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Electrocardiographic changes during induced therapeutic hypothermia in comatose survivors after cardiac arrest

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World Journal of Cardiology 2015年第7期7卷 423-430页

作者： Pablo Salinas Esteban Lopez-de-Sa Laura Pena-Conde Ana Viana-Tejedor Juan Ramon Rey-Blas Eduardo Armada jose Luis Lopez-Sendon Instituto Cardiovascular Hospital Clínico San Carlos Acute Cardiac Care Unit Division of CardiologyHospital Universitario La Paz

AIM: To assess the safety of therapeutic hypothermia(TH) concerning arrhythmias we analyzed serial electrocardiograms(ECG) during ***: All patients recovered from a cardiac arrest with Glasgow < 9 at admission were treated with induced mild TH to 32-34℃. TH was obtained with cool fluid infusion or a specific intravascular device. Twelvelead ECG before,during,and after TH,as well as ECG telemetry data was recorded in all patients. From a total of 54 patients admitted with cardiac arrest during the study period,47 patients had the 3 ECG and telemetry data available. ECG analysis was blinded and performed with manual caliper by two independent cardiologists from blinded copies of original ECG,recorded at 25 mm/s and 10 mm/m V. Coronary care unit staff analyzed ECG telemetry for rhythm disturbances. Variables measured in ECG were rhythm,RR,PR,QT and corrected QT(QTc by Bazett formula,measured in lead v2) intervals,QRS duration,presence of Osborn's J wave and U wave,as well as ST segment displacement and T wave amplitude in leads Ⅱ,v2 and ***: Heart rate went down an average of 19 bpm during hypothermia and increased again 16 bpm with rewarming(P < 0.0005,both). There was a nonsignificant prolongation of the PR interval during TH and a significant decrease with rewarming(P = 0.041). QRS duration significantly prolonged(P = 0.041) with TH and shortened back(P < 0.005) with rewarming. QTc interval presented a mean prolongation of 58 ms(P < 0.005) during TH and a significant shortening with rewarming of 22.2 ms(P = 0.017). Osborn or J wave was found in 21.3% of the patients. New arrhythmias occurred in 38.3% of the patients. Most frequent arrhythmia was non-sustained ventricular tachycardia(19.1%),followed by severe bradycardia or paced rhythm(10.6%),accelerated nodal rhythm(8.5%) and atrial fibrillation(6.4%). No life threatening arrhythmias(sustained ventricular tachycardia,polymorphic ventricular tachycardia or ventricular fibrillation) occurred during TH.

关键词： Cardiac arrest Therapeutic hypothermia Post-cardiac arrest síndrome Cardiac arrythmias QT interval

孕前母亲和父亲的持久性有机污染物暴露与后代出生的大小:LIFE研究

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环境与职业医学 2015年第4期32卷 357-357页

作者： Candace A.Robledo Edwina Yeung Pauline Mendola Rajeshwari Sundaram jose Maisog Anne M.Sweeney Dana Boyd Barr Germaine M.Buck Louis

[背景]持久性有机污染物（POPs）是发育毒物,但母亲和父亲均受到POPs暴露对其后代出生大小的影响尚不清楚。[目的]探讨母亲和父亲63种POPs（其中包括五大类污染物）的血清浓度与其后代出生大小测量值之间的关联。[方法]测定234对夫妇在... 详细信息

