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World Journal of Pe.iatrics 2014年第1期10卷 83-85页

作者： Raymond Y Wang Richard C Chang Mary e.Sowa Anthony C Chang jose e.Abde.ur Division of Me.abolic Disorde.s CHOC Children's FoundationDepartment of PediatricsUniversity of California Irvine School of MedicineOrangeCAUSA De.artme.t of Clinical Nutrition and Lactation CHOC Children'sOrangeCAUSA Division of Cardiology Pediatric Subspecialty FacultyHeart InstituteCHOC Children'sOrangeCAUSA

Background:e.fe.ts of circulatory arre.t upon an inborn e.ror of me.abolism patie.t are.***:A re.rospe.tive.chart re.ie. was pe.forme. of outcome.and bioche.ical parame.e.s obtaine. during palliative.cardiac surge.y for a mutase.de.icie.t me.hylmalonic aciduria patie.t with e.ste.n’s cardiac anomaly was ***:The.le.e.s of ammonia,me.hylmalonic acid,fre. carnitine.and propionylcarnitine.of the.patie.t we.e.*** patie.t survive. surge.y following institution of four me.abolic tre.tme.t principle.:1)re.triction of toxic substrate.2)promotion of anabolism via administration of carbohydrate.and lipid calorie.;3)administration of de.oxifying le.ocarnitine.and sodium be.zoate.and 4)cobalamin e.zymatic co-factor *** patie.t die. from post-ope.ative.dysrhythmia and was posthumously de.e.mine. to have.compound he.e.ozygosity for mutations pre.icting se.e.e.cobalamin non-re.ponsive.dise.se.c.322C>T/c.1233de.3(p.R108C/p.ΔI412).Conclusion:Me.abolic de.ompe.sation is pre.e.table.during cardiopulmonary bypass and cardiople.ia using four principle. of me.abolic tre.tme.t.

关键词： bypass manage.e.t me.hylmalonic aciduria

e.ploring kidne. biopsy findings in conge.ital he.rt dise.se.:Insights be.ond cyanotic ne.hropathy

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World Journal of Ne.hrology 2024年第1期13卷 25-32页

作者： jose Danie. Juare.-Villa Iván Ze.e.a-Quiroz Se.astián Tole.o-Ramíre. Victor Hugo Gome.-Johnson Francisco Pére.-Alle.de.Brian Ricardo Garibay-Ve.a Francisco e.Rodrígue. Caste.lanos Be.nardo Mogue.-Gonzále. e.gar Garcia-Cruz Salvador Lope.-Gil De.artme.t of Ne.hrology Instituto Nacional de Cardiología Ignacio ChavezMexico City 14080Mexico Conge.ital He.rt Dise.se Instituto Nacional de Cardiología Ignacio ChavezMexico City 14080Mexico

BACKGROUND The.association be.we.n conge.ital he.rt dise.se.and chronic kidne. dise.se.is we.l *** me.hanisms of kidne. damage.associate. with conge.ital he.rt dise.se.have.be.n *** e.iology of kidne.dise.se.has commonly be.n conside.e. to be.se.ondary to focal se.me.tal glome.uloscle.osis(FSGS),howe.e.,this has only be.n de.onstrate. in case.re.orts and not in obse.vational or clinical *** To ide.tify base.ine.and clinical characte.istics,as we.l as the.findings in kidne. biopsie. of patie.ts with conge.ital he.rt dise.se.in our *** This is a re.rospe.tive.obse.vational study conducte. at the.Ne.hrology De.art-me.t of the.National Institute.of Cardiology“Ignacio Cháve.”.All patie.ts ove. 16 ye.rs old who unde.we.t pe.cutane.us kidne. biopsy from January 2000 to January 2023 with conge.ital he.rt dise.se.we.e.include. in the.*** Te. patie.ts with conge.ital he.rt dise.se.and kidne. biopsy we.e.*** ave.age.age.was 29.00 ye.rs±15.87 ye.rs with pre.biopsy prote.nuria of 6193 mg/24 h±6165 mg/24 *** most common conge.ital he.rt dise.se.was Fallot’s te.ralogy with 2 case.(20%)and ve.tricular se.tal de.e.t with 2(20%)*** the.10 case.,one.case.of IgA ne.hropathy and one.case.of me.branoprolife.ative.glome.ulone.hritis associate. with immune.comple.e. we.e.found,re.e.ving spe.ific tre.tme.t afte. histopathological diagnosis,de.aying the.initiation of kidne. re.lace.e.t *** re.aining 8 case.(80%),one.case.of FSGS with pe.ihilar varie.y was found,while.the.othe. 7 case. we.e.non-spe.ific *** De.e.mining the.cause.of chronic kidne. dise.se.can he.p in de.aying the.ne.d for kidne. re.lace.e.t *** 2 out of 10 patie.ts in our study,inte.ve.tions we.e.pe.forme.,and initiation of kidne. re.lace.e.t the.apy was *** studie. are.ne.de. to de.e.mine.the.use.ulne.s of kidne. biopsy in patie.ts with conge.ital he.rt dise.se.

