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The Beauty of Being a Variant： H2A.Z and the SWR1 complex in Plants

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Molecular Plant 2009年第4期2卷 565-577页

作者： Rosana March-Diaz jose c. Reyes Andalusian center for Molecular Biology and Regenerative Medicine (cABIMER) CSIC Americo Vespucio s/n E-41092 Sevilla Spain

Numerous studies have shown that the nucleosome is a dynamic structure that strongly influences gene expression. Dynamism concerns different nucleosomal characteristics, including position, posttranslational modifications, and histone composition. Thus, within the nucleosome, canonical histones can be exchanged by histone variant proteins with specific functions--a process known as ‘histone replacement＇. The histone variant H2A.Z has an important function in transcription and, during the last few years, its role in plant development and immune response has become evident. compiling genetic and biochemical studies from several laboratories has revealed that plants contain a multiprotein complex, similar to the SWR1/SRcAP complex from yeast and animals, involved in H2A.Z deposition. Despite intense research in different organisms, the mechanism by which H2A.Z influences transcription is still unknown. However, recent results from Arabidopsis have shown a strong inverse correlation between H2A.Z and DNA methylation, suggesting that H2A.Z might protect genes from silencing.

关键词： chromatin structure and remodeling epigenetics gene regulation floral induction.

Towards Bio-impedance Based Labs： A Review

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Journal of Electrical Engineering 2016年第3期4卷 116-127页

作者： Pablo Perez Andres Maldonado Alberto Yufera Gloria huertas Adoracion Rueda jose Luis huertas Instituto de Microelectr6nica de Sevilla Universidad de Sevilla CSIC Sevilla 41092 Spain Dpt. Electronic Technology ETSIL Universidad de Sevilla Sevilla 41012 Spain Dpt. Electronic and Electromagnetism F. Physics Universidad de Sevilla Sevilla 41012 Spain

In this article, some of the main contributions to BI （Bio-Impedance） parameter-based systems for medical, biological and industrial fields, oriented to develop micro laboratory systems are summarized. These small systems are enabled by the development of new measurement techniques and systems （labs）, based on the impedance as biomarker. The electrical properties of the life mater allow the straightforward, low cost and usually non-invasive measurement methods to define its status or value, with the possibility to know its time evolution. This work proposes a review of bio-impedance based methods being employed to develop new Loc （Lab-on-a-chips） systems, and some open problems identified as main research challenges, such as, the accuracy limits of measurements techniques, the role of the microelectrode-biological impedance modeling in measurements and system portability specifications demanded for many applications.

关键词： Bio-impedance sensing signal conditioning circuits microelectrode OBT (Oscillation Based Test) Loc.

Analytical solution for the size of the minimum dominating set in complex networks

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International Journal of Modeling, Simulation, and Scientific computing 2017年第1期8卷 67-82页

作者： jose c.Nacher Tomoshiro Ochiai Department of Information Science Faculty of Science Toho UniversityMiyama 2-2-1 FunabashiChiba 274-8510Japan Faculty of Social Information Studies Otsuma Women’s University 2-7-1 Karakida Tama-shiTokyo 206-8540Japan

Domination is the fastest-growing field within graph theory with a profound diversity and impact in real-world applications,such as the recent breakthrough approach that identifies optimized subsets of proteins enriched with cancer-related *** its conceptual simplicity,domination is a classical NP-complete decision problem which makes analytical solutions elusive and poses difficulties to design optimization algorithms for finding a dominating set of minimum cardinality in a large ***,we derive for the first time an approximate analytical solution for the density of the minimum dominating set(MDS)by using a combination of cavity method and ultra-discretization(UD)*** derived equation allows us to compute the size of MDS by only using as an input the information of the degree distribution of a given network.

关键词： Minimum dominating set analytical solution statistical methods complex networks

Tuna classification using super learner ensemble of region-based cNN-grouped 2D-LBP models

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Information Processing in Agriculture 2022年第1期9卷 68-79页

作者： Jisha Anu jose c.Sathish Kumar S.Sureshkumar Rajiv Gandhi Institute of Technology KottayamIndia Government Engineering college IdukkiIndia Kerala University of Fisheries and Ocean Studies KochiIndia

Tuna is superior among the marine fishes that are exported in the forms of raw fish and processed *** of Tuna into their species is done in industries manually,and the process is *** work proposes an automated system for classifying Tuna spe-cies based on their *** ensemble of region-based deep neural networks is used.A sub region contrast stretching operation is applied to enhance the *** fish image is then divided into three regions and is augmented before giving as input to pre-trained convolutional neural networks(cNN).After fine-tuning the models,the output from the last convolutional layer is given to a grouped 2D-local binary pattern descriptor(G2DLBP).Statistical features from the descriptor are applied to different classifiers,and the best clas-sifier for each image region model is *** ensemble methods are subse-quently used to combine the three cNN-G2DLBP *** the ensemble techniques,super learner ensemble method with random forest(RF)classifier using 5-fold cross-validation shows the highest classification accuracy of 97.32%.The perfor-mance of different ensemble methods is analyzed in terms of accuracy,precision,recall,and *** proposed system shows an accuracy of 93.91% when evaluated with an independent test *** ensemble of region-based cNN with textural features from G2DLBP is applied for the first time for fish classification.

