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现代装饰 2024年第3期 62-69页

作者： jose luis esteban penelas(设计) Yolanda Hernandez Lorente(设计) Maria esteban Casanas(设计) Antonio Guijarro(设计) Marina Rodriguez Sotoca(设计) Kevin Roman Cruz(设计) Yakaterina Savina(设计) Imagen Subliminal(摄影) 舒禹(编译) 不详 Miguel de Guzman+Rocio Romero

建筑呈现明显的后工业美学特征,内设有一个微生物和化学分析实验室,功能设施极为复杂,使用中需要极高的功能效率与超先进的图像兼容。设计重新激活地区周围的强大工业景观,通过穿孔立面,过滤环境并生成独特的室内景观。

关键词：微生物实验室工业景观室内景观功能设施美学特征

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New environmental factors related to diabetes risk in humans:Emerging bisphenols used in synthesis of plastics

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World Journal of Diabetes 2023年第8期14卷 1301-1313页

作者： Rafael Moreno-Gómez-Toledano María Delgado-Marín Alberto Cook-Calvete Claudia González-Cucharero Nunzio Alcharani Beatriz Jiménez-Guirado Ignacio Hernandez Rafael Ramirez-Carracedo Laura Tesoro Laura Botana Sandra Sánchez-esteban Javier Diez-Mata jose luis Zamorano Ricardo J.Bosch Carlos Zaragoza Marta Saura Universidad de Alcalá Department of Biological Systems/PhysiologyAlcaláde Henares 28871Spain Cardiology Department University Hospital Ramón y CajalMadrid 28034Spain Laboratory of Cardiovascular Pathophysiology Joint Translational Research UnitUniversity Francisco de Vitoria School of MedicineMadrid 28034Spain Instituto Ramón y Cajal de Investigación Sanitaria-IRYCIS Madrid 28034Spain

BACKGROUND Diabetes mellitus(DM)is one of the largest global health emergencies of the 21st *** recent years,its connection with environmental pollutants,such as bisphenol A(BPA),has been demonstrated;consequently,new structurally similar molecules are used to replace BPA in the plastics industry(BPS,BPF and BPAF).AIM To carry out a systematic review to allow coherent evaluation of the state of the ***,a meta-analysis was performed to unify the existing quantitative *** Firstly,a systematic review was carried out,using the terms“(bisphenol)AND(Diabetes OR Hyperglycemia)”,to maximize the number of ***,three authors analyzed the set of ***,a meta-analysis was performed for each BP,using RevMan *** addition,funnel plots were developed to study publication *** The systematic analysis of the literature revealed 13 recent articles(2017–2023)related to the study *** qualitative analysis showed interesting data linking diabetes to the three most widely used substitute BPs in the industry:BPS,BPF and ***,the meta-analysis determined a positive relationship with BPS,BPF and BPAF,which was only statistically significant with *** There is a need to apply the precautionary principle,regulating the use of new ***,replacing BPA with BPS,BPF or BPAF is unlikely to protect the population from potential health risks,such as DM.

关键词： Bisphenol S Bisphenol F Bisphenol AF Diabetes mellitus Systematic review Meta-analysis

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Rare germline copy number variants in colorectal cancer predisposition characterized by exome sequencing analysis

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Journal of Genetics and Genomics 2018年第1期45卷 41-45页

作者： Sebastia Franch-Exposito Clara esteban-Jurado Pilar Garre Isabel Quintanilla Saray Duran-Sanchon Marcos Diaz-Gay Laia Bonjoch Miriam Cuatrecasas Esther Samper Jenifer Munoz Teresa Ocana Sabela Carballal Maria Lopez-Ceron Antoni Castells Maria Vila-Casadesus Sophia Derdak Steven Laurie Sergi Beltran Jaime carvajal luis Bujanda Clara Ruiz-Ponte Jordi Camps Meritxell Gironella Juan jose Lozano Francesc Balaguer Joaquin Cubiella Trinidad Caldes Sergi Castellvi-Bel Gastroenterology Department Hospital Clinic de Barcelona August Pi i Sunyer Biomedical Research Institute CIBER of Hepatic and Digestive Diseases University of Barcelona Barcelona 08036 Spain Molecular Oncology Laboratory Hospital Clinico San Carlos Health Research Institute of the Hospital Clinico San Carlos Madrid 28040 Spain Department of Pathology Hospital Clinic de Barcelona Barcelona 08036 Spain EPICOLON consortium Bioinformatics Platform CIBER of Hepatic and Digestive Diseases Barcelona 08036 Spain National Center of Genomic Analysis Science Park of Barcelona Barcelona 08028 Spain Andalusian Developmental Biology Institute CSIC-Pablo de Olavide University-Andalusian Regional Government SeviUa 41013 Spain Gastroenterology Department Hospital Donostia-Biodonostia Institute CIBER of Hepatic and Digestive Diseases University of the Basque Country (UPV/EHU) San Sebastian 20080 Spain Galician Public Foundation of Genomic Medicine (FPGMX) CIBER of Rare Diseases Genomics Medicine Group Hospital Clinico Universitario University of Santiago de Compostela Santiago de Cornpostela 15706 Spain Castroenterology Department Complexo Hospitalario Universitario de Ourense Ourense Biomedical Research Institute Ourense 32005 Spain

