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Alginate modifies the physiological impact of CeO2nanoparticles in corn seedlings cultivated in soil

Journal of Environmental Sciences 2014年第2期26卷 382-389页

作者： Lijuan Zhao jose r.peralta-videa Bo Peng Susmita Bandyopadhyay Baltazar Corral-Diaz Pedro Osuna-Avila Milka O.Montes Arturo A.Keller Jorge L.Gardea-Torresdey Chemistry Department The University of Texas at El Paso 500 West University Avenue University of California Center for Environmental Implications of Nanotechnology The University of Texas at El Paso 500 West University Avenue Environmental Science and Engineering PhD program The University of Texas at El Paso 500 West University Avenue Department of Biological Sciences The University of Texas at El Paso 500 West University Avenue Universidad Aut'onoma De Ciudad Ju'arez Plutarco Elias Calles # 1210 Fovissste Chamizal. Ciudad Juarez Chihuahua 32310 Mexico Chemistry Department University of Texas of the Permian Basin Odessa Bren School of Environmental Sciences and Management 3420 Bren Hall University of California

Alginates are naturally occurring components of organic matter in natural soil whose effects on nanoparticle （NP） toxicity to plants is not well understood. In the present study, corn plants were grown for one month in soil spiked with 400 mg/kg CeO2 NPs with various alginate concentrations. After one month of growth in the NPs impacted soil, plants were harvested and analyzed for Ce and mineral element concentrations. Chlorophyll concentration and heat shock protein 70, used as biomarkers for oxidative stress, were also evaluated. results showed that, compared to CeO2 NPs treatment, alginate at 10, 50, and 100 mg/kg increased Ce concentration in roots by approximately 46%, 38%, and 29% and by 115%, 45%, and 56% in shoots, respectively. CeO 2 NPs without alginate increased Mn accumulation in roots by 34% compared to control. CeO2 NPs with low and medium alginate increased Mn by ca. 92% respect to NPs without alginate and by ca. 155% respect to control. CeO2 NPs without/with alginate significantly increased accumulation of Fe and Al in roots. In addition, alginate at 50 mg/kg increased Zn accumulation in roots by 52% compared to control. In shoots, K increased at all NP treatments but the accumulation of other elements was not affected. Alginate enlarged the impact of CeO2 NPs to corn plants by reducing chlorophyll a content and triggering overexpression of heat shock protein 70.

关键词： CeO2 NPs alginate nutrient uptake chlorophyll heat shock protein

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随机扩增多态性DNA技术研究发现二氧化钛纳米颗粒对西葫芦具有基因毒性(英文)

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2014年第8期15卷 618-623页

作者： Fabiola MOrENO-OLIVAS Vincent U.GANT Jr. Kyle L.JOHNSON jose r.peralta-videa Jorge L.GArDEA-TOrrESDEY Depertment of Chemistry The University of Texas at El Paso El Paso TX 79968 USA University of California Center for Environmental Implications of Nanotechnology (UC CEIN) The University of Texas at El Paso El Paso TX 79968 USA Department of Biological Sciences and Border Biomedical research Center The University of Texas at El Paso El Paso TX 79968 USA Environmental Science and Engineering PhD Program The University of Texas at El Paso El Paso TX 79968 USA

研究目的:二氧化钛(TiO2)纳米颗粒已经广泛应用于化妆品、防晒霜、涂料和牙膏等。这些纳米颗粒性质非常稳定,能在废水和生物固体中转移和分散。现有研究表明,TiO2纳米颗粒对动物正常生理活动具有毒性等负面作用。但是,它们对植物是否具... 详细信息

研究目的:二氧化钛(TiO2)纳米颗粒已经广泛应用于化妆品、防晒霜、涂料和牙膏等。这些纳米颗粒性质非常稳定,能在废水和生物固体中转移和分散。现有研究表明,TiO2纳米颗粒对动物正常生理活动具有毒性等负面作用。但是,它们对植物是否具有毒性特别是是否会产生植物基因毒性至今尚不清楚。因此,本文使用随机扩增多态性DNA技术研究TiO2纳米颗粒是否对西葫芦具有基因毒性,为TiO2纳米颗粒排放进入环境后的潜在植物毒性风险评价提供依据。创新要点:首次发现了TiO2纳米颗粒对西葫芦具有基因毒性。重要结论:采用随机扩增多态性DNA技术,发现TiO2纳米颗粒污染处理的西葫芦样品与未处理样品的基因组DNA图谱相比,不仅在谱带强度有明显差异,而且存在谱带消失和新谱带产生现象,表明TiO2纳米颗粒对西葫芦具有基因毒性。

