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Extrahepatic cholestasis associated with paracoccidioidomycosis:Challenges in the differential diagnosis of biliopancreatic neoplasia

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2531-2540页

作者： jose Sebastiao dos santos Vitor de Moura Arrais William jose Rosseto Ferreira Ricardo Ribeiro Correa Filho Mariangela Ottoboni Brunaldi Rafael Kemp Ajith Kumar Sankanrakutty Jorge Elias Junior Fernando Bellissimo-Rodrigues Roberto Martinez Edson Zangiacomi Martinez jose Celso Ardengh Faculdade de Medicina de Ribeirao Preto da Universidade de Sao paulo(FMRP-USP) Departamento de Cirurgia e AnatomiaRibeirao Preto 14049-900Sao PauloBrazil Universidade de Sao paulo Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP)Departamento de PatologiaRibeirao Preto 14048900Sao PauloBrazil Universidade de Sao paulo Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP)Departamento de Imagens MédicasHematologia e Oncologia ClínicaRibeirao Preto 14048900Sao PauloBrazil Universidade de Sao paulo Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP)Departamento de Medicina SocialRibeirao Preto 14015-010Sao PauloBrazil Universidade de Sao paulo Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP)Departamento de Clínica MédicaRibeirao Preto 14015-010Sao PauloBrazil Universidade de Sao paulo Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP)Departamento de Cirurgia e AnatomiaRibeirao Preto 14049-900Sao PauloBrazil and Hospital MoriahServico de Endoscopia DigestivaSao Paulo 04084-002Sao PauloBrazil

BACKGROUND Paracoccidioidomycosis(PCM)may involve the hepatic pedicle and peripan creatic lymph nodes,cause damage to the bile duct and manifest,exceptionally,in combination with extrahepatic cholestasis(EHC),making investigation and treatment *** To investigate the management of patients with visceral PCM admitted with *** All patients diagnosed with PCM treated in a public,tertiary teaching hospital between 1982 and 2020 were retrospectively *** also identified with EHC were allocated to two groups according to the treatment approach for the purpose of comparing clinical,laboratory,and imaging findings,resources used for etiological diagnosis,treatment results,and *** analyses were performed using the linear mixed-effects model(random and fixed effects),which was adjusted using the PROC MIXED procedure of the SAS®9.0 software,and Fisher’s exact *** Of 1645 patients diagnosed with PCM,40(2.4%)had *** these,20(50.0%)lived in the rural area and 29(72.5%)were men,with a mean age of 27.1 years(3-65 years).Jaundice as first symptom and weight loss of at least 10 kg were observed in 16 patients(40.0%),and a mass in the head of the pancreas was observed in 8(20.0%).The etiological diagnosis was made by tissue collection during surgery in 4 cases(10.0%)and by endoscopic methods in 3 cases(7.5%).Twenty-seven patients(67.5%)received drug treatment alone(Group 1),whereas 13(32.5%)underwent endoscopic and/or surgical procedures in combination with drug treatment(Group 2).EHC was significantly reduced in both groups(40.7% in Group 1,with a mean time of 3 months;and 38.4% in Group 2,with a mean time of 7.5 months),with no statistically significant difference between *** recurrence rates,associated mainly with treatment nonadherence,were similar in both groups:37% in Group 1 and 15.4% in Group *** mortality rate was 18.5% in Group 1 and 23% in Group 2,with survival estimates of 71.3% and 72.5%,respectively,with

关键词： Cholestasis Jaundice Obstructive Blastomycosis Paracoccidioides Diagnosis Treatment

Soil properties characterization for land-use planning and soil management in watersheds under family farming

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International Soil and Water Conservation Research 2022年第1期10卷 119-128页

作者： jose Miguel Reichert paulo Ivonir Gubiani Danilo Rheinheimer dos santos Dalvan jose Reinert Celso Aita Sandro jose Giacomini Soils Department Universidade Federal de Santa Maria(UFSM)Santa MariaRSBrazil

