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Single nucleotide polymorphism(SNP)in genes of lupus:A Philippine study(SIGLA-PH)

Rheumatology & Autoimmunity 2022年第1期2卷 22-30页

作者： Michael L.Tee Cherica A.Tee jose b.neva.o jr Angeline Therese Santiago Aedrian A.Abrilla Carlo M.Lapid Francis A.Tablizo Joshua A.Dizon El K.b.Morado Eva Maria Cutiongco-Dela Paz College of Medicine University of the Philippines ManilaManilaPhillipines Institute of Human Genetics National Institutes of HealthUniversity of the Philippines ManilaManilaPhillipines College of Medicine and Philippine General Hospital University of the Philippines ManilaManilaPhillipines Core Facility for bioinformatics Philippine Genome CenterUniversity of the PhilippinesManilaPhillipines National Institutes of Health University of the Philippines ManilaManilaPhillipines

background:Systemic lupus erythematosus(SLE)is a complex prototypic autoimmune disease,with a prevalence of 20–150 per 100,000,most commonly affecting women at child-bearing ***-wide association studies and fine mapping of candidate regions have paved the way for greater understanding of SLE as a disease of genetic–environmental susceptibility and the functions of the genes ***:This study was conducted to determine the association of selected single nucleotide polymorphisms(SNPs)from established genomic databases based on theoretical risk and protective odds ratios>2.5 oro susceptibility of developing SLE among ***:We analyzed data from 310 SLE patients and 318 *** identified eight significant SNPs namely rs9271100,rs9271366,rs9272105,rs9275328,rs2647087,rs12734338,rs17885098,and rs3883013 to be associated with an increased risk of developing SLE among ***:Eight SNPs were found to be associated with the development of SLE among *** to previous genetic studies in lupus patients,majority of the SNPs were found in the major histocompatibilty complex genes in the HLA *** study identified two unique SNPs that will be validated as potential diagnostic markers for *** findings of this study may contribute to the development of a polygenic risk score in determining susceptibility to SLE among Filipinos.

关键词： genetics lupus SLE SNP susceptibility

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Soil boron fertilization:The role of nutrient sources and rootstocks in citrus production

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Journal of Integrative Agriculture 2017年第7期16卷 1609-1616页

作者： Dirceu Mattos jr Franz W R Hippler Rodrigo M boaretto Eduardo S Stuchi jose A Quaggio Centro de Citricultura Sylvio Moreira Instituto AgronSmicoCordeiropolis(SP)13490-970Brazil Estacao Experimental de Citricultura de bebedouro Bebedouro(SP)14700-970Brazil Centro de Solos e Recursos Ambientais Instituto Agronomico/Bara de ItapuraCampinas(SP)13020-902Brazil

boron （b） is a key element for citrus production, especially in tropical regions, where the nutrient availability is commonly low in the soil. In addition, information about doses, fertilizer sources, methods of application, and particularly, differential nutrient demand of scion/rootstock combinations are required for efficient fertilization of commercial groves. In a non-irri- gated sweet orange orchard （cv. Natal）, grafted onto Rangpur lime, Swingle citrumelo or Sunki mandarin, we studied the application of two sources of b： boric acid （17% b, soluble in water） and ulexite （12% b, partiaJly soluble in water） at four levels of supply （control without b, and soil application of 2, 4 and 6 kg ha-1 yr-1 of b）. The experiment was carried out for three years （2004-2006）. boron availability in the soil and concentration in the leaves, as well as the fruit yield and quality of trees were evaluated. Soil b extracted with hot water and total leaf b positively correlated with doses of the nutrient applied to the trees. Levels of b in the soil and in the leaves did not vary with fertilizer sources. Fruit yield of trees grafted onto Rangpur lime and Swingle citrumelo was more responsive to b doses than those grafted onto Sunki mandarin. The maximum fruit yield of trees grafted onto Swingle was obtained with 3.2 kg ha-1 yr-1 of b, and leaf b level of 280 mg kg-1 that point out to a highest demand for b when this combination was compared with other rootstocks. Furthermore, fertilization with b did not affect the quality of fruits, but correlated with b and potassium （K） concentrations in the leaves. These results also support that the current recommendations for levels of b in leaves should be revisited.

