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Endothelial Nitric Oxide Synthase Gene Polymorphism and Periodontal Disease

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Open Journal of Blood Diseases 2012年第2期2卷 34-37页

作者： Fernanda Gobbi Amorim Maria Bernadete Depoli Giovana Machado Souza Simoes Bianca Prandi Campagnaro Clarissa Loureiro Tonini Iuri Drumond Louro jose Airton Arruda Elisardo Corral Vasquez Silvana dos santos Meyrelles Biotechnology Graduate Program Health Sciences CenterFederal University of Espirito SantoVitoriaBrazil Department of Physiological Sciences Health Sciences CenterFederal University of Espirito SantoVitoriaBrazil Intercath-Meridional Hospital CariacicaBrazil.

The endothelial isoform of nitric oxide synthase (eNOS) is responsible for the physiological production of NO in endo-thelial cells and platelets. There is evidence that the G894T polymorphism of the eNOS gene is associated with this enzyme's basal activity and NO production, which could contribute to the pathogenesis of periodontal diseases (PD). Therefore, this study was designed to investigate the role of G894T polymorphism in the eNOS gene as a predisposing factor to periodontal disease. In this study we investigated the association of this polymorphism with PD in an admix-ture population (N = 119) separated into three groups: Healthy control, Moderate and Severe PD, without statistical differences among them for risk factors for PD, such as age, gender and smoking status. We observed that the GG ge-notype was associated with the progression of PD as indicated by an increase in frequency of approximately 18% in the Moderate and 26% in the Severe groups compared to the Healthy control group (p = 0.0302). This finding indicates that patients carrying the GG genotype have a greater chance of developing PD compared with those carrying the T allele, and it reinforces the notion that genetic factors contribute to the development and aggravation of PD.

关键词： eNOS Polymorphism Periodontal Disease

Nodular Amyloidosis Overlapping and Polymyositis in a Patient with Skin Manifestations Lupus Fax: Case Report

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Journal of Biosciences and Medicines 2017年第11期5卷 33-40页

作者： Eneas Van Der Maas do Bem Filho Laiza Maria dos santos Couto Antonio Luiz da Costa Soares Jr Pedro Paulo Andrade Thiago Sande Miguel sebastiao Celio Horta Coelho Filho Daniel Almeida da Costa Livia Cristina de Melo Pino Thayro Van Der Maas do Bem The Medical School at the Center of Higher Education of Valenca ValencaBrazil

Amyloidosis is the result of fibrous and insoluble amyloid protein deposition in extracellular spaces of tissues and organs, including the skin. Through the analysis of medical records, clinical condition and laboratory tests, this article proposes a rare case report of an adult patient with symptoms and diagnosis of polymyositis, histopathology of nodular amyloidosis with skin lesions suggestive of lupus. The patient is still being followed at the dermatology clinic of Valença Medical School, in order to improve the prognosis and prevent the progression of existing symptoms.

关键词： Nodular Amyloidosis Polymyositis

Evaluation of the neuropharmacological properties of nerol in mice

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World Journal of Neuroscience 2013年第1期3卷 32-38页

作者： Thiago Henrique Costa Marques Maria Leonildes Boavista Gomes Castelo Branco Marques Douglas dos santos Lima Halmisson D’arley santos Siqueira jose Damasceno Nogueira Neto Maria do Socorro Boavista Gomes Castelo Branco Alexandre Araujo de Souza Damiao Pergentino de Sousa Rivelilson Mendes de Freitas Northeast Biotechnology Network Federal University of Piauí(UFPI)TeresinaBrazil Pharmacology Universidade Federal do Piauí(UFPI)TeresinaBrazil Pharmaceutics Sciences Chemistry DepartmentFederal University of Piauí(UFPI)TeresinaBrazil Department of Pharmacy Federal University of Sergipe(UFS)Sao CristovaoBrazil Department of Biochemistry and Pharmacology Campus Ministro Petronio PortelaFederal University of Piauí(UFPI)TeresinaBrazil

