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New insights into the relevance of mobile DNA to cancer resistance in blind mole rats:new lessons for cancer therapy

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Cellular & Molecular Immunology 2022年第4期19卷 458-459页

作者： Victor M.Arce jose a.costoya Molecular Oncology Laboratory MOL Departamento de FisioloxíaCentro Singular de Investigación en Medicina Molecular e Enfermidades Crónicas(CiMUS)Facultade de MedicinaUniversidade de Santiago de CompostelaInstituto de Investigación Sanitaria de Santiago de Compostela(IDIS)15782Santiago de CompostelaSpain

Although mammals differ substantially in their cancer incidence rates and in the importance of age as a cancer risk factor,there is a scaling of cancer incidence to the lifespan in most *** evolution has selected strategies that maximize reproductive success,which include the development of efficient mechanisms to defer the initiation of cancer until postreproductive age[1].Owing to this,cancers are very rare among wild animals(which do not typically live beyond their reproductive ages).

关键词： cancer insight resistance

Cancer cells escape the immune system by increasing stemness through epigenetic reprogramming

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Cellular & Molecular Immunology 2023年第1期20卷 6-7页

作者： jose a.costoya Victor M.Arce Molecular Oncology Laboratory MOL Departamento de FisioloxíaCentro Singular de Investigación en Medicina Molecular e Enfermidades Crónicas(CiMUS)Facultade de MedicinaUniversidade de Santiago de CompostelaInstituto de Investigación Sanitaria de Santiago de Compostela(IDIS)15782Santiago de CompostelaSpain

Cancer stem cells(CSCs),also known as tumor initiating cells,are a minority subpopulation of undifferentiated cancerous cells within the entire tumor that hold self-renewal capacity and differentiation *** are critical for tumor progression,heterogeneity and metastasis and play a major role in chemo-and radiation-resistance and tumor recurrence[1].Although the molecular mechanisms underlying the ability of CSCs to give rise to new tumors and promote resistance to many cancer therapies are not completely understood,increasing knowledge suggests potential roles for these cells in the evasion of immune surveillance[2,3].

关键词： Cancer programming initiating

Unveiling the brain’s symphony:exploring the necessity and sufficiency of neural networks in behavior control

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Neural Regeneration Research 2025年第1期20卷 186-187页

作者： Fernando jose Bustos Instituto de Ciencias Biomedicas Facultad de Medicina y Facultad de Ciencias de la VidaUniversidad Andres BelloSantiagoChile Millennium Nucleus of Neuroepigenetics and Plasticity(EpiNeuro) SantiagoChile

Since the pioneering work by Broca and Wernicke in the 19th century,who examined individuals with brain lesions to associate them with specific behaviors,it was evident that behaviors are complex and cannot be fully attributable to specific brain areas ***,they involve connectivity among brain areas,whether close or *** that time,this approach was considered the optimal way to dissect brain circuitry and *** pioneering efforts opened the field to explore the necessity or sufficiency of brain areas in controlling behavior and hence dissecting brain ***,the connectivity of the brain and the mechanisms through which various brain regions regulate specific behaviors,either individually or collaboratively,remain largely *** animal models,researchers have endeavored to unravel the necessity or sufficiency of specific brain areas in influencing behavior;however,no clear associations have been firmly established.

关键词： behavior connectivity neural

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Perceptions and emotions in postoperative recovery of patients with perianal diseases

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World Journal of Psychiatry 2025年第1期15卷 179-184页

作者： Bryan Adrian Priego-Parra jose Maria Remes-Troche Digestive Physiology and Gastrointestinal Motility Lab Instituto de Investigaciones Médico-BiológicasUniversidad VeracruzanaVeracruz 91700Mexico

This article examines the complex relationship between disease perception,negative emotions,and their impact on postoperative recovery in patients with perianal *** conditions not only cause physical discomfort,but also carry a significant emotional burden,often exacerbated by social ***-logical factors,including stress,anxiety,and depression,activate neuroendocrine pathways,such as the hypothalamic–pituitary–adrenal axis,disrupting the gut microbiota and leading to *** disruption can delay wound healing,prolong hospital stay,and intensify *** on the findings of Hou et al,our article highlights the critical role of illness perception and negative emotions in shaping recovery *** advocates for a holistic approach that integrates psychological support and gut microbiota modulation,to enhance healing and improve overall patient outcomes.