关键词： boric acid ulexite fertilization via soil leaf analysis fruit quality citrus

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Soil-transmitted helminth egg contamination from soil of indigenous communities in selected barangays in Tigaon, Camarines Sur, Philippines

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Asian Pacific Journal of Tropical Medicine 2020年第9期13卷 409-414页

作者： James owen C.Delaluna Mary Jane C.Flores Vicente Y.belizario jr. jose Isagani b.Janairo Derick Erl P.Sumalapao biology Department College of ScienceDe La Salle UniversityManila Philippines biological Control Research Unit Center for Natural Sciences and Environmental ResearchDe La Salle UniversityManila Philippines Department of Parasitology College of Public HealthUniversity of the PhilippinesManila Philippines Department of Epidemiology and biostatistics College of Public HealthUniversity of the PhilippinesManila Philippines

objective:To provide baseline data on the prevalence and intensity of soil-transmitted helminthiasis egg contamination in the soil among indigenous ***:A total of 317 soil samples from three barangays of indigenous communities communities in Tigaon,Camarines Sur,Philippines were examined for soil-transmitted helminthiasis egg contamination using optimized sugar flotation ***:of the soil samples examined,141(44.48%)were contaminated by Ascaris spp.,Toxocara spp.,and Trichuris *** cumulative prevalence varying across the study sites(Pominant in all study sites,followed by Toxocara *** Trichuris *** a prevalence of 41.96%,7.57%,and 5.36%,***,Toxocara *** the highest intensity of contamination,followed by Ascaris *** Trichuris *** term of geometric mean soil-transmitted helminthiasis eggs recovered per one gram soil sample(34.25,21.45,and 11.85 respectively).Each study site harbors significant amount of soiltransmitted helminthiasis eggs and zoonotic Toxocara eggs,which present high risk of soil-transmitted helminthiasis infection,particularly among children observed to play and cohabitate with animals known to be hosts of these ***:The alarming rate of soil-transmitted helminthiasis and Toxocara egg contamination reported in this study suggests that additional measures should be undertaken to control soil-transmitted helminthiasis and zoonotic intestinal infections in the country.

关键词： Indigenous peoples Soil-transmitted helminths Ascaris Toxocara Trichuris Public health

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Investigation of Galactic open cluster remnants： the case of NGC 7193

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Research in Astronomy and Astrophysics 2017年第1期17卷 31-54页

作者： Mateus de Souza Angelo Joao Francisco Coelho dos Santos jr Wagner jose barbosa Corradi Francisco Ferreira de Souza Maia Andres Eduardo Piatti Departamento de Fisica ICEx Universidade Federal de Minas Gerais Av. Antonio Carlos 6627 31270-901 Belo Horizonte MG Brazil observatorio Astronomico Universidad Nacional de Cordoba Laprida 854 5000 Cordoba Argentina Consejo Nacional de Investigaciones Cientificas y Tecnicas Av. Rivadavia 1917 C1033AAJ Buenos AiresArgentina

Galactic open clusters （oCs） that survive the early gas-expulsion phase are gradually de- stroyed over time by the action of disruptive dynamical processes. Their final evolutionary stages are characterized by a poorly populated concentration of stars called an open cluster remnant （oCR）. This study is devoted to assessing the real physical nature of the oCR candidate NGC 7193. GMoS/Gemini spectroscopy of 53 stars in the inner target region were obtained to derive radial velocities and at- mospheric parameters. We also employed photometric and proper motion data. The analysis method consists of the following steps：（i） analysis of the statistical resemblance between the cluster and a set of field samples with respect to the sequences defined in color-magnitude diagrams （CMDs）; （ii） a 5-dimensional iterative exclusion routine was employed to identify outliers from kinematical and posi- tional data; （iii） isochrone fitting to thes× （J - Ks） CMD of the remaining stars and the dispersion of spectral types along empirical sequences in the （J - H） × （H - Ks） diagram were checked. A group of stars was identified for which the mean heliocentric distance is compatible with that obtained via isochrone fitting and whose metallicities are compatible with each other. Fifteen of the member stars observed spectroscopically were identified together with another 19 probable members. our results indi- cate that NGC 7193 is a genuine oCR, of a once very populous oC, for which the following parameters were derived： d = 501±46 pc, t = 2.5±1.2 Gyr, （[Fe/H]） = -0.17±0.23 and E（b-V） = 0.05±0.05. Its luminosity and mass functions show depletion of low mass stars, confirming the oCR is in a dynam- ically evolved state.