The search for therapeutic agents that will provide the ground for man and an improvement in their quality of life is ceaseless. The nerol (cis-2,6-dimethyl-2,6-octadien-8-ol) is a monoterpene which can be found in various medicinal plants as Lippia spp and Melissa officinalis L. The objective of this study was to analyze the acute effect of nerol in the central nervous system (CNS) by performing behavioral tests in mice (open field, elevated plus-maze, light/dark and rota rod tests). We used male albino mice (Mus musculus), Swiss variety, adult with 2 month-old. The animals were divided into five groups (n = 8) for each experimental protocol, and they were administered intraperitoneally (i.p.), respectively, Tween 80 0.05% dissolved in saline solution 0.9%, nerol (30, 60 or 90 mg/kg) or diazepam (2 mg/kg). In the open field test, all groups treated with nerol showed a significant decrease in motor activity (number of crossings, rearings and groomings) when compared with vehicle group. In the elevated plus-maze test, nerol groups significantly increased the number of entries and time of permanence in the open arms when compared with vehicle group. In the light-dark test, nerol groups showed a significant increase the time of permanence in the room clear when compared with vehicle group. In the rota rod test, the groups treated with nerol didn’t show modification in time spent and number of falls in the revolving bar when compared with vehicle group. These results indicate a possible anxiolytic effect of nerol in mice.

关键词： Anxiety Behaviors Mice Nerol Essential Oils

Bredemeyera floribunda Wild Elemental Content and Comparison with Nutritional Recommendation for Adults:Medicinal Plant Used by the Brazilian Rural Population to Treat Fatigue and Exhaustion

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American Journal of Plant Sciences 2020年第3期11卷 323-343页

作者： Paula Fabiana Saldanha Tschinkel Elaine Silva de Padua Melo Daniela Granja Arakaki Valdir Aragao do Nascimento Melina Ribeiro Fernandes Nayara Vieira Lima Luana Carolina santos Leite Hugo santos Pereira Kassia Roberta Nogueira da Silva Francisco jose Mendes dos Reis Valter Aragao do Nascimento Group of Spectroscopy and Bioinformatics Applied to Biodiversity and Health School of MedicinePostgraduation Program in Health and Development in the Midwest RegionFederal University of Mato Grosso do SulSchool of MedicineCampo GrandeBrazil Institute of Chemistry of the Federal University of Mato Grosso do Sul Campo GrandeBrazil

Bredemeyera floribunda Wild (Polygalaceae), also known as pau-de-ovo is a medicinal plant used to treat snakebites, as tonic and fortifiers to treat fatigue and exhaustion. The aim of the present study was to document the knowledge of herbal sellers in the preparation of the so-called “B. floribunda fortifier” and to compare the plant root content with the recommended nutritional values and the permitted limit for medicinal plants. The study revealed that, unlike other regions of Brazil, in the Midwest region, the root of the plant is used as food to treat fatigue and exhaustion. The contents in B. floribunda root decreased in the following order: Ca > K > P > Na > Fe > Mg > Si > Mn > Zn > Cu. Daily intake of 30 grams of B. floribunda roots are considered as an excellent source of Cr, Cu, Mn and Se for people 19 to 50 years of age according to the RDA. In addition, Cu and Fe showed content above the established limit for medicinal plants stipulated by other countries. The root of the plant has low K, Mg, P, Na and Zn content. When the contents in roots of the plant are below the oral dose of reference, consumption of this plant can be considered safe and without risk to human health. On the other hand, concentration of elements such as Cu, Fe, Ni, Al, Cr and Se exceeding the allowable limit may cause serious health problems due to prolonged ingestion and large amounts consumed daily. The Brazilian legislation does not establish a permissible limit of macro- and micro-elements in medicinal plants;thus, the results presented in this study will contribute to the Brazilian public health policy on medicinal plants.

关键词： Macroelements Microelements Bredemeyera floribunda Wild Pau-De-Ovo ICP OES

Monitoring of Ionizing Radiation Using Geiger Instrument during February to April 2015 in Sao jose dos Campos, SP, Brazil

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Journal of Environmental Science and Engineering(A) 2015年第6期4卷 282-285页

作者： Inacio Malmonge Martin Marcelo Pego Gomes Bogos Nubar Sismanoglu Thiago Adriano dos santos Joao Paulo Correa Department of Physics Technological Institute of Aeronautics Sao Jose Dos Campos 12228-900 Brazil Department of Mechanical Engineering University of Taubate Taubate 12060-440 Brazil

