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Effects of obstructive sleep apnea and its treatment over the erectile function： a systematic review

Asian Journal of Andrology 2017年第3期19卷 303-310页

作者： Felix Campos-Juanatey Marcos Fernandez-Barriales Monica Gonzalez jose a portillo-martin Urology Department Marques de Valdecilla University Hospital Santander 39008 Spain Institute of Investigation Marques de Valdecilla Santander 39011 Spain Oral and Maxillofacial Surgery Department Araba University Hospital Araba 01004 Spain Sleep and Ventilation Unit Marques de Valdecilla University Hospital Santander 39008 Spain Medical and Surgical Sciences Department School of Medicine University of Cantabria Santander 39011 Spain.

Erectile dysfunction （ED） is considered a condition with a broad range of etiologies. Obstructive sleep apnea （OSA） syndrome is one of the lesser studied risk factors for ED. We intend to summarize the current evidence on the relationship between OSA and sexual impairment, focusing on the results in terms of erectile function of the different therapies offered to OSA patients. A systematic review was conducted, selecting articles related to the physiology of OSA and ED, and to the treatments of OSA syndrome and their reported outcomes in erectile and sexual function. Higher prevalences of ED in the OSA groups have been published. However, whether this effect on the erectile function occurs in the entire range of OSA severities remains unclear. Several hypotheses were proposed to explain the physiology of this association. Continuous Positive Airway Pressure as a treatment for OSA patients with ED has achieved a significative improvement in the sexual parameters in most of the studies. Phosphodiesterase type 5 inhibitors （iPDE5） on demand are useful as a treatment for ED in this subgroup of patients, with high satisfaction rates. The surgical treatment for the OSA evidenced benefits over the erectile function, and the effect on the sexual satisfaction of the therapy using Mandibular Advancement Devices is still undefined.

关键词： continuous positive airway pressure erectile dysfunction obstructive sleep apnea operative surgical procedures phosphodiesterase type 5 inhibitors

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A Sufficient Degree Condition for a Graph to Contain All Trees of Size k

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Acta Mathematica Sinica,English Series 2011年第1期27卷 135-140页

作者： Camino BALBUENA Alberto MARQUEZ jose Ramon portillo Departament de Matemhtica Aplicada III Universitat Politecnica de Catalunya C/ Jordi Girona 1-3 (Edifici C2 Despatx 302) 08034 Barcelona Spain Departamento de Matemdtica Aplicada I Universidad de SeviUaE.T.S. de Informdtica Avda. Reina Mercedes s//n 41012 SeviUa Spain

The Erdos-Sos conjecture says that a graph G on n vertices and number of edges e（G）〉 n（k - 1）/2 contains all trees of size k. In this paper we prove a sufficient condition for a graph to contain every tree of size k formulated in terms of the minimum edge degree ξ（G） of a graph G defined as {（G） = min{d（u）＋ d（v） - 2 ： uv ∈ E（G）}. More precisely, we show that a connected graph G with maximum degree △（G） ≥ k and minimum edge degree {（G）〉 2k - 4 contains every tree of k edges if dG（x）＋ dG（y） ≥ 2k - 4 for all pairs x, y of nonadjacent neighbors of a vertex u of dG（u） ≥ k.

关键词： Erdos-Sos conjecture

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Predator-prey distance and latency to flee from an immobile predator： functional relationship and importance

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Current Zoology 2016年第2期62卷 117-122页

作者： William E. COOPER JR jose martin Department of Biology Indiana University Purdue University Fort Wayne Fort Wayne IN 46805 USA Departamento de Ecologia Evolutiva Museo Nacional de Ciencias Naturales CSIC Madrid Spain

When an immobile prey has detected an immobile predator nearby, predation risk is greater when the predator is closer. Consequently, prey flee with shorter latency as standing distance （predator-prey distance when both are still） decreases. Since it was first reported in 2009, this relationship has been confirmed in the few species studied. However, little is known about the functional relationship between standing distance and latency to flee （LF）. We hypothesized that LF increases as standing distance increases at short distances, but reaches a plateau at longer distances where prey can escape reliably if attacked. We simulated immobile predators by moving slowly into positions near striped plateau lizards Sceloporus virgatus, stopping and then remaining immobile, and recording LF from the stopping time. LF increased from shorter to longer standing distances in a decelerating manner. The relationship was concave downward, and LF was indistinguishable among the longer standing distance groups. Latency to flee appears to reach a plateau or approach an asymptotic value as stand- ing distance increases. The effect size of standing distance was large, indicating that S. virgatus sensi- tively adjusts LF to the level of risk associated with standing distance. Relationships between risk assessment and theoretical zones associated with risk, its assessment by prey, and escape decisions are discussed. Effect sizes of standing distance were substantial to large in all studies to date, indicating that standing distance is an important predation risk factor when both predator and prey are immobile.

关键词： antipredatory behavior escape behavior latency to flee squamata standing distance.

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Are ATXN2 variants modifying our understanding about neural pathogenesis,phenotypes,and diagnostic?

