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Diagnostic strategy for occult hepatitis B virus infection

World Journal of Gastroenterology 2011年第12期17卷 1553-1557页

作者： Sara Ocana Maria luisa Casas Ingrid Buhigas jose luis lledo Service of Clinical Laboratory Hospital Universitario Fundación AlcorcónAv Budapest-128922 AlcorcónMadrid 28036Spain Service of Biochemistry Hospital Universitario Fundación Alcorcón.Av Budapest-1.28922 AlcorcónMadrid 28036Spain Service of Gastroenterology Hospital Universitario Fundación Alcorcón.Av Budapest-1.28922 AlcorcónMadrid 28036Spain Navarro Service of Gastroenterology Hospital Universitario Fundación AlcorcónAv Budapest-1.28922 AlcorcónMadrid 28036Spain

In 2008,the European Association for the study of the liver(EASL) defined occult hepatitis B virus infection (OBI) as the"presence of hepatitis B virus(HBV) DNA in the liver(with detectable or undetectable HBV DNA in the serum) of individuals testing hepatitis B surface antigen(HBsAg) negative by currently available assays".Several aspects of occult HBV infection are still poorly understood,including the definition itself and a standardized approach for laboratory-based detection,which is the purpose of this *** clinical significance of OBI has not yet been established;however,in terms of public health,the clinical importance arises from the risk of HBV ***,it is important to detect high-risk groups for occult HBV infection to prevent *** main issue is,perhaps,to identify the target population for screening *** is very low or undetectable in occult HBV infection,even when the most sensitive methods are used,and the detection of the viral DNA reservoir in hepatocytes would provide the best evaluation of occult HBV prevalence in a defined set of ***,this diagnostic approach is obviously unsuitable:blood detection of occult hepatitis B requires assays of the highest sensitivity and specificity with a lower limit of detection<10 IU/mL for HBV DNA and<0.1 ng/mL for HBsAg.

关键词： Occult hepatitis B virus infection Hepatitis B surface antigen Hepatitis B virus DNA Anti-HBc

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Prevalence of occult hepatitis B virus infection

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World Journal of Gastroenterology 2011年第12期17卷 1538-1542页

作者： Maria luisa Gutiérrez-García Conrado M Fernandez-Rodriguez jose luis lledo-Navarro Ingrid Buhigas-Garcia Service of Gastroenterology Hospital Universitario Fundación AlcorcónAv Budapest-128922 AlcorcónMadridSpain

Occult hepatitis B virus(HBV) infection(OBI) is characterized by the persistence of HBV DNA in the liver tissue in individuals negative for the HBV surface *** prevalence of OBI is quite variable depending on the level of endemic disease in different parts of the world,the different assays utilized in the studies,and the different populations *** studies have been carried out on OBI prevalence in different areas of the world and categories of *** studies show that OBI prevalence seems to be higher among subjects at high risk for HBV infection and with liver disease than among individuals at low risk of infection and without liver disease.

关键词： Occult hepatitis B virus infection Hepatitis B virus DNA Anti-HBc Hepatitis B virus seronegative Hepatitis C Crytogenetic hepatitis Dialysis Human immunodeficiency virus Blood donors

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Multiple intrahepatic pseudocysts in acute pancreatitis

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World Journal of Gastroenterology 2007年第34期13卷 4655-4657页

作者： David Casado luis Sabater Julio Calvete Empar Mayordomo luis Aparisi Juan Sastre Salvador lledo Department of Surgery Liver Biliary and Pancreatic Unit University of Valencia Spain Department of Pathology University of Valencia Spain Laboratory of Pancreatic Function Hospital Clinic University of Valencia Spain Department of Physiology University of Valencia Spain

Liver pseudocysts are a very rare complication in acute pancreatitis with only a few cases previously described. The lack of experience and literature on this condition leads to difficulties in the differential diagnosis and management. We report herein a case of acute pancreatitis who developed multiple intrahepatic pseudocysts. After complete imaging evaluation, the diagnosis was still unclear and the patient was operated on. The presence of liver lesions in patients with acute pancreatitis should raise the possibility of intrahepatic pseudocysts.

