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Physical exercise in the prevention and treatment of Alzheimer’s disease

Journal of Sport and Health Science 2020年第5期9卷 394-404页

作者： Adrian De la Rosa Gloria Olaso-Gonzalez Coralie Arc-Chagnaud Fernando Millan Andrea Salvador-Pascual Consolacion Garcıa-Lucerga Cristina Blasco-Lafarga Esther Garcia-Dominguez Aitor Carretero Angela G.Correas jose Vina mari Carmen Gomez-Cabrera Freshage Research Group Department of PhysiologyFaculty of MedicineUniversity of Valenciaand CIBERFESInsitute of Health Research-INCLIVAValencia 46010Spain INRA UMR866 Muscle dynamics and metabolismUniversity of MontpellierF-34060MontpellierFrance Department of Physiotherapy Faculty of PhysiotherapyUniversity of ValenciaValencia 46010Spain Physical Education and Sports Department University of ValenciaValencia 46010Spain

Dementia is one of the greatest global challenges for health and social care in the 21st ***’s disease(AD),the most common type of dementia,is by no means an inevitable consequence of growing *** lifestyle factors may increase,or reduce,an individual’s risk of developing *** has been written over the ages about the benefits of exercise and physical *** the risk factors associated with AD is a low level of physical *** relationship between physical and mental health was established several years *** this review,we discuss the role of exercise(aerobic and resistance)training as a therapeutic strategy for the treatment and prevention of *** adults who exercise are more likely to maintain *** address the main protective mechanism on brain function modulated by physical exercise by examining both human and animal *** will pay especial attention to the potential role of exercise in the modulation of amyloid b turnover,inflammation,synthesis and release of neurotrophins,and improvements in cerebral blood *** changes in lifestyle in presymptomatic and predementia disease stages may have the potential for delaying one-third of dementias *** interventions that include the adoption of an active lifestyle should be recommended for older populations.

关键词： Aerobic exercise Dementia Exercise training Lifestyle factors Multidomain interventions Resistance exercise

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A New Phasor Estimator for PMU Applications:P Class and M Class

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Journal of Modern Power Systems and Clean Energy 2020年第1期8卷 55-66页

作者： jose R.Razo-Hernandez Arturo Mejia-Barron David Granados-Lieberman Martin Valtierra-Rodriguez jose F.Gomez-Aguilar ENAP-Research Group Facultad de IngenieríaUniversidad Autónoma de Querétaro(UAQ)San CayetanoC.P.76807México ENAP-Research Group Departamento de Ingeniería ElectromecánicaInstituto Tecnológico Superior de Irapuato(ITESI)Colonia El CopalC.P.36821México CONACyT-Centro Nacional de Investigación y Desarrollo Tecnológico(CENIDET) Tecnológico Nacional de MéxicoInterior Internado Palmira S/NCol.PalmiraC.P.62490México

Phasor measurement units(PMUs)are fundamental tools in the applications of modern power systems,where synchronized phasor estimations are *** accuracy and dynamic performance requirements for phasor,frequency,and rate of change of frequency(ROCOF)estimations are established in the IEEE Std.C37.118.1-2011 along with the IEEE Std.C37.118.1 a-2014,where two PMU performances are suggested:P class filters for applications requiring fast response and M class filters for applications requiring high rejection to aliased *** this paper,a methodology to design new phasor estimators that satisfy the P class and M class requirements in PMUs is *** proposed methodology is based on finite impulse response filters,brick-wall filters,and complex filter design concepts,where frequency range,time performance,harmonic rejection and out-of-band interference requirements are considered in its design.A comparative analysis using the reference model given by the IEEE Std.C37.118.1 is *** results show the effectiveness of the phasor estimators under steady-state and dynamic conditions according to the PMU standard,making them suitable tools for applications in power systems.

关键词： Brick-wall filter complex filter IEEE Std.C37.118.1 M class P class phasor measurement unit(PMU) phasor estimator

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Optimal Multimodel Representation by Laguerre Filters Applied to a Communicating Two Tank System

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Journal of Systems Science & Complexity 2018年第3期31卷 621-646页

作者： SAMEH Adaily ABDELKADER Mbarek TAREK Garna jose Ragot Laboratory of Automatic Control Signal and Image Processing National Engineering School of Monastir University of Monastir 5019 Tunisia Higher Institute of Applied Science and Technology of Sousse University of Sousse 4003 Tunisia Center of Research on Automatic of Nancy CNRS 2 Avenue de la for de Haye 54516 Vandoeuvre Cedex France.