关键词： Tuna classification convolutional neural network Grouped 2D-local binary pattern Super learner ensemble

Evaluation of Education of Veterinarians in Animal Welfare Issues

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Journal of Agricultural Science and Technology(A) 2015年第2期5卷 136-140页

作者： Stella Maris huertas Deborah cesar jose Piaggio Andres Gil Faeultad de Veterinaria Universidad de la Republica Lasplaces 1550 CP 11600 Montevideo Uruguay Instituto Plan Agropecuario Bulevard Artigas 3802 CP 11700 Montevideo Uruguay

Education of veterinarians in animal welfare issues is important to improve the welfare and health of animals. A questionnaire to 250 veterinarians related to their knowledge on animal welfare issues has been carried out at the Veterinary School of the University of the Republic, Uruguay, during March-April 2012. The questions were related to the courses on animal welfare veterinarians received, their main field of work, the importance given to the information offered and the quality of the topics addressed. From the total of veterinarians surveyed, 45% （112） answered the questionnaire. Of those who responded, 47% attended to three or more animal welfare courses, 18% assisted to two courses and 22% to one. The occupation of the 82% of respondents was with beef and dairy cattle （large animals） or in the meat industry equally. 10% works with small animals （especially pets） and poultry （production and industry）. The 95% of respondents considered that animal welfare is very important for their daily work with animals 65% reported that animal welfare concepts have high applicability in their job. 85% considered that animal welfare should be part of the veterinary curricula and 100% expressed their compliance to be present in other courses on the subject. These results emphasize the importance afforded by Uruguayan veterinarians to improve their knowledge on animal welfare and to continue including specific courses in the veterinary curricula.

关键词： Animal welfare veterinarians veterinary curricula continuing education.

Mercury uptake and effects on growth in Jatropha curcas

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Journal of Environmental Sciences 2016年第10期28卷 120-125页

作者： jose Marrugo-Negrete jose Durango-Hernandez jose Pinedo-Hernandez German Enamorado-Montes Sergi Diez University of cordoba Faculty of Basic Sciences Department of Chemistry Water Applied and Environmental Chemistry Group Monteria Colombia Environmental chemistry Department Institute of Environmental Assessment and Water Research ID█A-CSIC E-08034 Barcelona Spain

The use of metal-accumulating plants for the phytoremediation of contaminated soils is gaining more attention. Mercury （Hg）-contaminated soils from historical gold mines represent a potential risk to human health and the environment. Therefore, Jatropha curcas plant, that has shown its tolerance to these environments, is a species of particular interest to implement phytoremediation techniques in gold mining sites. In this work, the behavior of J. curcas was assessed in different hydroponic cultures fortified with Hg at concentrations of 5, 10, 20, 40, and 80μg Hg/mL （T5, T10, T20, T40 and T80, respectively）. After exposure, plant growth, net photosynthesis, leaf area, and Hg accumulation were determined and variables such as net Hg uptake, effective Hg accumulation, translocation and bioaccumu- lation factors were calculated. Accumulation of Hg in root and leaf tissues increased with respect to the Hg concentrations in the hydroponic culture, with statistically significant differences （p 〈 0.05） among treatments. Moreover, Hg concentration in roots was 7 and 12-fold higher in average than in plant leaves and shoots, respectively. Many effects were found in the development of plants, especially related with loss of biomass and leaf area, with significant growth inhibition related to control values （〉50% with treatment T5）. Moreover, percentage of inhibition was even higher （〉60%） with same treatment for net photosynthesis. Finally, it should be highlighted that for T40 and T80 treatments, plant growth and photosynthesis were almost completely depleted （88%-95%）.

关键词： Jatropha curcasPhytoextractionMercuryHydroponicGrowth inhibition

Which Inspection Approach Is Better to Prevent Drug Fraud: Announced or Unannounced?

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Journal of Systems Science & complexity 2018年第6期31卷 1571-1590页

作者： ZHANG Manman ZHANG Juliang cHENG T.c.E. SALLAN jose Maria HUA Guowei Department of Logistics Management School of Economics and ManagementBeijing Jiaotong UniversityBeijing 100044China. Department of Logistics and Maritime Studies The Hong Kong Polytechnic UniversityHung HornKowloonHong KongChina Department d'Organizacio d'Empreses Universitat Politecnica de CatalunyaTerrassa 08222Spain.

