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First isolation and identification of H1N1 swine influenza viruses in Colombian pig farms

Health 2012年第10期4卷 983-990页

作者： Gloria Consuelo Ramirez-Nieto Cesar Augusto Diaz Rojas Victor Julio Vera Alfonso Jairo Jaime Correa jose dario mogollon galvis Línea de Microbiología y Epidemiología Posgrado en Salud Animal Facultad de Medicina Veterinaria y de Zootecnia Universidad Nacional de Colombia Bogotá Colombia

The pig industry in Colombia has grown 30% in the last decade achieving high levels of technology and efficiency;in spite of that, respiratory diseases remain a constraint. Since 1970, serological evidence and histological findings suggested the role of swine influenza virus (SIV) as part of the porcine respiratory disease complex;nevertheless, elusive and molecular typing isolates are missing. This study was aimed at isolating SIV from intensive pig farms and to achieve molecular characterization to determine strains circulating in the field. In order to accomplish this goal, 242 samples were taken from nasal swabs, 25 from bronchial washes and 8 from lung tissue. Samples were collected during a period of three years, between 2008 and 2010 and were originated from 78 farms of the three main pig production regions of the country. The samples were transported in BHI broth with 2% antibiotic and antimycotic solution and stored at –70?C until processed. The swabs were inoculated in 9 - 11 days old embryo chicken eggs and in MDCK (Madin Darby Canine Kidney) cell cultures with the addition of trypsin. The isolates were identified by the HA (hemoagglutination) test and by RT-PCR targeting the HA (hemagglutinin), NA (Neuraminidase) and M (Matrix) genes. Full length sequence of the HA and NA glycoproteins from four selected virus isolates was conducted (Macrogen?. USA). As a result, fifteen SIV isolates from nine farms distributed in the three regions were obtained. Twelve of the isolates are related to the swine origin H1N1 virus that caused the 2009 influenza pandemic. The remaining three viruses were related to classical swine influenza viruses.

关键词： Swine Influenza H1N1 Colombia First Isolation Classical Pandemic

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Ion channels, phosphorylation and mammalian sperm apacitation

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Asian Journal of Andrology 2011年第3期13卷 395-405,511页

作者： Pablo E Visconti dario Krapf jose Luis de la Vega-Beltran Juan jose Acevedo Alberto Darszon Department of Veterinary and Animal Science Paige Labs University of Massachusets Amherst MA 01003 USA Institute of Molecular and Cell Biology of Rosario （CONICETUNR） and Area Biologia Facultad de Ciencias Biologicas y Farmaceuticas UNR Rosario 2000 Argentina Departamento de Genetica del Desarrollo y Fisiologia Molecular Institute de Biotecnologia Universidad Nacional Autonoma de Mexico （UNAM） Cuemavaca Merelos C.P. 62510 Mexico Departamento de Fisiologia y Farmacologia Facultad de Medicina Universidad Autenoma del Estado de Morelas Cuernavaca C.P. 62510 Mexico

Sexually reproducing animals require an orchestrated communication between spermatozoa and the egg to generate a new individual. Capacitation, a maturational complex phenomenon that occurs in the female reproductive tract, renders spermatozoa capable of binding and fusing with the oocyte, and it is a requirement for mammalian fertilization. Capacitation encompasses plasma membrane reorganization, ion permeability regulation, cholesterol loss and changes in the phosphorylation state of many proteins. Novel tools to study sperm ion channels, image intracellular ionic changes and proteins with better spatial and temporal resolution, are unraveling how modifications in sperm ion transport and phosphorylation states lead to capacitation. Recent evidence indicates that two parallel pathways regulate phosphorylation events leading to capacitation, one of them requiring activation of protein kinase A and the second one involving inactivation of ser/thr phosphatases. This review examines the involvement of ion transporters and phosphorylation signaling processes needed for spermatozoa to achieve capacitation. Understanding the molecular mechanisms leading to fertilization is central for societies to deal with rising male infertility rates, to develop safe male gamete-based contraceptives and to preserve biodiversity through better assisted fertilization strategies.