This paper presents the development of a new nonlinear representation by exploiting the multimodel approach and the new linear representation ARX-Laguerre for each operating region. The resulting multimodel, entitled ARX-Laguerre multimodel, is characterized by the parameter number reduction with a recursive representation. However, a significant reduction of this multimodel is subject to an optimal choice of Laguerre poles characterizing each local linear model ARX-Laguerre. Therefore, the authors propose an optimization algorithm to estimate, from input/output measurements, the optimal values of Laguerre poles. The ARX-Laguerre multimodel as well as the proposed optimization algorithm are tested on a continuous stirred tank reactor system （CSTR）. Moreover, the authors take into account a practical validation on an experimental communicating two tank system （CTTS）.

关键词： ARX-Laguerre model Laguerre poles multimodel approach optimization

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An overview on nucleation theories and models

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Journal of Rare Earths 2019年第10期37卷 1015-1022页

作者： Marcos Flavio de Campos jose Adilson de Castro Department of Mechanical Engineering Federal Fluminense University

Several different models for coercivity are discussed. There are two main situations: i) nanocrystalline magnets, with grain size bellow the single domain particle size, and ii) magnets with grain size above single domain particle size. The described theories and models are general, and can be applied in either NdFeB magnets, SmFeCoCuZr or strontium ferrite magnets. The spring effect observed in isotropic nanocrystalline magnets can be explained with the Stoner-Wohlfarth model. Modifications of the StonerWohlfarth model are necessary to take into account the effect of interaction between grains. When the grain size is above the single domain size, energy considerations show that nucleation should occur at the surface of grains. Nucleation is interpreted as a two-step process, where domain wall displacement occurs for grain size above single domain size, after a nucleus is first formed. The effect of grain size on the coercive field is discussed.

关键词： Coercivity Nucleation Grain size Spring effect Nd-Fe-B Permanent magnet

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Weighted variation inequalities for differential operators and singular integrals in higher dimensions

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Science China Mathematics 2017年第8期60卷 1419-1442页

作者： MA Tao TORREA jose L. XU QuanHua School of Mathematics and Statistics Wuhan University Departamento de Matemticas Universidad Autónoma de Madrid Institute for Advanced Study in Mathematics Harbin Institute of Technology Laboratoire de Mathematiques Universite de Franche-Comte Institut Universitaire de France

We prove weighted q-variation inequalities with 2 详细信息

We prove weighted q-variation inequalities with 2

关键词： variation inequalities A_(p) weights differential operators singular integrals vector-valued variationin equalities

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Cellular senescence: is the problem a solution for muscle repair?

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Cellular & Molecular Immunology 2023年第5期20卷 429-431页

作者： jose M.Izquierdo Centro de Biologia Molecular Severo Ochoa Consejo Superior de Investigaciones CientificasUniversidad Autonoma de Madrid(CSIC/UAM)C/Nicolas Cabrera 1Campus de Cantoblanco28049 MadridSpain

In their recent article in Nature,Moiseeva et *** that senescent cells are integral components of the skeletal muscle regenerative niche,showing that they repress regeneration in response to different types of injuries in young mice and that this regeneration is even more profound in aged *** observations point to selective links between the conservation of cell identity traits and two universal senescence hallmarks(i.e.,inflammation and matrix remodeling/fibrosis)across cell types,regeneration times,and aging statuses.

关键词： showing injuries regeneration

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SIR model applied in dynamics of COVID-19 contagion in S˜ao Lu´ıs-MA,Brazil

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International Journal of Modeling, Simulation, and Scientific Computing 2021年第3期12卷 99-111页

作者： Felix Silva Costa Italo jose Lima De Sousa jose Adson Reis Santos Department of Mathematics and Informatics State University of Maranhao Sao Luıs MA 65054-970Brazil

The dynamics of COVID-19 contagion investigated in S˜ao Lu′ıs-MA,Brazil,is based on the SIR model.S˜ao Lu′ıs was the first city in Brazil to implement the lockdown to control the *** SIR model’s definition and properties are presented in addition to the ways of estimating its *** estimation of their values is due to a database released on the Maranh˜ao State Health Department website during the period March 20 to July 2,*** analysis of the proliferation of the disease shows the evolution of the COVID-19 in the *** graphs illustrate that result.