关键词： Pancreatic pseudocyst Liver pseudocyst Intrahepatic pseudocyst

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The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercado Aranza I.Torrado-Tapias Iris K.Salgado jose M.Santiago Samuel E.Ocasio Rivera Dina P.Bracho-Rincon luis H.Pagan Rivera Jorge D.Miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

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CFD modelling:The most useful tool for developing mesoscale urban canopy parameterizations

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Building Simulation 2021年第3期14卷 407-419页

作者： Riccardo Buccolieri jose luis Santiago Alberto Martilli Dipartimento di Scienze e Tecnologie Biologiche edAmbientali University ofSalentoS.P.6 Lecce-MonteroniLecce 73700Italy Environment Department Research Center for EnergyEnvironment and Technology(CIEMAT)Madrid 28040Spain

1 Introduction The fact that most of the world’s population lives in cities(UN-Habitat 2016)has increased interest in urban *** models,such as the Weather Research and Forecasting(WRF)model(***/weather-research-and-forecasting-model),are used to reproduce the meteorology and climatology over cities and around them,where the complex interactions between the atmosphere and urban surfaces(buildings,vegetation,urban obstacles,etc.)induce strong heterogeneity in the flow properties within the urban canopy layer(UCL)(Di Sabatino et al.2013;Lateb et al.2016;Tominaga and Stathopoulos 2016).

关键词： meteorology urban forecasting

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Invasive-invaded system of non-Lipschitz porous medium equations with advection

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International Journal of Biomathematics 2021年第7期14卷 299-327页

作者： jose luis Diaz Palencia Escuela Politecnica Superior Universidad Francisco de Vitoria Ctra.Pozuelo-Majadahonda Km 1 80028223Pozuelo de AlarconMadrid

This work provides analytical results towards applications in the field of invasive-invaded systems modeled with nonlinear diffusion and with *** results focus on showing regularity,existence and uniqueness of weak solutions using the condition of a nonlinear slightly positive parabolic operator and the reaction-absorption monotone *** coupling in the reaction-absorption terms,that characterizes the species interaction,impedes the formulation of a global comparison principle that is shown to exist ***,this work provides analytical solutions obtained as selfsimilar minimal and maximal profiles.A propagating diffusive front is shown to exist until the invaded specie notes the existence of the *** the desertion of the invaded st arts,the diffusive front vanishes globally and the nonlinear diffusion concentrates only on the propagating tail which exhibits finite ***,the invaded specie is shown to exhibit an exponential decay along a characteristic *** exponential decay is not trivial in the nonlinear diffusion case and confirms that the invasive continues to feed on the invaded during the desertion.

关键词： Nonlinearity reaction absorption coupled system diffusion porous media

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Update and actual trends on bacterial infections following liver transplantation

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World Journal of Gastroenterology 2008年第32期14卷 4977-4983页

作者： jose luis del Pozo Division of Infectious Diseases Department of Medicine Mayo Clinic Rochester

Recent advances in effective antimicrobial prophylactic strategies have led to a decline in the incidence of opportunistic infections in liver transplant recipients. However, morbidity and mortality due to infectious diseases remain as major problems. Bacterial infections occurring early after transplant are mainly related to the technical aspects of the procedure. By contrast, after the first postoperative days and beyond, the nature and variety of infectious complications change. Opportunistic bacterial infections are uncommon after 6 mo in patients receiving stable and reduced maintenance doses of immunosuppression with good graft function and little is documented about these cases in the literature. Transplant recipients may be more susceptible to some pathogens, such as the Nocardia species, Legionella species, Listeria monocytogenes , Mycoplasma species, Salmonella species or Rhodococcus equi. Respiratory infections due to capsulated bacteria, such as Streptococcus pneumoniae and Haemophilus intTuenza, can be life- threatening if not promptly treated in this population. These late bacterial infections may be very difficult to recognize and treat in this population. In this article, we review what has been described in the literature with regards to late bacterial infections following liver transplantation.