关键词： capacitation ion channels lipids phosphorylation sperm

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Spacecraft collision avoidance challenge:Design and results of a machine learning competition

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Astrodynamics 2022年第2期6卷 121-140页

作者： Thomas Uriot dario Izzo Luís FSimões Rasit Abay Nils Einecke Sven Rebhan jose Martinez-Heras Francesca Letizia Jan Siminski Klaus Merz The European Space Agency Noordwijk2201 AZthe Netherlands ML Analytics LisbonPortugal FuturifAI CanberraAustralia Honda Research Institute Europe GmbH Offenbach 63073Germany ESOC Space Debris OfficeDarmstadt 64293Germany

Spacecraft collision avoidance procedures have become an essential part of satellite *** and constantly updated estimates of the collision risk between orbiting objects inform various operators who can then plan risk mitigation *** measures can be aided by the development of suitable machine learning(ML)models that predict,for example,the evolution of the collision risk over *** October 2019,in an attempt to study this opportunity,the European Space Agency released a large curated dataset containing information about close approach events in the form of conjunction data messages(CDMs),which was collected from 2015 to *** dataset was used in the Spacecraft Collision Avoidance Challenge,which was an ML competition where participants had to build models to predict the final collision risk between orbiting *** paper describes the design and results of the competition and discusses the challenges and lessons learned when applying ML methods to this problem domain.

关键词： space debris collision avoidance competition kelvins

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Covalent functionalization of decellularized tissues accelerates endothelialization

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Bioactive Materials 2021年第11期6卷 3851-3864页

作者： Eleonora Dal Sasso Annj Zamuner Andrea Filippi Filippo Romanato Tiziana Palmosi Luca Vedovelli dario Gregori jose Luís Gòmez Ribelles Teresa Russo Antonio Gloria Laura Iop Gino Gerosa Monica Dettin Department of Cardiac Thoracic and Vascular Sciences and Venetian Institute of Molecular MedicinePaduaItaly Department of Industrial Engineering University of PaduaPaduaItaly LIFELAB Program Consorzio per la Ricerca SanitariaCORISVeneto RegionItaly Department of Physics and Astronomy“G.Galilei” University of PaduaPaduaItaly Fondazione Bruno Kessler TrentoItaly Institute of Pediatric Research Citt`a della Speranza PaduaItaly Center for Biomaterials and Tissue Engineering CBITUniversitat Polit`ecnica de Val`enciaVal`enciaSpain Biomedical Research Networking Center on Bioengineering Biomaterials and Nanomedicine(CIBER-BBN)ValenciaSpain Institute of Polymers Composites and BiomaterialsNational Research Council of ItalyNaplesItaly

In the field of tissue regeneration,the lack of a stable endothelial lining may affect the hemocompatibility of both synthetic and biological *** drawbacks might be prevented by specific biomaterial functionalization to induce selective endothelial cell(EC)*** bovine pericardia and porcine aortas were selectively functionalized with a REDV tetrapeptide at 10^(-5)M and 10^(-6)M working *** scaffold-bound peptide was quantified and REDV potential EC adhesion enhancement was evaluated in vitro by static seeding of human umbilical vein *** viable cells and MTS production were statistically higher in functionalized tissues than in *** histoarchitecture,geometrical features,and mechanical properties were unaffected by peptide *** selective immobilization of REDV was effective in accelerating ECs adhesion while promoting proliferation in functionalized decellularized tissues intended for blood-contacting applications.

关键词： Decellularized pericardium Decellularized aorta Covalent functionalization Endothelialization REDV Mechanical analysis

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A nonlinear relapse model with disaggregated contact rates:Analysis of a forward-backward bifurcation

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Infectious Disease Modelling 2023年第3期8卷 769-782页

作者： Jimmy Calvo-Monge Fabio Sanchez Juan Gabriel Calvo dario Mena Escuela de Matematica Universidad de Costa RicaCiudad Universitaria Rodrigo FacioSan Jose11501Costa Rica Centro de Investigacion en Matematica Pura y Aplicada Universidad de Costa RicaCiudad Universitaria Rodrigo FacioSan Jose11501Costa Rica

Throughout the progress of epidemic scenarios,individuals in different health classes are expected to have different average daily contact *** contact heterogeneity has been studied in recent adaptive models and allows us to capture the inherent differences across health statuses *** with reinfection bring out more complex scenarios and offer an important application to consider contact ***,we developed a nonlinear differential equation model to explore the dynamics of relapse phenomena and contact differences across health *** incidence rate function is formulated,taking inspiration from recent adaptive *** incorporates contact behavior for individuals in each health *** use constant contact rates at each health status for our analytical results and prove conditions for different forward-backward bifurcation *** relationship between the different contact rates heavily in-fluences these *** examples highlight the effect of temporarily recov-ered individuals and initial conditions on infected population persistence.

