检索结果-南通市图书馆

Microphysiological systems for solid tumor immunotherapy:opportunities and challenges

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Microsystems & nanoengineering 2023年第6期9卷 77-106页

作者： Sara Abizanda-Campo María Virumbrales-Muñoz Mouhita Humayun Ines Marmol David J.Beebe Ignacio Ochoa Sara Oliván jose M.Ayuso Department of Dermatology University of Wisconsin-MadisonMadisonWIUSA University of Wisconsin Carbone Cancer Center MadisonWIUSA Department of Biomedical Engineering University of WisconsinMadisonWIUSA Tissue Microenvironment Lab(TME lab) Aragón Institute of Engineering Research(I3A)University of ZaragozaZaragozaSpain Instituto de Investigación Sanitaria Aragón(IISA) ZaragozaSpain Centro Investigación Biomédica en Red.Bioingeniería Biomateriales y Nanomedicina(CIBER-BBN)ZaragozaSpain Department of Obstetrics and Gynecology University of Wisconsin-MadisonMadisonWIUSA Department of Biological Engineering Massachusetts Institute of Technology CambridgeCambridgeMAUSA Department of Pathology&Laboratory Medicine University of WisconsinMadisonWIUSA

Immunotherapy remains more effective for hematologic tumors than for solid *** of the main challenges to immunotherapy of solid tumors is the immunosuppressive microenvironment these tumors generate,which limits the cytotoxic capabilities of immune effector cells(e.g.,cytotoxic T and natural killer cells).This microenvironment is characterized by hypoxia,nutrient starvation,accumulated waste products,and acidic ***-hijacked cells,such as fibroblasts,macrophages,and T regulatory cells,also contribute to this inhospitable microenvironment for immune cells by secreting immunosuppressive cytokines that suppress the antitumor immune response and lead to immune ***,there is a strong interest in developing new drugs and cell formulations that modulate the tumor microenvironment and reduce tumor cell immune *** systems(MPSs)are versatile tools that may accelerate the development and evaluation of these therapies,although specific examples showcasing the potential of MPSs remain *** in microtechnologies have led to the development of sophisticated microfluidic devices used to recapitulate tumor *** resulting models,also known as microphysiological systems(MPSs),are versatile tools with which to decipher the molecular mechanisms driving immune cell antitumor cytotoxicity,immune cell exhaustion,and immune cell exclusion and to evaluate new targeted ***,we review existing microphysiological platforms to study immuno-oncological applications and discuss challenges and opportunities in the field.

关键词： immunotherapy versatile solid

Implicit Continuous User Authentication for Mobile Devices based on Deep Reinforcement Learning

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computer Systems Science & Engineering 2023年第2期44卷 1357-1372页

作者： Christy James jose M.S.Rajasree Government Engineering College Idukki685603India APJ Abdul Kalam Technological University Thiruvananthapuram695016India

The predominant method for smart phone accessing is conﬁned to methods directing the authentication by means of Point-of-Entry that heavily depend on physiological biometrics like,ﬁngerprint or *** continuous authentication initiating to be loftier to conventional authentication mechanisms by continuously conﬁrming users’identities on continuing basis and mark the instant at which an illegitimate hacker grasps dominance of the ***,divergent issues remain *** research aims to investigate the power of Deep Reinforcement Learning technique to implicit continuous authentication for mobile devices using a method called,Gaussian Weighted Cauchy Kriging-based Continuous Czekanowski’s(GWCK-CC).First,a Gaussian Weighted non-local Mean Filter Preprocessing model is applied for reducing the noise pre-sent in the raw input face *** Kriging Regression function is employed to reduce the ***,Continuous Czekanowski’s Clas-siﬁcation is utilized for proﬁcient classiﬁcation between the genuine user and *** this way,the proposed GWCK-CC method achieves accurate authen-tication with minimum error rate and *** assessment of the pro-posed GWCK-CC method and existing methods are carried out with different factors by using UMDAA-02 Face *** results conﬁrm that the proposed GWCK-CC method enhances authentication accuracy,by 9%,reduces the authen-tication time,and error rate by 44%,and 43%as compared to the existing methods.

