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Digital Chinese Medicine 2023年第3期6卷 295-306页

作者： prakash Ramakrishnan Jayaram Rajangam Binoy Varghese Cherian jose prakash dharmian Department of Pharmacology Crescent School of PharmacyB.S.Abdur Rahman Crescent Institute of Science and TechnologyChennaiTamil Nadu 600048India Department of Pharmacology Shri Venkateshwara College of PharmacyPondicherryTamil Nadu 605001India Department of Pharmaceutical Chemistry Saveetha College of PharmacyChennaiTamil Nadu 602117India Department of Pharmaceutics Crescent School of PharmacyB.S.Abdur Rahman Crescent Institute of Science and TechnologyChennaiTamil Nadu 600048India

目的本研究旨在探讨硬毛巴豆(CH)提取物在链脲佐菌素(STZ)大鼠中的神经保护作用。方法(1)亚慢性毒性试验包括24只成年大鼠,雌雄不限,体重160~200 g,分为4组,每组6只。第1组大鼠给予二甲基亚砜(DMSO)与生理盐水混合物;第2、3、4组大鼠灌... 详细信息

目的本研究旨在探讨硬毛巴豆(CH)提取物在链脲佐菌素(STZ)大鼠中的神经保护作用。方法(1)亚慢性毒性试验包括24只成年大鼠,雌雄不限,体重160~200 g,分为4组,每组6只。第1组大鼠给予二甲基亚砜(DMSO)与生理盐水混合物;第2、3、4组大鼠灌胃给药硬毛巴豆甲醇提取物(MECH),剂量分别为100、200和400 mg/kg,连续28天。将功能观察组合和自发活动分级作为其神经行为活动的一部分,并对脑区(如皮质和海马)进行神经病理学异常分析。(2)研究动物体重为160~200 g的成年雄性Wistar大鼠,分为5组,每组6只,包括对照组(Ⅰ)、STZ组(Ⅱ)、多奈哌齐组(Ⅲ)、MECH组(100 mg/kg,Ⅳ)和MECH组(200 mg/kg,Ⅴ)。第Ⅰ组大鼠口服柠檬酸盐缓冲液和DMSO生理盐水混合物(14天)。第Ⅱ组大鼠在第1天和第3天侧脑室注射链脲佐菌素(3 mg/kg,双侧ICV-STZ),随后给予生理盐水DMSO混合物(14天)。第Ⅲ、Ⅳ和Ⅴ组大鼠在第1天和第3天给予STZ,随后口服多奈哌齐[3 mg/(kg·d)]和MECH[100和200 mg/(kg·d)](14天)。检测大鼠Morris水迷宫(MWM)和被动回避试验(PAT)等学习记忆指标。完成行为学实验后处死动物,取脑,用紫外可见分光光度计测定乙酰胆碱酯酶(AChE)、脂质过氧化(LPO)、谷胱甘肽(GSH)和超氧化物歧化酶(SOD)水平。使用总荧光发射光谱法测定caspase-3水平。通过酶联免疫吸附测定(ELISA)检测β淀粉样蛋白(Aβ)水平,同时对CA1海马区进行组织病理学分析。结果(1)亚慢性毒性结果显示,各组MECH大鼠的旷场试验参数(包括线交叉、直立、进入中广场、排便或排尿)无显著差异(P>0.05)。组织病理学结果显示,与对照组大鼠相比,经过MECH治疗的大鼠两个区域的神经元细胞中均未产生任何病变和炎症。(2)研究主要发现STZ处理大鼠在学习和记忆参数受损显著增加(P<0.001),AChE、caspase-3、Aβ(1-40和1-42)和LPO水平均显著升高(P<0.001),且SOD和GSH水平显著降低(P<0.01)。此外,在海马区发现神经元损伤。相反,STZ诱导大鼠的行为和生化损伤与MECH治疗呈剂量依赖性降低。结论MECH通过其抗氧化作用可显著预防STZ诱导的记忆缺陷,胆碱能功能的恢复可能是行为改善的原因。因此,MECH可能治疗包括阿尔茨海默病在内的认知障碍。