关键词： open cluster remnants - Galactic open clusters

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Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in brazil

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World Journal of Gastroenterology 2019年第38期25卷 5862-5882页

作者： Rogerio Serafim Parra Julio MF Chebli Heda MbS Amarante Cristina Flores jose ML Parente odery Ramos Milene Fernandes jose jr Rocha Marley R Feitosa omar Feres Antonio S Scotton Rodrigo b Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile o Santana Ligia Y Sassaki Rogerio S Hossne Mauro bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari Department of Surgery and Anatomy Ribeirao Preto Medical SchoolUniversity of Sao PauloRibeirao PretoSP 14049-900Brazil Hospital Universitario da Universidade Federal do Piaui TeresinaPI 64049-550Brazil Carolina D Gonclves Isabella M GuimaraesUniversidade Federal do Rio de JaneiroRio de JaneiroRJ 21941-913Brazil Universidade do Estado da bahia -SalvadorBA 41150-000Brazil Department of Internal Medicine Botucatu Medical School at Sao Paulo State University(UNESP)BotucatuSP 18618-687Brazil Instituto Goiano de Gastroenterologia e Endoscopia Digestiva Ltda GoianiaGO 74535-170Brazil Kaiser Clinica Sao Jose do Rio PretoSP 15015-110Brazil Escola Paulista de Medicina Sao PauloSP 04023-900Brazil UNIFESP Disciplina de GastroenterologiaSao PauloSP 04040-002Brazil Faculdade de Medicina do AbC Santo AndreSP 09060-870Brazil Faculdade de Medicina UFMG Belo HorizonteMG30130-100Brazil Inflammatory bowel Disease Center Federal University of Juiz de ForaJuiz de ForaMG 36036-247Brazil Takeda Pharmaceuticals brazil Sao PauloSP 04709-011Brazil 不详 Hospital de Clinicas da Universidade Federal do Parana CuritibaPR 80060-900Brazil Hospital de Clinicas de Porto Alegre Porto Alegre-RS 90035-007Brazil Universidade Federal do Piaui TeresinaPI 64073-500Brazil Hospital de Clínicas da Universidade Federal do Parana CuritibaPR 80060-900Brazil CTI Clinical Trial&Consulting Services Lisbon 1070-274Portugal CMIP Centro Mineiro de Pesquisa Juiz de ForaMG 36010-570Brazil Hospital Nossa Senhora das Gracas CuritibaPR 80810-040Brazil

bACKGRoUND Inflammatory bowel diseases(IbD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general *** about disease control,patient-reported outcomes(PRos),treatment patterns and use of healthcare resources is relevant to optimizing IbD *** To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IbD patients in *** A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,*** PRo assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory bowel Disease Questionnaire(IbDQ),and the WPAI *** about healthcare resources and treatment during the previous 3 years was collected from medical ***-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PRos,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at *** in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IbDQ overall score was 164.0/*** to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(Pork productivity impairment was 20%and 5%for CD and UC patients,re

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis Quality of life Healthcare resources

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Hepatitis b infection among adults in the philippines:A national seroprevalence study

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World Journal of Hepatology 2013年第4期5卷 214-219页

作者： Stephen N Wong Janus P ong Madalinee Eternity D Labio oscar T Cabahug Maria Lourdes o Daez Erlinda V Valdellon jose D Sollano jr Marilyn o Arguillas Section of Gastroenterology University of Santo Tomas HospitalManila 1008Philippines Section of Gastroenterology University of the Philippines-Philippine General HospitalManila 1000Philippines Center for Liver Disease Management and Transplantation The Medical CityPasig 1605Philippines College of Medicine University of the East Ramon Magsaysay Memorial Medical CenterQuezon City 1113Philippines Department of Internal Medicine Davao Doctors HospitalDavao 8000Philippines