[背景]持久性有机污染物（POPs）是发育毒物,但母亲和父亲均受到POPs暴露对其后代出生大小的影响尚不清楚。[目的]探讨母亲和父亲63种POPs（其中包括五大类污染物）的血清浓度与其后代出生大小测量值之间的关联。[方法]测定234对夫妇在受孕前血清中的9种有机氯杀虫剂、1种多溴联苯（PBB）、7种全氟烷基化学物（PFCs）、10种多溴联苯醚（PBDEs）和36种多氯联苯（PCBs）的浓度。采用多元线性回归估计化学物浓度的自然对数转换（ln转换）值每增加1 SD,所导致的出生体重、身长、头围和婴儿重量指数的差异。对每一对父母单独进行模型估计,调整母亲的年龄、孕前体质指数（kg/m2）等其他混杂因素,并且所有的模型都包含婴儿性别与各种化学品的交互作用项。[结果]女童（n=117）出生体重显著较低（范围为84-195 g）与母亲血清DDT、PBDE-28、PBDE-183浓度的ln转换值增加每增加1 SD、以及父亲血清PBDE-183和PCB-167浓度的ln转换值每增加1 SD相关联。男童（n=113）出生体重较低（范围为98-170 g）与母亲（PCBs 138、153、167、170、195、209和全氟辛基磺酰）和父亲（PCB-172和PCB-195）的POPs血清浓度具有统计学意义的关联,而父亲血清中PBDE-66和PBDE-99浓度均与较高的出生体重相关联。后代头围、身长和婴儿重量指数的差异也与父母的POPs暴露相关联。

关键词： LIFE POPs 有机氯杀虫剂血清浓度多溴联苯醚婴儿性别重量指数头围多元线性回归模型估计

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Zara供应链的极速传奇

会计师 2006年第6期 66-66页

作者： Kasra Ferdows Michael A. Lewis jose A.D. Machuca

当货车的载货量只有一半时，你会让它发车并跨越整个欧洲吗？你会每周两次，把衣服挂在衣架上直接发到日本零售店吗？你会在衣服上架仅仅两周后，就把它们从柜台上撤掉吗？

关键词：供应链传奇零售店衣服货量柜台

资本项目向高度流动性的金融市场开放如何导致拉美两轮半的“疯狂、惊恐和崩溃”周期

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演化与创新经济学评论 2014年第1期 14-58页

作者：何塞·加布里埃尔·帕尔玛李黎力李双双(译) 贾根良(校) 剑桥大学经济系中国人民大学经济学院密苏里大学堪萨斯分校

拉美已经历了三轮周期的资本流入,且前两轮均以重大金融危机收场。本文旨在从凯恩斯、明斯基、金德尔伯格的金融经济学的视角来剖析由这第二轮周期(包括拉美和东亚)所导致的金融危机。我将试图表明,无论这些新近开放资本项目、实现金融... 详细信息

拉美已经历了三轮周期的资本流入,且前两轮均以重大金融危机收场。本文旨在从凯恩斯、明斯基、金德尔伯格的金融经济学的视角来剖析由这第二轮周期(包括拉美和东亚)所导致的金融危机。我将试图表明,无论这些新近开放资本项目、实现金融自由化的发展中国家试图采取何等不同的路径来解决随后资本流入激增所带来的吸收问题,它们都无法逃脱金融危机的厄运。因此,这些金融危机的频发主要是源自过度流动性且'友好监管的'金融市场所固有的内在因素,从而是完全理应遭受和基本可以预见的。并且,这些危机并非只是意味着主要市场的失灵,而是表明了系统性的市场失败。它们是友好监管且过度流动性的金融市场之下自由运作的理性经济人自发行为的后果,而历史一再表明,这些经济人从过去的错误中吸取教训的能力却相当有限。

关键词：金融危机的诱因拉美东亚金融自由化新自由主义经济改革系统性市场失灵

Eurytrematosis: An emerging and neglected disease in South Brazil

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World Journal of Experimental Medicine 2015年第3期5卷 160-163页

作者： Claiton Ismael Schwertz Neuber jose Lucca Aleksandro Schafer da Silva Piotr Baska Gustavo Bonetto Mateus Eloir Gabriel Fábio Centofanti Ricardo Evandro Mendes Department of Veterinary Pathology Instituto Federal Catarinense-Campus Concórdia Department of Animal Science Universidade do Estado de Santa Catarina Department of Preclinical Sciences Faculty of Veterinary Medicine Warsaw University of Life Sciences Merial Animal Health