关键词： Deep reinforcement learning gaussian weighted non-local meanﬁlter cauchy kriging regression continuous czekanowski’s implicit continuous authentication mobile devices

Contributions to data transmission at critical moments on unmanned aerial vehicles

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2023年第8期36卷 247-257页

作者： jose Enrique RODRIGUEZ David SEGURADO Manuel SAnCHEZ jose Javier MARTInEZ Rafael GOnZALEZ national Institute of Aerospace Technology Madrid 28850Spain Department of Computer Science University of AlcalaAlcala de HenaresMadrid 28054Spain

As for unmanned aircraft, the knowledge of the aircraft performance is directly related with the navigation, guidance, and control system programming. Therefore, the measured data in each phase of the flight must be sufficiently precise to obtain a good characterization of *** article proposes new methods of sending information to ground, which make it possible to know the aircraft behavior accurately, and for this purpose, four contributions have been made for ALO(Avión Ligero de Observación, Spanish acronym for Light Observation Aircraft). Currently, the characterization is based on data obtained at ten samples per second, insufficient to acquire detailed knowledge of what happened during the whole flight of an aircraft. As a result of these contributions, many more samples per second of accelerations and angular velocities are obtained at the most critical moments of the flight, such as takeoff or landing. Among the improvements included are data compression techniques, providing references to locate the measured data in time and identifying labels of each parameter.

关键词： Critical moments Data transmission Datacompression tech-niques Radio-modem Recommended Standard 232(RS-232) Unmannedaerial vehicle

Intelligent Classification Model for Biomedical Pap Smear Images on IoT Environment

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2022年第5期71卷 3969-3983页

作者： CSS Anupama T.J.Benedict jose Heba FEid nojood O Aljehane Fahd n.Al-Wesabi Marwa Obayya Anwer Mustafa Hilal Department Electronics and Instrumentation Engineering V.R.Siddhartha Engineering CollegeVijayawada520007India Department of Computer Applications Government Arts&Science CollegeKanyakumari629401India Faculty of Science AL-Azhar UniversityCairo11651Egypt Faculty of Computers and Information Technology University of Tabuk47512Saudi Arabia Department of Computer Science College of Science&Art at MahayilKing Khalid University62529Saudi Arabia&Faculty of Computer and ITSana’a University31220Yemen Department of Biomedical Engineering College of EngineeringPrincess Nourah bint Abdulrahman University11564Saudi Arabia Department of Computer and Self Development Preparatory Year DeanshipPrince Sattam bin Abdulaziz UniversityAlkharj16278Saudi Arabia

Biomedical images are used for capturing the images for diagnosis process and to examine the present condition of organs or *** image processing concepts are identical to biomedical signal processing,which includes the investigation,improvement,and exhibition of images gathered using x-ray,ultrasound,MRI,*** the same time,cervical cancer becomes a major reason for increased women’s mortality *** cervical cancer is an identified at an earlier stage using regular pap smear *** this aspect,this paper devises a new biomedical pap smear image classification using cascaded deep forest(BPSIC-CDF)model on Internet of Things(IoT)*** BPSIC-CDF technique enables the IoT devices for pap smear image *** addition,the pre-processing of pap smear images takes place using adaptive weighted mean filtering(AWMF)***,sailfish optimizer with Tsallis entropy(SFO-TE)approach has been implemented for the segmentation of pap smear ***,a deep learning based Residual network(Resnet50)method was executed as a feature extractor and CDF as a classifier to determine the class labels of the input pap smear *** order to showcase the improved diagnostic outcome of the BPSICCDF technique,a comprehensive set of simulations take place on Herlev *** experimental results highlighted the betterment of the BPSICCDF technique over the recent state of art techniques interms of different performance measures.

关键词： Biomedical imaging pap smear images internet of things deep learning cervical cancer disease diagnosis

Home range variability and philopatry in Cinereous vultures(Aegypius monachus)breeding in Iberia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Avian Research 2023年第4期14卷 586-592页

作者： Jorge García-Mací Ernesto Alvarez Manuel Galan Juan jose Iglesias-Lebrija Marc Galvez Gerard Plana núria Vallverdú Vicente Urios Grupo de Investigacion Zoología de Vertebrados Universidad de AlicanteApdo.99E-03080AlicanteSpain GREFA(Grupo de Rehabilitacion de la Fauna Autoctonay su Habitat) C/Monte del Pilar S/NE-28220MajadahondaSpain Cos d’Agents Rurals de la Generalitat de Catalunya Spain Associacio Trenca LleidaSpain