AIM:To determine the prevalence of hepatitis b surface antigen(HbsAg)seropositivity among adult ***:Testing for HbsAg was performed on serum samples from persons aged ≥ 20 years old who participated in the National Nutrition and Health Survey(NNHeS)conducted in *** on age,sex,marital status,educational attainment,employment status,and income were *** this study,marital status was classified as never married or otherwise(i.e.,married,divorced,separated,widowed);educational attainment was classified as high school graduate or below or at least some tertiary education;and employment status was classified as currently employed or currently *** income was divided into 4 quartiles in Philippine pesos(PhP):Q1,≤ PhP 53064;Q2,PhP 53065-92192;Q3,PhP 92193-173387;and Q4,≥ PhP *** estimates were weighted so that they represented the general *** and demographic factors were correlated with HbsAg *** analysis was used to determine independent predictors of HbsAg ***:A total of 2150 randomly selected adults,20 years and over,out of the 4753 adult participants of NNHeS were tested for *** HbsAg seroprevalence was 16.7%(95%CI:14.3%-19.1%),which corresponded to an estimated 7278968 persons infected with hepatitis *** was no significant difference between males and females(17.5% vs 16.0%;P = 0.555).This corresponded to an estimated 3721775 men and 3557193 women infected with hepatitis *** HbsAg seroprevalence peaked at age 20-39 years old,with declining prevalence in the older age *** only independent predictor of HbsAg seropositivity was the annual income,with persons in the highest income quartile being less likely to be HbsAg positive(age-adjusted oR = 0.51;95%CI:0.30-0.86)compared to subjects in the lowest income ***,marital status,educational attainment,and employment status were not found to be independent predictors of HbsAg serop

关键词： Prevalence Hepatitis b Survey Philippines Asia

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DETECTIoN AND DEPTH PRoFILING oF ^(19)F USING RESoNANCES IN THE ^(19)F(α,p) ^(22)Ne REACTIoN

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Nuclear Science and Techniques 1990年第Z1期1卷 56-61页

作者： L.C.McIntyre jr. J.A.Leavitt M.D.Ashbaugh b.Dezfouly-Arjomandy Z.Lin J.oder R.F.C.Farrow S.S.P.Parkin University of Arizona TucsonAZ 85721USA IbM Research Division Alamaden Research Center San JoseCA 95120-6099USA

Resonances in the reaction 19F (α ,p) 22Ne have been used to detect and depth profile 19F in solid targets. Incident alpha particles in the range 2100-2500 keV were used and protons were detected at θ=135° with a large solid angle surface barrier detector covered to stop elastically scattered alpha particles. This technique is a simple, nuclide specific probe and is particularly useful in detecting 19F in the presence of heavy elements such as GaAs where conventional Rutherford backscattering is ineffective. Examples using this technique on epitaxially grown thin films containing LaF3 layers will be presented.

关键词： Fluorine Depth profile Nuclear reaction analysis

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金龟子绿僵菌分生孢子暴露在b段紫外光下毒力的降低

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安徽农业大学学报 2008年第2期35卷 246-249页

作者： Edimara A Francisco Drauzio E N Rangel Newton La Scala jr José C barbosa Antnia do C b Correia Departamento de Fitossanidade Faculdade de Ciências Agrárias e Veterinárias de JaboticabalUniversidade Estadual PaulistaJaboticabalSP14884-900Brazil Departamento de Fitossanidade Faculdade de Ciências Agrárias e Veterinárias de JaboticabalUniversidade Estadual PaulistaJaboticabalSP14884-900BrazilDepartament of BiologyUtah State UniversityUT 884322-5305USA Currently Address:Universidade do Vale do ParaíbaInstituto de Pesquisa e Desenvolvimento.Av.Shishima Hifumi2911 Urbanova So Jose dos CamposSP 12244-000 Brazil Departamento de Ciências Exatas Faculdade de Ciências Agrárias e Veterinárias de JaboticabalUniversidade Estadual Paulista JaboticabalSP14884-900Brazil

The UV-A and UV-b wavelengths of solar radiation may seriously reduce viability of Metarhizium anisopliae conidia,a fungus used extensively in brazil for insect pest *** conidial tolerances to UV-A and UV-b radiation were studied for one isolate(IbCb 425) commercially available product produced on rice *** or oil emulsion conidial suspensions were irradiated for 0(control),2,or 3 h using the solar simulator filtered with diacetate filter to remove UV-C radiation which afforded 652 mW·m-2 in the spectral range of 280～370 *** UV tolerance was based on conidial germination(viability) and virulence to Diatraea saccharalis *** formulated with oil emulsion had higher survival after 3 h of UV exposure,but the virulence of the conidia previously exposed to 2 h of UV radiation were similar when oil formulated or *** mortality of *** caterpillars exposed to non-UV-irradiated conidia was greater than that of larvae exposed to irradiated conidia,and the LT50 values were lower for the non-irradiated suspensions than for those *** apparent reduction in virulence was directly related reduction in viability or delay of germination of UV-irradiated conidia.

