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Pancreatic cancer,autoimmune or chronic pancreatitis,beyond tissue diagnosis:Collateral imaging and clinical characteristics may differentiate them

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World Journal of Gastrointestinal Oncology 2023年第6期15卷 925-942页

作者： Ana I Tornel-Avelar jose Antonio Velarde ruiz-Velasco Mario Pelaez-Luna Department of Gastroenterology Hospital Civil of Guadalajara“Fray Antonio Alcalde”Guadalajara 44340JaliscoMexico Research Division School of Medicine/Department of Gastroenterology Universidad Nacional Autonoma de México/National Institute of Medical Sciences and Nutrition“Salvador Zubiran”Tlalpan 14000Mexico CityMexico

Pancreatic ductal adenocarcinoma(PDAC)is one of the most lethal malignancies and is developing into the 2nd leading cause of cancer-related ***,the clinical and radiological presentation of PDAC may be mirrored by other inflammatory pancreatic masses,such as autoimmune pancreatitis(AIP)and massforming chronic pancreatitis(MFCP),making its diagnosis *** AIP and MFCP from PDAC is vital due to significant therapeutic and prognostic *** diagnostic criteria and tools allow the precise differentiation of benign from malignant masses;however,the diagnostic accuracy is *** pancreatic resections have been performed in AIP cases under initial suspicion of PDAC after a diagnostic approach failed to provide an accurate *** is not unusual that after a thorough diagnostic evaluation,the clinician is confronted with a pancreatic mass with uncertain *** those cases,a re-evaluation must be entertained,preferably by an experienced multispecialty team including radiologists,pathologists,gastroenterologists,and surgeons,looking for disease-specific clinical,imaging,and histological hallmarks or collateral evidence that could favor a specific *** aim is to describe current diagnostic limitations that hinder our ability to reach an accurate diagnosis among AIP,PDAC,and MFCP and to highlight those disease-specific clinical,radiological,serological,and histological characteristics that could support the presence of any of these three disorders when facing a pancreatic mass with uncertain diagnosis after an initial diagnostic approach has been unsuccessful.

关键词： Pancreas cancer Chronic pancreatitis Autoimmune pancreatitis Pancreas mass Endoscopic ultrasound Diagnosis

Liquid biopsy approach to pancreatic cancer

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World Journal of Gastrointestinal Oncology 2021年第10期13卷 1263-1287页

作者： Sonia Perales Carolina.torres Cristina Jimenez-Luna jose Prados Joaquina Martinez-Galan jose Manuel Sanchez-Manas Octavio Caba Department of Biochemistry and Molecular Biology I Faculty of SciencesUniversity of GranadaGranada 18071Spain Department of Biochemistry and Molecular Biology III and Immunology Faculty of SciencesUniversity of GranadaGranada 18071Spain Institute of Biopathology and Regenerative Medicine(IBIMER) Center of Biomedical Research(CIBM)University of GranadaGranada 18100Spain Department of Medical Oncology Hospital Universitario Virgen de las NievesGranada 18011Spain School for International Postgraduate Studies University of GranadaGranada 18071Spain

Pancreatic cancer(PC)continues to pose a major clinical *** has been little improvement in patient survival over the past few decades,and it is projected to become the second leading cause of cancer mortality by *** dismal 5-year survival rate of less than 10%after the diagnosis is attributable to the lack of early symptoms,the absence of specific biomarkers for an early diagnosis,and the inadequacy of available *** patients are diagnosed when the disease has already metastasized and cannot be *** interception is vital,actively intervening in the malignization process before the development of a full-blown advanced *** early diagnosis of PC has a dramatic impact on the survival of patients,and improved techniques are urgently needed to detect and evaluate this disease at an early *** is difficult to obtain tissue biopsies from the pancreas due to its anatomical position;however,liquid biopsies are readily available and can provide useful information for the diagnosis,prognosis,stratification,and follow-up of patients with PC and for the design of individually tailored *** aim of this review was to provide an update of the latest advances in knowledge on the application of carbohydrates,proteins,cell-free nucleic acids,circulating tumor cells,metabo-lome compounds,exosomes,and platelets in blood as potential biomarkers for PC,focusing on their clinical relevance and potential for improving patient outcomes.