Environmental monitoring of small,rural watersheds was one of the components of the Natural Re-sources Management and Rural Poverty Alleviation Program(RS-Rural)in southern *** purpose of the monitoring was to assess the impact of promoting soil conservation and environment manage-ment practices adopted by farmers and funded by the *** four small monitored watersheds,in a total of 95 plots representing distinct land use and soil management,surface soil was collected to characterize ground-zero of the Program by determining several soil physical,chemical and microbio-logical *** component analysis(PCA)shows soil physical,chemical and biological properties were decisive in defining the agricultural soils in the rural watersheds with family *** sensitivity to chemical properties provides an opportunity to improve soil quality if soil management focuses on altering those *** management practiced by tobacco farmers leads to rapid,intense degradation of some natural soil properties,especially those related to the dynamics of soil organic matter,compared with more conservationist uses(forest,regrowth,and grassland).Thus,soil management must be reoriented to avoid the progress of degradation and recover soil physical and biological *** crops and by land-abandonment to allow natural vegetation are important management strategies for the degraded soils used for tobacco production,increasing soil organic matter,nutrients and microbial activity and thus allowing further crop *** conclusion,wa-tersheds with tobacco cropping have soils with lower quality than when under no-tillage grain pro-duction,requiring changes in land use and soil management.

关键词： Natural resources management Environmental monitoring Soil conservation Soil quality Alleviating poverty

Orthobiologics in the treatment of hip disorders

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World Journal of Stem Cells 2021年第4期13卷 304-316页

作者： Andre Vinicius Saueressig Kruel Lucas Leite Ribeiro paulo David Gusmao Stephany Cares Huber jose Fabio santos Duarte Lana Department of Orthopedics Regenesis Clínica MédicaBento GonçalvesRS 95700-066Brazil Department of Orthopedics Instituto Médico SalusSão PauloSP 01308-050Brazil Department of Hematology University of CampinasCampinasSP 13334-170Brazil Department of Orthopedics the Bone and Cartilage InstituteIndaiatubaSP 13334-170Brazil

Orthobiologics are biological materials that are intended for the regeneration or healing of bone,cartilage and soft *** this review we discuss the use of orthobiologics for hip disorders providing an *** orthobiologics included in this article are hyaluronic acid,platelet rich plasma,bone marrow,adipose tissue and expanded mesenchymal stem *** explain the concepts and definitions of each orthobiological product,and the literature regarding its use in the hip *** paucity of guidelines for the production and characterization of the biological products leads to uneven results across the *** biologic therapy has indications and benefits;however,noteworthy are the characterization of the orthobiologics,the application method and outcome analysis for further improvement of each technique.

关键词： Orthobiologics Hip disorders Platelet-rich plasma Mesenchymal stem cells Bone marrow Adipose tissue

Phenolic compounds of green tea: Health benefits and technological application in food

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Asian Pacific Journal of Tropical Biomedicine 2016年第8期6卷 709-719页

作者： jose Manuel Lorenzo paulo Eduardo Sichetti Munekata Meat Technological Center of Galicia Galicia Street No.4 Parque Tecnolgico de Galicia San Cibrao das Vinas Department of Food Engineering Faculty of Animal Science and Food Engineering University of Sao Paulo

Green tea has been an important beverage for humans since ancient times, widely consumed and considered to have health benefits by traditional medicine in Asian countries. Green tea phenolic compounds are predominately composed of catechin derivatives, although other compounds such as flavonols and phenolic acids are also present in lower proportion. The bioactivity exerted by these compounds has been associated with reduced risk of severe illnesses such as cancer, cardiovascular and neurodegenerative diseases. Particularly, epigallocatechin gallate has been implicated in alteration mechanisms with protective effect in these diseases as indicated by several studies about the effect of green tea consumption and mechanistic explanation through in vitro and in vivo experiments. The biological activity of green tea phenolic compounds also promotes a protective effect by antioxidant mechanisms in biological and food systems, preventing the oxidative damage by acting over either precursors or reactive species. Extraction of phenolic compounds influences the antioxidant activity and promotes adequate separation from green tea leaves to enhance the yield and/or antioxidant activity. Application of green tea phenolic compounds is of great interest because the antioxidant status of the products is enhanced and provides the product with additional antioxidant activity or reduces the undesirable changes of oxidative reactions while processing or storing *** this scenario, meat and meat products are greatly influenced by oxidative deterioration and microbial spoilage, leading to reduced shelf life. Green tea extracts rich in phenolic compounds have been applied to increase shelf life with comparable effect to synthetic compounds, commonly used by food industry. Green tea has great importance in general health in technological application, however more studies are necessary to elucidate the impact in pathways related to other diseases and food applications.