关键词：模拟阳光无性孢子表述无性孢子萌芽毒性

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Assessment of inconclusive left main coronary lesions: lessons from an intravascular ultrasound study

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上海医学 2007年第S1期30卷 109-109页

作者： Gary S.Mintz Stéphane G.Carlier jose de Ribamar Costa jr Koichi Sano Joanna Lui Giora Weisz Issam Moussa George D.Dangas Roxana Mehran Edward M.Kreps Michael Collins Gregg W.Stone Jeffrey W.Moses Junbo Ge Martin b.Leon Department of Cardiology Zhongshan HospitalFudan UniversityShanghai 200032China Columbia University Medical Center and Cardiovascular Research Foundation New YorkUSA

objective Angiographic assessment of a left main coronary artery (LMCA) stenosis is often difficult and unreliable. Intravascular ultrasound (IVUS) assessment of absolute lumen dimensions has been shown to correlate with fractional flow reserve (FFR) and to predict clinical outcome in patients with a LMCA stenosis. Methods During 21 months period (october, 2004 to July, 2006), 153 patients (ostial lesions, n=47; Non-ostial lesion, n=106) underwent IVUS evaluation specifically to assess the severity of an angiographically inconclusive LMCA narrowing. IVUS analysis included plaque morphology; external elastic membrane (EEM), lumen, plaque cross-sectional areas (CSA), plaque burden (plaque CSA/ EEM) and remodeling index (lesion EEM CSA/reference EEM CSA). Results overall, minimum lumen area (MLA) and diameter (MLD) and plaque burden measured 8.2 mm2, 2.6 mm, and 59.3 %, respectively. An MLAbeen shown to correlate with a FFR ostial lesions and 44.5% in non-ostial lesions. In particular, ostial LMCA lesions had a larger MLA and a smaller plaque burden than non-ostial lesions (Table). Conclusions Patients referred for LMCA evaluation commonly have insignificant narrowing. Negative remodeling was prominent at the LMCA ostium. These patients deserve IVUS assessment before revascularization.

关键词： intravascular plaque remodeling stenosis burden severity lumen absolute dimensions correlate

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Intravascular ultrasound assessment of the incidence and predictors of edge dissections and intramural hematomas after drug-eluting stent implantation

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上海医学 2007年第S1期30卷 32-32页

作者： Gary S.Mintz Stéphane G.Carlier jose de Ribamar Costa jr Koichi Sano Joanna Lui Giora Weisz Issam Moussa George D.Dangas Roxana Mehran Edward M.Kreps Michael Collins Gregg W.Stone Jeffrey W.Moses GE Junbo Martin b.Leon Department of Cardiology Zhongshan HospitalFudan UniversityShanghai 200032China Columbia University Medical Center and Cardiovascular Research Foundation New York USA.

objective We used intravascular ultrasound (IVUS) to assess incidence, predictors, morphology, and angiographic findings of edge dissections and intramural hematomas after drug-eluting stent (DES) implantation. Methods We studied 887 patients with 1 045 non-in-stent restenosis lesions in 977 native arteries undergoing DES implantation with IVUS imaging, and compared the dissected stent end to the non-dissected stent end. Results Eighty-two dissections were detected; 51.2% (42/82) involved the proximal and 48.8% (40/82) the distal stent edge. When compared to the non-dissected stent end, residual plaque area [(8.0±4.3) mm2 vs (5.2±3.0) mm2, Pburden [(52±12)% vs (36±15)%, Pburden≥50% was more frequent (62% vs 17%, Posits (52.5% vs 35.6%, P=0.03) more common; and the lumen/stent area (0.86±0.16 vs 1.02±0.18, Pors of stent edge dissection were residual plaque eccentricity (oR=1.3, Pburden≥50% (oR=7.3, Pomas occurred in 34.1% (28/82) of *** predictors of intramural hematomas were plaque eccentricity (oR=1.4, P=0.005), plaque burden≥50% (oR=7.1, P=0.02), and mean lumen diameter to stent diameter ratio (oR=0.37, P=0.04).Concluslon IVUS identified edge dissections after 9.4% of DES implantations. Residual plaque eccentricity and significant plaque burden predicted coronary stent edge dissections. Dissections in less diseased reference segments with an arc of normal vessel wall (greater plaque eccentricity) more often evolved into an intramural hematoma.

关键词： stent eluting plaque implantation burden restenosis intravascular incidence lumen dissection

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