均具有多峰行为,其有利于颗粒微观内力作用下的颗粒紧密堆积.因此基于低粘度与高固相含量的控制,可获得具有高密度的精细复合坯体,其包括高岭土/石墨以及飞灰/石墨/高岭土.从悬浮体制备到素坯形成的一系列胶态成型工艺中,其重要因素主要包括混合粉体的组分配比、分散剂含量、各种粉体的粒度分布以及固相质量分数等,它们对流变性、生态性与力学性能均产生直接地影响.

关键词：流变学生态悬浮体含碳复合材料素坯胶态成型电解质分散剂高岭土粉体

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