关键词：随机扩增多态性DNA技术 TiO2 纳米颗粒基因组DNA 西葫芦毒性

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Unveiling the brain’s symphony:exploring the necessity and sufficiency of neural networks in behavior control

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Neural regeneration research 2025年第1期20卷 186-187页

作者： Fernando jose Bustos Instituto de Ciencias Biomedicas Facultad de Medicina y Facultad de Ciencias de la VidaUniversidad Andres BelloSantiagoChile Millennium Nucleus of Neuroepigenetics and Plasticity(EpiNeuro) SantiagoChile

Since the pioneering work by Broca and Wernicke in the 19th century,who examined individuals with brain lesions to associate them with specific behaviors,it was evident that behaviors are complex and cannot be fully attributable to specific brain areas ***,they involve connectivity among brain areas,whether close or *** that time,this approach was considered the optimal way to dissect brain circuitry and *** pioneering efforts opened the field to explore the necessity or sufficiency of brain areas in controlling behavior and hence dissecting brain ***,the connectivity of the brain and the mechanisms through which various brain regions regulate specific behaviors,either individually or collaboratively,remain largely *** animal models,researchers have endeavored to unravel the necessity or sufficiency of specific brain areas in influencing behavior;however,no clear associations have been firmly established.

关键词： behavior connectivity neural

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An in vitro and in silico study of anti-dermatophytic activity of gossypol from fruits of Thespesia populnea(L.)*** Correa

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Asian Pacific Journal of Tropical Biomedicine 2021年第12期11卷 543-552页

作者： Anuthara r Sebastian jose Midhun Jyothis Mathew Microbiology research Lab School of BiosciencesMahatma Gandhi UniversityKottayamKeralaIndia

Objective:To isolate,purify,and characterize gossypol from the fruits of Thespesia populnea(L)*** Correa,test its antidermatophytic activity,identify its targets on the dermatophyte,and confirm the binding of gossypol with the fungal target by molecular docking ***:Gossypol from Thespesia populnea was characterized by high performance liquid chromatography,liquid chromatographmass spectrometry,Fourier transform infrared spectroscopy,and nuclear magnetic *** anti-dermatophytic activity of gossypol was tested against four different dermatophytes,*** mentagrophytes,Trichophyton rubrum,Microsporum canis,and Microsporum *** mentagrophytes was selected for further *** inhibitory mode of action of gossypol on Trichophyton mentagrophytes was determined by analyzing the modulation of gene expression in various pathways of the ***:Gossypol inhibited all the *** minimum inhibitory concentrations were 12.5μg/mL for Trichophyton mentagrophytes and Microsporum canis and 25μg/mL for Trichophyton rubrum and Microsporum *** minimum fungicidal concentrations were 50μg/mL for Trichophyton mentagrophytes,100μg/mL for Microsporum canis and Trichophyton rubrum,and 200μg/mL for Microsporum *** inhibited the mrNA expression of metalloprotease(MEP4)and isocitrate lyase(ICL).The binding of gossypol with the enzymes was confirmed by molecular docking *** best docking poses were found and the low binding energies were recorded with the two target ***:Gossypol is a potential antifungal agent and can be further explored as an anti-dermatophytic drug.

关键词： Thespesia populnea Gossypol Anti-dermatophytic activity Trichophyton mentagrophytes Mechanism of action Gene expression Molecular docking Metalloprotease MEP4 Isocitrate lyase ICL

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A New Phasor Estimator for PMU Applications:P Class and M Class

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Journal of Modern Power Systems and Clean Energy 2020年第1期8卷 55-66页

作者： jose r.razo-Hernandez Arturo Mejia-Barron David Granados-Lieberman Martin Valtierra-rodriguez jose F.Gomez-Aguilar ENAP-research Group Facultad de IngenieríaUniversidad Autónoma de Querétaro(UAQ)San CayetanoC.P.76807México ENAP-research Group Departamento de Ingeniería ElectromecánicaInstituto Tecnológico Superior de Irapuato(ITESI)Colonia El CopalC.P.36821México CONACyT-Centro Nacional de Investigación y Desarrollo Tecnológico(CENIDET) Tecnológico Nacional de MéxicoInterior Internado Palmira S/NCol.PalmiraC.P.62490México

Phasor measurement units(PMUs)are fundamental tools in the applications of modern power systems,where synchronized phasor estimations are *** accuracy and dynamic performance requirements for phasor,frequency,and rate of change of frequency(rOCOF)estimations are established in the IEEE Std.C37.118.1-2011 along with the IEEE Std.C37.118.1 a-2014,where two PMU performances are suggested:P class filters for applications requiring fast response and M class filters for applications requiring high rejection to aliased *** this paper,a methodology to design new phasor estimators that satisfy the P class and M class requirements in PMUs is *** proposed methodology is based on finite impulse response filters,brick-wall filters,and complex filter design concepts,where frequency range,time performance,harmonic rejection and out-of-band interference requirements are considered in its design.A comparative analysis using the reference model given by the IEEE Std.C37.118.1 is *** results show the effectiveness of the phasor estimators under steady-state and dynamic conditions according to the PMU standard,making them suitable tools for applications in power systems.