In recent years,there are many crimes related drug fraud occuring in china and many experts think that the main cause is that china Food and Drug Administration (cFDA)adopts announced inspection (AI).In order to circumvent this difficulty,cFDA has exploited unannounced inspection (UI)since *** this paper,the authors study the problem of which one performs better, AI or ***,the authors consider a supervisor,which decides the inspection approach,inspection strength and punishment to force the firm to put self-inspection effort to meet the requirements of Good Manufacturing Practice,and a firm,which produces a drug and decides its self-inspection effort. The authors use game theory to model this problem,characterize the equilibrium policies under AI, and compare the effects of the two approaches on preventing drug fraud under complete and incomplete *** results show that under the complete information,UI performs better if the firm's technical level and the inspection cost are low and AI performs better *** the supervisor doesn't know the firm's technical level,if the low technical level is high,AI performs ***, UI performs better if the inspection cost is low and AI performs better if the inspection cost is high.

关键词： Drug inspection game theory healthcare incomplete information public policy.

challenges and improvement strategies in the hospitalization of chronic multimorbid patients

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World Journal of clinical cases 2025年第3期13卷 35-41页

作者： Andres Fontalba-Navas Francisco Pozo Muñoz Rogelio Garcia cisneros Maria jose Garcia Larrosa Maria del Mar callejon Gil Ignacio Garcia Delgado Maria Belen Jimenez Martinez Antequera Hospital Northern Málaga Integrated Healthcare AreaAntequera 29200AndalusiaSpain Department of Public Health and Psychiatry University of MálagaMálaga 29010Spain Antequera Hospital Northern Málaga Antequera Integrated Healthcare AreaAntequera 29200MálagaSpain

BAcKGROUND Addressing the growing challenge of hospitalizing chronic multimorbid patients,this study examines the strain these conditions impose on healthcare systems at a local level,focusing on a pilot *** diseases and complex patients require comprehensive management strategies to reduce healthcare burdens and improve patient *** proven effective,this pilot model has the potential to be replicated in other healthcare settings to enhance the management of chronic multimorbid *** To evaluate the effectiveness of the high complexity unit(HcU)in managing chronic multimorbid patients through a multidisciplinary care model and to compare it with standard hospital *** The study employed a descriptive longitudinal approach,analyzing data from the Basic Minimum Data Set(BMDS)to compare hospitalization variables among the HcU,the Internal Medicine Service,and other services at Antequera Hospital throughout *** HcU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity *** The study employed a descriptive longitudinal approach,analyzing data from the BMDS to compare hospitalization variables among the HcU,the Internal Medicine Service,and other services at Antequera Hospital throughout *** HcU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity *** This study demonstrates the effectiveness of the HcU in managing patients with complex chronic diseases through a multidisciplinary *** coordinated care provided by the HcU results in improved patient outcomes,reduced unnecessary hospitalizations,and better management of patient *** superiority of the HcU compared to standard care is evident in key outcomes such as fewer readmissions and higher patient satisfaction,reinforcing its value as a model of ca

关键词： High complexity unit chronic multimorbidity Patient-centered care Integrated care Healthcare management

Enzymatic conversion of Sugarcane Lignocellulosic Biomass as a Platform for the Production of Ethanol,Enzymes and Nanocellulose

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Journal of Renewable Materials 2018年第2期6卷 203-216页

作者： cristiane S.Farinas jose Manoel Marconcini Luiz Henrique c.Mattoso Nanotechnology National Laboratory for Agriculture(LNNA) Embrapa InstrumentationRua XV de Novembro 145213561-206São CarlosSPBrazil

The conversion of sugarcane lignocellulosic biomass into fuels,chemicals and high-value materials using the biochemical pathway is considered the most sustainable alternative for the implementation of future ***,the first large-scale cellulosic ethanol plants that have started operating worldwide apply the enzymatic hydrolysis process to convert biomass into simple sugars that are fermented to ethanol by ***,several technological challenges still need to be addressed in order to obtain commercially competitive *** review describes current challenges and perspectives regarding the enzymatic hydrolysis step for processing sugarcane lignocellulosic biomass within the *** developments in terms of process configuration strategies and opportunities for the implementation of a sugarcane biorefinery,in which the production of ethanol is integrated into the production of high-value products such as enzymes and nanocellulose,are discussed in view of the demands of the current bioeconomy.

关键词： Enzymatic hydrolysis bioethanol sugarcane nanocellulose biorefinery