The trematodes of the genus Eurytrema are low pathogenic pancreatic parasites, but can be related to a decrease in cattle productive performance and eventually death. Parasitized animals develop chronic interstitial pancreatitis and may show a productive performance drop and emaciation. Human infection by Eurytrema sp. has already been reported in other countries as an incidental finding during autopsy or routine tests, but the parasite has not been found in humans in Brazil. However, it is possible that a large number of people could be infected, since parasitological tests have low sensitivity and the parasite is neglected as a pathogen for humans and even animals. Attempts to control and treat Eurytrematosis have generally presented low effectiveness. With the aim to control the disease and provide more information regarding its pathogenicity, our research group is developing a number of studies about Eurytrema spp. We hope to determine the damage in productivity, as well as, establish an efficient protocol for treatment and control of Eurytrematosis based on immunoprophylaxis and antiparasitical drug therapy.

关键词： Public health Pathology Diseases of cattle Oxidative stress Parasitical immunoprofilaxis

Periodic Modulation of Nonlinearity in a Fiber Bragg Grating: A Numerical Investigation

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Beta-blocker therapy in elderly patients with renal dysfunction and heart failure

Journal of Electromagnetic Analysis and Applications（电磁分析与应用期刊） 2012年第2期

作者： Antonio Francisco Gomes Furtado Filho José Rubens Rodrigues de Sousa Apiano Ferreira de Morais Neto jose Wally Mendonça Menezes Antonio Sergio Bezerra Sombra

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Journal of Geriatric Cardiology 2021年第1期18卷 20-29页

作者： Juan Martínez-Milla Marcelino Cortés García Julia Anna Palfy Mikel Taibo Urquía Marta López Castillo Ana Devesa Arbiol Ana Lucía Rivero Monteagudo María Luisa Martín Mariscal Inés Jiménez-Varas Sem Briongos Figuero Juan Antonio Franco-Pelaéz JoséTuñón Department of Cardiology Hospital Universitario Fundación Jiménez Díaz-Quirónsalud Centro Nacional de Investigaciones Cardiovasculares MadridSpain Department of Cardiology Hospital Central de Asturias Department of Cardiology Hospital Universitario Ruber-Quirónsalud Department of Cardiology Hospital Universitario Infanta Leonor Department of Endocrinology Hospital Clínico San Carlos Universidad Autónoma de Madrid CIBERCV MadridSpain

OBJECTIVE To assess the role of beta-blockers(BB)in patients with chronic kidney disease(CKD)aged≥75 *** AND RESULTS From January 2008 to July 2014,we included 390 consecutive patients≥75 years of age with ejection fraction≤35%and glomerular filtration rate(GFR)≤60 m L/min per 1.73 m^*** analyzed the relationship between treatment with BB and mortality or cardiovascular *** mean age of our population was 82.6±4.1 *** ejection fraction was 27.9%±6.5%.GFR was 60-45 m L/min per 1.73 m^2 in 50.3%of patients,45-30 m L/min per 1.73 m^2 in 37.4%,and<30 m L/min per 1.73 m^2 in 12.3%.At the conclusion of follow-up,67.4%of patients were receiving *** median follow-up was28.04(IR:19.41-36.67)*** the study period,211 patients(54.1%)died and 257(65.9%)had a major cardiovascular event(death or hospitalization for heart failure).BB use was significantly associated with a reduced risk of death(HR=0.51,95%CI:0.35-0.74;P<0.001).Patients receiving BB consistently showed a reduced risk of death across the different stages of CKD:stage IIIa(GFR=30-45 m L/min per 1.73 m^2;HR=0.47,95%CI:0.26-0.86,P<0.0001),stage IIIb(GFR 30-45 m L/min per 1.73 m^2;HR=0.55,95%CI:0.26-1.06,P=0.007),and stages IV and V(GFR<30 m L/min per 1.73 m~2;HR=0.29,95%CI:0.11-0.76;P=0.047).CONCLUSIONS The use of BB in elderly patients with HFr EF and renal impairment was associated with a better *** of BB should be encouraged when possible.