关键词： Phenolic profile Healthy Neurodegenerative diseases Extraction of polyphenols Antioxidant mechanism Food stability

Fiber Optic Intensity-Modulated Sensors： a Review in Biomechanics

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Photonic Sensors 2012年第4期2卷 315-330页

作者： paulo RORIZ Antonio RAMOS jose L. santos jose A. SIMOES Department of Mechanics University of Aveiro 3810-193 Aveiro Portugal Faculty of Sciences University of Porto Rua do Campo Alegre 687 4150-179 Porto Portugal

Fiber optic sensors have a set of properties that make them very attractive in biomechanics. However, they remain unknown to many who work in the field. Some possible causes are scarce information, few research groups using them in a routine basis, and even fewer companies offering turnkey and affordable solutions. Nevertheless, as optical fibers revolutionize the way of carrying data in telecommunications, a similar trend is detectable in the world of sensing. The present review aims to describe the most relevant contributions of fiber sensing in biomechanics since their introduction, from 1960s to the present, focusing on intensity-based configurations. An effort has been made to identify key researchers, research and development （R＆D） groups and main applications.

关键词： Biomechanics fiber optic sensors intensity-modulated sensors

Water-Based Processing of Fiberboard of Acrylic Resin Composites Reinforced With Cellulose Wood Pulp and Cellulose Nanofibrils

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Journal of Renewable Materials 2019年第5期7卷 403-413页

作者： Emanoele Maria santos Chiromito Eliane Trovatti Antonio jose Felix Carvalho Department of Materials Engineering São Carlos School of EngineeringUniversity of São PauloAv.João Dagnone110013563-120São Carlos-SP-Brazil University of Araraquara-UNIARA R.Carlos Gomes1217CEP 14801-320AraraquaraSPBrazil

Despite the great potential of cellulose wood pulp and cellulose nanofibrils as reinforcing filler in thermoplastics,its use is limited due to its tendency to form agglomerates and due to its high hydrophilic *** we describe fiberboard composites with high contents of wood pulp or cellulose nanofibrils,and a resin of poly(styrene-methyl-methacrylate-acrylic acid)used as water-based *** wood pulp and cellulose nanofibrils were used directly in the form of water *** method is based on the flocculation of the polymer emulsion followed by agglomeration of a mixture of the polymer emulsion and cellulose suspension,leading to the co-precipitation of the composite material,which can be easily separated from the water *** with acrylic polymer/cellulose fibers in the proportions of 75:25,50:50 and 25:75 wt%were *** were characterized by scanning electron microscopy(SEM),Fourier transform infrared spectroscopy(FTIR),thermogravimetric analysis(TGA),dynamic mechanical analysis(DMA)and water absorption *** analysis revealed a very good dispersion of the fibers without evidence of agglomeration,which led to superior mechanical *** results showed the effectiveness of the methodology and the potential of cellulose wood pulp and CNF as reinforcement fillers in fiberboard composites and any other high fiber-content materials.

关键词： Cellulose wood pulp cellulose nanofibrils composites acrylic resin emulsion fiberboard

Novel nanocomposites based on a strawberry-like gold-coated magnetite （Fe@Au） for protein separation in multiple myeloma serum samples

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Nano Research 2015年第4期8卷 1189-1198页

作者： jose E. Araujo Carlos Lodeiro jose L. Capelo Benito Rodrfguez-Gonzalez Alcindo A. dos santos~ Hugo M. santos Javier Ferna.ndez-Lodeiro BIOSCOPE Research Group UCIBIO-REQUIMTE Department of Chemistry Faculty of Science and Technology University NOVA of Lisbon 2829-516 Caparica Portugal PROTEOMASS Scientific Society Madan Parque Rua dos Inventores 2825-182 Caparica Portuga Scientific and Technological Research Assistance Centre (CACTI) University of Vigo Vigo Spain Instituto de Quimica Universidade de Sao Paulo Av. Prof. Lineu Prestes 748 CxP 26077 Sao Paulo 05508-000 Brazil