Large scavengers are strongly dependent on environmental conditions and carrion distribution and abundance,so season and breeding-related factors may influence the spatial ecology of species such as the Cinereous Vulture(Aegypius monachus),the largest European *** holds one of the biggest populations worldwide,but some aspects of the spatial ecology of the species in this region remain *** this study,17 adult Cinereous Vultures were GPS-tracked in order to study their spatial ecology during the adult *** average monthly home ranges(95%Kernel Density Estimation,KDE)and core areas(50%KDE)were 6543±19,935 km^(2)and 1174±4004 km^(2),*** average monthly home range fidelity ranged between 50 and 73%.Differences in movement-related variables between the seasonal periods(incubation,chick-rearing and non-breeding)were *** the chick-rearing period,the monthly accumulated distance was higher than during the other periods:3316±1108(chick-rearing)vs.1621±622(incubation)vs.1726±1159 km per month(nonbreeding).Additionally,large home range sizes were more frequent during the chick-rearing *** are two likely causes for these seasonal ***,chick-rearing entails a higher energetic expenditure by the parental individuals in foraging activities,so larger movements and foraging areas are expected during this ***,the flight is favoured during spring and summer due to environmental *** chick-rearing and warm months is a great evolutionary advantage for soaring-gliding raptors,as it allows them to cover larger areas with low energy ***,six individuals tagged as nestlings highlight the philopatric behaviour of the species:vultures settle their breeding areas 54±51 km from their natal nest(range=9–138 km).

关键词： Bird of prey Movement ecology Philopatry Raptor Scavenger

Soil properties characterization for land-use planning and soil management in watersheds under family farming

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

International Soil and Water Conservation Research 2022年第1期10卷 119-128页

作者： jose Miguel Reichert Paulo Ivonir Gubiani Danilo Rheinheimer dos Santos Dalvan jose Reinert Celso Aita Sandro jose Giacomini Soils Department Universidade Federal de Santa Maria(UFSM)Santa MariaRSBrazil

Environmental monitoring of small,rural watersheds was one of the components of the natural Re-sources Management and Rural Poverty Alleviation Program(RS-Rural)in southern *** purpose of the monitoring was to assess the impact of promoting soil conservation and environment manage-ment practices adopted by farmers and funded by the *** four small monitored watersheds,in a total of 95 plots representing distinct land use and soil management,surface soil was collected to characterize ground-zero of the Program by determining several soil physical,chemical and microbio-logical *** component analysis(PCA)shows soil physical,chemical and biological properties were decisive in defining the agricultural soils in the rural watersheds with family *** sensitivity to chemical properties provides an opportunity to improve soil quality if soil management focuses on altering those *** management practiced by tobacco farmers leads to rapid,intense degradation of some natural soil properties,especially those related to the dynamics of soil organic matter,compared with more conservationist uses(forest,regrowth,and grassland).Thus,soil management must be reoriented to avoid the progress of degradation and recover soil physical and biological *** crops and by land-abandonment to allow natural vegetation are important management strategies for the degraded soils used for tobacco production,increasing soil organic matter,nutrients and microbial activity and thus allowing further crop *** conclusion,wa-tersheds with tobacco cropping have soils with lower quality than when under no-tillage grain pro-duction,requiring changes in land use and soil management.

关键词： natural resources management Environmental monitoring Soil conservation Soil quality Alleviating poverty

Rheological and tribological approaches as a tool for the development of sustainable lubricating greases based on nano-montmorillonite and castor oil

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Friction 2021年第2期9卷 415-428页

作者： jose Enrique MARTÍn-ALFOnSO María jose MARTÍn-ALFOnSO Concepción VALEnCIA María Teresa CUBERES Department of Chemical Engineering and Materials Science Campus de“El Carmen”University of HuelvaChemical Product and Process Technology Research Center(Pro2TecS)Huelva 21071Spain Department of Applied Mechanics and Project Engineering University of Castilla-La ManchaAlmadén 13400Spain

This study investigates the development of novel montmorillonite/castor oil blends to formulate sustainable lubricating greases to promote the replacement of petrochemicals industry-derived materials by substances obtained from renewable ***,the effect of the thickener concentration on the rheological,chemical,thermal,tribological properties,and atomic force microscopy(AFM)microstructure of these systems were *** results showed that the C20A nanoclay content could be used to modulate the viscosity values,the linear viscoelastic functions,and tribological properties of these montmorillonite *** general,these gel-like dispersions exhibited remarkable lubricant properties;the samples showed values of the friction coefficient and wear scars similar or lower than those obtained with model bentonite grease.