关键词： Brick-wall filter complex filter IEEE Std.C37.118.1 M class P class phasor measurement unit(PMU) phasor estimator

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Secreted protein acidic and rich in cysteine(SPArC)induces epithelial-mesenchymal transition,enhancing migration and invasion,and is associated with high Gleason score in prostate cancer

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Asian Journal of Andrology 2019年第6期21卷 557-564页

作者： Fernanda Lopez-Moncada Maria jose Torres Enrique A Castellon Hector r Contreras Department of Basic and Clinic Oncology Faculty of Medic泊eUniversity of ChileSantiago 8389100Chile

Secreted protein acidic and rich in cysteine(SPArC)is a matricellular protein highly expressed in bone tissue that acts as achemoattractant factor promoting the arrival of prostate cancer(PCa)cells to the bone ***,the contribution of SPArCduring the early stages of tumor progression remains *** this study,we show that SPArC is highly expressed in PCa tissueswith a higher Gleason *** stable knockdown and overexpression of SPArC in PC3 and LNCaP cells,respectively,here wedem on strate that en doge nous SPArC induces the epithelial-mesenchymal tran sition(EMT),decreasing E-cadheri n and cytokeratin18 and increasing N-cadheri n and vime ***,SPArC in duces the expression of EMT regulatory tran scription factors Snailfamily transcriptional repressor 1(Snail),Snail family transcriptional repressor 2(Slug),and zinc finger E-box binding homeobox 1(Zeb1).In addition,SPArC knockdown in PC3 cells decreases migration and invasion in vitro,without modifying cell *** results indicate that SPArC might facilitate tumor progression by modifying the cellular phenotype in cancer cells.

关键词： epithelial-mesenchymal transition invasion migration prostate cancer secreted protein acidic and rich in cysteine(SPArC)

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Use of Soft-Computing Techniques to Study the Influence of External Factors during the Emotional Evaluation of Visual Stimuli

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Journal of Electrical Engineering 2018年第2期6卷 116-123页

作者： Arturo peralta Antonio Fernandez-Caballero jose M. Latorre jose A. Olivas Eduardo Conde Dept. of lnformation Technologies and Systems University of Castilla La Mancha Ciudad Real 13071 Spain Dept. of Information Systems University of Castilla La Mancha Albacete 02006 Spain Dept. of Psychology University of Castilla La Mancha Albacete 02008 Spain Dept. of Business Organization National University of Distance Education Madrid 28040 Spain

At present, all people know that, during the performance of any activity, each person is always under the influence of a set of external factors that can influence in their results. In fact, all people know that factors such as hour, accumulated fatigue, or mood, can be very influential in the productivity. However, there are other less studied factors that can equally be influential, to a greater or lesser extent. For this reason, in the present work are used different techniques belonging to Soft Computing, with the objective of detecting those most influential factors by the execution of a set of experiments under different simulated circumstances in a controlled environment.

关键词： Emotional interpretation pattern recognition decision trees clustering

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Mercury uptake and effects on growth in Jatropha curcas

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Journal of Environmental Sciences 2016年第10期28卷 120-125页

作者： jose Marrugo-Negrete jose Durango-Hernandez jose Pinedo-Hernandez German Enamorado-Montes Sergi Diez University of Cordoba Faculty of Basic Sciences Department of Chemistry Water Applied and Environmental Chemistry Group Monteria Colombia Environmental Chemistry Department Institute of Environmental Assessment and Water Research ID█A-CSIC E-08034 Barcelona Spain