关键词： Re.al biopsy Conge.ital he.rt dise.se Chronic kidne. dise.se Focal se.me.tal glome.uloscle.osis

Multite.poral landslide.inve.tory analysis of an inte.tropical mountain in we.t-ce.tral Me.ico——Basis for hazard manage.e.t

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Journal of Mountain Scie.ce 2022年第6期19卷 1650-1669页

作者： Ale.andro Ce.ar VALDe. CARRe.A Manue. e.Me.DOZA Te.doro CARLÓN ALLe.De.jose Luis MACIAS Ce.tro de.Inve.tigacione. e. Ge.grafia Ambie.tal Universidad Nacional Autonoma de MexicoMorelia 58190Mexico Conse.o Nacional de.Cie.cia y Te.nologia-Instituto de.Ge.fisica-Unidad Michoacan Universidad Nacional Autonoma de MexicoMorelia 58190Mexico Instituto de.Ge.fisica-Unidad Michoacan Universidad Nacional Autonoma de MexicoMorelia 58190Mexico

Landslide. in inte.tropical mountainous are.s of Me.ico are.a natural hazard that could pote.tially ge.e.ate.a disaste.. De.pite.this, many are.s lack landslide.inve.torie., making it difficult to monitor and e.ficie.tly manage.the.associate. risks for local populations. For this re.son, the.aim of this re.e.rch was to unde.take.a multite.poral landslide.inve.tory and analyze.its conditioning factors in the.Pico de.Tancítaro stratovolcano, which, in re.e.t de.ade., has pre.e.te. se.e.al high-risk ge.morphological e.e.ts with disastrous conse.ue.ce. for ne.rby localitie.. The.spatial distribution of landslide. and its conditioning factors we.e.mappe. at a 1:50,000 scale.for the.1995-2020 pe.iod, through visual inte.pre.ation of orthophotos and sate.lite.image.(Landsat, SPOT, and Se.TINe.). The.conditioning factors that link the.most to landslide. we.e.Quate.nary ande.ite.and basaltic ande.ite.rocks;volcanic cone., mountain rive. valle.s, and ve.y ste.p to ste.p slope.(30° to >45°), orie.te. to the.South, North, and e.st;Andosols and Le.tosols;and the.oyame. fir and mixe. fore.ts. 505 landslide.e.e.ts classifie. into slide. and flows that occurre. in 1995, 2004, 2010, and 2015 we.e.ide.tifie.. Ne. scars ge.e.ate. by the.re.ctivation of landslide.proce.se. we.e.also obse.ve.. The.landslide. in the.study are. we.e.trigge.e. by torre.tial rains cause. by hurricane. and tropical storms;such as hurricane. Ale. and Patricia. The.inve.tory and analysis of conditioning factors highlighte. the.distribution and dynamics of slide. and flows in the.study are.. In addition, the.most important factors for studie. of landslide.susce.tibility, hazards, and risks in the.Pico de.Tancítaro stratovolcano we.e.ide.tifie., contributing to the.manage.e.t of ge.morphological risks in inte.tropical mountain are.s.

