检索结果-南通市图书馆

Adipose tissue derived stromal cells in a gelatin-based 3D matrix with exclusive ascorbic acid signalling emerged as a novel neural tissue engineering construct:an innovative prototype for soft tissue

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Regenerative Biomaterials 2022年第1期9卷 444-459页

作者： Catherine Ann Martin Subathra Radhakrishnan jose luis Gòmez Ribelles Omana Anna Trentz Nivethaa EAK Mettu Srinivas Reddy Mohamed Rela Narayana Kalkura Subbaraya Crystal Growth Centre Anna UniversityGuindyChennai-600025India Cell Laboratory National Foundation for Liver ResearchNo.7CLC works RoadChennai-600044India Center for Biomaterials and Tissue Engineering(CBIT) Universitat Politècnica de Vale`nciaValencia 46022Spain Biomedical Research Networking Centre in Bioengineering Biomaterials and Nanomedicine(CIBER-BBN)Valencia 46022Spain MIOT Institute of Research MIOT Hospitals4/112Mount Poonamallee RoadChennai-600089India

The current study investigated a triad,which comprises of adipose tissue derived stem cells isolated from infrapatellar fat pad and gelatin/polyvinyl alcohol(PVA)-based matrix with exclusive ascorbic acid ***,the bio-mechanical properties of the gelatin–PVA blended scaffolds in wet condition are equivalent to the ECM of soft tissues in general,in this study,the triad was tested as a model for neural tissue *** from being cytocompatible and biocompatible,the porosity of the scaffold has been designed in such a manner that it facilitates the cell signalling and enables the exchange of nutrients and *** highly proliferative stem cells from Passage 2 were characterized using both,mesenchymal and embryonic stem cell *** an initial exploration the mesenchymal stem cells at Passage 4 were exposed to ascorbic acid and basic fibroblast growth factor signalling for neuronal differentiation in 2D environment *** MSCs successfully differentiated and acquired neuron specific markers related to cytoskeleton and ***,three phases of experiments have been conducted on the 3D gelatin/PVA matrix to prove their efficacy,the growth of stem cells,growth of differentiated neurons and the in situ growth and differentiation of *** scaffold was conducive and directed MSCs to neuronal lineage under specific ***,this organotypic model triad could open a new avenue in the field of soft tissue engineering as a simple and effective tissue construct.

关键词： adipose derived stem cells(ASCs) ascorbic acid soft tissue engineering triad neuronal differentiation

Topical Applications of Thiosulfinate-Enriched Allium sativum Extract Accelerates Acute Cutaneous Wound Healing in Murine Model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2020年第11期26卷 812-818页

作者： Juan luis Santiago Eva Maria Galan-Moya jose Ramon Munoz-Rodriguez Miguel Angel de la Cruz-Morcillo Francisco Javier Redondo-Calvo Ignacio Gracia-Fernandez Peter M.Elias jose Manuel Perez-Ortiz Mao-Qiang Man Dermatology Service Hospital General Universitario de Ciudad RealCiudad Real(13004)Spain Translational Research Unit Hospital General Universitario de Ciudad RealCiudad Real(13004)Spain Translational Oncology Laboratory Centro Regional de Investigaciones BiomedicasUniversidad de Castilla-La ManchaAlbacete(02008)Spain Instituto de Tecnologia Quimica y Medioambiental Universidad de Castilla-La ManchaCiudad Real(13004)Spain Dermatology Service Vetera ns Affairs Medical Centerand Department of DermatologyUniversity of CaliforniaSan FranciscoCA(94121)USA Dermatology Hospital Southern Medical UniversityGuangzhou(510091)China