关键词：神经炎症硬毛巴豆阿尔茨海默病链脲佐菌素脑室内

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Jamun(Syzygium cumini(L.)Skeels)seed bioactives and its biological activities:A review

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Food Bioscience 2022年第6期50卷 2035-2050页

作者： Manoj Kumar Muzaffar Hasan jose M.Lorenzo Sangram Dhumal Jyoti Nishad Nadeem Rais Aman Verma Sushil Changan Mrunal Deepak Barbhai Radha Deepak Chandran Ravi Pandiselvam Marisennayya Senapathy Abhijit Dey prakash Chandra Pradhan Pran Mohankumar Vishal P.Deshmukh Ryszard Amarowicz Mohamed Mekhemar Baohong Zhang Chemical and Biochemical Processing Division ICAR – Central Institute for Research on Cotton TechnologyMumbai400019India Department of Biology East Carolina UniversityGreenvilleNC27858USA Agro Produce Processing Division ICAR – Central Institute of Agricultural EngineeringBhopal462038India Centro Tecnológico de la Carne de Galicia rúa Galicia n◦4Parque Tecnológico de GaliciaSan Cibrao das Viñas32900OurenseSpain Área de Tecnología de los Alimentos Facultad de Ciencias de OurenseUniversidad de Vigo32004OurenseSpain Division of Horticulture RCSM College of AgricultureKolhapur416004MaharashtraIndia Department of Food Technology Shaheed Rajguru College of Applied Sciences for WomenUniversity of Delhi110096India Department of Pharmacy Bhagwant UniversityAjmer305004India Division of Plant Improvement and Pest Management ICAR – Central Arid Zone Research Institute (CAZRI)JodhpurIndia Division of Crop Physiology Biochemistry and Post-Harvest TechnologyICAR – Central Potato Research InstituteShimla171001India School of Biological and Environmental Sciences Shoolini University of Biotechnology and Management SciencesSolan173229India Department of Veterinary Sciences and Animal Husbandry Amrita School of Agricultural SciencesAmrita Vishwa Vidyapeetham UniversityCoimbatore642109Tamil NaduIndia Division of Physiology Biochemistry and Post-Harvest TechnologyICAR – Central Plantation Crops Research Institute (CPCRI)Kasaragod671 124KeralaIndia Department of Rural Development and Agricultural Extension College of AgricultureWolaita Sodo UniversityWolaita SodoEthiopia Department of Life Sciences Presidency University86/1 College StreetKolkata700073West BengalIndia Sardarkrushinagar Dantiwada Agricultural University BanaskanthaGujarat385506India School of Agricultural Sciences Karunya Institute of Technology and SciencesCoimbatore641114Tamil NaduIndia Bharati Vidyapeeth (Deemed to be University) Yashwantrao Mohite Institute of ManagementKaradIndia Institute of Animal

Jamun(Syzygium cumini Skeels)is a nutritious fruit and has historically been used as both as an edible and a traditional *** jamun seed is an inedible by-product of the ***,their high concentration of phytochemicals makes them valuable components of *** studies on diverse biological activities of jamun seeds have warranted their application in human health and biomedical *** review paper discusses critically the phytochemical composition of jamun seeds and the bioactivities,including their antioxidant,anti-inflammatory,anti-cancer,antidiabetic,anti-microbial,anti-obesity,hepato-protective,cardio and gastro-protective *** bioactivity of jamun seed is related to the presence of phenols,flavonoids,steroids,alkaloids,triterpenoids,tannins,and *** research in vivo,and in vitro experiments with human and animal cell models support the idea that jamun seed extract can be valuable additions in food and biomedical fields due to the diverse bio-functional ***,in-depth and systematic in vivo clinical trials using human subjects must be conducted to confirm the safe consumption limit and establish other therapeutic roles of jamun seeds for their abundant utilization as a nutraceutical or pharmacological ***,research is required to understand the exact mechanisms of the bioactivities exhibited by jamun seeds.

关键词： Bioactivity Jamun seeds Phytochemicals Health promoting activity

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