关键词： Liver transplant Bacterial infections Nocardia species Listeria species Legionella species Mycoplasma species Bartonella species

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Structural performance assessment of GFRP elastic gridshells by machine learning interpretability methods

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Frontiers of Structural and Civil Engineering 2022年第10期16卷 1249-1266页

作者： Soheila KOOKALANI Bin CHENG jose luis Chavez TORRES Department of Civil Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Civil Engineering Technical University of LojaLoja 110102Ecuador

The prediction of structural performance plays a significant role in damage assessment of glass fiber reinforcement polymer(GFRP)elastic gridshell *** learning(ML)approaches are implemented in this study,to predict maximum stress and displacement of GFRP elastic gridshell *** ML algorithms,including linear regression(LR),ridge regression(RR),support vector regression(SVR),K-nearest neighbors(KNN),decision tree(DT),random forest(RF),adaptive boosting(AdaBoost),extreme gradient boosting(XGBoost),category boosting(CatBoost),and light gradient boosting machine(LightGBM),are implemented in this *** features of structural performance considered in this study are the maximum stress as f1(x)and the maximum displacement to self-weight ratio as f2(x).A comparative study is conducted and the Catboost model presents the highest prediction ***,interpretable ML approaches,including shapely additive explanations(SHAP),partial dependence plot(PDP),and accumulated local effects(ALE),are applied to explain the *** is employed to describe the importance of each variable to structural performance both locally and *** results of sensitivity analysis(SA),feature importance of the CatBoost model and SHAP approach indicate the same parameters as the most significant variables for f1(x)and f2(x).

关键词： machine learning gridshell structure regression sensitivity analysis interpretability methods

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Magnetofection as a new tool to study microglia biology

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Neural Regeneration Research 2019年第5期14卷 767-768页

作者： jose luis Venero Miguel Angel Burguillos Instituto de Biomedicina de Sevilla (IBiS)/Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla and Departamento de Bioquímica y Biología Molecular Facultad de Farmacia Universidad de Sevilla Department of Biochemistry University of Cambridge

Microglia are the resident macrophages of the brain,originally described by Pio del Rio-Hortega(a student of Santiago Ramon y Cajal)in a series of studies in *** those pioneering studies,many others have followed to describe microglia as complex and multitasking cells with many diverse roles under physiological(*** key role in synapse pruning during development)or diseased *** exist as sentinels or surveyors of the environment that surround neurons,becoming reactive upon a wide array of stimuli and consequently developing an appropriate inflammatory *** fact,a neuroinflammatory response driven by microglia is found in virtually every disease process that occurs within the central nervous ***,a better understanding of the mechanisms governing the microglia response is the key to improving the outcome of neurodegenerative conditions.

关键词： Magnetofection new tool study microglia biology

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Machine Learning-Based Radio Access Technology Selection in the Internet of Moving Things

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China Communications 2021年第7期18卷 13-24页

作者： Ramon Sanchez-Iborra luis Bernal-Escobedo jose Santa Dept.Engineering and Applied Techniques University Centre of Defence at the Spanish Air Force Academy30729 San JavierSpain Dept.Information and Communication Engineering University of Murcia30100 MurciaSpain Dept.of Electronics Computing Technology and ProjectsTechnical University of Cartagena30202 CartagenaSpain

The Internet of Moving Things(IoMT)takes a step further with respect to traditional static IoT *** this line,the integration of new eco-friendly mobility devices such as scooters or bicycles within the Cooperative-Intelligent Transportation Systems(C-ITS)and smart city ecosystems is crucial to provide novel *** this end,a range of communication technologies is available,such as cellular,vehicular WiFi or Low-Power Wide-Area Network(LPWAN);however,none of them can fully cover energy consumption and Quality of Service(QoS)***,we propose a Decision Support System(DSS),based on supervised Machine Learning(ML)classification,for selecting the most adequate transmission interface to send a certain message in a multi-Radio Access Technology(RAT)set *** ML algorithms have been explored taking into account computing and energy constraints of IoMT enddevices and traffic ***,a real implementation of a decision tree-based DSS for micro-controller units is presented and *** attained results demonstrate the validity of the proposal,saving energy in communication tasks as well as satisfying QoS requirements of certain urgent *** footprint of the real implementation on an Arduino Uno is 444 bytes and it can be executed in around 50µs.

关键词： internet of moving things multi-RAT CITS classification personal mobility

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