Measures of ionizing radiation were observed in a tower which is 20 meters above the ground relative height. They show a distinct period of 24 hours oscillation during this Februaryl 1 to April 11, 2015. It is suggested that these oscillations originate from radon gas （222Rn） vented from the ground floor. One Russian specific Geiger tube with associated electronics developed at ITA was used, Monitoring of ionizing radiation from 30 keV to l0 MeV shows that the X and gamma rays up to 3.0 MeV is prevalent in the region comes from the Radon gas 222Rn that decay in 214Bi and 214pb in the energies of the gamma rays 0.269, 0.609 and 1.05 MeV respectively. Then, with this simple, portable instrument was possible to monitoring the dynamics of radon gas in the region every interval minutes.

关键词： Atmosphere radon gas gamma radiation.

Dengue Climate Variability in Rio de Janeiro City with Cross-Wavelet Transform

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Journal of Environmental Protection 2022年第3期13卷 261-276页

作者： Suellen Araujo Franco dos santos Hugo Abi Karam Augusto José Pereira Filho Jú lio Cesar Barreto da Silva jose Luis Flores Rojas Julio Migue Angeles Suazo Isela Leonor Vá squez Panduro Cesar Arturo Sanchez Peñ a Departamento de Meteorologia Instituto de Geoci&ecirc ncias Universidade Federal do Rio de Janeiro (UFRJ) Rio de Janeiro Brasil Departamento de Ciê ncias Atmosfé ricas Instituto de Astronomia Geofísica e Ci&ecirc ncias Atmosfé ricas Universidade de S&atilde o Paulo (IAG-USP) S&atilde o Paulo Brasil Programa de Pós-Graduaç ã o em Ciê ncias Ambientais Universidade Estadual do Rio de Janeiro (UERJ) Rio de Janeiro Brasil Instituto Geofísico do Peru (IGP) Lima Per&uacute Facultad de Ingeniería Forestal y Ambiental. Universidad Nacional Autó noma de Tayacaja Daniel Herná ndez Morillo (UNAT) Pampas Per&uacute Universidad Tecnoló gicadel Perú Faculdad de Engenier&iacute a Industrial Lima Per&uacute Centro de Previsã o do Tempo e Estudos Climá ticos Cachoeira Paulista Brasil Programa de Pó s-Graduaç ã o em Computaç ã o Aplicada Instituto Nacional de Pesquisas Espaciais (INPE) S&atilde o José dos Campos S&atilde o Paulo SP Brasil

Dengue is one of the most prominent tropical epidemic diseases present in the Rio de Janeiro city and Southeast part of Brazil, due to the widespread conditions of occurrence of the dengue vector, the mosquito Aedesaegypti, such as high-temperature days interlaced with afternoon or nocturnal rainstorms in summer. This work has the objective of investigating the relationships between variabilities of the El Ni?o-South Oscillation (ENSO) and greater epidemics of dengue in Rio de Janeiro city. To accomplish this goal, the analysis and signal decomposition by cross-wavelet transform (WT) was applied to obtain the cross variability associated with variations of power and phase of both signals by characteristic periods and along with the time series. Data considered in the analysis are (the decimal logarithm of normalized value) of the monthly available notifications of dengue worsening, provided by the public health system of Brazil, and the Southern Oscillation Index (SOI) Ni?o 3.4 data, provided by the National Oceanic and Atmospheric Administration (NOAA), in the period 2000-2017. A maximum cross-wavelet power close to 0.45 was obtained for the representative period of 1 year and also to periods between 3 and 4 years, associated with the positive phase of the SOI index (i.e. , La Ni?a) or with a transition to the positive phase. The evolution of the combined variability of SOI and dengue can be expressed by progressive differences in phase along the time, eventually resulting in yielding phases (i.e., La Niña-Dengue epidemic).