关键词： Pancreatic cancer Biomarkers Liquid biopsy Clinical management Cancer interception Cancer monitoring

A rare sighting: left atrial appendage thrombus seen on transthoracic echocardiogram

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Journal of Geriatric Cardiology 2021年第3期18卷 238-239页

作者： jose ruiz Fadi Kandah Maedeh Ganji Robert F.Percy Srinivasan Sattiraju Department of Cardiology UF Health JacksonvilleJacksonvilleFlUnited States Department of Internal Medicine UF Health JacksonvilleJacksonvilleFlUnited States

The left atrial appendage(LAA)is the most common site of left atrial thrombus with more than 90%of thrombi formed within this structure.[1]Transesophageal echocardiography(TEE)is the gold standard imaging technique for identifying LAA thrombus,with sensitivity and specificity both of 95%–100%.[1,2]An imaging modality that is used on most cardiac patients is the transthoracic echocardiogram(TTE).While quick and noninvasive,it is not known for its ability to detect left atrial appendage *** a thrombus on TTE is a great advantage as it allows for rapid initiation of anticoagulation and avoidance of cardioversion early in atrial fibrillation *** case demonstrates the rare occurrence of a patient who was found to be in atrial fibrillation in the setting of thyrotoxicosis who was subsequently discovered to have a left atrial appendage thrombus on TTE.

关键词： thrombus atrial structure.

Biotinylated polyurethane-urea nanoparticles for targeted theranostics in human hepatocellular carcinoma

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Nano Research 2015年第5期8卷 1729-1745页

作者： Genoveva MorraI-ruiz Pedro Melgar-Lesmes Andrea Lopez-Vicente Conxita Solans Maria jose Garcia-Celma Department of Pharmacy and Pharmaceutical Technology Faculty of Pharmacy University of Barcelona Av Joan XXIII s/n 08028 Barcelona Spain Institute of Advanced Chemistry of Catalonia (IQAC) CS/C Jordi Girona 18-26 08034 Barcelona Spain Networking Research Center on Bioengineering Biomaterials and Nanomedicine CIBER-BBN Spain

Over the past years, significant efforts have been devoted to explore novel drug delivery and detection strategies for simultaneous therapy and diagnostics. The development of biotinylated polyurethane-urea nanoparticles as theranostic nanocarriers for targeted drug and plasmid delivery, for fluorescence detection of human hepatocellular carcinoma cells, is described herein. These targeted nanoparticles are specifically designed to incorporate biotin into the polymeric matrix, since many tumor types overexpress receptors for biotin as a mechanism to boost uncontrolled cell growth. The obtained nanoparticles were spherical, exhibited an average diameter ranging 110-145 nm, and showed no cytotoxicity in healthy endothelial cells. Biotinylated nanoparticles are selectively incorporated into the perinuclear and nuclear area of the human hepatocellular carcinoma cell line, HepG2, in division, but not into growing, healthy, human endothelial cells. Indeed, the simultaneous incorporation of the anticancer drugs, phenoxodiol or sunitinib, together with plasmid DNA encoding green fluorescent protein, into these nanoparticles allows a targeted pharmacological antitumor effect and furthermore, selective transfection of a reporter gene, to detect these cancer cells. The combined targeted therapy and detection strategy described here could be exploited for liver cancer therapy and diagnostics, with a moderate safety profile, and may also be a potential tool for other types of cancer.

关键词： cancer therapy DNA nanoparticles polyurethane theranostics

Fluoroquinolones for the treatment of latent Mycobacterium tuberculosis infection in liver transplantation

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World Journal of Gastroenterology 2019年第26期25卷 3291-3298页

作者： jose Tiago Silva Rafael San-Juan Mario Fernández-ruiz José María Aguado Unit of Infectious Diseases Hospital Universitario "12 de Octubre" Instituto de Investigación Hospital "12 de Octubre" (imas12) School of Medicine Universidad Complutense