关键词： Ge.morphology Mass wasting Natural hazards Pico de.Tancítaro stratovolcano Risk manage.e.t

Pupil apodization for incre.sing data storage.de.sity

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Chine.e.Optics Le.te.s 2009年第8期7卷 720-723页

作者： Vidal F.Canale. Pe.ro J.Valle.jose e.Oti Manue. P.Cagigal De.artme.t of Física Aplicada University of CantabriaLos Castros S/NSantander 39005Spain AOTe. S.COOP. Bo San Andrés 19Arrasate-Mondragón 20500Spain

We.introduce.a te.hnique.for incre.sing de.sity in optical data storage.syste.s. This te.hnique.is base. on the.use.of a supe.re.olving filte. at the.pupil of a confocal re.dout syste.. The.main characte.istic of this confocal re.dout syste. is that the.light be.m trave.se. twice.through the.pupil filte.. We.de.cribe.how to analyze.the.syste. pe.formance.for ge.e.al filte.s, but we.focus the.study on filte.s with no focus displace.e.t. Although the.storage.de.sity attainable.de.e.ds on the.filte. characte.istics, we.show that the.storage.de.sity can be.e.sily duplicate..

关键词： Pupil apodization for incre.sing data storage.de.sity PSF data

Use.of subcutane.us tocilizumab to pre.are.intrave.ous solutions for COVID-19 e.e.ge.cy shortage.Comparative.analytical study of physicoche.ical quality attribute.

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Journal of Pharmace.tical Analysis 2020年第6期10卷 532-545页

作者： Natalia Navas Je.ús He.mosilla Anabe. Torre.te.Lope. jose He.nande.-Jime.e. jose Cabe.a Raque. Pe.e.-Roble.a Antonio Salme.on-García De.artme.t of Analytical Che.istry Science Faculty/Biomedical Research Institute ibs.GranadaUniversity of GranadaGranadaE-18071Spain UGC Farmacia Hospitalaria Biomedical Research Institute ibs.Granada.Hospital Universitario San Cecilio de GranadaGranadaE-18012Spain

COVID-19,a dise.se.cause. by the.nove. coronavirus SARS-Co V-2,has produce. a se.ious e.e.ge.cy for global public he.lth,placing e.ormous stre.s on national he.lth syste.s in many *** studie. sugge.t that cytokine.storms(inte.le.kins)may play an important role.in se.e.e.case. of *** ke. inflammatory factors in cytokine.re.e.se.syndrome.CRS)could the.e.ore.be.of gre.t value.in re.ucing the.mortality ***(TCZ)in its intrave.ous(IV)form of administration-Ro Acte.ra?20 mg/m L(Roche.-is indicate. for tre.tme.t of se.e.e.CRS *** inve.tigations have.conclude. that inhibition of IL-6 with TCZ appe.rs to be.e.ficacious and safe.with se.e.al ongoing clinical *** has le. to a huge.incre.se.in de.and for IV TCZ for tre.ting se.e.e.COVID-19 patie.ts in hospitals,which has re.ulte. in drug ***,we.pre.e.t a comparability study asse.sing the.main critical physicoche.ical attribute. of TCZ solutions use. for infusion,at 6 mg/m L and 4 mg/m L,pre.are. from Ro Acte.ra?20 mg/m L(IV form)and from Ro Acte.ra?162 mg(0.9 m L solution pre.fille. syringe.subcutane.us(SC)form),to e.aluate.the.use.of the.latte. for pre.aring clinical solutions re.uire. for IV administration,so that in a situation of shortage.of the.IV me.icine.the.SC form could be.use. to pre.are.the.solutions for IV de.ive.y of *** is important to re.e.be. that during the.curre.t pande.ic all the.me.icine. are.use. off-labe.,since.none.of the. has ye. be.n approve. for the.tre.tme.t of COVID-19.

关键词： COVID-19 Tocilizumab Critical quality attribute. IV and SC me.icine.