A new process to produce magnetite partially coated with strawberry-like gold nanoparticles in aqueous media is reported. The fast response to magnetic fields and optical properties of gold nanoparticle-based colloidal systems are the two main advantages of this new Fe@Au nanomaterial. These advantages allow for the use of this new colloidal nanomaterial for various purposes in proteomics and biomedicine, as proteins can bind to the surface, and the surface can also be funcfionalized. As proof-of-concept, the new Fe@Au nanoparticles have been assessed in biomarker discovery as a tool for pre-concentration and separation of proteins from complex proteomes. To this end, sera from healthy people were compared with sera from patients diagnosed with multiple myeloma. The application of this new Fe@Au nanomaterial combined with mass spectrometry has allowed for the identification of 53 proteins, and it has also shown that the heat shock protein HSP75 and the plasma protease C1 inhibitor are potential biomarkers for diagnostics and control of multilvle mveloma vro^ression.

关键词： nanoproteomics strawberry-nanopartides multifunctional hybridnanoparticles biomarkers multiple myeloma

Mining Contribution to Municipalities Development

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Journal of Environmental Science and Engineering(B) 2017年第8期6卷 436-442页

作者： jose Aroudo Mota jose Emanoel de Carvalho Nazairio Jorge Filipe dos santos jose oswaldo Siqueira paulo Cesar Horta Moreira ITV(Vale Institute of Technology) Belem 66055-090Brazil Ferrosos Norte Vale S.A.Parauapebas 68515-000Brazil

Mining activity in Brazil has significantly contributed to the country ***,this contribution is not always fully noticed by *** study aims to bring more evidence to this mining activity contribution,based on highly regarded development indicators,such as the HDI(Human Development Index),created by the UNDP(United Nations Development Programme).The HD1 was traditionally designed as an instrument to evaluate the degree of countries development and was subsequently deployed to states and municipalities(IDHM(Municipal Human Development Index)for Brazilian municipalities).In addition to lDHM released by the UNDP,FIRJAN(Federation of the Industries of the State of Rio de Janeiro)developed its own IFDM(FIR JAN Municipal Development Index).The statistical analysis shows that the average of the municipalities with mining activities has superior development indices than those with non-mining activities,especially in the two major mining states:Minas Gerais and Parfi.

关键词： Mineral activity human development 1DHM(Municipal Human Development Index) IFDM(F1RJAN MunicipalDevelopment Index).

Influence of peanut skin extract on shelf-life of sheep patties

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Asian Pacific Journal of Tropical Biomedicine 2016年第7期6卷 586-596页

作者： paulo Eduardo Sichetti Munekata Rafaella de Paula Paseto Fernandes Mariza Pires de Melo Marco Antonio Trindade jose Manuel Lorenzo Department of Food Engineering Faculty of Animal Science and Food EngineeringUniversity of Sao Paulo Department of Basic Sciences Faculty of Animal Science and Food Engineering University of Sao Paulo Department of Basic Sciences Faculty of Animal Science and Food EngineeringUniversity of Sao Paulo Meat Technologicial Center of Galicia

Objective: To evaluate the phenolic profile and antioxidant activity in vitro of peanut skin extract(PSE) and effect of PSE on characteristics of sheep patties during ***: PSE phenolic profile was evaluated in LC–MS analysis and by total phenolic content, 1,1-diphenyl-2-picrylhydrazyl radical scavenging capacity and ferric reducing/antioxidant power. Patties elaborated with sheep meat were packaged in modified atmosphere and storage at(2 ± 1)C. The analyses were performed every 5 days for 20 days on microbial counts, physico-chemical properties, lipid oxidation, protein stability and sensory ***: The major group of phenolic compounds in PSE was the proanthocyanidins followed by other flavonoids, which are related to potential phenolic content and antioxidant activity. The addition of PSE and butyl hydroxytoluene(BHT) reduced the microbial counts during the storage time, caused reduction on the loss of redness and sensory properties over time. The lipid and protein oxidation in sheep patties was effectively inhibited by PSE and ***: The present results showed the potential application of PSE as a natural alternative to replace synthetic antioxidants(BHT) for increasing the quality and extending the shelf-life of sheep patties.

关键词： Peanut skin extract henolic profile Lipid and protein oxidation Microbial counts