关键词： lubricating greases nanoclay vegetable oil rheology tribology

FeedEfficiencyService: An architecture for the comparison of data from multiple studies related to dairy cattle feed efficiency indices

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Information Processing in Agriculture 2022年第3期9卷 378-396页

作者： Heitor Magaldi Linhares Regina Braga Wagner Antonio Arbex Mariana Magalhaes Campos Fernanda Campos jose Maria n.David Victor Stroele Programa de Pos-Graduacao em Ciencia da Computacao Universidade Federal de Juiz de ForaCampus UniversitarioRua JoseLourenco Kelmers/n-Sao PedroJuiz de ForaMinas Gerais 36036-900Brasil Brazilian Agricultural Research Corporation-Embrapa Av.Eugenio do Nascimento610-AeroportoJuiz de Fora-MGMinas Gerais 36038-330Brasil

The increased demand for food worldwide,the reduced land availability for livestock pro-duction,the increasing cost of animal feed and the need for mitigating livestock-related greenhouse gas emissions have driven the search for animal feeding systems that proves more *** tackle this problem,we propose the use of computational support to help researchers compare data on feed efficiency,therefore improving economic and environ-mental *** a solution,we present an integrative architecture capable of combining heterogeneous data from multiple experiments related to dairy cattle feed efficiency *** proposed architecture,called FeedEfficiencyService,classifies animals according to feed efficiency indices and allows visualizations through ontologies and inference *** results obtained from a case study with researchers from the Brazilian Agri-cultural Research Corporation–Dairy Cattle(EMBRAPA)demonstrate that this architecture is a supporting tool in their daily work *** researchers highlighted the importance of the proposed architecture as it allows analyzing animal data,comparing experiments,having reliable data analyses,and standardizing and organizing data from *** novelty of our approach is the use of ontologies and inference engines to enable the discovery of new knowledge and new relationships between data from feed efficiency-related *** store such data,relationships,and analyses of results in an inte-grated *** solution ensures unified access to the processing history and data from diverse experiments,including those conducted at external research centers.

关键词： Dairy Cattle

Pyrenetetraone-based covalent organic framework as an effective electrocatalyst for oxygen reduction reaction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

nano Research 2022年第5期15卷 3907-3912页

作者： Paloma Garcia-Arroyo Emiliano Martinez-Perinan Jorge J.Cabrera-Trujillo Elena Salagre Enrique G.Michel jose I.Martinez Encarnacion Lorenzo jose L.Segura Departamento de Quimica Organica I Facultad de CC.QuimicasUniversidad Complutense de Madrid28040 MadridSpain Departamento de Quimica Analitica y Analisis Instrumental Facultad de CienciasUniversidad Autónoma de Madrid28049 MadridSpain Departamento de Fisica de la Materia Condensada Universidad Autónoma de Madrid28049 MadridSpain Condensed Matter Physics Center(IFIMAC) Universidad Autónoma de Madrid28049 MadridSpain Departamento de nanoestructuras SuperficiesRecubrimientos y Astrofisica MolecularInstituto de Ciencia de Materiales de Madrid(ICMMCSIC)28049 MadridSpain Instituto Madrileno de Estudios Avanzados en nanociencia(IMDEA-nanociencia) 28049 MadridSpain Institute for Advanced Research in Chemical Sciences(IAdChem) Universidad Autonoma de Madrid28049 MadridSpain

A novel porous and crystalline two-dimensional(2D)electrochemically active covalent organic framework(COF)based on ortho-quinone units has been prepared as an innovative approach towards the development of organic cathode materials with multiple redox sites as an efficient electrocatalyst for the oxygen reduction reaction(ORR).In contrast with most of the previously reported COFs as electrocatalysts for the ORR,the electrocatalytic application of this material towards ORR has been investigated without adding any metal or conductive supporting material and avoiding any additional carbonization ***,the electrochemical properties of the COF material have been compared with two analogue amorphous frameworks with similar chemical composition,which points out the important role of the enhanced crystallinity and porosity of the COF network in its superior performance as an electrocatalyst towards ORR.

关键词： electrocatalysis oxygen reduction reaction metal free pyrenetetraone covalent organic framework