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A Transactive Energy Model for Smart Metering Systems Using Blockchain

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CSEE Journal of Power and Energy Systems 2021年第5期7卷 943-953页

作者： Juan C.Olivares-Rojas Enrique reyes-Archundia jose A.gutierrez-Gnecchi Ismael Molina-Moreno Jaime Cerda-Jacobo Arturo Mendez-Patino National Technological Institute of Mexico/Technological Institute of Morelia-Division of Graduate Studies and Research MoreliaMichoacan 58120Mexico. School of Electrical Engineering Michoacan University of San Nicolas de HidalgoMorelia 58030.Mexico

The lowering cost of electricity generation technologies by renewable means has caused the role of end-users to change from being a simple consumer to a producer of their *** new role has been called a prosumer and has contributed to modifying electricity markets,by allowing prosumers to merchandize the energy surplus to electricity companies and other *** fundamental key to any economic transaction is trust between the ***,new technologies,such as blockchain,are transforming transaction security,and allowing decentralization of the smart power *** study presents the development of a transactional model of electrical energy using the infrastructure of smart metering and blockchain systems to allow the commercialization of electrical energy by *** results show that for the Mexican electricity market,they can he good alternatives hy reducing subsidies and being more profitable than current rates.

关键词： Data visualization fault diagnosis IoT network photovoltaic system wireless remote monitoring

Software SOLEEC Applied for Parabolic Trough Solar Collector Designing

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Journal of Mechanics Engineering and Automation 2014年第7期4卷 565-574页

作者： Ernesto Enciso-Contreras Juan Gabriel Barbosa-Saldafia jose alfredo Jimenez-Bemal Claudia del Carmen gutierrez-Torres SEPI-ESIME Zacatenco-LABINTHAP lnstituto Politecnico Nacional Mexico City 07738 Mexico

The present work describes software SOLEEC （copyright 03-2012-070510302900-01 Mexico）, a numerical tool for PTC （parabolic trough collector） designing. Software SOLEEC is divided into two main parts. The first one allows solar resource assessment for a specific place on the Earth. The computation and assessment can be done for a specific day on the year, for one specific month and the monthly averages along the year. The last one gives annual charts such as： solar constant, Earth declination, insolation hours, and sunrise and sunset hours. The second part has four different execution options for PTC designing, that is, using options one and two user can get five different designs based on receiver outer diameter evaluating solar radiation data along the full year or only one solar radiation value （monthly）, on the other hand options three and four were developed to compute the thermal evaluation for an operating collector for twelve solar radiation values （annually） or a specific month computation, respectively.

关键词： Software PTC solar radiation.

Neoadjuvant Radiotherapy in Stage I Cancer of the Lower Rectum

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Journal of Cancer Therapy 2014年第6期5卷 560-564页

作者： Antonio jose Tiburcio Alves Junior Gustavo Alejandro gutierrez Espinoza Luciane Hiane Oliveira Sergio Oliva Banci Joaquim Simoes Neto Odorino Hideyoshi Kagohara jose alfredo Reis Junior jose alfredo Reis Neto Coloproctology Department Clínica Reis Neto Campinas Brazil Coloproctology Department Clinica Reis Neto Catholic University Campinas Campinas Brazil Surgery Department Catholic University of Campinas Campinas Brazil Surgery Department Clinica Reis Neto Catholic University Campinas Campinas Brazil

Introduction: The mortality rate in cancer of the lower rectum is related to the incidence of local recurrence, in the first 5 years. For stage I tumors, local excision has being increasingly used, but recent studies showed a higher incidence rate of local recurrence. Therefore, preoperative radiotherapy should be considered even for these tumors, as an attempt to prevent recurrence and provide cure. Objective: To show the effectiveness of neoadjuvant radiotherapy in stage I cancer of the lower rectum of a cohort population. Materials and Method: A cohort study in a prospective database was made with a total of 75 patients considered as stage I cancer of the lower rectum. Preoperative long course of 4500 cG radiotherapy was performed in this selected group of patients and followed up for a minimum period of five years. Results: Stage I/TI group had 27 patients. All of them presented complete response to the treatment and did not need to be submitted to surgery. Five years follow up with no recurrence. The stage I/TII group had 48 patients. After neoadjuvant radiotherapy, 8 patients had to be submitted to surgery for persistent tumor. All were submitted to full total local excision (FTLE), but anatomopathological examination showed no residual cancer. Conclusion: Preoperative long course of 4500 cG irradiation, not only reduced the local recurrence and mortality rate in lower rectal cancer, but also reduced indication for surgery in patients with stage I cancer of the lower rectum.