The use of metal-accumulating plants for the phytoremediation of contaminated soils is gaining more attention. Mercury （Hg）-contaminated soils from historical gold mines represent a potential risk to human health and the environment. Therefore, Jatropha curcas plant, that has shown its tolerance to these environments, is a species of particular interest to implement phytoremediation techniques in gold mining sites. In this work, the behavior of J. curcas was assessed in different hydroponic cultures fortified with Hg at concentrations of 5, 10, 20, 40, and 80μg Hg/mL （T5, T10, T20, T40 and T80, respectively）. After exposure, plant growth, net photosynthesis, leaf area, and Hg accumulation were determined and variables such as net Hg uptake, effective Hg accumulation, translocation and bioaccumu- lation factors were calculated. Accumulation of Hg in root and leaf tissues increased with respect to the Hg concentrations in the hydroponic culture, with statistically significant differences （p 〈 0.05） among treatments. Moreover, Hg concentration in roots was 7 and 12-fold higher in average than in plant leaves and shoots, respectively. Many effects were found in the development of plants, especially related with loss of biomass and leaf area, with significant growth inhibition related to control values （〉50% with treatment T5）. Moreover, percentage of inhibition was even higher （〉60%） with same treatment for net photosynthesis. Finally, it should be highlighted that for T40 and T80 treatments, plant growth and photosynthesis were almost completely depleted （88%-95%）.

关键词： Jatropha curcasPhytoextractionMercuryHydroponicGrowth inhibition

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Challenges and improvement strategies in the hospitalization of chronic multimorbid patients

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World Journal of Clinical Cases 2025年第3期13卷 35-41页

作者： Andres Fontalba-Navas Francisco Pozo Muñoz rogelio Garcia Cisneros Maria jose Garcia Larrosa Maria del Mar Callejon Gil Ignacio Garcia Delgado Maria Belen Jimenez Martinez Antequera Hospital Northern Málaga Integrated Healthcare AreaAntequera 29200AndalusiaSpain Department of Public Health and Psychiatry University of MálagaMálaga 29010Spain Antequera Hospital Northern Málaga Antequera Integrated Healthcare AreaAntequera 29200MálagaSpain

BACKGrOUND Addressing the growing challenge of hospitalizing chronic multimorbid patients,this study examines the strain these conditions impose on healthcare systems at a local level,focusing on a pilot *** diseases and complex patients require comprehensive management strategies to reduce healthcare burdens and improve patient *** proven effective,this pilot model has the potential to be replicated in other healthcare settings to enhance the management of chronic multimorbid *** To evaluate the effectiveness of the high complexity unit(HCU)in managing chronic multimorbid patients through a multidisciplinary care model and to compare it with standard hospital *** The study employed a descriptive longitudinal approach,analyzing data from the Basic Minimum Data Set(BMDS)to compare hospitalization variables among the HCU,the Internal Medicine Service,and other services at Antequera Hospital throughout *** HCU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity *** The study employed a descriptive longitudinal approach,analyzing data from the BMDS to compare hospitalization variables among the HCU,the Internal Medicine Service,and other services at Antequera Hospital throughout *** HCU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity *** This study demonstrates the effectiveness of the HCU in managing patients with complex chronic diseases through a multidisciplinary *** coordinated care provided by the HCU results in improved patient outcomes,reduced unnecessary hospitalizations,and better management of patient *** superiority of the HCU compared to standard care is evident in key outcomes such as fewer readmissions and higher patient satisfaction,reinforcing its value as a model of ca

关键词： High complexity unit Chronic multimorbidity Patient-centered care Integrated care Healthcare management

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Comparative study of degradation of toluene and methyl isobutyl ketone(MIBK)in aqueous solution by pulsed corona discharge plasma

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Journal of Environmental Sciences 2021年第3期33卷 382-396页

作者： Jerin jose Ligy Philip Department of Civil Engineering Indian Institute of Technology MadrasChennai 600036India

Effectiveness of pulsed power plasma for the degradation of two toxic volatile organic compounds(VOCs),toluene and methyl isobutyl ketone(MIBK),in aqueous solution was *** plasma degradation of MIBK has been studied for the first *** influence of initial concentration of target compound,solution pH and scavengers on percentage degradation was evaluated.100%removal of 200 mg/L of toluene and MIBK was achieved both in liquid and gaseous phases after 12 and 16 min of plasma treatment,*** first order rate constant of toluene and MIBK degradation(for 200 mg/L each)was 0.421 and 0.319 min~(-1)respectively when they were treated individually,and these values decreased slightly during degradation of their *** degradation was slower than toluene and it might be due to semi volatile and hydrophilic nature of *** effect of initial concentration of toluene and MIBK showed different degradation *** degradation of both the compounds was obtained in neutral pH and in absence of scavengers.·OH radical was the major reactive species involved in their *** degradation in real environmental matrices showed that removal reduced significantly in secondary effluent due to scavenging of reactive species by various ions and organic *** total number of degradation intermediates identified in case of toluene and MIBK was 11 and 14 respectively and formate was the one recalcitrant byproduct *** degradation pathway of toluene and MIBK involving reactions of reactive oxygen and nitrogen species and reductive species is proposed.

关键词： Degradation pathway Methyl isobutyl ketone(MIBK) OH radical Pulsed power plasma Toluene

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