关键词： COVID-19 population dynamics SIR model

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A versatile microfluidic device for multiple ex vivo/ in vitro tissue assays unrestrained from tissue topography

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Microsystems & Nanoengineering 2020年第1期6卷 806-819页

作者： jose M.de Hoyos-Vega Alan M.Gonzalez-Suarez jose L.Garcia-Cordero Unidad Monterrey Centro de Investigacion y de Estudios Avanzados del IPNVia del conocimiento 201Parque PIITApodacaNL 66628Mexico

Precision-cut tissue slices are an important in vitro system to study organ function because they preserve most of the native cellular microenvironments of organs,including complex intercellular ***,during sample manipulation or slicing,some of the natural surface topology and structure of these tissues is lost or ***,we introduce a microfluidic platform to perform multiple assays on the surface of a tissue section,unhindered by surface *** device consists of a valve on one side and eight open microchannels located on the opposite side,with the tissue section sandwiched between these two *** the valve is actuated,eight independent microfluidic channels are formed over a tissue *** strategy prevents cross-contamination when performing assays and enables *** irregular tissues such as an aorta,we conducted multiple in vitro and ex vivo assays on tissue sections,including short-term culturing,a drug toxicity assay,a fluorescence immunohistochemistry staining assay,and an immune cell assay,in which we observed the interaction of neutrophils with lipopolysaccharide(LPS)-stimulated *** microfluidic platform can be employed in other disciplines,such as tissue physiology and pathophysiology,morphogenesis,drug toxicity and efficiency,metabolism studies,and diagnostics,enabling the conduction of several assays with a single biopsy sample.

关键词： metabolism topography versatile

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Oral delivery of insulin with Desmodium gangeticum root aqueous extract protects rat hearts against ischemia reperfusion injury in streptozotocin induced diabetic rats

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Asian Pacific Journal of Tropical Medicine 2010年第2期3卷 94-100页

作者： Gino A.Kurian jose Paddikkala School of Chemical and Biotechnology SASTRA UniversityThirumalaisamudramThanjavurTamil NaduIndia613402 Department of Plant Biotechnology Amala Cancer Research CenterAmalanagarTrichurKeralaIndia

Objective:To evaluate the effect of insulin administered via oral route with the help of aqueous extract of Desmodium gangeticum(DG) root in rendering cardio protection against ischemia reperfusion injury in diabetic ***:Diabetes mellitus was induced in rats by theβ-cell toxin,streptozotocin(STZ,60 mg/kg).Isolated rat(IR) heart was used to investigate the effect of insulin mixed DG pretreatment on ischemia reperfusion *** respiratory enzymes and microsomal enzymes were used to assess the metabolic recovery of myocardium. Cardiac marker enzymes were used to find the functional recovery,which were compared with that of the STZ treated IR ***:Compared with IR control group,rat treated with insulin mixed DG showed a significant functional and metabolic recovery of myocardium from the insult of ischemia *** though orally administered insulin mixed DG displayed a slow but prolonged hypoglycemic effect,the cardio protection it provided was more significant than when it was given intra *** the above result indicates that insulin mixed DG can overcome the barriers in the gastrointestinal tract and be ***:The above results indicate the efficacy of insulin mixed DG in protecting the heart from ischemia reperfusion induced injury in diabetic *** the study gives additional information that herbal extracts can be used to transport insulin across the membrane and found to be a feasible approach for developing the oral delivery of insulin,as well as other peptide drugs.

关键词： Desmodium gangeticum Insulin Oral delivery Myocardial ischemia reperfusion

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Estimation of Higher Heating Value for MSW Using DSVM and BSOA

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Intelligent Automation & Soft Computing 2023年第4期36卷 573-588页

作者： Jithina jose T.Sasipraba Sathyabama Institute of Science and Technology Chennai600119India

In recent decades,the generation of Municipal Solid Waste(MSW)is steadily increasing due to urbanization and technological *** col-lection and disposal of municipal solid waste cause considerable environmental degradation,making MSW management a global ***-to-energy(WTE)using thermochemical process has been identiﬁed as the key solution in this *** evaluating many automated Higher Heating Value(HHV)predic-tion approaches,an Optimal Deep Learning-based HHV Prediction(ODL-HHVP)model for MSW management has been *** objective of the ODL-HHVP model is to forecast the HHV of municipal solid waste,based on its oxy-gen,water,hydrogen,carbon,nitrogen,sulphur and ash *** addition,the ODL-HHVP model contains a Deep Support Vector Machine(DSVM)regres-sion component that can accurately predict the *** addition,the Beetle Swarm Optimization(BSO)method is utilised as a hyperparameter optimizer in conjunction with the DSVM model,resulting in the highest HHV prediction accu-racy.A comprehensive simulation study is conducted to validate the performance of the ODL-HHVP *** Multiple Linear Regression(MLR),Genetic Pro-gramming(GP),Resilient backpropagation(RP),Levenberg Marquardt(LM)and DSVM approaches have attained an ineffective result with RMSEs of 4.360,2.870,3.590,3.100 and 3.050,*** experimentalﬁndings demon-strate that the ODL-HHVP technique outperforms existing state-of-art technolo-gies in a variety of respects.

关键词： Municipal solid waste deep learning predictive models higher heating value parameter tuning

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