关键词： Dengue Fever Cross-Wavelet Transform Analysis El Niño-Southern Oscillation Index

Monitoring of Ionizing Radiation and Rain Intensity during May to October 2015 in S^o Jos~ dos Campos, Brazil

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Journal of Environmental Science and Engineering(B) 2016年第3期5卷 115-117页

作者： Inacio Malmonge Martin Thiago Adriano dos santos Franklin Andrade da Silva Marcelo Pego Gomes Bogos Nubar Sismanoglu Physics Department Institute Technological of Aeronautics (1TA) Sao Jose dos Campos 12228-900 Brazil

Radiation affects the environment and local human activity in any location of the earth＇s surface. Due to this fact, the aim of this study was to monitor the ionizing radiation and rain intensity using portable devices. During May 23 to October 2, 2015, it was made measures the intensity of gamma radiation from 30 keV to 10.0 MeV at a height of 25 meters in Sao Jos6 dos Campos city, SP, Brazil. It was used a crystal of sodium iodide scintillator 3 - 3 inches coupled to a photomultiplier and associated electronic. The measurements were made continually with minute＇s interval throughout the period and it was monitored rain intensity every minute at the same height of the tower. In this job, it was possible to correlate rain-radiation and it was observed which gamma radiation has a directly proportional relationship with rain and visible frequency of 1 day.

关键词： Gamma radiation rain intensity radon gas gamma scintillator.

High Order of Accuracy for Poisson Equation Obtained by Grouping of Repeated Richardson Extrapolation with Fourth Order Schemes

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Computer Modeling in Engineering & Sciences 2021年第8期128卷 699-715页

作者： Luciano Pereira da Silva Bruno Benato Rutyna Aline Roberta santos Righi Marcio Augusto Villela Pinto Graduate Program in Numerical Methods in Engineering Federal University of ParanaCuritiba81531-980Brazil Graduate Program in Space Sciences and Technologies Aeronautics Institute of TechnologySao Jose dos Campos12228-900Brazil Department of Mechanical Engineering Federal University of ParanaCuritiba81531-980Brazil

In this article,we improve the order of precision of the two-dimensional Poisson equation by combining extrapolation techniques with high order *** high order solutions obtained traditionally generate non-sparse matrices and the calculation time is very *** can obtain sparse matrices by applying compact *** this article,we compare compact and exponential finite difference schemes of fourth *** numerical solutions are calculated in quadruple precision(Real*16 or extended precision)in FORTRAN language,and iteratively obtained until reaching the round-off error magnitude around 1.0E−*** procedure is performed to ensure that there is no iteration *** Repeated Richardson Extrapolation(RRE)method combines numerical solutions in different grids,determining higher orders of *** main contribution of this work is based on a process that initializes with fourth order solutions combining with RRE in order to find solutions of sixth,eighth,and tenth order of *** multigrid Full Approximation Scheme(FAS)is also applied to accelerate the convergence and obtain the numerical solutions on the fine grids.

关键词： Tenth order accuracy RRE compact scheme exponential scheme multigrid finite difference

Application of Non-destructive Testing to Evaluate the Performance of Bridges Structures

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Journal of Civil Engineering and Architecture 2017年第1期11卷 1-7页

作者： Diego Jesus de Souza Elaine Souza dos santos Eric Pianizolli Flor Gabriel Pereira Marinho Giovana Costa Reus Heloise Cristine Cezario Leticia Andrade Camara Department of Civil Engineering University of Ottawa Ottawa K2P0M1 Canada Department of Civil Construction Universidade Federal do Parana Sao Jose dos Pinhais 83040-334 Brazil Department of Civil Construction Universidade Federal do Parana Linhares 29902-190 Brazil Department of Civil Construction Universidade Federal do Parana Curitiba 80630-280 Brazil Department of Civil Construction Universidade Federal do Parana Campo Largo 83604-230 Brazil Department of Civil Construction Universidade Federal do Parana Curitiba 80060-120 Brazil

Bridges are important elements in road system and can influence the entire economy of cities and region. Usually, these structures have high financial investments for their constructions, in this way, maintenance and conservation become so important. Inspection is a technical activity that covers several operations, including performance analysis; examination; final performance report, other operations may be necessary, such as maintenance work, recovery, strengthening and rehabilitation. Technical examination together with some test methods allows a critical and parametric judgment of the bridge performance by minimizing the subjectivity of visual evaluations, and permits a more detailed diagnosis. This paper discusses the methodology to perform tests to complement the assessment recommended by DNIT （Brazilian National Department of Transport Infrastructure）, which consists only on a visual judgment. This approach provides technical basis to classify the bridges as its need and urgency of maintenance.

关键词： Non-destructive testing bridges concrete durability.