关键词： CKD GFR Beta-blocker therapy in elderly patients with renal dysfunction and heart failure

数字地面模型新进展:TIN2.0、3D表面塑型线和自由形态建模工具

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中国园林 2020年第9期36卷 36-41页

作者： [葡萄牙]何塞·米格尔·拉米拉斯 [葡萄牙]保罗·法里尼亚·马克斯原茵(译) 李傲雪(译) 波尔图大学科学系风景园林学波尔多大学科学系 CIBIO(波尔图大学遗传资源和生物多样性研究中心) 英国谢菲尔德大学建筑学系波尔图大学科学系清华大学建筑学院北京100084

竖向设计是人类在景观中进行的基本活动。人类对室外空间的任何干预都涉及对地表形态的设计。在过去的几十年中,数字设计的发展不仅改变了表现的方法,而且改变了设计的过程。就地形建模而言,该技术实现了三维可视化和任务自动化,例如土... 详细信息

竖向设计是人类在景观中进行的基本活动。人类对室外空间的任何干预都涉及对地表形态的设计。在过去的几十年中,数字设计的发展不仅改变了表现的方法,而且改变了设计的过程。就地形建模而言,该技术实现了三维可视化和任务自动化,例如土方计算和自动产生横截面。但在重点考察最新的建筑信息模型(BIM)如何应用和实施这项技术时,不难发现地形建模过程并没有充分利用技术带来的潜在优势。实际上,三维建模工具、基于组件的建模和分析、设计验证,以及协同设计是可以集成到数字地面模型中的。识别了现有数字建模解决方案中的主要缺陷并为其进一步发展提供机会,提出了一项整合性的数字地面模型建模过程,该过程引入了TIN2.0曲面,对现有的TIN曲面进行了升级,允许在同一曲面中同时存在规则三角网和不规则三角网,并开发了一套基于三维线和自由形态设计工具的建模工具,推动风景园林信息模型框架的发展以满足风景园林师及其他专业人士,如建筑师和土木工程师进行地形建模的需求。通过案例研究对提出的建模过程进行了测试和验证。结果表明,生成的数字曲面具有较高精度,可以具象地表现地形,允许设计过程在三维线或自由形态设计工具的基础上进行。所有地形建模均在三维数字模型上进行。

关键词：风景园林数字地面模型风景园林信息模型(LIM) 竖向设计数字模型工具

Nat Med:靶向两分子或有助于彻底治愈白血病

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现代生物医学进展 2017年第17期17卷 I0001-I0001页

作者： Meenu Kesarwani, Zachary Kincaid, Ahmed Gomaa, Erika Huber, Sara Rohrabaugh, Zain Siddiqui, Muhammad F Bouso, Kakajan Komurov, James C Mulloy, jose A Cancelas, H Leighton Grimes Mohammad Azam Tahir Latif Ming Xu H Leighton Grimes Mohammad Azam Division of Experimental Hematology Cincinnati Children’s Hospital Medical Center Cincinnati Ohio USA Department of Medicine University of Cincinnati Cincinnati Ohio USA Department of Anesthesia and Critical Care University of Chicago Chicago Illinois USA Division of Immunobiology Cincinnati Children’s Hospital Medical Center Cincinnati Ohio USA Division of Pathology Cincinnati Children’s Hospital Medical Center Cincinnati Ohio USA.

科学家在癌细胞内发现两个信号蛋白能够让癌细胞抵抗化疗。研究表明阻断这两种蛋白能够增强化疗对人类白血病小鼠模型的治疗效果。相关研究结果发表在国际学术期刊NatureMedicine上。研究人员发现在治疗中阻断c-Fos和Dusp1这两个蛋白能... 详细信息

科学家在癌细胞内发现两个信号蛋白能够让癌细胞抵抗化疗。研究表明阻断这两种蛋白能够增强化疗对人类白血病小鼠模型的治疗效果。相关研究结果发表在国际学术期刊NatureMedicine上。研究人员发现在治疗中阻断c-Fos和Dusp1这两个蛋白能够治愈一些受激酶驱动且抵抗治疗的白血病和实体瘤。

关键词：白血病治愈 Nat Med 分子信号蛋白治疗效果国际学术期刊