Objective To determine whether topical applications of thiosulfinate-enriched Allium sativum extract(TASE)can accelerate acute cutaneous wound healing(WH)in a murine *** Keratinocyte viability and in vitro wound closure were assessed in keratinocyte *** of topical TASE(0.5μg/mL of allicin in 97%ethanol)on acute cutaneous WH were determined in a murine model of acute cutaneous *** mice were alternately assigned to the vehicle-and TASE-treated groups(n=6 per group).Expression levels of mRNA for keratinocyte differentiation marker-related proteins(filaggrin,loricrin and involucrin)and lipid synthetic enzymes(elongation of very long chain fatty acids protein 4(ELOVL4),fatty acid synthase(FA2H),3-hydroxy-3-methyl-glutaryl-coenzyme A reductase(HMGCoA),and serine palmitoyltransferase(SPT))were assessed using real-time quantitative polymerase chain reaction on day 3 and 8 after wounding,while transepidermal water loss(TEWL)rates were measured in wounded *** TASE accelerated WH both in vivo(40%vs.22%reduction in wound area,P<0.01)and in vitro(90%vs.65%reduction in wound area,P<0.01).Moreover,topical applications of TASE upregulated the expression levels of epidermal mRNA for ELOVL4,HMGCoA,SPT,filaggrin,loricrin and involucrin(P<0.05 ***-treated controls)on day 3 after ***,TASE significantly lowered TEWL rates in comparison with vehicle alone on day 8(33.06±2.09 g/(m^2·h)vs.24.60±2.04 g/(m^2·h),P<0.01).Conclusions Topical applications of TASE stimulated keratinocyte proliferation and formation of epidermal permeability barrier function,leading to acceleration of acute cutaneous *** products containing TASE could be used to manage acute cutaneous WH.

关键词： Allium sativum thiosulfinate wound healing permeability barrier keratinocytes proliferation

Spoon-assisted autologous particulate bone graft harvesting technique

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Plastic and Reconstructive Surgery 2024年第2期6卷 106-108页

作者： Inigo Aragon Nino Clara Lopez Martínez Carolina Cuesta Urquía Agustín Pascual Camps jose luis Del Castillo Pardo de Vera jose luis Cebrian Carretero Oral and Maxillofacial Surgery Department La Paz University Hospital28046 MadridSpain

Particulate bone plays a crucial role in various oral and maxillofacial surgical procedures,including reconstruction,implantation,and craniofacial *** bone and deproteinized bovine bone xenografts are the two primary resources used for such procedures,with the former demonstrating superior cost-effectiveness and reduced comorbidity rates,particularly in cases involving donor ***,a significant challenge lies in acquiring uniformly sized autologous particulate bone specimens,with existing tools often yielding coarse particles at a high ***,commercial bone xenograft solutions are frequently favored despite lower *** technical note introduces a novel technique for swiftly,safely,and efficiently obtaining autologous particulate bone *** procedure involves the use of a motor handpiece fitted with a micro drill and surgical spoon to collect the bone *** continuous irrigation with saline maintains a clear surgical field during the milling *** collected bone particles are then transferred to a metal capsule for further *** technique offers a promising solution to the challenge of inconsistent particle size associated with harvesting using traditional methods,providing surgeons with a reliable and efficient method of obtaining autologous particulate bone samples.

关键词： Bone grafting Reconstructive surgery Craniofacial surgery Implant surgery Autologous bone

负载型钌催化剂催化山梨醇氢解制乙二醇(英)

在线全文

学校读者我要写书评

暂无评论

催化学报 2014年第5期35卷 614-621页

作者： Inmaculada Murillo Leo Manuel Lopez Granados jose luis Garcia Fierro Rafael Mariscal Group of Sustainable Energy and Chemistry Institute of Catalysis and Petrochemistry(CSIC)

Supported Ru catalysts were prepared by wet impregnation to evaluate the role of different oxide supports(Al_2O_3,SiO_2,TiO_2,ZrO_2) in sorbitol hydrogenolysis to glycols.X-ray diffraction,transmission electron microscopy,hydrogen chemisorption,X-ray photoelectron spectroscopy,and NH3temperature-programmed desorption were used to characterize the catalysts,which were active in the hydrogenolysis of *** support affected both the physicochemical properties and catalytic behavior of the supported Ru *** characterization results revealed that the Ru/Al_2O_3catalyst has a high surface acidity,partially oxidized Ru species on the surface,and a higher surface Ru/Al atomic ratio,which gave it the highest selectivity and yield to glycols.