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Neural Regeneration Research 2022年第11期17卷 2445-2447页

作者： jose Miguel Laffita-Mesa martin Paucar Per Svenningsson Department of Clinical Neuroscience(CNS) Karolinska Universitetssjukhuset

ATXN2 one gene with multiple phenotype effects:ATXN2 gene encodes a cytosolic protein(ataxin-2)with pleiotropic functions(see below).This gene contains a number of exonic Cytosine-Adenine-Guanine(CAG)-repeats which encodes a polyglutamine tract(polyQ)in the N-terminal intrinsically disordered region(IDR)of the ***2CAG repeats are interrupted by CAA codons which is relevant only for DNA and RNA but not for protein since CAA also encodes glutamine(Q).

关键词： pathogenesis neural interrupted

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A New Phasor Estimator for PMU Applications:P Class and M Class

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Journal of Modern Power Systems and Clean Energy 2020年第1期8卷 55-66页

作者： jose R.Razo-Hernandez Arturo Mejia-Barron David Granados-Lieberman martin Valtierra-Rodriguez jose F.Gomez-Aguilar ENAP-Research Group Facultad de IngenieríaUniversidad Autónoma de Querétaro(UAQ)San CayetanoC.P.76807México ENAP-Research Group Departamento de Ingeniería ElectromecánicaInstituto Tecnológico Superior de Irapuato(ITESI)Colonia El CopalC.P.36821México CONACyT-Centro Nacional de Investigación y Desarrollo Tecnológico(CENIDET) Tecnológico Nacional de MéxicoInterior Internado Palmira S/NCol.PalmiraC.P.62490México

Phasor measurement units(PMUs)are fundamental tools in the applications of modern power systems,where synchronized phasor estimations are *** accuracy and dynamic performance requirements for phasor,frequency,and rate of change of frequency(ROCOF)estimations are established in the IEEE Std.C37.118.1-2011 along with the IEEE Std.C37.118.1 a-2014,where two PMU performances are suggested:P class filters for applications requiring fast response and M class filters for applications requiring high rejection to aliased *** this paper,a methodology to design new phasor estimators that satisfy the P class and M class requirements in PMUs is *** proposed methodology is based on finite impulse response filters,brick-wall filters,and complex filter design concepts,where frequency range,time performance,harmonic rejection and out-of-band interference requirements are considered in its design.A comparative analysis using the reference model given by the IEEE Std.C37.118.1 is *** results show the effectiveness of the phasor estimators under steady-state and dynamic conditions according to the PMU standard,making them suitable tools for applications in power systems.

关键词： Brick-wall filter complex filter IEEE Std.C37.118.1 M class P class phasor measurement unit(PMU) phasor estimator

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On the Structure of Graded Leibniz Algebras

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Algebra Colloquium 2015年第1期22卷 83-96页

作者： Antonio J. Calderon martin jose M. Sfinchez Delgado Departamento de Matemdticas Universidad de Cadiz 11510 Puerto Real Cadiz Spain

We study the structure of graded Leibniz algebras with arbitrary dimension and over an arbitrary base field K. We show that any of such algebras ￡ with a symmetric G-support is of the form ￡ = U-∑jIj with U a subspace of ￡1, the homogeneous component associated to the unit element 1 in G, and any Ij a well described graded ideal of ￡, satisfying [Ij, Ik]= 0 if j≠ k. In the case of ￡ being of maximal length, we characterize the gr-simplicity of the algebra in terms of connections in the support of the grading.

关键词： graded Leibniz algebra infinite dimensional Leibniz algebra structure theory

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Phenotyping and other breeding approaches for a New Green Revolution

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Journal of Integrative Plant Biology 2014年第5期56卷 422-424页

作者： jose Luis Araus Jiansheng Li martin A.J.Parry Jiankang Wang University of Barcelona Barcelona National Maize Improvement Center Chinese Agricultural University Rothamsted Research Harpenden Herts Institute of Crop Science The Chinese Academy of Agricultural Sciences Beijing

Food security is a global concern in view of the ongoing global （social and climate） change. The challenges to food securityfrom global change, sharply increasing food and feed demands, whereas increasing the frequency and severity of stresses,coupled with degradation and scarcity of natural resources, are indeed urgent and real （Prasanna et al. 2013）. Crop productionmust double by 2050 to meet future production demands （Tilman et al. 2011）. The ability to achieve this increaserepresents a significant challenge to plant breeders. Crop yields must increase at a rate of 2.47o per year, yet the averagerate of increase is only 1.3% with yields stagnating in up to 40% of land under cereal production （Ray et al. 2012, 2013）. Therefore,crops with higher yield potential and more resistant to abiotic stress conditions are needed to address such challenges.