关键词： Rectal Cancer Cancer of the Lower Rectum Irradiation Preoperative Radiotherapy Local Recurrence Mortality Survival

Production and activity of matrix metalloproteinases during liver fibrosis progression of chronic hepatitis C patients

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World Journal of Hepatology 2021年第2期13卷 218-232页

作者： Moises Martinez-Castillo Abigail Hernandez-Barragan Ivonne Flores-Vasconcelos Marina Galicia-Moreno Dorothy Rosique-Oramas jose Luis Perez-Hernandez Fatima Higuera-De la Tijera Eduardo E Montalvo-Jave Aldo Torre-Delgadillo Paula Cordero-Perez Linda Muñoz-Espinosa David Kershenobich Gabriela gutierrez-reyes Liver Pancreas and Motility LaboratoryUnit of Experimental MedicineSchool of MedicineGeneral Hospital of MexicoUniversidad Nacional Autonoma de MexicoMexico City 06726Mexico Department of Molecular Biology and Genomics Institute of Molecular Biology in Medicine and Gene TherapyHealth Science University CenterUniversity of GuadalajaraGuadalajara 06726Mexico Department of Gastroenterology General Hospital of Mexico“Dr.Eduardo Liceaga”Mexico City 06726Mexico Department of General Surgery General Hospital of Mexico“Dr.Eduardo Liceaga”School of MedicineUniversidad Nacional Autonoma de MexicoMexico City 06726Mexico Hepatology and Liver Transplant National Institute of Medical Sciences and Nutrition“Salvador Zubirán”Mexico City 06726Mexico University Hospital“Dr.JoséEleuterio González ”Autonomous University of Nuevo LeonMonterrey 06726Mexico

BACKGROUND Matrix metalloproteinases(MMPs)participate in the degradation of extracellular matrix compounds,maintaining the homeostasis between fibrogenesis and fibrolytic processes in the ***,there are few studies on the regulation of liver MMPs in fibrosis progression in *** To assess the production activity and regulation of matrix metalloproteinases in liver fibrosis stages in chronic hepatitis C(CHC).METHODS A prospective,cross-sectional,multicenter study was *** patients were categorized in fibrosis grades through FibroTest®and/or FibroScan®.Serum MMP-2,-7,and-9 were determined by western blot and multiplex suspension array *** were validated by the Kruskal-Wallis and Mann-Whitney U *** Spearman correlation coefficient and area under the receiver operating characteristic curve were *** and gelatinase activity was determined through the Azocoll substrate and zymogram test,whereas tissue inhibitor of metalloproteinase-1 production was determined by dot blot *** Serum concentrations of the MMPs evaluated were higher in CHC patients than in healthy ***-7 distinguished early and advanced stages,with a correlation of 0.32(P<0.001),and the area under the receiver operating characteristic displayed moderate sensitivity and specificity for MMP-7 in F4(area under the receiver operating characteristic,0.705;95%confidence interval:0.605-0.805;P<0.001).Collagenolytic activity was detected at F0 and F1,whereas gelatinase activity was not detected at any fibrosis *** inhibitor of metalloproteinase-1 determination showed upregulation in F0 and F1 but downregulation in F2(P<0.001).CONCLUSION High concentrations of inactive MMPs were present in the serum of CHC patients,reflecting the impossibility to restrain liver fibrosis *** could be good diagnostic candidates and therapeutic targets for improving novel strategies to reverse liver fibrosis in CHC.

关键词： Extracellular matrix Matrix metalloproteinases Liver fibrosis Chronic hepatitis C Fibrogenesis Fibrolysis

Cerebral dopamine neurotrophic factor transfection in dopamine neurons using neurotensin-polyplex nanoparticles reverses 6-hydroxydopamine-induced nigrostriatal neurodegeneration

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Neural Regeneration Research 2022年第4期17卷 854-866页