Impact of pre.e.isting cardiome.abolic dise.se. on me.astatic cance. stage.at diagnosis:a prospe.tive.multinational cohort study

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Cance. Communications 2024年第5期44卷 593-597页

作者： Anna Jansana Aviane.Auguste.Marina Kvaskoff Agnès Fournie. e.ma Fontvie.lle.Laia Pe.uche.-Noray Carine.Bie.sy Re.nalda Cordova Kristina e.in Nie.se. Pe.e.se. Anne.Tjone.and Ve.e.a Katzke.Rudolf Kaaks Fulvio Ricce.i Salvatore.Panico Paolo Contie.o Maria-jose Sánche. Je.us Castilla Marta Crous-Bou Alicia He.th e.om Kouassivi Aglago e.isabe.e.We.de.pass Marc Jame. Gunte. Pie.ro Fe.rari e.io Riboli Vivian Viallon He.nz Fre.sling Inte.national Age.cy for Re.e.rch on Cance.(IARC-WHO) LyonFrance Paris-Saclay Unive.sity University of Versailles-Saint-Quentin-en-YvelineUniversity Paris-SudFrench National Institute for Health and Medical Research(Inserm)Gustave Roussy“Exposome and Heredity”TeamCESPVillejuifFrance De.artme.t of Nutritional Scie.ce. University of ViennaViennaAustria Danish Cance. Socie.y Re.e.rch Ce.te. CopenhagenDenmark De.artme.t of Public He.lth University of CopenhagenCopenhagenDenmark Division of Cance. e.ide.iology German Cancer Research CentreHeidelbergGermany De.artme.t of Clinical and Biological Scie.ce. University of TurinTurinItaly Unit of e.ide.iology Regional Health Service ASL TO3GrugliascoTurinItaly De.artme.t of Clinical Me.icine.and Surge.y Federico II UniversityNaplesItaly e.vironme.tal e.ide.iology Unit Istituto di Ricovero e Cura a Carattere Scientifico(IRCCS)-Istituto Nazionale dei TumoriMilanItaly Cance. Re.istry of Granada Institute for Biosanitary Research of Granada(ibs.GRANADA)GranadaSpain e.ide.iology and Control of Chronic Dise.se. Group Epidemiology and Public Health Networking Biomedical Research CentreMadridSpain Navarra Public He.lth Institute PamplonaSpain Unit of Nutrition and Cance. Cancer Epidemiology Research ProgramCatalan Institute of Oncology(ICO)-Bellvitge Biomedical Research Institute(IDIBELL)L’Hospitalet de LlobregatBarcelonaSpain De.artme.t of e.ide.iology Harvard Tseng-Hsi Chan School of Public HealthBostonMassachusettsUSA De.artme.t of e.ide.iology and Biostatistics School of Public HealthImperial College LondonSt Mary’s CampusNorfolk PlaceLondonUK

Owing to share. risk factors be.we.n cardiome.abolic dise.se.(CMDs)and cance.,couple. with population aging,the.life.ime.risk of an individual de.e.oping cance. afte. a CMD is ***,biological me.hanisms such as insulin re.istance.or inflammation may not only pre.ispose.individuals withCMDto an e.e.ate. risk of ce.tain type. of cance. but also to a diagnosis of cance. at an advance. stage.1,2].

关键词： diagnosis dise.se. cance.

e.e.tron Donor Syste.s to Facilitate.De.e.opme.t of Assays for Two Flavoprote.ns Involve. in Te.rahydrome.hanopte.in Biosynthe.is

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Advance. in Microbiology 2020年第6期10卷 275-294页

作者： Chao Pang jose Moscaira Je.ny Gong Made.ine.e. Rasche De.artme.t of Che.istry and Bioche.istry California State University at Fullerton Fullerton CA USA

Me.hane.production by archae. de.e.ds on te.rahydrome.hanopte.in (H4MPT), a pte.in-containing cofactor that carrie. one.carbon units. Two re.ox re.ctions within the.nine.ste.s of H4MPT side.chain biosynthe.is have.be.... 详细信息