Colorectal cancer （CRC） is one of the most common neoplasms and an important cause of mortality worldwide （http：//globocan. ***]）. Approximately 35% of the variation in CRC susceptibility is likely due to heritable factors （Lichtenstein et al., 2000}. Genetic variations in the human genome include single nucleotide variants （SNVs）, short insertions and deletions, and larger structural variants resulting in gain or loss of genomic DNA larger than 1 kb, such as copy number variants （CNVs）. Leaving aside the importance of CNVs in sporadic tumor development, these variants can also be present in the germline DNA of healthy individuals from the general population and be considered polymorphic.

关键词： WHOLE-EXOME GENE

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The Usefulness of Magnetic Resonance Imaging in the Preoperative Study and Postoperative Control in the Laparoscopic Treatment of the Incisional Hernia

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Surgical Science 2015年第8期6卷 376-382页

作者： J.C.Martín del Olmo luis García-Vallejo jose Nunez Gestal Pablo Concheiro Coello Francisco Blanco Antona Miguel Toledano Trincado Javier Sanchez Gonzalez M.Luz Martín esteban L.Colao Carlos Vaquero Puerta Miguel Carbajo Surgery Department Medina del Campo HospitalValladolidSpain Surgery Department CHUSCalle Rua de Ramon BaltarSantiago de CompostelaSpain Radiology Department CHUSCalle Rua de Ramon BaltarSantiago de CompostelaSpain Department of General and Digestive Surgery Medina del Campo HospitalValladolidSpain Surgery Department University of ValladolidValladolidSpain CEOAD ValladolidSpain

Background and Objectives: The aim of this study is to evaluate the usefulness of Magnetic Resonance Imaging (MRI) for planning surgery and postoperative control of complex cases of abdominal wall hernia. Methods: Included in a prospective data base with more than 350 patients treated in two centers, a prospective study over ten patients with complex incisional hernias was designed. In all cases, preoperative diagnosis study and postoperative imaging control by MR Imaging were established. In the early and late follow-up controls, local and general complications were specifically noted and studied by MRI in each case. Results: The preoperative MRI was effective method for an adequate understanding of the defects and hernia sack content. In the postoperative control, the MRI was useful in the follow-up of the mesh integration, detection of complications and diagnosis of the relapsing. Conclusion: In our experience the MRI test is specially recommended in the preoperative workup of complex cases of incisional hernia.

关键词： Incisional Hernia MR Imaging Laparoscopic Eventroplasty

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索磷布韦/维帕他韦用于伴代偿期肝硬化的慢性基因3型HCV患者:一项针对2期和3期临床试验的综合分析

索磷布韦/维帕他韦用于伴代偿期肝硬化的慢性基因3型HCV患者:一项...

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第十届全国疑难及重症肝病大会

作者： Stuart Keith Roberts Maria Buti Graham R.Foster jose luis Calleja Ajit Sood Vasily A.Isakov Ola R Hj Weiland luisa Stamm Liyun Ni Evguenia Svarovskaia Diana Brainard David L.Wyles Juan Antonio Pineda Alexander Thompson Rafael esteban Alessandra Mangia Alfred Hospital

背景在当前的直接作用抗病毒药物时代中,基因3型HCV感染和伴有肝硬化的患者成为更加难以治愈的人群。已经有多项2期和3期临床试验评估了SOF/VEL用于基因3型和伴有代偿期肝硬化的患者时的效果。方法本研究是针对来自于在一项2期试验和5项...