关键词： PLANT breeding PHENOTYPE GREEN Revolution FOOD security CEREAL products

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New Technologies,Tools and Approaches for Improving Crop Breeding

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Journal of Integrative Plant Biology 2012年第4期54卷 210-214页

作者： Parry, martin A. J. Wang, Jiankang Luis Araus, jose Rothamsted Res Harpenden Herts England Chinese Acad Agr Sci Beijing 100193 Peoples R China Univ Barcelona Barcelona Spain

Most crops were first domesticated about 13 000 to 11 000 years ago. Humans are dependent on crops for survival, and from the beginnings of agriculture have been energetically involved in developing crops that better serve their needs （Allard 1999）. During the last decades breeding has contributed approximately a 50% contribution to increasing the world＇s food crop production. However, plant breeding only began to adopt a scientific approach in the 1900s, when Mendel＇s hybridization experiment was rediscovered. Mendelian genetics and the development of the statistical concepts of randomJzatJon and replication had considerable impact on plant breeding methods （Hallauer et al. 1988）. In spite of the fact that scientific crop breeding has only existed for one century, it is a discipline that is developing very quickly. The major objective of crop breeding programs is to develop new genotypes that are genetically superior to those currently available for specific environments. To achieve this objective, breeders employ a range of selection methods and technologies （Hallauer et al. 1988; Falconer and Mackay 1996; Allard 1999）.

关键词： PLANT breeding PLANT breeders CLIMATIC changes FOOD security EFFECT of drought on plants PLANT genetics NUCLEOTIDE sequence

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Predicting the clothing insulation through machine learning algorithms:A comparative analysis and a practical approach

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Building Simulation 2024年第5期17卷 839-855页

作者： Pablo Aparicio-Ruiz Elena Barbadilla-martin jose Guadix Jesus Munuzuri Grupo de Ingenieria de Organizacion Escuela Tecnica Superior de IngenieriaUniversidad de SevillaCamino de los Descubrimientos S/N41092SevilleSpain

Since indoor clothing insulation is a key element in thermal comfort models,the aim of the present study is proposing an approach for predicting it,which could assist the occupants of a building in terms of recommendations regarding their *** that,a systematic analysis of input variables is exposed,and 13 regression and 12 classification machine learning algorithms were developed and *** results are based on data from 3352 questionnaires and 21 input variables from a field study in mixed-mode office buildings in *** temperature at 6 a.m.,indoor air temperature,indoor relative humidity,comfort temperature and gender were the most relevant features for predicting clothing *** comparing machine learning algorithms,decision tree-based algorithms with Boosting techniques achieved the best *** proposed model provides an efficient method for forecasting the clothing insulation level and its application would entail optimising thermal comfort and energy efficiency.

关键词： clothing insulation simulation adaptive thermal comfort behavioural adaptive actions machine learning

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Neurological manifestations with jugular vein thrombosis linked to an inflammatory profile may be a sequela of long COVID

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Neuroprotection 2023年第2期1卷 170-175页

作者： Elizabeth Mendoza-portillo Estefania Aleman-Navarro G.Aleph Prieto Yvonne Rosenstein jose J.Lozano-Nuevo Araceli Perez-Lopez Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suarez Ciudad de MéxicoMéxico Instituto de Biotecnología Universidad Nacional Autónoma de México(UNAM)CuernavacaMorelosMéxico Instituto de Neurobiología UNAM-JuriquillaQuerétaroMéxico Institute for Memory Impairments and Neurological Disorders University of California-IrvineIrvineCaliforniaUSA Hospital General de Ticomán Secretaría de Salud de la Ciudad de MéxicoCiudad de MéxicoMéxico Unidad de Investigación en Biomedicina Facultad de Estudios Superiores IztacalaUNAMTlalneplantlaEstado de MéxicoMéxico

More than 670 million cases of coronavirus disease 2019(COVID-19)have been recorded worldwide in the 3 years since the start of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** 45%of survivors of COVID-19 develop a syndrome known as long-term COVID,in which symptoms persist even months after the acute *** 76%of patients with long COVID experience neurological ***,patients who have survived COVID-19 have an increased risk of cerebral venous *** case report describes a 41-year-old woman who developed neurological manifestations associated with jugular vein thrombosis 24 h after administration of the Oxford–AstraZeneca(ChAdOx1 nCoV-19)vaccine(AstraZeneca-Serum Institute of India).She had been infected with SARS-CoV-2 three months before *** initially suspected to be a case of vaccine-induced immune thrombotic thrombocytopenia(VITT)in view of her recent vaccination,the patient did not have any hallmarks of VITT,such as thrombocytopenia,an increased D-dimer level,or antibodies against platelet ***,the neurological manifestations were associated with a high concentration of inflammatory cytokines,including interleukin(IL)-6,IL-17A,and IL-21,and elevated neutrophil levels in cerebrospinal fluid,suggesting that inflammatory immune components had a role in the development of thrombotic events and pointing to an alternative *** this case,the laboratory results indicated that the neurological manifestations associated with jugular vein thrombosis were not associated with ***,we propose that the thrombosis of the left jugular vein was a sequela of SARS-CoV-2 infection.

关键词： cerebral venous thrombosis long COVID vaccine

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