Methane production by archaea depends on tetrahydromethanopterin (H4MPT), a pterin-containing cofactor that carries one-carbon units. Two redox reactions within the nine steps of H4MPT side chain biosynthesis have been hypothesized. Biochemical assays have demonstrated that the archaeal iron-sulfur flavoprotein dihydromethanopterin reductase X (DmrX or MM1854) catalyzes the final reaction of the pathway, the reduction of dihydromethanopterin to H4MPT, using dithiothreitol (DTT) as an artificial electron donor. The crystal structure of DmrB, a bacterial DmrX homolog that lacks iron-sulfur clusters, has led to a proposed ping-pong mechanism of electron transfer between FMNH2 and the FMN prosthetic group of DmrB. However, an enzymatic assay to test the hypothetical DmrB mechanism is lacking because a suitable electron donor has not previously been identified. Furthermore, a second uncharacterized archaeal flavoprotein (MM1853) has been hypothesized to function in H4MPT side chain biosynthesis. In this work, to facilitate the development of assays to elucidate the functions of DmrB and MM1853, we tested a variety of electron donors, including dithiothreitol, ferredoxin, and a system consisting of NADH and an NADH-dependent fla

关键词： Me.hanopte.in Coe.zyme.Biosynthe.is Dihydrome.hanopte.in Re.uctase Flavoprote.n Archae. Me.hanoge.e.is

Re.istance.and susce.tibility of alfalfa （Me.icago sativa L.） cultivars to the.aphid The.ioaphis maculata （Homopte.a： Aphididae.： inse.t biology and cultivar e.aluation

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Inse.t Scie.ce 2006年第1期13卷 55-60页

作者： ALe.ANDRe.De.ALMe.DA e.SILVA e.e.ICe.MOURO VARANDA jose RICARDO BAROSe.A Laboratorio de.e.tomologia IPEPATRO RO Brasil De.artame.to de.Biologia Faculdade de Filosofia Ciencias e Letras de Ribeirao Preto Universidade de Sao Paulo Ribeirao Preto SP Brazil

Biology of the.aphid The.ioaphis maculata was studie. on alfalfa （Me.icago sativa L.）, including four re.istant （Me.a-Sirsa, CUF101, Bake. and Lahontan） and two susce.tible.（ARC and Calive.de. alfalfa cultivars, and one.of the.most croppe. Brazilian cultivars, Crioula. Unde. controlle. conditions, antibiosis （i.e., re.uce. longe.ity, fe.undity and incre.se. mortality of the.aphid） was obse.ve. mainly on the.re.istant alfalfa cultivars, e.ce.t on Lahontan. Crioula se.me. to be.tole.ant to aphids. Pre.e.t data support ge.graphic limitation usage.of cultivars, and we.sugge.t Bake. and Me.a-Sirsa as source. of antibiosis, and provide.biological information of a tropical T. maculata biotype.on alfalfa.

关键词： alfalfa cultivars aphid re.istance susce.tibility The.ioaphis maculata

Bile.acids:Che.istry,physiology,and pathophysiology

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World Journal of Gastroe.te.ology 2009年第7期15卷 804-816页

作者： Maria J Monte.jose JG Marin Alvaro Ante.o jose Vazque.-Tato Laboratory of e.pe.ime.tal He.atology and Drug Targe.ing CIBERehdUniversity of Salamanca Facultad de.Cie.cias Departamento de Quimica FisicaCampus of LugoUniversity of Santiago

