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中华儿科杂志 1999年第4期37卷 210-212页

作者：周湘 MANIAR,S 中日友好医院儿科

目的研究慢性代谢性酸中毒（ＣＭＡ）对胰岛素样生长因子（ＩＧＦ１）及其结合蛋白（ＩＧＦＢＰｓ）的影响。方法采用Ｗｅｓｔｅｒｎｌｉｇａｎｄｂｌｏｔ等方法，对随意进食组（ＡＬ）、尿毒症酸中毒组（ＵＡ）及其对照组尿毒症未合... 详细信息

目的研究慢性代谢性酸中毒（ＣＭＡ）对胰岛素样生长因子（ＩＧＦ１）及其结合蛋白（ＩＧＦＢＰｓ）的影响。方法采用Ｗｅｓｔｅｒｎｌｉｇａｎｄｂｌｏｔ等方法，对随意进食组（ＡＬ）、尿毒症酸中毒组（ＵＡ）及其对照组尿毒症未合并酸中毒组（ＵＢ）、非尿毒症酸中毒组（ＣＡ）及其对照组无酸中毒（ＣＮＡ）组的大白鼠进行了血清ＩＧＦＢＰ１～４的测定，对ＵＡ、ＵＢ组肝脏ＩＧＦＢＰｓｍＲＮＡ进行了测定。结果ＵＡ的大白鼠每日身长增长（０．２９±０．０２）ｃｍ，食物身长效益为（０．２２±０．０１）ｍｍ／ｇ，低于ＵＢ组［（０．３６±０．０４）ｃｍ，（０．３１±０．０２）ｍｍ／ｇ］（Ｐ＜０．０１）；ＣＡ组的大白鼠每日身长增长（０．４６±０．０３）ｃｍ，食物身长效益为（０．４１±０．０２）ｍｍ／ｇ，低于ＣＮＡ组［（０．６４±０．０２）ｃｍ，（０．５５±０．０２）ｍｍ／ｇ］（Ｐ＜０．０１）。ＵＡ组与ＵＢ组血清ＩＧＨＢＰ２的比值为０６１，ＣＡ组与ＣＮＡ组的比值为０５７（Ｐ＜０．０５）；两对比组血清ＩＧＦＢＰ１的比值分别为２．８９倍、３．２６倍（Ｐ＜０．０１）；肝脏的ＩＧＦＢＰ１ｍＲＮＡ，在ＵＡ组为（１．２１±０．４６）Ｄｅｎｓ，在Ｕ?

关键词：酸中毒胰岛素样生长因子 IGF-1 IGFBPs

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努尔苏丹2030年规划(1)——机遇区规划

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城市设计 2021年第1期 20-37页

作者：埃德·帕拉姆奥斯卡·麦当劳何塞·路易斯·克鲁亚历山德拉·威尔莫特淮泽宇(译) 将姚贝龙(译) 英国伦敦空间句法有限公司清华大学

本文介绍了英国空间句法公司于2020年为哈萨克斯坦首都努尔苏丹市制定的规划设计方案,着重介绍了设计中制定的6个“发展机遇区”的城市规划设计,包括私人主导的区域A和区域B项目,公共部门主导的区域c试点项目、区域d、区域E以及区域F。

关键词：努尔苏丹2030年规划机遇区规划私人主导开发公共部门主导开发

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composition and distribution of Mosquito Vectors in a Peri-Urban community Surrounding an Institution of Learning in Lafia Metropolis,Nasarawa State,central Nigeria

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Journal of Zoological Research 2022年第3期4卷 20-31页