关键词： Perianal disease Illness perception Gut microbiota Post-surgical outcomes Microbiota

Challenges and improvement strategies in the hospitalization of chronic multimorbid patients

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World Journal of Clinical Cases 2025年第3期13卷 35-41页

作者： Andres Fontalba-Navas Francisco Pozo Muñoz Rogelio Garcia Cisneros Maria jose Garcia Larrosa Maria del Mar Callejon Gil Ignacio Garcia Delgado Maria Belen Jimenez Martinez Antequera Hospital Northern Málaga Integrated Healthcare AreaAntequera 29200AndalusiaSpain Department of Public Health and Psychiatry University of MálagaMálaga 29010Spain Antequera Hospital Northern Málaga Antequera Integrated Healthcare AreaAntequera 29200MálagaSpain

BACKGROUND Addressing the growing challenge of hospitalizing chronic multimorbid patients,this study examines the strain these conditions impose on healthcare systems at a local level,focusing on a pilot *** diseases and complex patients require comprehensive management strategies to reduce healthcare burdens and improve patient *** proven effective,this pilot model has the potential to be replicated in other healthcare settings to enhance the management of chronic multimorbid *** To evaluate the effectiveness of the high complexity unit(HCU)in managing chronic multimorbid patients through a multidisciplinary care model and to compare it with standard hospital *** The study employed a descriptive longitudinal approach,analyzing data from the Basic Minimum Data Set(BMDS)to compare hospitalization variables among the HCU,the Internal Medicine Service,and other services at Antequera Hospital throughout *** HCU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity *** The study employed a descriptive longitudinal approach,analyzing data from the BMDS to compare hospitalization variables among the HCU,the Internal Medicine Service,and other services at Antequera Hospital throughout *** HCU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity *** This study demonstrates the effectiveness of the HCU in managing patients with complex chronic diseases through a multidisciplinary *** coordinated care provided by the HCU results in improved patient outcomes,reduced unnecessary hospitalizations,and better management of patient *** superiority of the HCU compared to standard care is evident in key outcomes such as fewer readmissions and higher patient satisfaction,reinforcing its value as a model of ca

关键词： High complexity unit Chronic multimorbidity Patient-centered care Integrated care Healthcare management

Mercury uptake and effects on growth in Jatropha curcas

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Journal of Environmental Sciences 2016年第10期28卷 120-125页

作者： jose Marrugo-Negrete jose Durango-Hernandez jose Pinedo-Hernandez German Enamorado-Montes Sergi Diez University of Cordoba Faculty of Basic Sciences Department of Chemistry Water Applied and Environmental Chemistry Group Monteria Colombia Environmental Chemistry Department Institute of Environmental Assessment and Water Research ID█A-CSIC E-08034 Barcelona Spain

The use of metal-accumulating plants for the phytoremediation of contaminated soils is gaining more attention. Mercury （Hg）-contaminated soils from historical gold mines represent a potential risk to human health and the environment. Therefore, Jatropha curcas plant, that has shown its tolerance to these environments, is a species of particular interest to implement phytoremediation techniques in gold mining sites. In this work, the behavior of J. curcas was assessed in different hydroponic cultures fortified with Hg at concentrations of 5, 10, 20, 40, and 80μg Hg/mL （T5, T10, T20, T40 and T80, respectively）. After exposure, plant growth, net photosynthesis, leaf area, and Hg accumulation were determined and variables such as net Hg uptake, effective Hg accumulation, translocation and bioaccumu- lation factors were calculated. Accumulation of Hg in root and leaf tissues increased with respect to the Hg concentrations in the hydroponic culture, with statistically significant differences （p 〈 0.05） among treatments. Moreover, Hg concentration in roots was 7 and 12-fold higher in average than in plant leaves and shoots, respectively. Many effects were found in the development of plants, especially related with loss of biomass and leaf area, with significant growth inhibition related to control values （〉50% with treatment T5）. Moreover, percentage of inhibition was even higher （〉60%） with same treatment for net photosynthesis. Finally, it should be highlighted that for T40 and T80 treatments, plant growth and photosynthesis were almost completely depleted （88%-95%）.