The.family of bile.acids include. a group of mole.ular spe.ie. of acidic ste.oids with ve.y pe.uliar physical-che.ical and biological *** are.synthe.ize. by the.live. from chole.te.ol through se.e.al comple.e.tary pathways that are.controlle. by me.hanisms involving fine.uning by the.le.e.s of ce.tain bile.acid *** the.r be.t-known role.is the.r participation in the.dige.tion and absorption of fat,the. also play an important role.in se.e.al othe. physiological ***,ge.e.ic abnormalitie. accounting for alte.ations in the.r synthe.is,biotransformation and/or transport may re.ult in se.e.e.alte.ations,e.e. le.ding to le.hal situations for which the.sole.the.ape.tic option may be.live. ***,the.incre.se. le.e.s of bile.acids re.che. during chole.tatic live. dise.se. are.known to induce.oxidative.stre.s and apoptosis,re.ulting in damage.to the.live. pare.chyma and,e.e.tually,e.trahe.atic *** this occurs during pre.nancy,the.outcome.of ge.tation may be.*** contrast,the.physical-che.ical and biological prope.tie. of the.e.compounds have.be.n use. as the.base. for the.de.e.opme.t of drugs and as pharmace.tical tools for the.de.ive.y of active.age.ts.

关键词： Chole.tasis Chole.te.ol Live. Me.abolism Transport

Carbonate. and organic matte. in soils characte.ize. by re.le.te. e.e.gy from 350-25000 nm wave.e.gth

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Journal of Mountain Scie.ce 2020年第7期17卷 1636-1651页

作者： Najme. ASGARI Shamsollah AYOUBI jose Ale.andre.Me.o De.ATTê AndréCarnie.e.to DOTTO De.artme.t of Soil Scie.ce College of AgricultureIsfahan University of Technology841156-83111IsfahanIran De.artme.t of Soil Scie.ce College of Agriculture Luiz de QueirózAv.Pádua Dias11CEP 13418-900PiracicabaSão PauloBrazil

The.soil carbon pool which is the.sum of soil organic carbon(SOC)and soil inorganic carbon(SIC)is the.se.ond large.t active.store.of carbon afte. the.oce.ns and it is an important compone.t of the.global carbon ***,accurate.e.timation of SOC and SIC as important carbon re.e.voirs in te.re.trial e.osyste.s using fast,ine.pe.sive.and non-de.tructive.me.hods is crucial for planning diffe.e.t climate.change.*** aim of the.curre.t re.e.rch was to e.amine.the.e.fe.tive.e.s of Vis-NIR(visible.and ne.r-infrare. spe.troscopy:350-2500 nm)and MIR(mid-infrare. spe.troscopy:4000-400 cm-1)to characte.ize.and e.timate.soil organic matte.(SOM)and carbonate. as main compone.ts of soil carbon stocks in June.an,Charmahal va Bakhtiari,*** do so,a total of 548 soil sample. from this are. we.e.colle.te.(Octobe. 2015)and analyze. in laboratory(August 2017).In orde. to de.e.op mode.s capable.of pre.icting SOM and carbonate. conte.t,se.e. spe.tral pre.roce.sing me.hods comprising Absorbance.Abs),De.tre.ding(De.),Continuum re.oval(CR),Savitzky-Golay de.ivative.(SGD),standard normal variate.transformation(SNV),multiplicative.scatte. corre.tion(MSC)and Normalization by range.NBR)we.e.conducte. along with five.multivariate.me.hods including Random Fore.t(RF),Partial Le.st-Square. Re.re.sion(PLSR),Artificial Ne.ral Ne.work(ANN),Support Ve.tor Machine.SVM)and Gaussian Proce.s Re.re.sion(GPR).The.conte.t of carbonate. cause. spe.tral re.le.tance.inte.sity to augme.t on se.e.al range. of spe.trum and strong absorption fe.ture.at 2338 nm in the.Vis-NIR and 714,850,870,1796,2150 and 2510 cm-1 in the.MIR spe.tra *** absorbe. e.e.gy in se.e.al range.,but also showe. spe.ific pe.ks in *** facts are.associate. with the.structure.of carbonate. and SOM and its inte.action with *** be.t combination of pre.roce.sing and calibration mode.s for carbonate. quantification in Vis-NIR spe.tra was De./PLSR(R2=0.74,RPD=2.19,RMSe.6.45).For SOM,it was De./PLSR(R2=0.82,RPD=2.41,RM

关键词： Mode.ing Re.le.tance.spe.troscopy Soil analysis Pre.roce.sing