Solid organ transplantation(SOT)is the best treatment option for end-stage organ *** immunosuppressive agents have reduced the incidence of graft rejection but have increased the risk of infection,particularly due to the reactivation of latent infections due to opportunistic agents such as Mycobacterium *** tuberculosis(TB)after SOT is a significant cause of morbidity and *** cases of posttransplant TB are secondary to reactivation of latent tuberculosis infection(LTBI)due to the effects of long-term immunosuppressive *** minimization strategies have been developed to diagnose LTBI and initiate treatment prior to *** with vitamin B6 supplementation is the treatment of ***,liver transplantation(LT)candidates and recipients have an increased risk of isoniazid-induced liver toxicity,leading to lower treatment completion rates than in other SOT ***(FQs)exhibit good in vitro antimycobacterial activity and a lower risk of drug-induced liver injury than *** the present review,we highlight the disease burden posed by posttransplant TB and summarize the emerging clinical evidence supporting the use of FQs for the treatment of LTBI in LT recipients and candidates.

关键词： Fluoroquinolones Mycobacterium tuberculosis Latent tuberculosis infection Liver transplantation Drug-induced liver graft injury

Coffee Leaf Rust(Hemileia vastatrix)Disease in Coffee Plants and Perspectives by the Disease Control

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Phyton-International Journal of Experimental Botany 2024年第5期93卷 923-949页

作者： Alexis Salazar-Navarro Victor ruiz-Valdiviezo jose Joya-Dávila Daniel Gonzalez-Mendoza Instituto de Ciencias Agrícolas de la Universidad Autónoma de Baja California(ICA-UABC) Nuevo LeónBaja California21705México Laboratorio de Biología Molecular del Instituto Tecnológico Nacional de Tuxtla Gutierrez(TecNM) Tuxtla GutierrezChiapas29050México Facultad de Ciencias Agronómicas Campus V.Universidad Autónoma de Chiapas(UNACH) VillafloresChiapas30470México

Coffee Leaf Rust(CLR)is caused by Hemileia vastatrix in Coffea *** is one of the most dangerous phytopathogens for coffee plantations in terms of coffee productivity and coffee cup *** this review,we resume the problem of CLR in Mexico and the pathogenesis of *** review abord plant-pathogen interactions which lead a compatible or incompatible interactions and result in CLR disease or resistance,*** review abord Coffea *** response pathways involved in *** ***,current measures to control *** proliferation and germination were aborded focused on phytosanitary actions,and biological and chemical ***,new trendlines to reduce the impact of CLR as nanoparticles and nanotechnology were analyzed.

关键词： Coffee leaf rust Coffea arabica pathogenesis nanoparticles biological control

How do we manage post-OLT redundant bile duct?

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World Journal of Gastroenterology 2013年第16期19卷 2501-2506页

作者： Victor torres Nicholas Martinez Gabriel Lee jose Almeda Glenn Gross Sandeep Patel Laura Rosenkranz Division of Gastroenterology and Nutrition Department of Medicine University of Texas Health Science Center at San Antonio Department of Pancreatic and Hepatobiliary Surgery University of Texas Health Science Center at San Antonio

AIM: To address endoscopic outcomes of post-Orthotopic liver transplantation (OLT) patients diagnosed with a "redundant bile duct" (RBD). METHODS: Medical records of patients who underwent OLT at the Liver Transplant Center, University Texas Health Science Center at San Antonio Texas were retrospectively analyzed. Patients with suspected biliary tract complications (BTC) underwent endoscopic retrograde cholangiopancreatography (ERCP). All ERCP were performed by experienced biliary endoscopist. RBD was defined as a looped, sigmoid-shaped bile duct on cholangiogram with associated cholestatic liver biomarkers. Patients with biliary T-tube placement, biliary anastomotic strictures, bile leaks, bile-duct stonessludge and suspected sphincter of oddi dysfunction were excluded. Therapy included single or multiple biliary stents with or without sphincterotomy. The incidence of RBD, the number of ERCP corrective sessions, and the type of endoscopic interventions were recorded. Successful response to endoscopic therapy was defined as resolution of RBD with normalization of associated cholestasis. Laboratory data and pertinent radiographic imaging noted included the pre-ERCP period and a follow up period of 6-12 mo after the last ERCP intervention. RESULTS: One thousand two hundred and eighty-two patient records who received OLT from 1992 through 2011 were reviewed. Two hundred and twenty-four patients underwent ERCP for suspected BTC. RBD was reported in each of the initial cholangiograms. Twentyone out of 1282 (1.6%) were identified as having RBD. There were 12 men and 9 women, average age of 59.6 years. Primary indication for ERCP was cholestatic pattern of liver associated biomarkers. Nineteen out of 21 patients underwent endoscopic therapy and 2/21 required immediate surgical intervention. In the endoscopically managed group: 65 ERCP procedures were performed with an average of 3.4 per patient and 1.1 stent per session. Fifteen out of 19 (78.9%) patients were successfully