关键词： Nonlinear relapse Nonlinear incidence MaMthematical model Backward bifurcation Adaptive behavior 2000 MSC 37N25 92B05

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Embedding physics domain knowledge into a Bayesian network enables layer-by-layer process innovation for photovoltaics

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npj Computational Materials 2020年第1期6卷 1592-1600页

作者： Zekun Ren Felipe Oviedo Maung Thway Siyu I.P.Tian Yue Wang Hansong Xue jose dario Perea Mariya Layurova Thomas Heumueller Erik Birgersson Armin G.Aberle Christoph J.Brabec Rolf Stangl Qianxiao Li Shijing Sun Fen Lin Ian Marius Peters Tonio Buonassisi Singapore-MIT Alliance for Research and Technology SMART Singapore 138602Singapore Solar Energy Research Institute of Singapore(SERIS) National University of SingaporeSingapore 117574Singapore Massachusetts Institute of Technology CambridgeMA 02139USA Institute of Materials for Electronics and Energy Technology(i-MEET) Friedrich-Alexander University Erlangen-Nürnberg91058 ErlangenGermany Helmholtz Institute HI-ErN Forschungszentrum JülichImmerwahrstrasse 291058 ErlangenGermany National University of Singapore Singapore 119077Singapore

Process optimization of photovoltaic devices is a time-intensive,trial-and-error endeavor,which lacks full transparency of the underlying physics and relies on user-imposed constraints that may or may not lead to a global ***,we demonstrate that embedding physics domain knowledge into a Bayesian network enables an optimization approach for gallium arsenide(GaAs)solar cells that identifies the root cause(s)of underperformance with layer-by-layer resolution and reveals alternative optimal process windows beyond traditional black-box *** Bayesian network approach links a key GaAs process variable(growth temperature)to material descriptors(bulk and interface properties,e.g.,bulk lifetime,doping,and surface recombination)and device performance parameters(e.g.,cell efficiency).For this purpose,we combine a Bayesian inference framework with a neural network surrogate device-physics model that is 100×faster than numerical *** the trained surrogate model and only a small number of experimental samples,our approach reduces significantly the time-consuming intervention and characterization required by the *** a demonstration of our method,in only five metal organic chemical vapor depositions,we identify a superior growth temperature profile for the window,bulk,and back surface field layer of a GaAs solar cell,without any secondary measurements,and demonstrate a 6.5%relative AM1.5G efficiency improvement above traditional grid search methods.

关键词： knowledge network enable

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钢铁业并购新趋势

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董事会 2010年第12期 52-54页

作者： dario Gaspar jose Roberto Dalmolim Livia Masiero Andre Rachik 科尔尼公司

政府意图提高资源可持续能力并增强本地竞争力,这是对采矿及钢铁行业影响力度最大的监管行为,此举通常意味着对本地企业实施保护及优惠政策。我们认为。

关键词：钢铁业并购监管行为可持续能力钢铁行业优惠政策本地企业竞争力

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Mobilizing Crop Biodiversity

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Molecular Plant 2020年第10期13卷 1341-1344页