作者： Manuel A.Fernandez-Parrilla David reyes-Corona Yazmin M.Flores-Martinez Rasajna Nadella Michael J.Bannon Lourdes Escobedo Minerva Maldonado-Berny Jaime Santoyo-Salazar Luis O.Soto-Rojas Claudia Luna-Herrera jose Ayala-Davila Juan A.Gonzalez-Barrios Gonzalo Flores Maria E.gutierrez-Castillo Armando JEspadas-Alvarez Irma A.Martínez-Dávila Porfirio Nava Daniel Martinez-Fong Departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa Institucional de Biomedicina Molecular Escuela Nacional de Medicina y HomeopatíaInstituto Politécnico NacionalCiudad de MéxicoMéxico Department of Biosciences IIIT-SrikakulamRajiv Gandhi University of Knowledge Technologies(RGUKT)Andhra PradeshIndia Department of Pharmacology Wayne State University School of MedicineDetroitMIUSA Departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de MéxicoTlalnepantla de BazEdo.de MéxicoMéxico Departamento de Fisiología Escuela Nacional de Ciencias BiológicasCiudad de MéxicoMéxico Laboratorio de Medicina Genómica Hospital Regional“1°de Octubre”ISSSTECiudad de MéxicoMéxico Laboratorio de Neuropsiquiatría Instituto de FisiologíaBenemérita Universidad Autónoma de PueblaPueblaPueblaMéxico Departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Programa de Nanociencias y nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Overexpression of neurotrophic factors in nigral dopamine neurons is a promising approach to reverse neurodegeneration of the nigrostriatal dopamine system,a hallmark in Parkinson's *** human cerebral dopamine neurotrophic factor(h CDNF)has recently emerged as a strong candidate for Parkinson's disease *** study shows that h CDNF expression in dopamine neurons using the neurotensinpolyplex nanoparticle system reverses 6-hydroxydopamine-induced morphological,biochemical,and behavioral *** independent electron microscopy techniques showed that the neurotensin-polyplex nanoparticles containing the h CDNF gene,ranging in size from 20 to 150 nm,enabled the expression of a secretable h CDNF in *** injection in the substantia nigra compacta on day 21 after the 6-hydroxydopamine lesion resulted in detectable h CDNF in dopamine neurons,whose levels remained constant throughout the study in the substantia nigra compacta and *** with the lesioned group,tyrosine hydroxylase-positive(TH^(+))nigral cell population and TH+fiber density rose in the substantia nigra compacta and striatum after h CDNF *** increase inβIII-tubulin and growth-associated protein 43 phospho-S41(GAP43 p)followed TH^(+)cell recovery,as well as dopamine and its catabolite *** reversal(80%)of drugactivated circling behavior and full recovery of spontaneous motor and non-motor behavior were ***-derived neurotrophic factor recovery in dopamine neurons that also occurred suggests its participation in the neurotrophic *** findings support the potential of nanoparticle-mediated h CDNF gene delivery to develop a disease-modifying treatment against Parkinson's *** Institutional Animal Care and Use Committee of Centro de Investigación y de Estudios Avanzados approved our experimental procedures for animal use(authorization No.162-15)on June 9,2019.

关键词： axonal growth brain-derived neurotrophic factor gene delivery nanoparticles neuritogenesis neuronal cytoskeleton neuroregeneration neurorestoration neurotrophic therapy Parkinson's disease reinnervation substantia nigra

Effect of the thin cell layer technique in the induction of somatic embryos in Pinus patula Schl. et Cham

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Journal of Forestry Research 2019年第4期30卷 1535-1539页

作者： Marco A.Ramirez-Mosqueda Lourdes G.Iglesias-Andreu Arturo A.Armas-Silva Esmeralda J.Cruz-gutierrez jose F.de la Torre-Sanchez Otto R.Leyva-Ovalle Carlos M.Galan-Paez Instituto de Biotecnologfa y Ecologfa Aplicada(INBIOTECA) Universidad Veracruzana.Av.de las Culturas Veracruzanas No.101Campus para la Culturalas Artes y el DeporteCol.Emiliano ZapataC.P.91090 XalapaVeracruzMexico Centro Nacional de Recursos Geneticos-INIFAP Boulevard de la Biodiversidad No.400 Rancho las CrucesC.P.47600 Tepatitlan de MorelosJaliscoMexico Facultad de Ciencias Bioldgicas y Agropecuarias Region Cordoba-Orizaba Universidad VeracruzanaC.P.94945 Amatlan de los ReyesVeracruzMexico

Pinus patula is a species commonly used for reforestation in ***,efficient methods for the mass production seedlings are *** particularly by somatic embryogenesis provides an option for the rapid multiplication of high-quality,genetically improved *** study induces somatic embryogenesis in this species using the thin cell layer(TCL)*** sources of explants(complete immature embryos;lTCL segments from immature embryos)were *** efficiency of TCL from longitudinal sections[lTCL]and transverse[tTCL]was *** results show using thin cell layers from immature embryos cultivated in 16 light/8 dark hours achieves induction of somatic embryos.A higher percentage of embryogenic callus was obtained when tTCL segments were used as an explant *** results produced somatic embryos from tTCL segments of an immature embryo without germinating the seed,making the process more time *** addition,this technique can be used to generate somatic embryogenesis in forest species that have low germination rates.

关键词： Pinus patula Somatic embryos Micropropagation Thin cell layer Maturation