关键词：负载钌催化剂山梨醇过负载二元醇 Ru Al2O3催化剂氢解 X射线光电子能谱透射电子显微镜

Acute hepatitis with autoimmune features after COVID-19 vaccine:coincidence or vaccine-induced phenomenon?

在线全文

学校读者我要写书评

暂无评论

Gastroenterology Report 2022年第1期10卷 628-631页

作者： jose M.Pinazo-Bandera Alicia Hernandez-Albujar Ana Isabel Garcia-Salguero Isabel Arranz-Salas Raul J.Andrade Mercedes Robles-diaz Division of Gastroenterology and Hepatology Instituto de Investigacion Biomedica de Malaga-IBIMAHospital Universitario Virgen de la VictoriaUniversidad de MalagaMalagaSpain Division of Anatomical Pathology Hospital Universitario Virgen de la VictoriaMalagaSpain Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas(CIBERehd) MadridSpain

Introduction Autoimmune diseases result from a breach of immunological self-tolerance and tissue damage by autoreactive T *** acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection is characterized by an inflam... 详细信息

关键词： autoimmune vaccine acute

Huge capacity spacial division multiplexing transmission and integrated optical switching technologies(Invited Paper)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Optics Letters 2016年第12期14卷 12-16页

作者： Naoya Wada Ben J.Puttnam Ruben S.luis Werner Klaus Jun Sakaguchi jose M.D.Mendinueta Yoshinari Awaji Satoshi Shinada Hideaki Furukawa National Institute of Information and Communications Technology Tokyo 184-8795 Japan

We review the research and development of beyond Pb/s capacity space-division-multiplexed transmission technology using multi-core optical fibers for satisfying the ever-increasing traffic demand. Moreover, we present an optical packet and circuit integrated network technology to improve switching capacity and flexibility in network nodes for the rapid traffic fluctuation and the data service diversification.

关键词： switching multiplexing satisfying fluctuation traffic packet frames transmit throughput overhead

Risk factors and classifications of hilar cholangiocarcinoma

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2013年第7期5卷 132-138页

作者： Miguel Angel Suarez-Munoz jose luis Fernandez-Aguilar Belinda Sanchez-Perez jose Antonio Perez-Daga Beatriz Garcia-Albiach Ysabel Pulido-Roa Naiara Marin-Camero Julio Santoyo-Santoyo General Digestive and Transplantation Surgery Service HPB and Liver Transplant UnitUniversity Hospital Carlos Haya29010 MalagaSpain

Cholangiocarcinoma is the second most common primary malignant tumor of the *** cholangiocarcinoma or Klatskin tumor represents more than 50% of all biliary tract cholangiocarcinomas.A wide range of risk factors have been identified among patients with Perihilar cholangiocarcinoma including advanced age,male gender,primary sclerosing cholangitis,choledochal cysts,cholelithiasis,cholecystitis,parasitic infection(Opisthorchis viverrini and Clonorchis sinensis),inflammatory bowel disease,alcoholic cirrhosis,nonalcoholic cirrhosis,chronic pancreatitis and metabolic *** classifications have been used to describe the pathologic and radiologic appearance of *** three systems most commonly used to evaluate Perihilar cholangiocarcinoma are the Bismuth-Corlette(BC) system,the Memorial Sloan-Kettering Cancer Center and the TNM *** BC classification provides preoperative assessment of local *** Memorial Sloan-Kettering cancer center proposes a staging system according to three factors related to local tumor extent:the location and extent of bile duct involvement,the presence or absence of portal venous invasion,and the presence or absence of hepatic lobar *** TNM classification,besides the usual descriptors,tumor,node and metastases,provides additional information concerning the possibility for the residual tumor(R) and the histological grade(G).Recently,in 2011,a new consensus classification for the Perihilar cholangiocarcinoma had been *** consensus was organised by the European Hepato-PancreatoBiliary Association which identified the need for a new staging system for this type of *** classification includes information concerning biliary or vascular(portal or arterial) involvement,lymph node status or metastases,but also other essential aspects related to the surgical risk,such as remnant hepatic volume or the possibility of underlying disease.