作者： Susan McCouch Zahra Katy Navabi Michael Abberton Noelle L.Anglin Rosa Lia Barbieri Michael Baum Kirstin Bett Helen Booker Gerald L.Brown Glenn J.Bryan Luigi Cattivelli David Charest Kellye Eversole Marcelo Freitas Kioumars Ghamkhar dario Grattipaglia Robert Henry Maria Cleria Valadares Inglis Tofazzal Islam Zakaria Kehel Paul J.Kersey Graham J.King Stephen Kresovich Emily Marden Sean Mayes Marie Noelle Ndjiondjiop Henry T.Nguyen Samuel Rezende Paiva Roberto Papa Peter W.B.Phillips Awais Rasheed Christopher Richards Mathieu Flouard Maria jose Amstalden Sampaio Uwe Scholz Paul D.Shaw Brad Sherman S.Evan Staton Nils Stein Jan Svensson Mark Tester jose Francisco Montenegro Valls Rajeev Varshney Stephen Visscher Eric von Wettberg Robbie Waugh Peter Wenzl Loren H.Rieseberg Plant Breeding and Genetics School of Integrated Plant SciencesCornell UniversityIthacaNY14853USA DivSeek Global Institute for Food Security110 Gymnasium PlaceUniversity of SaskatchewanSaskatoonSKS7N 0W9Canada lnternational Institute of Tropical Agriculture(IITA) PMB 5320Oyo RdIbadanNigeria International Potato Center(CIP)1895 Avenida La Molina Lima Peru 12Lima 15023Peru Embrapa Genetic Resources and Biotechnology Parque Estacjao BiologicaFinal Av W5 NorteCaixa Postal 0237270770-917-Brasilia DFBrazil International Center for Agricultural Research in the Dry Areas(I CAR DA) Station Exp.INRA-Quich.Rue Hafiane Cherkaoui.Agdal.Rabat-Instituts10111RabatMorocco Department of Plant Sciences University of Saskatchewan51 Campus Dr.SaskatoonSK S7N 5A8Canada Department of Plant Agriculture University of GuelphRm 316Crop Science Bldg50 Stone Rd EGuelphON N1G 2W1Canada Genome Prairie 111 Research DriveSuite 101SaskatoonSKS7N 3R2Canada The James Hutt on Institute Errol RoadInvergowrieDundeeDD25DAUK CREA Research Centre for Genomics and Bioinformaticsvia San Protaso 302Fiorenzuola d'Arda29017Italy Genome British Columbia 400-575 West 8th AvenueVancouverBCV5Z 0C4Canada International Wheat Genome Sequencing Consortium 2841 NE Marywood CtLee's SummitMO.64086USA Forage Science Grasslands Research CentreAgResearchPalmerston North4410New Zealand Queensla nd Alliance for Agriculture and Food Inn ovation University of QueenslandBrisbaneQLD 4072Australia Institute of Biotechnology and Genetic Engineering(IBGE) Bangabandhu Sheikh Mujibur Rahman Agricultural UniversityGazipur 1706Bangladesh Southern Cross University PO Box 157LismoreNSW 2480Australia Royal Botanic Gardens KewRichmondSurreyTW93AEUK Feed the Future Innovation Lab for Crop Improvement 431 Weill HallCornell UniversityIthacaNY14853USA Department of Botany and Biodiversity Research Centre University of British ColumbiaVancouverBC V6R 2A5Canada Crops For the Future(UK)CIC 76-80 Baddow Road ChelmsfordEs

Over the past 70 years,the world has witnessed extraordinary growth in crop productivity,enabled by a suite of technological advances,including higher yielding crop varieties,improved farm management,synthetic agrochemicals,and agricultural *** this"Green Revolution"intensified crop production,and is credited with reducing famine and malnutrition,its benefits were accompanied by several undesirable collateral effects(Pingali,2012).These include a narrowing of agricultural biodiversity,stemming from increased monoculture and greater reliance on a smaller number of crops and crop varieties for the majority of our *** reduction in diversity has created vulnerabilities to pest and disease epidemics,climate variation,and ultimately to human health(Harlan,1972).

关键词： intensified crops agricultural

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Author Correction:Embedding physics domain knowledge into a Bayesian network enables layer-by-layer process innovation for photovoltaics

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npj Computational Materials 2020年第1期6卷 955-955页

作者： Zekun Ren Felipe Oviedo Maung Thway Siyu I.P.Tian Yue Wang Hansong Xue jose dario Perea Mariya Layurova Thomas Heumueller Erik Birgersson Armin G.Aberle Christoph J.Brabec Rolf Stangl Qianxiao Li Shijing Sun Fen Lin Ian Marius Peters Tonio Buonassisi Singapore-MIT Alliance for Research and Technology SMART Singapore Singapore Solar Energy Research Institute of Singapore (SERIS) National University of Singapore Singapore Singapore Massachusetts Institute of Technology Cambridge USA Institute of Materials for Electronics and Energy Technology (i-MEET) Friedrich-Alexander University Erlangen-Nürnberg Erlangen Germany Helmholtz Institute HI-ErN Forschungszentrum Jülich Erlangen Germany National University of Singapore Singapore Singapore

In the original version of the published Article,there was ambiguity in Eq.(1).To improve clarity,Eq.(1)has been corrected to the following.

关键词： enable corrected ambiguity

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