关键词： Redundant bile duct Orthotopic liver transplantation Biliary complications Biliary stent Endoscopic retrograde cholangiopancreatography

Impact of the adherence to medical treatment on the main urinary metabolic disorders in patients with kidney stones

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Asian Journal of Urology 2021年第3期8卷 275-279页

作者： Braulio Omar Manzo jose David Cabrera Esteban Emiliani Hector Manuel Sanchez Brian Howard Eisner jose Ernesto torres Urology Department Hospital Regional de Alta Especialidad del BajioBlvd.Milenio#130Col.San Carlos la RonchaLeonGuanajuatoMexico Urology Department Fundacion PuigvertUniversidad Autonoma de BarcelonaBarcelonaSpain Urology Department Massachusetts General HospitalHarvard Medical SchoolBostonUSA

Objective:To assess the effect of the adherence to medical treatment on urinary parameters in the 24-h metabolic study of patients with kidney ***:A retrospective,longitudinal,descriptive,and observational study was carried out by reviewing the hospital electronic medical record from 2014 to *** adherence to drug treatment was measured 6 months after its initiation,and the numerical values of the metabolic studies were *** tests were performed to compare the difference before and after ***:Ninety patients were evaluated,with 73.3% of *** 180-day overall adherence rate was 61.2% in patients treated with a single drug and 85.4% in patients treated with multiple *** is a statistically significant increase in citrate levels in patients with good adherence in comparison with non-adherent patients(p=0.031 vs.p=0.528).Conclusions:Medical treatment and dietary measures in patients with kidney stones have an initial impact at 6 months on the values of the main urinary metabolic alterations that predispose to calculi formation;the most significant is seen in those patients with adherence to medical treatment for hypocitraturia.

关键词： Kidney stones Renal stones Metabolic disorders Medical treatment Citrate Oxalate Lithiasis

Assessment of agri-spillways as a soil erosion protection measure in Mediterranean sloping vineyards

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Journal of Mountain Science 2017年第6期14卷 1009-1022页

作者： Jesus RODRIGO-COMINO Stefan WIRTZ Eric C. BREVIK jose D.ruiz-SINOGA Johannes B.BIES Instituto de Geomorfologfa y Suelos Department of Geography University of Malaga 29071 Malaga Spain Physical Geography Trier University 542-85 Trier Germany Department of Natural Sciences 291 Campus Drive Dickinson State University Dickinson ND 58601 USA

Suitable vineyard soils enhance soil stability and biodiversity which in turn protects roots against erosion and nutrient losses. There is a lack of information related to inexpensive and suitable methods and tools to protect the soil in Mediterranean sloping vineyards(>25° of slope inclination). In the vineyards of the Montes de Málaga(southern Spain), a sustainable land management practice that controls soil erosion is actually achieved by tilling rills in the down-slope direction to canalize water and sediments. Because of their design and use, we call them agri-spillways. In this research, we assessed two agri-spillways(between 10 m and 15 m length, and slopes between 25.8° and 35°) by performing runoff experiments under extreme conditions(a motor driven pump that discharged water flows up to 1.33 l s^(-1) for 12 to 15 minutes: ≈1000 l). The final results showed: i) a great capacity by these rills to canalize large amounts of water and sediments; and, ii) higher water flow speeds(between 0.16 m s-1 and 0.28 m s^(-1)) and sediment concentrationrates(up to 1538.6 g l^(-1)) than typically found in other Mediterranean areas and land uses(such as badlands, rangelands or extensive crops of olives and almonds). The speed of water flow and the sediment concentration were much higher in the shorter and steeper rill. We concluded that agri-spillways, given correct planning and maintenance, can be a potential solution as an inexpensive method to protect the soil in sloping Mediterranean vineyards.

关键词： Agri-spillway Vineyards Runoff experiment Soil erosion Water discharge