背景在当前的直接作用抗病毒药物时代中,基因3型HCV感染和伴有肝硬化的患者成为更加难以治愈的人群。已经有多项2期和3期临床试验评估了SOF/VEL用于基因3型和伴有代偿期肝硬化的患者时的效果。方法本研究是针对来自于在一项2期试验和5项3期试验中接受12周的SOF/VELFDC治疗

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Electrocardiographic changes during induced therapeutic hypothermia in comatose survivors after cardiac arrest

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World Journal of Cardiology 2015年第7期7卷 423-430页

作者： Pablo Salinas esteban Lopez-de-Sa Laura Pena-Conde Ana Viana-Tejedor Juan Ramon Rey-Blas Eduardo Armada jose luis Lopez-Sendon Instituto Cardiovascular Hospital Clínico San Carlos Acute Cardiac Care Unit Division of CardiologyHospital Universitario La Paz

AIM: To assess the safety of therapeutic hypothermia(TH) concerning arrhythmias we analyzed serial electrocardiograms(ECG) during ***: All patients recovered from a cardiac arrest with Glasgow < 9 at admission were treated with induced mild TH to 32-34℃. TH was obtained with cool fluid infusion or a specific intravascular device. Twelvelead ECG before,during,and after TH,as well as ECG telemetry data was recorded in all patients. From a total of 54 patients admitted with cardiac arrest during the study period,47 patients had the 3 ECG and telemetry data available. ECG analysis was blinded and performed with manual caliper by two independent cardiologists from blinded copies of original ECG,recorded at 25 mm/s and 10 mm/m V. Coronary care unit staff analyzed ECG telemetry for rhythm disturbances. Variables measured in ECG were rhythm,RR,PR,QT and corrected QT(QTc by Bazett formula,measured in lead v2) intervals,QRS duration,presence of Osborn's J wave and U wave,as well as ST segment displacement and T wave amplitude in leads Ⅱ,v2 and ***: Heart rate went down an average of 19 bpm during hypothermia and increased again 16 bpm with rewarming(P < 0.0005,both). There was a nonsignificant prolongation of the PR interval during TH and a significant decrease with rewarming(P = 0.041). QRS duration significantly prolonged(P = 0.041) with TH and shortened back(P < 0.005) with rewarming. QTc interval presented a mean prolongation of 58 ms(P < 0.005) during TH and a significant shortening with rewarming of 22.2 ms(P = 0.017). Osborn or J wave was found in 21.3% of the patients. New arrhythmias occurred in 38.3% of the patients. Most frequent arrhythmia was non-sustained ventricular tachycardia(19.1%),followed by severe bradycardia or paced rhythm(10.6%),accelerated nodal rhythm(8.5%) and atrial fibrillation(6.4%). No life threatening arrhythmias(sustained ventricular tachycardia,polymorphic ventricular tachycardia or ventricular fibrillation) occurred during TH.

关键词： Cardiac arrest Therapeutic hypothermia Post-cardiac arrest síndrome Cardiac arrythmias QT interval

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在临床研究中,索磷布韦/维帕他韦用于伴随使用质子泵抑制剂的患者时安全有效

在临床研究中,索磷布韦/维帕他韦用于伴随使用质子泵抑制剂的患者...

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第十届全国疑难及重症肝病大会

作者： Rafael esteban Kosh Agarwal jose luis Calleja Jean Francois Dufour Steven L.Flamm Stuart C.Gordon luisa Stamm Liyun Ni Diana Brainard Kris V.Kowdley Curtis Cooper Juan Antonio Pineda Lluis Castells Maria Buti Sabela Lens UniversityofBarcelona SwedishMedicalCenter GileadSciencesInc. HospitalUniversitariValld’Hebron GileadSciences Inc. VallD’hebronUniversityHospital NorthwesternUniversityHealthSystem HospitalUniversitarioPuertaDeHierro HospitalUniversitarioVirgenDeValme UniversityofBern LiverUnit InternalMedicineDepartmentHospitalUniversitariVallDeHebrón InstituteofLiverStudies King’sCollegeHospitalNHSTrust HenryFordHealthSystem TheOttawaHospital

背景在1期药物相互作用数据可用之前,在有关索磷布韦/维帕他韦(SOF/VEL)的临床试验中禁止伴随使用质子泵抑制剂(PPI)。之后的临床研究允许使用最多20mg的奥美拉唑或等效剂量的药物。本分析评估了接受12周的SOF/VEL治疗并且报告伴随使用...

背景在1期药物相互作用数据可用之前,在有关索磷布韦/维帕他韦(SOF/VEL)的临床试验中禁止伴随使用质子泵抑制剂(PPI)。之后的临床研究允许使用最多20mg的奥美拉唑或等效剂量的药物。本分析评估了接受12周的SOF/VEL治疗并且报告伴随使用PPI的伴有和不伴有代偿期肝硬化的患者的疗效和安全性。

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