关键词： Jatropha curcasPhytoextractionMercuryHydroponicGrowth inhibition

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Comparative study of degradation of toluene and methyl isobutyl ketone(MIBK)in aqueous solution by pulsed corona discharge plasma

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Journal of Environmental Sciences 2021年第3期33卷 382-396页

作者： Jerin jose Ligy Philip Department of Civil Engineering Indian Institute of Technology MadrasChennai 600036India

Effectiveness of pulsed power plasma for the degradation of two toxic volatile organic compounds(VOCs),toluene and methyl isobutyl ketone(MIBK),in aqueous solution was *** plasma degradation of MIBK has been studied for the first *** influence of initial concentration of target compound,solution pH and scavengers on percentage degradation was evaluated.100%removal of 200 mg/L of toluene and MIBK was achieved both in liquid and gaseous phases after 12 and 16 min of plasma treatment,*** first order rate constant of toluene and MIBK degradation(for 200 mg/L each)was 0.421 and 0.319 min~(-1)respectively when they were treated individually,and these values decreased slightly during degradation of their *** degradation was slower than toluene and it might be due to semi volatile and hydrophilic nature of *** effect of initial concentration of toluene and MIBK showed different degradation *** degradation of both the compounds was obtained in neutral pH and in absence of scavengers.·OH radical was the major reactive species involved in their *** degradation in real environmental matrices showed that removal reduced significantly in secondary effluent due to scavenging of reactive species by various ions and organic *** total number of degradation intermediates identified in case of toluene and MIBK was 11 and 14 respectively and formate was the one recalcitrant byproduct *** degradation pathway of toluene and MIBK involving reactions of reactive oxygen and nitrogen species and reductive species is proposed.

关键词： Degradation pathway Methyl isobutyl ketone(MIBK) OH radical Pulsed power plasma Toluene

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Scale-Covariant Theory of Gravitation Through Self-Similarity

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Chinese Physics Letters 2012年第5期29卷 33-36页

作者： jose Antonio Belinchon Department of Nuclear Molecular and Atomic PhysicsUniversity Complutense of MadridE-28040Spain

We study the scale-covariant theory of gravitation proposed by Canuto under the self-similar *** considering the matter collineation approach,we deduce the form of the main quantities and obtain some restrictions on the behavior of the gauge function,φ(t).We apply the obtained results to study the Bianchi I,Ⅶo,Ⅸ and Kantowsky Sachs models,and arrive at the conclusion that instead of considering a varying G theory,the solution is only valid for a particular value of the parameter of the equation of state,γ,.This leads us to obtain φ(t) =const,and by taking into account the external condition,Gφ2 =const,we may arrive at the conclusion that G=***,all the obtained solutions are the same as the ones obtained in the framework of general relativity.

关键词： const conclusion considering

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Microwave photonics

Science China(Information Sciences) 2022年第12期65卷 49-112页

作者： Jianping YAO jose CAPMANY Microwave Photonics Research Laboratory School of Electrical Engineering and Computer Science University of Ottawa ITEAM Research Institute Universitat Politècnica de València iPronics Programmable Photonics

Microwave photonics, an interdisciplinary field that combines microwave engineering and photonic technology for the generation, transmission, processing, and control of microwave signals, to take advantage of the broad bandwidth, high frequency, and low loss offered by modern photonics, has been intensively researched for the last few decades, and numerous solutions have been proposed and demonstrated. In this article, an overview about microwave photonics is provided which covers the basic concepts of microwave photonics, photonic-assisted microwave signal generation, photonic-assisted microwave signal processing, and true time delay beamforming. The implementation of microwave photonic systems based on photonic integrated circuits is also reviewed, including the design, fabrication, and material platforms, application-specific photonic integrated circuits for microwave photonics, and programmable integrated microwave *** challenges and future applications of microwave photonics are also discussed.

关键词： microwave photonics photonic integrated circuits microwave photonic link microwave photonic signal processor optoelectronic oscillator radio over fiber

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