作者： Ombugadu,A. Jibril,A.B. Mwansat,G.S. Njila,H.L. Attah,A.S. pam,V.A. Benson,R.F. Maikenti,J.I. deme,G.G. Echor,B.O. Ayim,J.O. Uzoigwe,N.R. Adejoh,V.A. Ahmed,H.O. Aimankhu,O.P. da’an,S.A. Lapang,M.P. Kure,M.S. Samuel,M.d. Nkup,c.d. department of Zoology Faculty of ScienceFederal University of LafiaLafiaNasarawa StateNigeria department of Zoology Faculty of Natural SciencesUniversity of JosJosPlateau StateNigeria department of Science Laboratory Technology Faculty of Natural SciencesUniversity of JosJosPlateau StateNigeria State Key Laboratory of Ecology and conservation Institute of ZoologyChinese Academy of ScienceBeijing100101China A.P.Leventis Ornithological Research Institute University of Jos Biological ConservatoryP.O.Box 13404LamingaJos-EastPlateau StateNigeria department of Natural Science Oswald Waller College of Education LifidiP.O.Box 39Shendam LGAPlateau StateNigeria department of Biology School of Biological SciencesFederal University of TechnologyOwerriImo StateNigeria department of Biology College of ArtsScience and TechnologyKurgwiQua’an Pan LGAPlateau StateNigeria

Vector surveillance is very key in solving mosquito-borne health problems in *** this end,the composition and distribution of mosquito vectors in a peri-urban community surrounding an institution of learning in Lafia metropolis,Nasarawa State,central Nigeria was carried out between december 2016 and June *** Prokopack Aspirator was used to collect indoor resting mosquitoes between 6:00 *** 9:00 *** 30 randomly selected *** collected were knocked down and transferred into a well labelled petri-dish and taken to the laboratory for processing.A total of 664 mosquitoes were collected which spread across culex quinquefasciatus 572(86.14%),Anopheles gambiae 88(13.25%)and Aedes aegypti 4(0.60%).The abundance of mosquitoes in relation to seasons,species,sex,abdominal conditions as well as transmission indices across seasons significantly varied(Pdistribution of mosquito in relation to house types showed no significant difference(P>0.05).The inhabitants of the area should ensure that all drainages flow through so as to reduce mosquito breeding ***,members of the community should always protect themselves by sleeping under insecticide treated bed nets.

关键词： Mosquitoes Peri-urban area Institution Prokopack Aspirator House types Lafia

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diterpenoids from Scutellaria barbata induce tumour-selective cytotoxicity by taking the brakes off apoptosis

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Medicinal Plant Biology 2022年第1期1卷 8-23页

作者： Matthew L.Tomlinson Man Zhao Elaine J.Barclay Jie Li haixiu Li Juri Felix Lionel Hill Gerhard Saalbach Martin Rejzek dongfeng Yang Qing Zhao paul Kroon Wei Wang Yongping Bao Melanie-Jayne R.Howes Evangelos c.Tatsis cathie Martin The John Innes centre NorwichNR47UHUnited Kingdom college of Bioengineering and Biotechnology Zhejiang University of TechnologyHangzhou 310058China National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesShanghai Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China Royal Botanic Gardens Kew RichmondSurreyLondon TW93ABUnited Kingdom college of Life Sciences Zhejiang Sci-Tech UniversityXiasha Higher Education ZoneHangzhou 310018China Shanghai Key Laboratory of Plant Functional Genomics and Resources Shanghai Chenshan Botanical GardenShanghai Chenshan Plant Science Research CenterChinese Academy of SciencesShanghai 201602China Quadram Institute Bioscience Norwich Research ParkNorwichNR47UAUnited Kingdom Norwich Medical School University of East AngliaNorwichNorfolkNR47TJUnited Kingdom cEpaMS:cAS-JIc centre of Excellence in Plant and Microbial Sciences

Medicinal plants are an excellent source of structurally diverse,bio-active compounds with potential in the fight against *** of the most promising is Scutellaria barbata,prescribed traditionally for the treatment of *** A is the major diterpenoid,produced in specialized large,peltate trichomes on leaves of *** induces dose-dependent apoptosis,specifically in cancer *** major class of proteins down-regulated are pro-survival proteins,the Inhibitors of Apoptosis(IAPs),and IAP regulating *** propose that scutebarbatine A works by releasing the molecular brakes(the IAPs)on apoptosis in cell death-evading cancer *** between the cytotoxicity of methanolic extracts of *** leaves and decoctions(Ban Zhi Lian)prepared traditionally,showed substantially different chemical compositions and differential induction of *** suggest polyvalency between the constituents in both extracts,and ways to produce enhanced chemopreventive preparations for the treatment of cancer.

关键词： prescribed methanol structurally

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