关键词： Hilar cholangiocarcinoma Klatskin tumor Perihilar cholangiocarcinoma Bile duct cancer

Insights into the origin of precipitation moisture for tropical cyclones during rapid intensification process

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tropical Cyclone Research and Review 2024年第2期13卷 72-87页

作者： Albenis Perez-Alarcon jose C.Fernandez-Alvarez Ricardo M.Trigo Raquel Nieto luis Gimeno Centro de Investigacion Mari~na Universidade de VigoEnvironmental Physics Laboratory(EPhysLab)Campus As Lagoas s/nOurenseSpain Departamento de Meteorología Instituto Superior de Tecnologías y Ciencias AplicadasUniversidad de La HabanaLa HabanaCuba Instituto Dom Luiz(IDL) Facultade de Ci^enciasUniversidade de LisboaLisboaPortugal Departamento de Meteorologia Universidade Federal do Rio de JaneiroRio de JaneiroBrazil

In this study,we identiﬁed the moisture sources for the precipitation associated with tropical cyclones(TCs)during the rapid intensiﬁcation(RI)process from 1980 to 2018 by applying a Lagrangian moisture source diagnostic *** detected sixteen regions on a global scale for RI events distributed as follows:four in the North Atlantic(NATL),two in the Central and East Paciﬁc Ocean(NEPAC),the North Indian Ocean(NIO)and South Indian Ocean(SIO),and three in the South Paciﬁc Ocean(SPO)and the Western North Paciﬁc Ocean(WNP).The moisture uptake(MU)mostly was from the regions where TCs underwent *** Western NATL,tropical NATL,Caribbean Sea,the Gulf of Mexico and the Central America and Mexico landmass supported~85.4%of the precipitating moisture in the NATL,while the latter source and the eastern North Paciﬁc Ocean provided the higher amount of moisture in NEPAC(~84.3%).The Arabian Sea,the Bay of Bengal and the Indian Peninsula were the major moisture sources in NIO,contributing approximately 81.3%.The eastern and western parts of the Indian Ocean supplied most of the atmospheric humidity in SIO(~83.8%).The combined contributions(~87.9%)from the western and central SPO and the Coral Sea were notably higher in ***,TCs in the WNP basin mostly received moisture from the western North Paciﬁc Ocean,the Philippine Sea and the China Sea,accounting for 80.1%.The remaining moisture support in each basin came from the summed contributions of the remote ***,RI TCs gained more moisture up to 2500 km from the cyclone centre than those slow intensiﬁcation(SI)and the total MU was approximately three times higher during RI than ***,the patterns of the MU differences respond to the typical pathways of moisture transport in each basin.

关键词： Tropical cyclones Rapid intensiﬁcation Moisture sources Precipitation Lagrangian moisture tracking

Analysis of the Influence of Parafunctional Loads on the Bone-Prosthesis System: A Non-Linear Finite Element Analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Biomedical Science and Engineering 2021年第6期14卷 223-232页

作者： Henry Figueredo Losada Edison Gonçalves jose luis Valin luis Ide Faculty of Engineering University of the Republic Montevideo Uruguay Polytechnic School University of Sao Paulo Sao Paulo Brazil School of Mechanical Engineering Pontifical Catholic University of Valparaíso Valparaíso Chile Faculty of Dentistry University of Sao Paulo Sao Paulo Brazil

The present study evaluates the effects of occlusal loading on an implant-supported dental implant with external hexagon dental implant-abutment systems, using the finite element method analysis. Tensile analyses were performed to simulate different axial and obliquous masticatory loads. The influence of the variations in the contouring conditions of the interfaces was analyzed to weigh the osseointegration with linear and non-linear cases, by means of a parametric design. The geometry selected to place the prostheses was a jaw section, considering the properties of the set of cortical and trabecular bones. The results show that for non-linear contour conditions, the stress presents smaller value distributions and signals a different place in the screw-implant interface as the factor of the greater weight in this study. The location indicated that von Mises stress concentrations are not exclusive to the contact regions studied, moving to an area that is not in direct contact with the non-linear contact interfaces. In addition, the direction of load with an angle of 15 degrees presented the highest values of von Mises stress.

关键词： Biomechanics Analysis Non-Linear Dental Implant Finite Element Method